收费全文 | 12961篇 |
免费 | 880篇 |
国内免费 | 83篇 |
耳鼻咽喉 | 160篇 |
儿科学 | 370篇 |
妇产科学 | 383篇 |
基础医学 | 1451篇 |
口腔科学 | 601篇 |
临床医学 | 1051篇 |
内科学 | 2855篇 |
皮肤病学 | 297篇 |
神经病学 | 735篇 |
特种医学 | 393篇 |
外国民族医学 | 6篇 |
外科学 | 2022篇 |
综合类 | 363篇 |
一般理论 | 8篇 |
预防医学 | 917篇 |
眼科学 | 458篇 |
药学 | 1041篇 |
中国医学 | 66篇 |
肿瘤学 | 747篇 |
2023年 | 168篇 |
2022年 | 426篇 |
2021年 | 719篇 |
2020年 | 407篇 |
2019年 | 535篇 |
2018年 | 730篇 |
2017年 | 394篇 |
2016年 | 421篇 |
2015年 | 452篇 |
2014年 | 588篇 |
2013年 | 711篇 |
2012年 | 1042篇 |
2011年 | 1005篇 |
2010年 | 569篇 |
2009年 | 460篇 |
2008年 | 705篇 |
2007年 | 600篇 |
2006年 | 586篇 |
2005年 | 576篇 |
2004年 | 486篇 |
2003年 | 413篇 |
2002年 | 365篇 |
2001年 | 133篇 |
2000年 | 138篇 |
1999年 | 125篇 |
1998年 | 65篇 |
1997年 | 61篇 |
1996年 | 56篇 |
1995年 | 52篇 |
1994年 | 38篇 |
1993年 | 33篇 |
1992年 | 76篇 |
1991年 | 88篇 |
1990年 | 60篇 |
1989年 | 68篇 |
1988年 | 62篇 |
1987年 | 52篇 |
1986年 | 39篇 |
1985年 | 35篇 |
1984年 | 36篇 |
1983年 | 20篇 |
1982年 | 26篇 |
1981年 | 19篇 |
1980年 | 24篇 |
1979年 | 32篇 |
1978年 | 29篇 |
1977年 | 19篇 |
1975年 | 18篇 |
1974年 | 28篇 |
1973年 | 19篇 |
Area covered: The current review is provided to update recent developments in the clinical application of cyclin/CDK inhibitors to breast cancer with a focus on the anti-tumor immune response.
Expert opinion: The cyclin D1 gene encodes the regulatory subunit of a proline-directed serine-threonine kinase that phosphorylates several substrates. CDKs possess phosphorylation site selectivity, with the phosphate-acceptor residue preceding a proline. Several important proteins are substrates including all three retinoblastoma proteins, NRF1, GCN5, and FOXM1. Over 280 cyclin D3/CDK6 substrates have b\een identified. Given the diversity of substrates for cyclin/CDKs, and the altered thresholds for substrate phosphorylation that occurs during the cell cycle, it is exciting that small molecular inhibitors targeting cyclin D/CDK activity have encouraging results in specific tumors. 相似文献
Background
The objective of the study was to evaluate the outcomes of clinically localized prostate cancer treated with prostatectomy versus radiation therapy within the context of a prospective prostate cancer screening study.Patients and Methods
Within the PLCO (Prostate, Lung, Colorectal, and Ovary) trial, patients who were diagnosed with clinically localized prostate cancer and subsequently received treatment with prostatectomy or radiation therapy (with or without hormonal treatment) were included. Univariate and multivariate Cox regression analyses were then performed to determine factors affecting overall and prostate cancer-specific survival. Factors with P < .05 in univariate analysis were included in the multivariate analysis.Results
A total of 3953 patients were included in the current analysis. These included 2044 patients treated with prostatectomy and 1909 patients treated with radiation therapy with or without hormonal treatment. In an adjusted multivariate analysis for factors affecting overall survival, prostatectomy was associated with better overall survival compared with radiation therapy (hazard ratio, 0.548; 95% confidence interval [CI], 0.440- 681; P < .001). Likewise, in an adjusted multivariate analysis for factors affecting prostate cancer-specific survival, prostatectomy was associated with better prostate cancer-specific survival compared with radiation therapy (hazard ratio, 0.485; 95% CI, 0.286- 0.822; P = .007). Similar findings were found with propensity score matching and repeating the same analyses on the post-matching cohort.Conclusion
Prostatectomy seems to predict better overall and prostate cancer-specific survival compared with radiation therapy among patients with clinically localized prostate cancer diagnosed within the PLCO trial. 相似文献Purpose
To investigate the expression of IL-11 and its receptor IL-11Rα and to quantify density of CD163+ M2 macrophages in proliferative diabetic retinopathy (PDR). 相似文献Background
Herbal medicine has been widely utilized by pregnant women despite the limited available evidence regarding the safety and efficacy of that practice. The current available studies, from different countries, estimated that the use of herbal medicine during pregnancy range from 7% up to 96%. The aim of this study is to determine the prevalence, attitude, source of information, and reasoning behind the use of herbal medicine among pregnant women in Saudia Arabia.Methods
A cross-sectional study conducted using a convenience sample including pregnant women who visited the obstetric clinics at King Abdulaziz Medical City in Riyadh, Saudi Arabia. A survey was administered in order to evaluate the prevalence and perception toward herbal medicine use among pregnant women in Saudi Arabia.Results
A total of 297 pregnant women completed the survey. The results showed that 56% of the respondents have used some type of herbal medicine during their pregnancy. Olive oil was utilized in 26% of the respondents followed by cumin 20% and garlic 15%. In addition, 37% of the respondents used herbal medicine by their own initiative, while 33% and 12% used herbal medicine based on recommendations from their families and friends, respectively. Furthermore, 19% of the respondents reported a positive attitude toward herbal medicine use during pregnancy. In addition, the percentage of women with positive attitude was marginally higher among respondents with lower educational level.Conclusion
The prevalence of using herbal medicine is considerably high among pregnant women in Saudi Arabia. Unfortunately, the majority of the users relied on informal sources to use herbal medicine during pregnancy. 相似文献Areas covered: Approximately 10–45% of patients undergoing head-and-neck cancers surgery develop SSIs. SSIs can lead to delayed wound healing, increased morbidity and mortality as well as costs. Consequently, SSIs need to be avoided where possible, as even the surgery itself impacts on patients’ subsequent activities and their quality of life, which is exacerbated by SSIs. Several risk factors for SSIs need to be considered to reduce future rates, and care is also needed in the selection and duration of antibiotic prophylaxis.
Expert commentary: Head and neck surgeons should give personalized care especially to patients at high risk of SSIs. Such patients include those who have had chemoradiotherapy and need reconstructive surgery, and patients from lower and middle-income countries and from poorer communities in high income countries, who often have high levels of co-morbidity because of resource constraints. 相似文献