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目的探讨屏障系统动物室控制微生物污染,维持洁净的方法。方法将屏障系统动物室的乱流空气净化方式进行改进,在乱流室内增加能改变气流方式的无动力的设施,使室内气流改变为单向流动的方式。结果乱流动物室的沉降菌平均为47个,浮游菌平均为154.5个;单向气流动物室内的沉降菌平均为1.5个,浮游菌平均为7个。结论单向流优于乱流。这将为今后我国制定新的实验动物屏障系统环境标准提供技术数据。 相似文献
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YASUO AWAKURA MITSUO NONOMURA NORIYUKI ITOH ATSUSHI MAENO TAKUO FUKUYAMA 《International journal of urology》2003,10(5):281-283
A 75-year-old female presented with a 7-month history of intermittent macrohematuria and urinary retention. Physical examination revealed a firm, round mass on the anterior vaginal wall. The diagnosis by urethroscopy and radiological evaluation was localized urethral diverticular tumor. Pathological examination of the biopsy specimen revealed adenocarcinoma. The patient received two courses of intra-arterial and systemic chemotherapy using cisplatin, 5-fluorouracil and leucovorin, followed by radiation to the urethra. The tumor shrunk markedly after chemotherapy. The patient underwent total urethrectomy and vesicostomy. Two years after the operation, she had no evidence of recurrence. Adenocarcinoma of the female urethral diverticulum is rare and has been treated by surgery and/or radiation. The present case is the first case of it being treated by multimodality therapy including chemotherapy. 相似文献
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MICHAEL J. FELLNER KIMIE FUKUYAMA ALAN MOSHELL MARIA V. KLAUS 《The British journal of dermatology》1973,89(2):115-126
Antibodies directed against intercellular epithelial structures (ICE) have been important in the diagnosis of pemphigus vulgaris. Our study of thirty-seven patients with maculopapular eruptions following therapy with penicillins, clearly indicate that antibodies morphologically indistinguishable from those found by standard techniques in pemphigus vulgaris are also found here. Indirect staining by fluorescence and horse-radish peroxidase indicated localization against ICE identical to that seen in pemphigus, in about half the patients. Direct staining of skin from two penicillin-allergic patients revealed similar staining in the familiar pattern, which closely resembles the network of lines in giraffe skin. Detection of circulating antibody directed against a component of epithelium introduces new insight into the pathophysiology of maculopapular penicillin eruptions, although further work is required to show what the exact relationship is to pemphigus vulgaris, the potentially fatal skin disease. 相似文献
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K. YOSHINO N. KARIYA D. NAMURA I. NOJI K. MITSUHASHI H. KIMURA A. FUKUDA I. KIKUKAWA T. HAYASHI N. YAMAZAKI M. KIMURA K. TSUKIYAMA K. YAMAMOTO A. FUKUYAMA D. HIDAKA J. SHINODA H. MIBU Y. SHIMAKURA A. SAITO S. IKUMI K. UMEHARA F. KAMEI H. FUKUDA T. TOAKE Y. TAKAHASHI Y. MIYATA S. SHIOJI M. TOYODA N. HATTORI H. NISHIHARA R. MATSUSHIMA M. NISHIBORI O. HOKKEDO M. NOJIMA T. KIMURA M. FUJISEKI S. OKUDAIRA K. TANABE M. NAKANO K. ITO M. KURODA T. MATSUKUBO 《Journal of oral rehabilitation》2012,39(11):821-829
Summary The aim of this study was to investigate the risk factors affecting long‐term prognosis of autotransplantation of third molars with complete root formation in males at dental clinics. Participating dentists were requested to provide information on transplantations they had undertaken from 1 January 1990 to 31 December 2010. Data on a total of 708 teeth from 637 patients were collected. After data screening and elimination, participants of this study consisted of 183 teeth of 171 males ranging from 20 to 72 years of age (mean age, 44·8 years). The cumulative survival rate was 86·0% at the 5‐year mark, 59·1% at 10 years and 28·0% at 15 years. The mean survival time was 134·5 months, as calculated by the Kaplan–Meier method. Single factor analysis using the log‐rank test showed that the following factors had significant influence (P < 0·05) on survival of transplanted teeth: periodontal disease as the reason for recipient site tooth extraction, fewer than 25 present teeth and Eichner index Groups B1 to C. Cox regression analysis examined five factors: age, smoking habit, recipient site extraction caused by periodontal disease, fewer than 25 present teeth and Eichner index. This analysis showed that two of these factors were significant: fewer than 25 present teeth was 2·63 (95% CI, 1·03–6·69) and recipient site extraction caused by periodontal disease was 3·80 (95% CI, 1·61–9·01). The results of this study suggest that long‐term survival of transplanted teeth in males is influenced not only by oral bacterium but also by occlusal status. 相似文献
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TATSURO IZUMI HIROKO TAKESHIGE TOSHIHIKO ARAI MICHIKO SUGAMA MIKA MIZUSHIMA YUKIO FUKUYAMA GENGO MABUCHI 《Pediatrics international》1997,39(1):10-17
The long-term follow-up of chronic hyperinsulinemic seizures, epileptogenesis and other neurological complications in five patients who were treated with conservative therapy followed by pancreatectomy during the neonatal period and infancy, who were confirmed to have diffuse nesidioblastosis are described. The reaction pattern of the C-peptide (CPR) suppression test and its relation to the final extent of pancreatectomy was examined in four patients. The chronological change in electro-encephalography (EEG) and its epileptogenesis was also examined in each patient during hyperinsulinemic hypoglycemia, and during normoglycemia in a long-term post-pancreatectomy follow-up. All patients demonstrated several types of hypoglycemic seizures, ranging from apnea, erratic seizures, partial seizures evolving to generalized/unilateral tonic-clonic or tonic seizures, myoclonic seizures and EEG abnormalities. Four of five patients still suffered from epilepsy at the age of 4–22 years. The reaction pattern of the CPR suppression test showed dichotomy, with a hyper-reactive pattern in two patients who required total pancreatectomy to control hypoglycemia, and a suppression pattern in two other patients treated with 90–95% pancreatectomy. Neonatal onset and subsequent myoclonic seizures were ominous signs of epileptogenesis to various types of intractable epilepsy and other neurological sequelae. A prompt diagnosis and pancreatectomy of a sufficient extent at the first operation are essential. The CPR suppression test may be useful for a prompt diagnosis and selection of the extent of pancreatectomy. 相似文献