全文获取类型
收费全文 | 1163篇 |
免费 | 49篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 62篇 |
妇产科学 | 7篇 |
基础医学 | 103篇 |
口腔科学 | 23篇 |
临床医学 | 56篇 |
内科学 | 199篇 |
皮肤病学 | 44篇 |
神经病学 | 23篇 |
特种医学 | 50篇 |
外科学 | 170篇 |
综合类 | 285篇 |
预防医学 | 30篇 |
眼科学 | 35篇 |
药学 | 46篇 |
1篇 | |
中国医学 | 3篇 |
肿瘤学 | 74篇 |
出版年
2022年 | 8篇 |
2021年 | 16篇 |
2020年 | 16篇 |
2019年 | 13篇 |
2018年 | 20篇 |
2017年 | 16篇 |
2016年 | 12篇 |
2015年 | 30篇 |
2014年 | 33篇 |
2013年 | 36篇 |
2012年 | 55篇 |
2011年 | 47篇 |
2010年 | 72篇 |
2009年 | 65篇 |
2008年 | 84篇 |
2007年 | 77篇 |
2006年 | 72篇 |
2005年 | 42篇 |
2004年 | 63篇 |
2003年 | 26篇 |
2002年 | 41篇 |
2001年 | 36篇 |
2000年 | 25篇 |
1999年 | 24篇 |
1998年 | 30篇 |
1997年 | 33篇 |
1996年 | 29篇 |
1995年 | 21篇 |
1994年 | 21篇 |
1993年 | 9篇 |
1992年 | 17篇 |
1991年 | 15篇 |
1990年 | 8篇 |
1989年 | 8篇 |
1988年 | 11篇 |
1987年 | 6篇 |
1986年 | 9篇 |
1985年 | 7篇 |
1984年 | 9篇 |
1983年 | 2篇 |
1982年 | 7篇 |
1981年 | 5篇 |
1980年 | 3篇 |
1979年 | 5篇 |
1978年 | 8篇 |
1977年 | 6篇 |
1976年 | 6篇 |
1971年 | 2篇 |
1967年 | 2篇 |
1953年 | 1篇 |
排序方式: 共有1215条查询结果,搜索用时 7 毫秒
1.
2.
Brain cyclooxygenases (COX), the rate-limiting enzyme in prostaglandin synthesis, is rapidly and transiently induced by convulsions in hippocampal and cortical neurons. Previous studies have explored the protective effect of naproxen (non-selective COX-inhibitor) or rofecoxib (selective COX-2 inhibitor) against chemical kindling in mice. With this background, the present study was designed to explore the possible effect of nimesulide (a preferential COX-2 inhibitor) against pentylenetetrazol (PTZ)-induced kindling epilepsy in mice. To induce kindling, PTZ was injected in a subconvulsive dose (40 mg/kg, i.p.) every other day for 15 days. Nimesulide (2.5 or 5 mg/kg, p.o.) was administered each day 45 min before either PTZ or vehicle challenge. The intensity of kindling was assessed immediately after PTZ administration according to a prevalidated scoring scale. On 16th day i.e. 24 h after the last dose of PTZ, animals were sacrificed and various biochemical parameters were assessed in the whole brain. Compared with normal control group, PTZ-kindled mice had significantly higher levels of malondialdehyde, nitrite, myeloperoxidase but had lower levels of reduced glutathione in the whole brain homogenate. Chronic treatment with nimesulide (2.5 or 5 mg/kg, p.o.) for 15 days showed significant decrease in kindling score and could play a role in controlling the accompanying biochemical alterations due to PTZ. These results suggested that nimesulide, a preferential COX-2 inhibitor offered neuroprotection against PTZ-induced kindling in mice. 相似文献
3.
4.
5.
6.
7.
8.
The case of a horn-like hyperplasia of the caruncle of the left eye in a 3-month-old child is reported. An atavistic origin of this growth as a vestigial upper incisor is suggested from the anatomical location of the horn. 相似文献
9.
10.
Cauda equina nerve sheath tumors are usually small, well-encapsulated tumors. Sometimes they may attain very large proportions, cause extensive bony changes, and resemble ependymomas in the cauda equina. They may also infiltrate into adjacent soft tissue planes and retroperitoneal spaces and yet be histologically benign. An awareness of this entity ensures aggressive surgical removal at the time of exploration. Primary neuro-fibrosarcomas or malignant changes in primary nerve sheath tumors of the cauda equina are seen in patients with neurofibromatosis. 相似文献