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Kodam Sujatha Naidu Babu Ommi Anwita Mudiraj Phanithi Prakash Babu Rajeswar Rao Vedula 《Archiv der Pharmazie》2019,352(12)
Novel thiazolyl hydrazonothiazolamines and 1,3,4‐thiadiazinyl hydrazonothiazolamines were synthesized by a facile one‐pot multicomponent approach by the reaction of 2‐amino‐4‐methyl‐5‐acetylthiazole, thiosemicarbazide or thiocarbohydrazide and phenacyl bromides or 3‐(2‐bromoacetyl)‐2H‐chromen‐2‐ones in acetic acid with good to excellent yields. These new compounds were screened in vitro for their antimalarial activity; among them, four compounds, 4h, 4i, 4k, 4l , showed moderate activity with half‐maximal inhibitory concentration (IC50) values of 3.2, 2.7, 2.7, and 2.8 and 3.2, 3.2, 3.1, and 3.5 μM against chloroquine‐sensitive and ‐resistant strains of Plasmodium falciparum, respectively. Compound 4l inhibited the ring stage growth of P. falciparum 3D7 at an IC90 concentration of 12.5 µM in a stage‐specific assay method, where the culture is incubated with specific stages of P. falciparum for 12 hr, and no activity was found against the trophozoite and schizont stages, confirming that 4l may have potent action against the ring stage of P. falciparum. 相似文献
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Makan Cheraghpour Hossein Imani Shahrzad Ommi Seyed Moayed Alavian Elahe Karimi‐Shahrbabak Mehdi Hedayati Zahra Yari Azita Hekmatdoost 《Phytotherapy research : PTR》2019,33(8):2118-2125
This study aimed to evaluate the effects of hesperidin on nonalcoholic fatty liver disease (NAFLD) characteristics. In this randomized, double‐blind, controlled clinical trial, 50 NAFLD patients were supplemented with either 1‐g hesperidin capsule or identical placebo capsule for 12 weeks. During the intervention, both groups were advised to follow healthy lifestyle habits including dietary and physical activity recommendations. At the end of the study, hesperidin supplementation, compared with placebo, was associated with a significant reduction in alanine aminotransferase (p = .005), γ‐glutamyltransferase (p = .004), total cholesterol (p = .016), triglyceride (p = .049), hepatic steatosis (p = .041), high‐sensitivity C‐reactive protein (p = .029), tumor necrosis factor‐α, and nuclear factor‐κB (NF‐κB). In conclusion, our results indicate that hesperidin supplementation accompanied with lifestyle modification is superior to lifestyle modification alone in management of NAFLD at least partially through inhibiting NF‐κB activation and improving lipid profile. Further studies with higher dose of hesperidin are required to find the optimal dose. 相似文献
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Ommi Davood Hemmatinezhad Behsan Hafshejani Taghi Taktaz Khamesipour Faham 《Proceedings of the National Academy of Sciences, India. Section B.》2017,87(4):1285-1291
Proceedings of the National Academy of Sciences, India Section B: Biological Sciences - Carriage status of Campylobacter and Salmonella was investigated in houseflies in Shahrekord and Isfahan... 相似文献
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Soroor Advani Seyyed MohammadMahdi Hosseini Alireza Zali Davood Ommi Alireza Fatemi Reza Jalili Khoshnoud Farzad Ashrafi 《Clinical Case Reports》2021,9(12)
Transverse myelitis has been reported as a complication of COVID‐19 in recent studies. Here, we report two cases of transverse myelitis related to COVID‐19. Both patients underwent plasma exchange after being treated with antibiotics and corticosteroids which lead to the recovery of one of them. 相似文献
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