全文获取类型
收费全文 | 3052篇 |
免费 | 158篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 128篇 |
妇产科学 | 116篇 |
基础医学 | 306篇 |
口腔科学 | 21篇 |
临床医学 | 288篇 |
内科学 | 586篇 |
皮肤病学 | 105篇 |
神经病学 | 375篇 |
特种医学 | 280篇 |
外国民族医学 | 22篇 |
外科学 | 341篇 |
综合类 | 39篇 |
一般理论 | 3篇 |
预防医学 | 217篇 |
眼科学 | 17篇 |
药学 | 176篇 |
1篇 | |
中国医学 | 9篇 |
肿瘤学 | 185篇 |
出版年
2021年 | 32篇 |
2020年 | 23篇 |
2019年 | 47篇 |
2018年 | 49篇 |
2017年 | 38篇 |
2016年 | 44篇 |
2015年 | 41篇 |
2014年 | 72篇 |
2013年 | 84篇 |
2012年 | 127篇 |
2011年 | 125篇 |
2010年 | 83篇 |
2009年 | 82篇 |
2008年 | 102篇 |
2007年 | 103篇 |
2006年 | 118篇 |
2005年 | 97篇 |
2004年 | 96篇 |
2003年 | 94篇 |
2002年 | 88篇 |
2001年 | 90篇 |
2000年 | 91篇 |
1999年 | 85篇 |
1998年 | 60篇 |
1997年 | 48篇 |
1996年 | 58篇 |
1995年 | 52篇 |
1994年 | 43篇 |
1993年 | 33篇 |
1992年 | 72篇 |
1991年 | 69篇 |
1990年 | 63篇 |
1989年 | 76篇 |
1988年 | 69篇 |
1987年 | 55篇 |
1986年 | 70篇 |
1985年 | 58篇 |
1984年 | 46篇 |
1983年 | 28篇 |
1981年 | 28篇 |
1979年 | 27篇 |
1978年 | 32篇 |
1977年 | 23篇 |
1976年 | 31篇 |
1975年 | 27篇 |
1972年 | 19篇 |
1971年 | 26篇 |
1970年 | 37篇 |
1969年 | 26篇 |
1968年 | 24篇 |
排序方式: 共有3225条查询结果,搜索用时 31 毫秒
1.
James I. Geller MD Joseph G. Pressey MD Malcolm A. Smith MD Rachel A. Kudgus PhD Mariana Cajaiba MD Joel M. Reid PhD David Hall PhD Donald A. Barkauskas PhD Stephen D. Voss MD Steve Y. Cho MD Stacey L. Berg MD Jeffrey S. Dome MD PhD Elizabeth Fox MD Brenda J. Weigel MD 《Cancer》2020,126(24):5303-5310
2.
Juin Fok-Seang Linda C. Smith-Thomas Sally Meiners Elizabeth Muir Jian-Sheng Du Elizabeth Housden Alan R. Johnson Andreas Faissner Herbert M. Geller Roger J. Keynes John H. Rogers James W. Fawcett 《Brain research》1995,689(2):207
The adult mammalian central nervous system (CNS) lacks the capacity to support axonal regeneration. There is increasing evidence to suggest that astrocytes, the major glial population in the CNS, may possess both axon-growth promoting and axon-growth inhibitory properties and the latter may contribute to the poor regenerative capacity of the CNS. In order to examine the molecular differences between axon-growth permissive and axon-growth inhibitory astrocytes, a panel of astrocyte cell lines exhibiting a range of axon-growth promoting properties was generated and analysed. No clear correlation was found between the axon-growth promoting properties of these astrocyte cell lines with: (i) the expression of known neurite-outgrowth promoting molecules such as laminin, fibronectin andN-cadherin; (ii) the expression of known inhibitory molecules such tenascin and chondroitin sulphate proteoglycan; (iii) plasminogen activator and plasminogen activator inhibitor activity; and (iv) growth cone collapsing activity. EM studies on aggregates formed from astrocyte cell lines, however, revealed the presence of an abundance of extracellular matrix material associated with the more inhibitory astrocyte cell lines. When matrix deposited by astrocyte cell lines was assessed for axon-growth promoting activity, matrix from permissive lines was found to be a good substrate, whereas matrix from the inhibitory astrocyte lines was a poor substrate for neuritic growth. Our findings, taken together, suggest that the functional differences between the permissive and the inhibitory astrocyte cell lines reside largely with the ECM. 相似文献
3.
A genetic analysis of mammalian neuronal physiology might now be possible due to the development of defective herpes simplex virus vectors, which allow gene transfer directly into mature neurons, in culture or in the adult brain. Genetically altered proteins that play critical roles in neuronal physiology, including those responsible for the generation of action potentials, synthesis and release of neurotransmitters, and signal transduction enzymes, can now be stably expressed in neurons. The effect of such altered proteins on neuronal physiology can therefore be examined, using the tools of modern neuroscience. Genetic manipulation is biochemically specific and stable, and can be targeted both to a particular cell type and to a particular subregion of the cell to yield insights into the molecular basis for specific brain functions. 相似文献
4.
5.
Kinzl Geelen F. Ferrio Langsteiner Dubitscher Pfister H. Donalies Kranz G. A. Adam Koller v. Baeyer Zillig G. Rost Sjvall Einar Hahn Rubner Max H. Hofmann Bresowsky Mller H. Liguori-Hohenauer Geller Braun F. Leibbrand Tbben H. 《International journal of legal medicine》1940,33(4):353-364
International Journal of Legal Medicine - 相似文献
6.
There is a need to investigate methods by which drinkers canbe made aware of their level of alcohol impairment prior todriving. In the current research, 195 students at various bloodalcohol concentration (BAC) levels participated in an evaluationof three simple sobriety tests: a ruler drop/reaction time task,a balance test and a verbal task. Although self-reported measuresof impairment were the best predictors of BAC, both the rulerdrop and body balance tests accounted for significant portionsof BAC variance. These tasks were also perceived by the studentsas reflecting substantial driving ability. Unfortunately, asBAC increased, poor test performance was less likely to resultin a decision not to drive. These results are discussed in termsof the need to continue studying ways to educate drinkers abouttheir level of alcohol impairment so that they can make informeddrinking/driving decisions. 相似文献
7.
Psychopharmacology of children and adolescents: pharmacokinetics and relationships of plasma/serum levels to response. 总被引:1,自引:0,他引:1
B Geller 《Psychopharmacology bulletin》1991,27(4):401-409
This article reviews data from the literature on pharmacokinetics and on relationships of plasma/serum levels to response in the child and adolescent population. The following topics will be covered: saliva vs. serum monitoring, drug-drug interactions, enzyme induction, and the effect of febrile illnesses on protein binding. Similarity of elimination processes based on manifestations that are genetically determined across age groups will be contrasted to elimination mechanisms that are different for the pediatric group due to age specific developmental considerations. Age related differences in plasma/serum level response relationships will be discussed with respect to study population characteristics and pharmacodynamic implications. 相似文献
8.
Fady K. Balaa T. Clark Gamblin Allan Tsung J. Wallis Marsh David A. Geller 《Journal of gastrointestinal surgery》2008,12(2):338-343
Background Application of linear stapling devices for extrahepatic vascular control in liver surgery has been well-established. However,
the technique for use of stapling devices in hepatic parenchymal transection is not well defined.
Purpose To describe the safety and efficacy of our technique for use of vascular stapling devices in hepatic parenchymal transection
during open right hepatic lobectomy is the purpose of this study.
Methodology We reviewed our experience with 101 consecutive open right hepatic lobectomies performed by a single surgeon between January
2003 and July 2006, in which vascular staplers were utilized for the parenchymal transection phase.
Results Of the 101 patients who underwent resection, 53 (52%) were female. The mean age was 58 years. Malignant disease was the indication
for resection in the majority of patients (88%). Of those with cancer, 78% (69 of 89) had metastatic colorectal cancer, 6%
(5 of 89) had metastatic neuroendocrine tumor, 4% (4 of 89) had hepatocellular carcinoma, 4% (4 of 89) had cholangiocarcinoma,
and the remaining 8% were other metastatic cancers. Twelve patients (12%) underwent resection for hepatic adenoma or symptomatic
benign disease (FNH or hemangioma). Forty-eight patients (48%) underwent a major ancillary procedure at the time of hepatic
resection. Thirty-nine patients (39%) had a nonanatomic wedge resection of a left lobe lesion, 27 patients (27%) had one or
more lesions treated with radiofrequency ablation (RFA), and 6 patients (6%) were treated with a synchronous bowel resection.
The median total operative time was 336 min (range 155–620 min). A Pringle maneuver for temporary vascular inflow occlusion
was utilized in all cases, with a median time of 9 min (range 4–17 min). Ten patients (10%) required blood transfusion during
surgery or in the postoperative period. The maximum transfusion was 2 U of packed red blood cells (PRBC) in seven patients
and 1 U of PRBC in three patients. The mean nadir postoperative hematocrit was 28.2. All patients with malignant disease had
tumor-free margins at the completion of the procedure. The average hospital length of stay was 6.0 days. One patient (1%)
developed a clinically significant bile leak requiring a postoperative endoscopic retrograde cholangiography (ERCP). No patient
required reoperation. The 30 and 60-day postoperative survival was 100%.
Conclusion These findings indicate that application of vascular stapling devices for parenchymal transection in major hepatic resection
is a safe technique, with low transfusion requirements and minimal postoperative bile leak. The technique allows for rapid
transection of the entire right hepatic lobe in under 10 min. Short video clips of the technique will be demonstrated.
Presented at the 2007 American Hepato–Pancreato–Biliary Association, Las Vegas, Nevada, April 19–22, 2007 (oral presentation/video
presentation). 相似文献
9.
Although a great deal is known about the nature and severity of the recent financial crisis in agriculture, there has been little systematic study of the social and psychological effects of this crisis upon farm operators and their families. Using data from a statewide sample of Iowa farmers, this study tests some hypotheses about correlates of psychological stress. The findings suggest that many farm operators find their situations to be stressful and that such stress is related to the severity of their financial problems. In addition, the life-events perspective is examined in its utility to explain how adverse economic changes impact psychological well-being. 相似文献
10.
Ketai LH; Williamson MR; Telepak RJ; Levy H; Koster FT; Nolte KB; Allen SE 《Radiology》1994,191(3):665