全文获取类型
收费全文 | 7382篇 |
免费 | 645篇 |
国内免费 | 23篇 |
专业分类
耳鼻咽喉 | 110篇 |
儿科学 | 212篇 |
妇产科学 | 116篇 |
基础医学 | 954篇 |
口腔科学 | 247篇 |
临床医学 | 675篇 |
内科学 | 1541篇 |
皮肤病学 | 159篇 |
神经病学 | 612篇 |
特种医学 | 309篇 |
外国民族医学 | 1篇 |
外科学 | 1013篇 |
综合类 | 113篇 |
预防医学 | 517篇 |
眼科学 | 141篇 |
药学 | 478篇 |
1篇 | |
中国医学 | 28篇 |
肿瘤学 | 823篇 |
出版年
2023年 | 32篇 |
2022年 | 77篇 |
2021年 | 183篇 |
2020年 | 111篇 |
2019年 | 223篇 |
2018年 | 255篇 |
2017年 | 177篇 |
2016年 | 184篇 |
2015年 | 225篇 |
2014年 | 288篇 |
2013年 | 327篇 |
2012年 | 398篇 |
2011年 | 422篇 |
2010年 | 269篇 |
2009年 | 240篇 |
2008年 | 350篇 |
2007年 | 349篇 |
2006年 | 326篇 |
2005年 | 305篇 |
2004年 | 281篇 |
2003年 | 261篇 |
2002年 | 236篇 |
2001年 | 192篇 |
2000年 | 217篇 |
1999年 | 170篇 |
1998年 | 97篇 |
1997年 | 107篇 |
1996年 | 87篇 |
1995年 | 81篇 |
1994年 | 81篇 |
1993年 | 86篇 |
1992年 | 127篇 |
1991年 | 126篇 |
1990年 | 116篇 |
1989年 | 131篇 |
1988年 | 92篇 |
1987年 | 91篇 |
1986年 | 72篇 |
1985年 | 60篇 |
1984年 | 68篇 |
1983年 | 40篇 |
1982年 | 51篇 |
1981年 | 51篇 |
1980年 | 34篇 |
1979年 | 51篇 |
1978年 | 23篇 |
1977年 | 36篇 |
1976年 | 46篇 |
1975年 | 26篇 |
1971年 | 28篇 |
排序方式: 共有8050条查询结果,搜索用时 15 毫秒
1.
2.
A. Perez S. E. Clements E. Benton A. Robson B. Bhogal C. M. Stefanato D. McGibbon 《Clinical and experimental dermatology》2009,34(8):e931-e933
We report a case of localized bullous pemphigoid (BP) in a woman patient with primary lymphoedema tarda. There is only one previous case reported of localized pemphigoid in an area of lymphoedema, this being of the cicatricial variant. Slow circulation in the lymphatic vessels, increased capillary permeability with preferential localization of antibodies in the area, and potential cleavage of the epidermal junction due to increased hydrostatic pressure leading to autoimmunity, have all been advocated as possible pathogenic mechanisms. Nevertheless, we consider that the mechanism by which localized pemphigoid arises on lymphoedema remains elusive, based on a previous case of generalized BP sparing an area of postsurgical lymphoedema. 相似文献
3.
S. Regnier Z. Ouagari Z. L. Perez N. Veziris F. Bricaire E. Caumes 《Clinical and experimental dermatology》2009,34(8):e690-e692
We report the case of a patient infected with human immunodeficiency virus who presented with fever and a disseminated papulous eruption, diagnosed as cutaneous miliary tuberculosis. The diagnosis was made by histological examination of a skin biopsy, which showed numerous acid‐fast bacilli. A culture grown from a skin biopsy isolated a resistant Mycobacterium tuberculosis strain. The papules disappeared within a few days after starting treatment with pyrazinamide, isoniazid and moxifloxacin. 相似文献
4.
C4 concentrations and C4 deficiency alleles in systemic lupus erythematosus. 总被引:1,自引:0,他引:1 下载免费PDF全文
In a study of 66 patients with systemic lupus erythematosus (SLE) and 80 controls it was found that the presence of two deficiency (null) alleles of C4 had a significant effect on mean C4 concentrations in serum. In six controls who each had two C4 null alleles the mean C4 concentration in serum was 56% lower than in 43 controls without C4 null alleles; the nadir of the C4 concentration in four patients with SLE with two null alleles was also lower by a mean of 55% than in 32 patients who did not have null alleles. Reduced production of C4 allotypes in subjects with two null alleles may be an important determinant of total C4 concentration in patients with SLE. For optimal interpretation of C4 concentrations in SLE, C4 allotyping appears to be indicated, particularly to identify patients who have two null alleles of C4. 相似文献
5.
F Lanternier C Dalban L Perez F Bricaire D Costagliola E Caumes 《The international journal of tuberculosis and lung disease》2007,11(11):1203-1209
SETTING: Tuberculosis (TB) is frequent in human immunodeficiency virus (HIV) infected patients, but its treatment is hampered by adverse events and paradoxical reactions. OBJECTIVE: To examine the impact of HIV infection and other factors on the risk and spectrum of adverse events related to anti-tuberculosis treatment in a prospective cohort study conducted between January 2003 and August 2004. RESULTS: Of 105 patients treated for TB, 30 were HIV-infected. The overall incidence of adverse events was 122.5 +/- 18.5 per 100 patient-years (py) and the incidence of severe adverse events was 45.2 +/- 11.3/100 py. Age >50 years (OR 2.2, 95%CI 1.01-4.8, P = 0.046) and HIV infection (OR 3.9, 95%CI 2.1-7.5, P < 0.001) were independently associated with a higher risk of adverse events. Hepatitis (30.5/100 py) and neuropathy (28.6/100 py) were the most frequent adverse events. Hepatitis C virus infection was associated with hepatitis (OR 4.2, 95%CI 1.2-15.0, P = 0.028) and neuropathy with HIV infection (OR 3.8, 95%CI 1.1-13.7, P = 0.040). CONCLUSION: Adverse reactions to anti-tuberculosis drugs are frequent. HIV infection and age >50 years are factors associated with such reactions, while hepatitis C virus infection is a risk factor for hepatitis. 相似文献
6.
7.
Rodrigo O Perez Angelita Habr-Gama Igor Proscurshim Fábio G Campos Desiderio Kiss Joaquim Gama-Rodrigues Ivan Cecconello 《Journal of gastrointestinal surgery》2007,11(11):1431-8; discussion 1438-40
BACKGROUND: The role of local excision for pT2 distal rectal cancer has been challenged because of the observation of high rates of lymph node metastases and local failure. However, neoadjuvant chemoradiation therapy (CRT) has led to increased local disease control and significant tumor downstaging, possibly decreasing rates of lymph node metastases. In this setting, a possible role for local excision of ypT2 has been suggested. METHODS: A total of 401 patients with distal rectal cancer underwent neoadjuvant CRT. Tumor response assessment was performed after at least 8 weeks from CRT completion. One hundred and twelve patients with complete clinical response were not immediately operated on and were excluded from the study, and 289 patients with incomplete clinical response were managed by radical surgery. Patients with final pathological stage ypT2 were analyzed to determine the risk of unfavorable pathological features that could represent unacceptable risk for local failure after local excision. RESULTS: Eighty-eight (30%) patients had ypT2 rectal cancer. Final ypT status was not associated with pretreatment radiological staging (p = 0.62). ypT status was significantly associated with the risk of lymph node metastases, risk of perineural and vascular invasion, and recurrence (p = 0.001). Lymph node metastases were present in 19% of patients with ypT2 rectal cancer. The risk of lymph node metastases in ypT2 was associated with the presence of perineural invasion (47% vs 4%; p = <0.001), vascular invasion (59% vs 6%; p < 0.001), and decreased mean interval CRT surgery (12 vs 18 weeks; p < 0.001), but not with mean tumor size (3.2 vs 3.1 cm; p = 0.8). Disease-free and overall survival rates were significantly better for patients with ypT2N0 (p = 0.02 and 0.006, respectively). Fifty-five (63%) patients with ypT2 had at least one unfavorable pathological feature for local excision (lymph node metastases, vascular or perineural invasion, mucinous type or tumor size >3 cm). CONCLUSION: Lymph node metastases were present in 19% of patients with ypT2 and were significantly associated with poor overall and disease-free survival rates. The risk of lymph node metastases could not be predicted by radiological staging or tumor size. Radical surgery should be considered the standard treatment option for ypT2 rectal cancer after CRT. 相似文献
8.
9.
10.