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烧伤创伤后应激障碍的危险因素及预测因素的研究 总被引:2,自引:2,他引:2
烧伤通常是一件具有长期身体和心理影响的灾难性事件。创伤后应激障碍(posttraumatic stress disorder,PTSD),一直是烧伤病人心理研究领域里最常见的课题。烧伤引发PTSD的研究,国外从1980年开始,二十几年来有了一定的进展和成果,但仍处于起步阶段。无论烧伤患者还是医生对PTSD的认知率都很低,PTSD很容易被误诊和误治。笔者对烧伤病人PTSD流行病学、相关危险因素和预测因素等相关国内外文献进行综述研究,目的是探讨烧伤PTSD先前存在的风险因素和烧伤早期应激症状的预测意义,为烧伤PTSD早期鉴别和干预提供依据。 相似文献
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Objective To evaluate the effect of neurally adjusted ventilatory assist (NAVA) on prevention of ventilator-induced diaphragmatic dysfunction (VIDD) in ARDS rabbits.Methods Twenty New Zealand white rabbits were randomly divided into 4 groups: ( 1 ) control group ( n = 5 ); ( 2 ) Volume control (VC) group ( n = 5 ); ( 3 ) Pressure support ( PSV ) group ( n = 5 ); (4) NAVA group ( n = 5 ).In VC, PSV and NAVA groups, the rabbits were killed and the diaphragm was removed after 4 hours of ventilation.Animals in the control group were not mechanically ventilated, and the diaphragm was also removed immediately after anesthetizing.In all rabbits, malondialdehyde ( MDA), superoxide disrmutase (SOD) and glutathione(GSH) of diaphragm were measured.Structure of diaphragm was observed by light microscope, electron microscope, constituent ratio and mean cross-sectional area (CSA) of diaphragm fiber.Results (1)MDA: Compared with the control [(0.15 ±0.06)nmol/mg], PSV group[(0.30 ±0.11)nmol/mg], there was no significant difference in MDA of diaphragm in NAVA group [( 0.28 ± 0.19 )nmol/mg] (F = 2.730, P > 0.05).MDA in VC group [(0.40 ±0.16)nmol/mg] was significantly higher than the control group (P<0.05).(2) SOD: Compared with control [( 111 ± 12) U/mg], PSV group [(93 ± 4) U/mg], there was no significant difference in SOD of diaphragm in NAVA group [( 94 ± 9 )U/mg] (F=4.422,P >0.05).SOD in VC group [(80 ±21 )U/mg] was significantly lower than the control group(P <0.05).(3)GSH: Compared with control [(5.3 ± 1.0)mg/g] and PSV group [(4.5 ±1.2)mg/g], there was no significant difference in GSH of diaphragm in NAVA group [(5.6 ± 1.0) mg/g](F =3.001 ,P > 0.05 ).GSH in VC group [(3.3 ± 1.7)mg/g] is significantly lower than control and NAVA groups ( P < 0.05 ).( 4 ) Light microscope: In VC group, many changes were observed in the muscle, such as myofibrosis, necrosis, and some of muscle fibers became atrophy, but these were no obvious changes of pathological structure in control, PSV or NAVA groups.(5)Electron microscope: In control, PSV and NAVA groups, the ultrastructure of diaphragm was normal Different from the above 3 groups, some abnormal ultrastructure was observed in VC group, including disrupted myofibrils, swollen mitochondria.(6)CSA of diaphragm fiber: Compared with control and PSV group, there was no significant difference in CSA of diaphragm fiber in NAVA group ( P > 0.05 ); The CSA of type Ⅱ fibers in VC group was markedly lower than control group ( P < 0.05 ) .Conclusions Compared with volume control ventilation, NAVA may mitigate diaphragmatic oxidative stress, atrophy and injury, and prevent VIDD better than VC. 相似文献
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2021年7月17 日,中国医药教育协会中医药教育促进工作委员会2021年年会暨第二届中医适宜技术展示推广论坛在银川召开.本次大会由中国医药教育协会中医药教育促进工作委员会主办,中国中医科学院广安门医院南院区、中国中医药现代远程教育杂志社、北京三和同舟会议会展有限公司联合承办. 相似文献
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目的 :研究靶向下调小谷氨酰胺三角四肽重复区蛋白α抗体(small glutamine-rich tetratricopeptide repeatcontaining protein alpha,SGTA)的表达对肝癌Hu H7细胞周期及细胞增殖的影响。方法:选择Hu H7细胞系作为研究对象,进行血清饥饿释放同步化处理后采用Western Blot方法检测SGTA蛋白表达水平变化;通过SGTA特异性si RNA下调Hu H7细胞中SGTA的表达,采用细胞计数盒8(cell counting kit 8,CCK8)、流式细胞术等方法检测细胞增殖能力及细胞周期。结果:血清饥饿使Hu H7细胞生长周期停滞,血清释放后刺激Hu H7细胞增殖,Western Blot显示SGTA﹑增殖细胞核抗原(proliferating cell nuclear antigen,PCNA)蛋白随着细胞周期的进展表达增加,而细胞周期负性调控因子p27kip1蛋白表达却下降。SGTA缺失可引起cyclin A、cyclin B的表达下降、细胞增殖的下降以及细胞周期的阻滞。结论:SGTA特异性si RNA能明显抑制肝癌Hu H7细胞的增殖,细胞周期阻滞,提示其可为肝癌的靶基因治疗提供新的分子靶点。 相似文献
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中等职业教育的对象为处于身心发展阶段的青少年学生。这部分学生有因考入中等职业学校而兴奋者,有因中考落榜而失意者。面对就业及社会舆论的压力,他们当中有相当一部分人存在自卑、厌学、缺乏自信心和无成就感等心理问题。部分学生因学习成绩差甚至退学,也有许多学生缺少职业心理素质训练,缺少就业心理准备,导致毕业后在市场经济大潮中敬业精神、吃苦耐劳精神和竞争能力、承受挫折能力及岗位适应能力等明显不足。这些问题大多是一般性心理问题,主要是由学生在成长过程中出现的心理困惑和心理冲突引发的,可以通过自我调节或求助于心理咨询而得到解决。 相似文献