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1.
Liu Manman Liu Junli Zhang Xiaoyan Xiao Yichuan Jiang Gengru Huang Xinfang 《Clinical rheumatology》2021,40(3):1103-1112
Clinical Rheumatology - Decreased natural killer (NK) cells have been reported in systemic lupus erythematosus (SLE) patients. However, the role of NK cells in the pathogenesis of SLE is not well... 相似文献
2.
核素^99mTc—DTPA测定GFR与公式估算GFR的相关性研究 总被引:1,自引:0,他引:1
目的:探讨核素^99mTc—DTPA测定GFR与MDRD公式、简化MDRD公式估算GFR的相关性。方法:178例CKD患者,用核素^99mTc—DTPA测定GFR,同时测定血清肌酐、尿素氮和白蛋白,根据年龄和性别分别用MDRD和简化MDRD公式估算GFR。结果:核素^99mTc—DTPA测定的GFR与MDRD公式估算的GFR有显著性差异,P=0.0001,MDRD公式高估了GFR;核素^99mTc—DTPA测定的GFR与简化MDRD公式估算的GFR亦有显著性差异,P=0.0001,简化MDRD公式低估了GFR;MDRD公式估算的GFR与核素^99mTc—DTPA测定的GFR呈正相关,r=0.8292,P〈0.01;简化MDRD公式估算的GFR与核素^99mTc—DTPA测定的GFR值呈正相关,r=0.8277,P〈0.01。结论:MDRD公式、简化MDRD公式估算的GFR与核素^99mTc—DTPA测得的GFR有差异,需进一步校正后用于估算GFR。 相似文献
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目的:探讨慢性肾功能不全患者肾功能不同程度减退时血清醛固酮(Ald)水平的变化趋势及两者的相关性。方法:各种病因导致的慢性肾功能不全而未开始替代治疗的患者共42例按Cockcroft-Gault计算的内生肌酐清除率(Ccr)的不同分成三组,第1组Ccr≥60ml(min·1.73m2),第2组20ml/(min·1.73m2)≤Ccr<60ml/(min·1.73m2),第3组Ccr<20ml/(min·1.73m2)但未开始透析,比较三组患者的血浆肾素活性(PRA)、血管紧张素Ⅱ(AngⅡ)和血清Ald浓度(SACs),并对Ccr和SACs两者行相关性分析;PRA、AngⅡ和SACs的检测用放射免疫分析。结果:第3组患者的SACs较第1、2组显著升高(P<0.01),第2组患者的SACs也较第1组患者显著升高(P<0.05)。Ccr与SACs呈高度负相关(r=-0.685,P<0.001)。结论:慢性肾功能不全的患者,随着Ccr下降,SACs有逐渐升高的趋势。 相似文献
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为探讨糖尿病患者尿白蛋白排泄率(AER)与骨密度(BMD)的相关性,测定了106例糖尿病患者和20例正常人(对照组)24小时AER,根据糖尿病患者AER分为Ⅰ组即正常蛋白尿组、Ⅱ组即微量白蛋白尿组、Ⅲ组即大量白蛋白尿组,并分别测定其L2~4椎体、股骨近端BMD。结果显示,除Ⅰ、Ⅱ组男性患者腰椎BMD与对照组无明显差异外,其余各组、各部位BMD与对照组相比均明显下降(P<0.01);男女糖尿病AER正常患者分别与同性别对照组相比,其BMD亦降低(P<0.01)。糖尿病患者中,Ⅲ组BMD明显低于Ⅰ、Ⅱ组(P<0.05)。提示糖尿病肾病患者BMD比正常人低,大量蛋白尿组BMD较其它组显著下降。 相似文献
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目的检测实验性糖尿病不同时期系统和肾组织RAS活性变化。方法STZ-糖尿病大鼠随机分两组:糖尿病对照组(DC组)和Captopril治疗组(ACEID组),均予胰岛素治疗以维持中度高血糖,另设正常组(NC组)。病程7、30、90d时测系统和肾内肾素、ACE活性和ATII浓度。结果DC组在7、30d时PRA正常,至90d下降;血浆和肾内ATII、肾内TRA及血清ACE在7、30、90d时均升高。整个实验中ACE变化不明显。而ACEID组血浆ATII、30和90d肾内ACE及30d肾内ATII均明显下降,但90d肾内ATII仍高于NC组。结论糖尿病早期系统和肾组织RAS活性增加;长期ACEI治疗可能激活组织局部合成ATII的旁路途径。 相似文献
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Dan Zhang Ying Wu Chong Zhang Wenzhu Zhang Jun Zou Gengru Jiang 《Pathology, research and practice》2019,215(5):952-956
Background
The identification of the M-type phospholipase A2 receptor (PLA2R) is a breakthrough recognized as a major target for adults with idiopathic membranous nephropathy (IMN). However, the role PLA2R played in pediatric patients with IMN, particularly in Chinese, has yet to be determined.Methods
This retrospective study included 187 adult patients and 38 pediatric patients aged 17 years or younger with biopsy proved IMN. The pediatric cohort consisted of 27 children aged from 1 to 12 years and 11 children aged from 13 to 17. Glomerular expression of PLA2R was analyzed in stored, formalin-fixed, paraffin-embedded kidney biopsy sections.Results
PLA2R staining in glomerular deposits was observed in 82.7% and 42.1% of adult and pediatric patients with IMN, respectively. The PLA2R-positive staining patients with IMN presented with more severe clinical features than PLA2R-negative staining patients in both adult and pediatric cohorts. When compared to the young children patients with IMN, the adolescents exhibited a higher positive rate of PLA2R staining (81.8% versus 25.9%), similar to the adult patients.Conclusion
The clinical features and prevalence of PLA2R positive staining in adolescent patients with IMN were similar to adult patients, suggesting that they probably have a close etiology and pathogenesis. However, most of the young children patients with IMN were PLA2R negative staining, suggesting a different underlying etiology. 相似文献7.
Fujun Lin Dan Zhang Juan Chang Xuanli Tang Wenbin Guan Gengru Jiang Chun Zhu Fan Bian 《European journal of medical genetics》2018,61(2):84-88
Target antigens in idiopathic membranous nephropathy (MN) include the phospholipase A2 receptor (PLA2R), and in some cases, the thrombospondin type 1 domain-containing 7A (THSD7A). A notable phenomenon is the high rate of cancer (reported to be as high as 20%) in patients with THSD7A-associated MN. Neurofibromatosis type 1 (NF1) is an autosomal dominant disease caused by NF1 gene mutation, and clinically characterized by multiple cutaneous neurofibromas and café-au-lait spots. In this article, we report a patient with NF1 who developed THSD7A-associated MN when the NF1 skin lesions deteriorated. The patient, a 62-year-old male, was referred to us for nephrotic syndrome for 6 months. Physical examination revealed multiple cutaneous nodules throughout the entire body, and the patient noted recent increase in the numbers of these skin lesions. Cutaneous nodules excisional biopsy suggested NF1 and Sanger sequencing using genomic DNA extracted from peripheral blood revealed a previously reported heterozygous frameshift NF1 mutation (c.1541_1542delAG, p. Gln514fs). Renal biopsy revealed MN and immunohistochemistry (IHC) showed enhanced staining of THSD7A as well as PLA2R along the glomerular basement membrane whereas the serum level of THSD7A and PLA2R were both within normal range. The neurofibroma tissues were positive for THSD7A but not for PLA2R on IHC. The patient did not respond to 6-month treatment with glucocorticosteroid and cyclophosphamide. In this exceptional case, strong positive staining of THSD7A in both skin and renal biopsy samples, together with the temporal association between nephrotic syndrome and skin lesions and lack of treatment response, suggested the possibility that MN could be the result of immune response to THSD7A in NF1. This report may improve understanding of the mechanistic link between MN and cancer. 相似文献
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Aldosterone increases cation transport and contractility of vascular smooth muscle, but the specific transporter involved and how it is linked to smooth muscle tone is unknown. Because the Na-K-2Cl cotransporter (NKCC1) contributes to vascular smooth muscle contraction and is regulated by vasoactive compounds, we sought to determine whether this transporter is a target of aldosterone in rat aorta. Treatment of adrenalectomized rats with aldosterone for 7 days resulted in a 63% increase in NKCC1 activity as measured by bumetanide-sensitive efflux of 86Rb+. Treatment of normal aortas in culture with aldosterone for 3 and 7 days resulted in 29% and 47% increases in NKCC1 activity, respectively. Aldosterone had no acute effect on 86Rb+ efflux. Stimulation of NKCC1 was blocked by spironolactone, a mineralocorticoid receptor antagonist, but not by RU38486, a glucocorticoid receptor antagonist. Aldosterone did not augment the stimulation of NKCC1 by phenylephrine and did not increase NKCC1 mRNA as determined by real-time polymerase chain reaction. We conclude that aldosterone regulates the Na-K-2Cl cotransporter in vascular smooth muscle through classic mineralocorticoid receptors but not through changes in the abundance of NKCC1 mRNA. This could account for the increase in Na+, K+, and Cl- fluxes previously observed in vascular smooth muscle from mineralocorticoid-treated animals and may contribute to increased vascular tone. 相似文献
9.
Bicheng Liu Nan Chen Jinghong Zhao Aiping Yin Xiongfei Wu Changying Xing Gengru Jiang Junzhou Fu Mei Wang Rong Wang Jianying Niu Ping Fu Zhaohui Ni Fanfan Hou Jiuyang Zhao Jing Chen Yuqing Chen Wei Shi Jianghua Chen Wenge Li Gang Xu Ling Zhong Wenhu Liu Guohua Ding Yuichiro Kondo Changhe Yue Changlin Mei 《慢性疾病与转化医学(英文)》2022,8(2):134
10.
建立一种肾小球系膜细胞三维立体培养系统,该系统可以模拟肾小球系膜细胞在肾小球系膜区的生长环境,并证实在三维立体培养系统中.肾小球系膜细胞在24、48和72h的增殖作用比传统贴壁培养时明显缓慢。 相似文献