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Sartori Natália Sarzi de Andrade Nicole Pamplona Bueno da Silva Chakr Rafael Mendonça 《Clinical rheumatology》2020,39(5):1439-1447
Clinical Rheumatology - The TNF inhibitors were the first immunobiologicals used to treat rheumatic diseases, but their use is associated with an increased risk of tuberculosis. The primary... 相似文献
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Pavan Thais Rohde Bredemeier Markus Hax Vanessa Capobianco Karina Gatz da Silva Mendonça Chakr Rafael Xavier Ricardo Machado 《Clinical rheumatology》2018,37(2):475-481
Clinical Rheumatology - The objective of this study is to test the association of the severity of nailfold capillaroscopy (NFC) abnormalities with mortality in systemic sclerosis (SSc). One hundred... 相似文献
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Santo Rafaela CE Silva Jordana MS Lora Priscila S Moro Ana Laura D Freitas Eduarda C Bartikoski Bárbara J Andrade Nicole PB Palominos Penélope E Hax Vanessa Fighera Tayane M Spritzer Poli Mara Brenol Claiton V Chakr Rafael MS Filippin Lidiane I Baker Joshua F Xavier Ricardo M 《Clinical rheumatology》2020,39(12):3603-3613
Clinical Rheumatology - Rheumatoid arthritis (RA) is an inflammatory disease that leads to altered body composition. The loss of lean mass with a preservation or increase in fat mass has been... 相似文献
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Objective
To explore whether the risk of incident tibiofemoral (TF) osteoarthritis (OA) in the radiographically normal contralateral knee of overweight/obese women with unilateral knee OA is mediated by malalignment and/or preceded by increased turnover of subchondral bone.Methods
We used data of post hoc analyses from a randomized controlled trial. Cross‐sectional analyses evaluated the baseline association between frontal plane alignment and bone turnover in the medial TF compartment in 78 radiographically normal contralateral knees. Longitudinal analyses ascertained whether incident radiographic OA (TF osteophyte formation within 30 months) was associated with malalignment and/or increased bone turnover at baseline. Alignment subcategories (varus/neutral/valgus) were based on the anatomic axis angle. 99mTc–methylene diphosphonate uptake in a late‐phase bone scan was quantified in regions of interest in the medial tibia (MT) and medial femur (MF) and adjusted for uptake in a reference segment of the ipsilateral tibial shaft (TS).Results
MF and MT uptake in varus contralateral knees was 50–55% greater than in the TS. Adjusted MT uptake in varus contralateral knees was significantly greater than that in neutral and valgus contralateral knees (mean 1.55 versus 1.38 and 1.43, respectively; P < 0.05). Among 69 contralateral knees followed longitudinally, 22 (32%) developed TF OA. Varus angulation was associated with a marginally significant increase in the odds of incident OA (adjusted odds ratio 3.98, P = 0.067).Conclusion
While the small sample size limited our ability to detect statistically significant risk factors, these data suggest that the risk of developing bilateral TF OA in overweight/obese women may be mediated by varus malalignment. 相似文献9.
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Chakr VC Llapur CJ Sarria EE Mattiello R Kisling J Tiller C Kimmel R Poindexter B Tepper RS 《Pediatric pulmonology》2012,47(4):373-380
Some studies have suggested that lung clearance index (LCI) is age-independent among healthy subjects early in life, which implies that ventilation distribution does not vary with growth. However, other studies of older children and adolescents suggest that ventilation becomes more homogenous with somatic growth. We describe a new technique to obtain multiple breath washout (MBWO) in sedated infants and toddlers using slow augmented inflation breaths that yields an assessment of LCI and the slope of phase III, which is another index of ventilation inhomogeneity. We evaluated whether ventilation becomes more homogenous with increasing age early in life, and whether infants with chronic lung disease of infancy (CLDI) have increased ventilation inhomogeneity relative to full-term controls (FT). FT (N = 28) and CLDI (N = 22) subjects between 3 and 28 months corrected-age were evaluated. LCI decreased with increasing age; however, there was no significant difference between the two groups (9.3 vs. 9.5; P = 0.56). Phase III slopes adjusted for expired volume (S(ND)) increased with increasing breath number during the washout and decreased with increasing age. There was no significant difference in S(ND) between full-term and CLDI subjects (211 vs. 218; P = 0.77). Our findings indicate that ventilation becomes more homogenous with lung growth and maturation early in life; however, there is no evidence that ventilation inhomogeneity is a significant component of the pulmonary pathophysiology of CLDI. 相似文献