全文获取类型
收费全文 | 10585篇 |
免费 | 752篇 |
国内免费 | 167篇 |
专业分类
耳鼻咽喉 | 144篇 |
儿科学 | 260篇 |
妇产科学 | 192篇 |
基础医学 | 1719篇 |
口腔科学 | 148篇 |
临床医学 | 950篇 |
内科学 | 2185篇 |
皮肤病学 | 343篇 |
神经病学 | 920篇 |
特种医学 | 713篇 |
外科学 | 1249篇 |
综合类 | 64篇 |
现状与发展 | 2篇 |
一般理论 | 1篇 |
预防医学 | 490篇 |
眼科学 | 238篇 |
药学 | 972篇 |
中国医学 | 149篇 |
肿瘤学 | 765篇 |
出版年
2023年 | 87篇 |
2022年 | 324篇 |
2021年 | 479篇 |
2020年 | 228篇 |
2019年 | 341篇 |
2018年 | 356篇 |
2017年 | 276篇 |
2016年 | 435篇 |
2015年 | 530篇 |
2014年 | 629篇 |
2013年 | 720篇 |
2012年 | 981篇 |
2011年 | 934篇 |
2010年 | 562篇 |
2009年 | 444篇 |
2008年 | 607篇 |
2007年 | 549篇 |
2006年 | 521篇 |
2005年 | 399篇 |
2004年 | 352篇 |
2003年 | 278篇 |
2002年 | 261篇 |
2001年 | 149篇 |
2000年 | 152篇 |
1999年 | 105篇 |
1998年 | 59篇 |
1997年 | 41篇 |
1996年 | 39篇 |
1995年 | 35篇 |
1994年 | 31篇 |
1993年 | 25篇 |
1992年 | 45篇 |
1991年 | 47篇 |
1990年 | 50篇 |
1989年 | 53篇 |
1988年 | 21篇 |
1987年 | 37篇 |
1986年 | 34篇 |
1985年 | 34篇 |
1984年 | 26篇 |
1983年 | 20篇 |
1979年 | 19篇 |
1976年 | 11篇 |
1973年 | 11篇 |
1972年 | 15篇 |
1971年 | 19篇 |
1970年 | 14篇 |
1969年 | 13篇 |
1968年 | 10篇 |
1966年 | 12篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
Yeon Seok Lee June Hyunkyung Lee Jae Eun Choi Joo Young Kim Tae Young Han 《Pediatric dermatology》2021,38(1):290-291
Erythema induratum of Bazin (EIB) is a form of tuberculid resulting from hypersensitivity to tuberculosis antigen. EIB occurs most commonly in middle‐aged women and is not typically seen in children. Here, we present a rare case of EIB, presenting as a chronic nodular panniculitis, in a 10‐year‐old Korean boy. 相似文献
3.
Clinical usefulness of intraductal ultrasonography for the management of acute biliary pancreatitis
下载免费PDF全文
![点击此处可从《Journal of gastroenterology and hepatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
4.
5.
6.
Muscarinic receptors play key roles in the control of gastrointestinal smooth muscle activity. However, specific physiological functions of each subtype remain to be determined. Single cell RT-PCR experiments showed that all five subtypes of muscarinic receptors were present in circular smooth muscle cells of the guinea-pig gastric antrum. Nonselective cation channels (NSCC) activated by ACh or CCh are coupled to pertussis toxin (PTX)-sensitive Go protein through m4 subtype as well as m2 and m3 subtypes in guinea-pig stomach. CCh-activated currents (I(CCh)), especially the steady-state I-V relationship of I(CCh) showed a chracteristic U-shaped curve; reversal potential of around 0 mV and inward rectification at around +15 mV and a negative slope conductance at negative potential range. Under physiological conditions, the measured single channel conductance of NSCC was approximately 25 pS. The single channel conductance was modulated by external monovalent and divalent cations including Na+, Cs+, Li+, and Ca2+ through changing both the open probability and unitary conductance. Through the NSCC, Ca2+ can move into the cell from extracellular solution as well as Na+. Calculated fractional Ca2+ current of I(CCh) (f(Ca)) was around 1% at the 2 mM [Ca2+]o and at the 4 mM [Ca2+]o, f(Ca) was 2.3%. Quinidine blocked I(CCh) potently in a reversible manner; IC50 was 0.25 microM. There were two kinds of I(CCh) modulations through Ca(2+)-dependent pathways in guinea-pig gastric smooth muscle cells; 1) Facilitation of I(CCh) via Ca2+/CaM-dependent MLCK pathway, 2) Desensitization of I(CCh) via Ca(2+)-dependent PKC pathway. In the mouse stomach, all seven types of TRPC mRNA were detected with RT-PCR. On the basis of electrophysiological, pharmacological, and molecular biological experiments, we reported the mTRPC5 as a candidate for the NSCC activated by muscarinic stimulation in mouse stomach. 相似文献
7.
8.
Blockade of LTB4-induced chemotaxis by bioactive molecules interfering with the BLT2-Gαi interaction
BLT2, a low-affinity leukotriene B4 (LTB4) receptor, is a member of the G-protein coupled receptor (GPCR) family and is involved in the pathogenesis of inflammatory diseases such as asthma. Despite its clinical implications, however, no pharmacological inhibitors are available. In the present study, we screened for small molecules that interfere with the interaction between the third intracellular loop region of BLT2 (BLT2iL3) and the Gαi3 protein subunit (Gαi3), using a high-throughput screening (HTS) assay with a library of 1040 FDA-approved drugs and bioactive compounds. We identified two small molecules—purpurin [1,2,4-trihydroxy-9,10-anthraquinone; IC50 = 1.6 μM for BLT2] and chloranil [tetrachloro-1,4-benzoquinone; IC50 = 0.42 μM for BLT2]—as specific BLT2-blocking agents. We found that blockade of the BLT2iL3-Gαi3 interaction by these small molecules inhibited the BLT2-downstream signaling cascade. For example, BLT2-signaling to phosphoinositide-3 kinase (PI3K)/Akt phosphorylation was completely abolished by these molecules. Furthermore, we observed that these small molecules blocked LTB4-induced chemotaxis by inhibiting the BLT2-PI3K/Akt-downstream, Rac1-reactive oxygen species-dependent pathway. Taken together, our results show that purpurin and chloranil interfere with the interaction between BLT2iL3 and Gαi3 and thus block the biological functions of BLT2 (e.g., chemotaxis). The present findings suggest a potential application of purpurin and chloranil as pharmacological therapeutic agents against BLT2-associated inflammatory human diseases. 相似文献
9.
From 1980 to 1990 152 patients underwent Fontan operation at our institution. The following patient groups amenable for Fontan operation were identified: 1) patients with tricuspid atresia (n=82, 54.0%); 2) patients with single ventricle (n=31,20.3%), 3) patients with a wide variety of “complex”, non correctable cardiac malformations (n=39, 25.7%). Actuarial survival rate was 83.8±3.1% (mean±SEM) at 10 years. Follow up revealed, that more than 90.0% of the patients feel better than before operation, about 50.0% are without cyanosis, more than 70.0% are in sinus rhythm, and 90.0% of the patients are socialized according to their age. Considering the poor prognosis of these patients without an operation, the Fontan procedure offers a sufficient palliative method in the therapeutic approach up to now. 相似文献
10.
Suk Hee Heo Yong Yeon Jeong Sang Soo Shin Tae Woong Chung Heoung Keun Kang 《Korean journal of radiology》2007,8(2):180-183
We report an uncommon case of solitary, small hepatic angiosarcoma that was initially considered as a hemangioma. We present the imaging findings, with an emphasis on the initial and follow-up CT and MR findings, as well as report on the more suggestive findings of angiosarcoma than those of a hemangioma. 相似文献