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1.
Shigeki Yamagishi Kiyoshi Koizumi Tomomi Hirata Kyoji Hirai Jiro Kurita Kazuo Shimizu 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2005,53(6):313-316
We report a 59-year-old woman who underwent thoracoscopic extirpation of the intrapulmonary cystic lymphangioma which was located in the subpleural space of the left upper lobe. A chest X-ray showed a solitary round nodule in the left pulmonary hilum. A computed tomography scan revealed a mass shadow at the interlobar region surrounding the interlobar pulmonary artery. A round nodule was recognized as low signal intensity on T1-weighted images by magnetic resonance imaging. There was biphasic signal intensity on T2-weighted images as well. Radiologically, we diagnosed this lesion as a benign cystic tumor in the lung. Thoracoscopic observation revealed a cystic lesion just beneath the visceral pleura of the upper lobe adjacent to the interlobular pulmonary artery. As this suggested a benign bronchogenic cyst, we performed extirpation of the cyst under thoracoscopy. After this operation, the cyst was diagnosed as an intrapulmonary cystic lymphangioma pathologically. 相似文献
2.
Takahashi S Okada K Nagasawa H Shimada Y Sakamoto H Itoi E 《Virchows Archiv : an international journal of pathology》2004,444(5):454-458
We describe a case history of a 24-year-old male with osteogenesis imperfecta (OI) who developed osteosarcoma of the left thigh. High-dose ifosfamide therapy caused marked tumor regression of multiple lung metastases. Immunohistochemically, the tumor cells were diffusely positive for the p53 protein. Mutation of the p53 gene was not detected by direct genomic sequencing of exons 4–8. The radiographic characteristics, including irregularly distributed osteolytic lesions and cortical discontinuity, should not be confused with hyperplastic callus formation, a benign process. A biopsy is critical to establish the differential diagnosis between osteosarcoma and common hyperplastic callus formation in OI; however, it must be applied with great care. 相似文献
3.
Kyoji Yamamoto M.D. Keiichi Fujimoto Takashi Matsushiro Keisuke Ota 《Journal of gastroenterology》1990,25(6):758-761
A case of lymphoepithelial cyst in the pancreas was reported. A 64-year-old man without any specific compalints was found
to have a cystic lesion in the anterior portion of the pancreas, as revealed by ultrasonography of the abdomen at an annual
medical examination in 1988. This was dissected easily from the pancreas. Histologically, it was diagnosed to be a benign
lymphoepithelial cyst in the pancreas. Cysts of this type are rare, and their histogenesis is also not well understood. 相似文献
4.
Kenji Abe Kanayo Kobayashi Saori Yoshino Kyoji Taguchi Hiroshi Nojima 《Drug and chemical toxicology》2015,38(2):167-173
An itch is experientially well known that the scratching response of conditions such as atopic dermatitis is enhanced under psychological stress. Morphine is typical narcotic drug that induces a scratching response upon local application as an adverse drug reaction. Although long-term treatment with morphine will cause tolerance and dependence, morphine withdrawal can cause psychologically and physiologically stressful changes in humans. In this study, we evaluated the effects of morphine withdrawal on histamine-induced scratching behavior in mice. Administration of morphine with progressively increasing doses (10–50?mg/kg, i.p.) was performed for 5 consecutive days. At 3, 24, 48, and 72?hr after spontaneous withdrawal from the final morphine dose, histamine was intradermally injected into the rostral part of the back and then the number of bouts of scratching in 60?min was recorded and summed. We found that at 24?hr after morphine withdrawal there was a significant increase in histamine-induced scratching behavior. The spinal c-Fos positive cells were also significantly increased. The relative adrenal weight increased and the relative thymus weight decreased, both significantly. Moreover, the plasma corticosterone levels changed in parallel with the number of scratching bouts. These results suggest that morphine withdrawal induces a stressed state and enhances in histamine-induced scratching behavior. Increased reaction against histamine in the cervical vertebrae will participate in this stress-induced itch enhancement. 相似文献
5.
6.
Matsuda Hiroshi Okita Kyoji Motoi Yumiko Mizuno Toshiki Ikeda Manabu Sanjo Nobuo Murakami Koji Kambe Taiki Takayama Toshiki Yamada Kei Suehiro Takashi Matsunaga Keiko Yokota Takanori Tateishi Ukihide Shigemoto Yoko Kimura Yukio Chiba Emiko Kawashima Takahiro Tomo Yui Tachimori Hisateru Kimura Yuichi Sato Noriko 《Annals of nuclear medicine》2022,36(12):1039-1049
Annals of Nuclear Medicine - Amyloid positron emission tomography (PET) can reliably detect senile plaques and fluorinated ligands are approved for clinical use. However, the clinical impact of... 相似文献
7.
8.
Glial cells are generally considered to contribute to retaining the integrity of neural function through the protection of
neuronal cells against neurodegenerative insults and also expected to play a potential role in the protection of cerebrovascular
systems from various toxic insults of hemorrhaged blood, thus proposing a possible implication of glial cells in the recovery
of brain function from the damage caused by cerebral hemorrhage. Based on this hypothetical idea, the direct effect of hemin
on the expression of genes encoding heme oxygenase-1 (HO-1), vascular endothelial growth factor (VEGF), and brain-derived
neurotrophic factor (BDNF) in glial cells was examined using rat C6 glioma cells as an in vitro model system. Hemin elevated
both HO-1 and VEGF mRNA levels in the glioma cells at the concentration causing no critical damage to the cells, and the elevation
of BDNF mRNA levels was also observed by exposing the cells to hemin under the same conditions. Furthermore, the elevation
of VEGF and BDNF mRNA levels induced by hemin was blocked by pretreatment of the cells with the agents inhibiting not only
HO-1 gene expression but also its enzymatic activity. These pharmacological studies indicate that hemin can induce the enhancement
of VEGF and BDNF gene expression probably through the mechanism mediated by HO-1 activity in the glioma cells, proposing the
possibility that glial cells are capable of contributing to the recovery of brain function from the damage caused by cerebral
hemorrhage through the production of neurogenic and angiogenic factors. 相似文献
9.
Steroidal glycosides from the rhizomes of Dioscorea spongiosa 总被引:2,自引:0,他引:2
Yin J Kouda K Tezuka Y Tran QL Miyahara T Chen Y Kadota S 《Journal of natural products》2003,66(5):646-650
A water extract of the rhizomes of Dioscorea spongiosa, which showed antiosteoporotic activity, was examined, and four new pregnane glycosides, named spongipregnolosides A-D (1-4), and two new cholestane glycosides, named spongiosides A (5) and B (6), were isolated together with 15 known glycosides. Their structures were determined on the basis of spectroscopic analysis and chemical methods. Among the isolated compounds, spongioside A (5), hypoglaucin G (7), methylprotodioscin (8), and (R)-oct-1-en-3-yl O-alpha-l-arabinopyranosyl-(1-->6)-alpha-d-glucopyranoside (9) showed potent inhibition against bone resorption induced by parathyroid hormone in a bone organ culture system. 相似文献
10.
Keiichi Jimbo Kazuhiko Mori Susumu Aikou Mitsuhiro Okazaki Tomoaki Sato Kyoji Moriya Yoko Kawase-Koga Yoshiyuki Mori Yuki Kanno Yukinori Yamagata Koichi Yagi Masato Nishida Hiroharu Yamashita Sachiyo Nomura Yasuyuki Seto 《Esophagus》2017,14(2):153-158