全文获取类型
收费全文 | 224篇 |
免费 | 7篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 16篇 |
儿科学 | 26篇 |
妇产科学 | 18篇 |
基础医学 | 10篇 |
口腔科学 | 8篇 |
临床医学 | 57篇 |
内科学 | 34篇 |
皮肤病学 | 3篇 |
神经病学 | 7篇 |
特种医学 | 15篇 |
外科学 | 15篇 |
综合类 | 8篇 |
预防医学 | 11篇 |
眼科学 | 2篇 |
药学 | 5篇 |
肿瘤学 | 7篇 |
出版年
2024年 | 1篇 |
2023年 | 1篇 |
2022年 | 1篇 |
2021年 | 2篇 |
2020年 | 1篇 |
2019年 | 4篇 |
2018年 | 6篇 |
2017年 | 6篇 |
2016年 | 3篇 |
2015年 | 3篇 |
2014年 | 8篇 |
2013年 | 9篇 |
2012年 | 8篇 |
2011年 | 5篇 |
2010年 | 12篇 |
2009年 | 12篇 |
2008年 | 7篇 |
2007年 | 12篇 |
2006年 | 2篇 |
2005年 | 4篇 |
2004年 | 4篇 |
2003年 | 3篇 |
2001年 | 7篇 |
2000年 | 4篇 |
1999年 | 2篇 |
1998年 | 10篇 |
1997年 | 10篇 |
1996年 | 12篇 |
1995年 | 5篇 |
1994年 | 6篇 |
1993年 | 5篇 |
1992年 | 6篇 |
1991年 | 6篇 |
1990年 | 1篇 |
1989年 | 7篇 |
1988年 | 7篇 |
1987年 | 13篇 |
1986年 | 5篇 |
1985年 | 3篇 |
1984年 | 2篇 |
1983年 | 3篇 |
1982年 | 2篇 |
1980年 | 3篇 |
1978年 | 2篇 |
1977年 | 3篇 |
1976年 | 2篇 |
1974年 | 1篇 |
1971年 | 1篇 |
排序方式: 共有242条查询结果,搜索用时 15 毫秒
1.
Jennifer C. Chen Katrina L. Schmid Brian Brown Marion H. Edwards Bibianna SY Yu John KF Lew 《Clinical & experimental optometry》2003,86(5):323-330
Purpose: Caucasian children with myopia have elevated response accommodative vergence to accommodation (AC/A) ratios. The purpose of this study was twofold: to determine if response AC/A ratios vary with refractive error and with myopic progression rate in Hong Kong Chinese children, and to determine the effect of beta‐adrenergic antagonism with topical timolol application on AC/A ratios. Methods: Thirty children aged eight to 12 years participated in the study. All refractive errors were corrected with spectacle lenses. Accommodative responses were measured using a Shin‐Nippon autorefractor and concurrent changes in vergence were assessed using a vertical prism and a Howell‐Dwyer card at three metres and 0.33 metre. Accommodative demand was altered using plus or minus two dioptre lenses and lens‐ and distance‐induced response AC/A ratios were calculated. Measurements were repeated 30 minutes after the instillation of topical timolol maleate (0.5 per cent). Results: AC/A ratios appeared higher in progressing myopic children but the difference was not statistically significant. Timolol application reduced accommodative convergence (AC) in the stable myopes (reduction = ‐3 ± 1.14A) but not in the emmetropes (0.69 ± 0.9P) or progressing myopes (0.16 ± 0.43A) and this difference between refractive groups was statistically s ignificant (F2,27= 3.766; P= 0.036). However, timolol did not produce a significant change in the accommodative response to positive or negative lenses or response AC/A ratios. Conclusions: We did not find that AC/A ratios in myopic Chinese children were elevated and therefore, it is unlikely that elevated AC/A ratios are responsible for the high levels of myopia that occur in Hong Kong. The finding that timolol reduced AC in the stable myopes suggests that the autonomic control of accommodative convergence in these children may be different from that in emmetropic children and those with progressing myopia. 相似文献
2.
3.
Leukotriene B4 (LTB4) and the protein kinase C activator, 4-beta-phorbol dibutyrate (PDBu), both induced a pronounced and concentration-dependent stimulation of hydrogen peroxide (H2O2) generation by purified guinea pig peritoneal eosinophils in the concentration range 1 nM-1 microM. The LTB4 response was inhibited competitively by the specific LTB4 receptor antagonist, U-75302, with a KB of 25 nM, while the concentration-response curves for both stimuli were shifted rightwards (3.8-fold and 2.8-fold for LTB4 and PDBu, respectively) by the competitive protein kinase C inhibitor, 1-O-hexadecyl-2-O-methylglycerol at a concentration of 300 microM. LTB4 appears, therefore, to induce respiratory burst in eosinophils via a receptor-mediated mechanism involving protein kinase C. 相似文献
4.
Human high molecular weight kininogen (HMWK), a single-chain protein with mol wt 120,000, is cleaved by human urinary kallikrein (HUK) to release kinin from within a disulfide loop and form a two-chain protein that retains all the procoagulant activity of the native molecule. Cleavage of HMWK by HUK is associated with a reduction in size to mol wt 115,000, as assessed by SDS-PAGE of unreduced protein, whereas the two chains of the reduced protein present together as a single broad band with mol wt 64,000. The 64,000 chain with procoagulant activity was chromatographically separated from the nonfunctional chain of similar size. The homogeneous procoagulant chain had an amino acid composition similar to that of smaller procoagulant ("light") chains isolated by others upon cleavage of HMWK with plasma kallikrein and elicited an antiserum that was monospecific by Ouchterlony analysis and inhibited the procoagulant function of HMWK. Thus, the limited proteolysis of HMWK by HUK has permitted, for the first time, the isolation of a stable procoagulant chain that is equal in size to the nonfunctional chain. The common terminology of "heavy" and "light" chain for kinin-free kininogen obtained with plasma kallikrein reflects the continued degradation of the procoagulant carboxyterminal chain and is not appropriate for the initial two-chain product formed when kinin is released from HMWK. It is proposed that the initial cleavage products of HMWK be designated the A-chain, the B-fragment, and the C- chain, representing the amino-terminal chain, the released vasoactive peptide containing the bradykinin sequence, and the carboxy-terminal procoagulant chain, respectively. Thus, intact HMWK would contain, in sequence, A, B, and C regions. 相似文献
5.
M E Norré 《American journal of otolaryngology》1987,8(1):31-35
Rehabilitation treatment is based on experimental data concerning compensation and adaptation in peripheral vestibular lesions. Patients with a steady state of peripheral vestibular dysfunction are candidates for rehabilitation therapy. Provoked (positioning) vertigo resulting from such lesions is treated by individually selected exercises (vestibular habituation training). Functional evaluation is indispensable for patient selection. In accordance with experimental data, the exercises are selected individually by testing patients with a vestibular habituation training test battery. The favorable effect of vestibular habituation treatment is suggested by comparison with drug and sham treatments in similar cases. 相似文献
6.
Nicole Warren Kathleen F. Norr Gwen Brumbaugh Keeney 《Health care for women international》2013,34(6):482-498
Our team explored the lived experiences of rural auxiliary midwives, or matrones, in Mali. Since matrones attend more births than all other health workers combined, they are critical to efforts to reduce maternal mortality. Currently, their experiences are not well understood. This study used interpretive phenomenology to describe the experiences of seven matrones. We suggest that matrones provide a vital connection between traditional approaches to birth and the biomedical services offered by the formal health sector. Matrones’ unique role as both health professionals and rural women creates challenges and opportunities that affect their effectiveness and personal lives. 相似文献
7.
Laurence Claes Astrid Müller Jan Norré Leen Van Assche Steve Wonderlich James E. Mitchell 《European eating disorders review》2012,20(2):126-131
The aim of the present study was to investigate the association among compulsive buying (CB), compulsive internet use (CIU) and reactive/regulative temperament in a sample of 60 female patients with eating disorders. All patients were assessed by means of the Compulsive Buying Scale, the CIU scale, the Eating Disorder Inventory—2, the Behavioral Inhibition System/Behavioral Activation System scales, the Dimensional Assessment of Personality Pathology and the effortful control scale of the Adult Temperament Questionnaire. The results showed a positive association between CB and CIU, both categorized as impulse control disorders, not otherwise specified. Both CB and CIU showed significantly positive correlations with emotional lability, excitement seeking and lack of effortful control (more specifically lack of inhibitory and lack of activation control). The implication of these findings for the treatment of both disorders will be discussed. Copyright © 2011 John Wiley & Sons, Ltd and Eating Disorders Association. 相似文献
8.
The focus on quality of life issues in wound care has justly taken a far greater importance. With the acceptance that pain can be a major factor to the patient, and in particular, pain at dressing change comes the opportunity for avoidance and/or reduction strategies. Whilst pain has been associated with wound infection for millennia, it is only much more recently that this has received due attention from research and clinical practice. In this study, the nature of pain, changes in pain and pain associated with infection are the focal points. A Delphi approach, now a frequently used tool in wound care research, has been used to obtain expert opinion on these aspects of management. 相似文献
9.
Vonderheid SC Norr KF Handler AS 《Western journal of nursing research》2007,29(3):258-76; discussion 277-83
To improve the effectiveness of prenatal care, there is a need to understand the association between health promotion content and health behaviors during pregnancy. The purpose of this study was to determine the association between prenatal health promotion content and health behaviors during pregnancy among low-income African American and Mexican American women. Twenty-two recommended health promotion topics and their related health behaviors were measured. Structured interviews on health promotion topics and health behaviors were conducted with 159 pregnant women receiving prenatal care at a low-risk urban clinic. Wide variation was found in the number of health promotion topics discussed. Bivariate and regression analyses examined the association between content topics and behaviors. Healthier behaviors were associated with women's reports of discussing more health promotion topics, using fewer substances prepregnancy, and having a more positive attitude toward pregnancy. Data suggest that increasing prenatal health promotion content during routine visits might improve the effectiveness of prenatal care. 相似文献
10.