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排序方式: 共有296条查询结果,搜索用时 15 毫秒
1.
Seven middle-aged men with manifest type II diabetes mellitus underwent an endurance training programme for 10–15 weeks. The maximal aerobic capacity, as well as the endurance capacity, was improved by 10% (p<0.05). The intramuscular glycogen store increased by more than 80% (p<0.05) from 350 μmol/g dw (dry weight), and the activities of citrate synthase and 3-hydroxy-acyl-CoA dehydrogenase increased by more than 50% (p<0.05) and 30% (p<0.05). The activity of glycogen synthase was decreased by approximately 20% (p<0.05), whereas lactate dehydrogenase remained unchanged. Capillaries/fibre and fibre area increased by more than 50% (p<0.05) and 30% (p<0.05) leaving the area of supply constant. Training did not influence fasting blood lipids and glucose, glycosylated hemoglobin, oral glucose tolerance, and insulin response to an oral glucose load measured 72 hours post-exercise. It is concluded that patients with manifest type II diabetes, as normoglycaemic individuals, adapt to physical training. However, no persistent effect on glucohomeostasis and lipaemia is produced by short-term training in the diabetic patients. 相似文献
2.
A Decrease in Pulmonary Vein Diameter After Radiofrequency Ablation Predicts the Development of Severe Stenosis 总被引:3,自引:0,他引:3
ALEXANDER BERKOWITSCH THOMAS NEUMANN OKAN EKINCI HARALD GREISS THORSTEN DILL KLAUS KURZIDIM MALTE KUNISS HANS J. SCHNEIDER HEINZ F. PITSCHNER 《Pacing and clinical electrophysiology : PACE》2005,28(S1):S83-S85
A decrease in ostial pulmonary vein (PV) diameter was observed in patients on the day after radiofrequency ablation of atrial fibrillation (AF). This study examined whether a relative reduction in PV diameter on day 1 (RRPVD1) after the procedure predicts the late development of severe PV stenosis (PVS). The study included 104 consecutive patients (mean age = 55 years, range 46–61, 34 women) with drug refractory AF. Pulmonary vein diameter was measured using MR angiography (MRA) on the day before and on day 1 after the ablation procedure. The MRA was repeated every 3 months after the procedure. Severe PVS was defined as a >70% diameter reduction from the initial ostial diameter. The cut-off of RRPVD1 was prespecified as 25% decrease in initial diameter. The data are presented as medians and interquartile range. A total of 357 PV were treated. The RRPVD1 was 0.0% (0.0–11.1%). Severe PVS was found in 18 PV during a follow-up of 12 months (range 6–13). The log-rank analysis confirmed a strong association between a RRPVD1 ≥25% and the development of PVS (hazard ratio: 7.1; 95% confidence interval 3.8–13.5, P < 0.0001). By multivariate Cox regression model, after adjustment of procedure variables, RRPVD1 was the strongest predictor of development of severe PVS. RRPVD1 ≥25% was a strong independent predictor of development of severe PVS. 相似文献
3.
The endogenous activity of the local renin-angiotensin system(RAS) and the anti-ischaemic properties of captopril were investigatedin electrically driven rabbit Langendorff hearts (constant pressure:70 cmH2O, Tyrode solution, Ca2+ 1.8 mmol.l1). Cumulativeconcentration-response curves showed no significant difference(P>0.05) between the reduction of the global coronary flow(CF) by exogenous angiotensin-I or angiotensin-II (EC50 = 1010mol.l1). It is concluded that the local RAS in isolatedrabbit hearts is highly sensitive, whereas its endogenous activityis very low due to very low endogenous angiotensin-I content.Myocardial ischaemia (MI) was induced by the occlusion of aleft coronary artery branch and MI was quantified from NADHsurface fluorescence photography. MI was significantly enlarged(+35%) (P <0.05) by exogenous angiotensin-I (6x109mol.l1). The reduction in CF and the increment in MIby angiotensin-I could be completely prevented by adding captoprilat a low concentration (106 mol.l1) to the perfusionbuffer. In the absence of exogenous angiotensin-I, captoprilalone (106 mol.l1) neither significantly enhancedCF (P >0.05), nor diminished MI (P >0.05), supportingthe finding of very low endogenous activity of tile local RASin this model. We, moreover, conclude that at a low concentration(106 mol.l1) captopril does not possess directcardioprotective properties independent of its ACE inhibitingaction. 相似文献
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Mature liver stages of cloned Plasmodium falciparum share epitopes with proteins from sporozoites and asexual blood stages 总被引:3,自引:0,他引:3
ANA SZARFMAN JEFFREY ALYON DAVID WALLIKER ISABELLA QUAKYI RUSSELL J. HOWARD SUSAN SUN W. RIPLEY BALLOU KLAUS ESSER WILLIAM T. LONDON ROBERT A. WIRTZ RICHARD CARTER 《Parasite immunology》1988,10(3):339-351
The liver merozoites of malaria parasites are of paramount importance, as they initiate the parasite invasion of red blood cells and start the cycle associated with the clinical features of malaria. Investigating liver merozoite antigen is difficult because of the lack of a rodent model of human malaria. In addition, only a low proportion of cells are obtained in vivo, the parasites from Cebus and Aotus monkeys are immature, and in-vitro experiments with liver cells are often confounded by contamination with the natural mosquito flora copurified with the sporozoites used for seeding the liver cultures. In our study, mature liver schizonts were shown to possess many of the antigenic determinants recognized by MoAbs and sera specific for defined sporozoite and blood-stage antigens. We employed an immunofluorescence procedure based on evaluating parasites in cryosections prepared from infected chimpanzee liver. Sufficient numbers of sectioned parasites were evaluated with each antibody to assure the reproducibility of the results, and the fixation procedure used was sufficiently non-destructive to parasite antigens so that clear differences between reactions of specific antibodies and negative controls were observed. Our evidence for sharing of epitopes by liver merozoites and sporozoites or by liver merozoites and asexual blood-stage parasites raises the possibility that immune responses elicited against sporozoites or asexual stage antigens being considered as vaccine candidates may also act against this important, little-studied stage of the parasite. 相似文献
7.
GABRIELE MARGOS KLAUS KURTENBACH † ELSA POSNETT GUY C. BARKER HIROYUKI MATSUOKA MICHAEL G. PATON ROBERT E. SINDEN 《Parasite immunology》1995,17(4):167-176
A surface protein of Plasmodium berghei ookinetes, Pbs21, was expressed in a baculovirus-insect cell system in cell culture and in Heliothis virescens larvae. Groups of BALB/c mice received two intraperitoneal inoculations of either i) Tris-buffer or homogenized H. virescens larvae infected with wild-type baculovirus; ii) enriched, homogenized ookinetes, or Hi) homogenizedH. virescens larvae expressing recombinant Pbs21 (rPbs21). All animals immunized with ookinetes or with rPbs21 had high litres of antibodies (IgG isotype) that bound to native Pbs21. The large majority of antibodies in immune sera of both groups recognized the antigen under non-reducing but not under reducing conditions. The predominant IgG-sub-classes in mice immunized with ookinetes was IgGl and in mice immunized with rPbs21, the subclasses were IgGl and IgG2a. Immunization with rPbs21 reduced the infec-tivity of P. berghei to mosquitoes by 91% compared to a 99% reduction following immunization with ookinetes. This preliminary data indicate that rPbs21 expressed in this eukaryotic system induces a transmission-blocking immunity which is more effective than that achieved using rPbsll expressed in Escherichia coli (Matsuoka et al. 1994). 相似文献
8.
Cardioverter Discharges Following Sensing of Electrical Artifact Due to Fluid Penetration in the Connector Port 总被引:1,自引:0,他引:1
CHRISTINE HIEF REA PODCZECK KLAUS FROHNER MICHAEL NURNBERG WILHELM KALTENBRUNNER FRANZ VEIT KONRAD STEINBACH 《Pacing and clinical electrophysiology : PACE》1995,18(8):1589-1591
We report a unique case of fluid penetration, 3 months after implantation, in the connector port of an automatic implantable Cardioverter defibrillator (ICD) with transvenous subcutaneous lead system. The patient had coronary artery disease and recurrent episodes of ventricular fibrillation, the fluid caused electrical signals interpreted as ventricular fibrillation by the device, which triggered shock delivery . 相似文献
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10.
AGGRESSIVENESS, ONSET OF DEPENDENCE, AND TREATMENT OUTCOME IN SOCIALLY WELL-ADAPTED ALCOHOLICS 总被引:2,自引:2,他引:0
MANN KARL; ACKERMANN KLAUS; JUNG MARTIN; MORLOCK PETER; MUNDLE GOTZ 《Alcohol and alcoholism (Oxford, Oxfordshire)》1998,33(1):16-19
Current typologies of alcoholism derive from the whole spectrumof afflicted persons. One type is characterized by variablessuch as early onset of dependence, violence, and aggressiveness.In previous research, this has been shown to be correlated withpoorer prognosis. We tested this association in a fairly homogeneoussubgroup of 258 socially rather well-adjusted male inpatients.Aggressiveness was assessed psychometrically. As a group, patientsdid not differ from general population norms. However, age wasnegatively correlated with aggressiveness. Even after takingpatients' age and duration of dependence into account, aggressivenesswas associated with an early onset of dependence and furtheraspects of drinking history, thus confirming results from previoustypology research. Overall treatment outcome after 6 and 12months was quite good, but was not influenced by aggression. 相似文献