全文获取类型
收费全文 | 513篇 |
免费 | 39篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 10篇 |
妇产科学 | 2篇 |
基础医学 | 75篇 |
口腔科学 | 6篇 |
临床医学 | 29篇 |
内科学 | 98篇 |
皮肤病学 | 12篇 |
神经病学 | 170篇 |
特种医学 | 16篇 |
外科学 | 28篇 |
综合类 | 3篇 |
一般理论 | 1篇 |
预防医学 | 25篇 |
眼科学 | 28篇 |
药学 | 37篇 |
中国医学 | 5篇 |
肿瘤学 | 9篇 |
出版年
2021年 | 8篇 |
2018年 | 7篇 |
2017年 | 8篇 |
2016年 | 9篇 |
2015年 | 7篇 |
2014年 | 10篇 |
2013年 | 11篇 |
2012年 | 10篇 |
2011年 | 17篇 |
2010年 | 11篇 |
2009年 | 15篇 |
2008年 | 14篇 |
2007年 | 25篇 |
2006年 | 21篇 |
2005年 | 20篇 |
2004年 | 21篇 |
2003年 | 20篇 |
2002年 | 25篇 |
2001年 | 15篇 |
2000年 | 10篇 |
1999年 | 12篇 |
1998年 | 9篇 |
1997年 | 13篇 |
1996年 | 8篇 |
1995年 | 5篇 |
1992年 | 8篇 |
1991年 | 10篇 |
1988年 | 9篇 |
1987年 | 12篇 |
1986年 | 8篇 |
1985年 | 12篇 |
1984年 | 5篇 |
1983年 | 8篇 |
1982年 | 4篇 |
1981年 | 5篇 |
1979年 | 4篇 |
1976年 | 10篇 |
1975年 | 5篇 |
1973年 | 6篇 |
1972年 | 4篇 |
1970年 | 4篇 |
1967年 | 5篇 |
1966年 | 6篇 |
1942年 | 5篇 |
1941年 | 5篇 |
1940年 | 4篇 |
1938年 | 5篇 |
1928年 | 4篇 |
1927年 | 4篇 |
1923年 | 7篇 |
排序方式: 共有555条查询结果,搜索用时 15 毫秒
1.
Zusammenfassung Die Autoren berichten über dem Formenkreis der zentralen Recklinghausenschen Krankheit zugehörige seltene Geschwulstarten und vergleichen dieselben untereinander. Fall 1 entspricht der als Seltenheit in der Weltliteratur bekannten Foerster-Gagelschen diffusen zentralen Schwannose — obzwar durch die Untersuchung, besonders bei Anwendung der spezifischen Versilberungsmethoden, die morphologischen Züge von der Tumorzelle nachgewiesen werden konnten und hiermit bewiesen wurde, daß es sich um eine diffuse, das ganze Zentralnervensystem überschwemmende Überproduktion von die verschiedenen Entwicklungsstufen der Makroglia verkörpernden Zellen handelt. Vom Gesichtspunkt einer genetischen Deutung ist der Vergleich des 1. Falles mit Fall 2, welcher einen typischen, jedoch stark betonten zentralen Recklinghausen darstellt. Aus alldem wird gefolgert, daß all diese Veränderungen die Ergebnisse einer Hyperfunktion der in der Nähe der Kammeroberfläche tätigen Matrix sein dürften. 相似文献
2.
3.
4.
E. Obál Jr. G. Benedek A. Jancsó-Gábor F. Obál 《Pflügers Archiv : European journal of physiology》1979,382(3):249-254
Salivary thermolytic mechanism (weight of salivary glands, effect of desalivation on water intake and body temperature, grooming activity) as well as escape behaviour and reaction to heat pain were studied in capsaicin-desensitized and control rats exposed to various warm ambient temperatures. Body temperature of the desensitized rats increased more than the controls at all the ambient temperatures studied (32, 34 and 36°C); however, significant differences in the mechanism of salivary cooling were obtained only at 34 and 36°C. Central impairment of saliva spreading in desensitized rats seems evident. Complete surgical desalivation did not increase hyperthermia of control and desensitized animals in warm environments. Therefore other mechanisms, primarily vasodilatatory, must also be involved in the rat's thermolytic normal response. Although desensitized rats did not show a tendency to escape from the warm environment their response to heat pain was normal. In conclusion, it is suggested that heat perception in desensitized animals is impaired; however, the existence of some capsaicin-insensitive thermolytic mechanisms (prone extension of the body) cannot be excluded.Supported by the Scientific Research Council, Ministry of Health, Hungary /4-05-0303-04-2/0/ and MTA-OM-MÉM-EÜM 70.211/79 相似文献
5.
Time course of hypo-osmotic swellings of human spermatozoa: evidence of ordered transition between swelling subtypes 总被引:2,自引:1,他引:2
Hossain AM; Rizk B; Barik S; Huff C; Thorneycroft IH 《Human reproduction (Oxford, England)》1998,13(6):1578-1583
The hypo-osmotic swelling test (HOST or HOS test) usually takes into
consideration the total HOS response value with no emphasis either on the
value of the response subtypes or the response evaluation time. This study
investigated the time course of HOS responses and analysed their
physiological relevance. Raw semen spermatozoa and Percoll washed
spermatozoa were used in the experiment. The morphological changes in the
sperm tail were monitored by incubating the spermatozoa in the hypo-
osmotic solution for 16 different time periods. The HOS reactive
spermatozoa and the type of HOS reaction (swelling subtypes) of the samples
subjected to different duration of treatment were identified under a phase
contrast microscope. Also the fate of individual spermatozoa in a
hypo-osmotic environment were monitored for 30 min. In spermatozoa exposed
to a hypo-osmotic solution, the motility lasted usually less than 2 min and
motility characteristics were uniquely different from that of the
spermatozoa under iso-osmotic conditions. The HOS response development was
permanent but the motility loss due to hypo-osmotic shock was reversible up
to 1 min of incubation. There was an indication of ordered transition among
the HOS swelling subtypes apparently initiating with subtype b destined to
c, d, e, f and g. Further, the subtypes a and g showed gradual decrease and
increase, respectively, while subtype b showed abrupt initial increase and
then gradual decrease. Transition from b to g could be direct or via one or
more than one subtypes. Ultrastructure based analysis indicated that HOS
response subtypes are the apparent reflection of the differences in the
cytoskeletal assembly of the sperm tail and thus may be identifying
different physiological variants in the sperm population. These results
indicate that shorter incubation is essential to document the kinetics of
various HOS responses but the conventional HOS test misses these important
HOS features because of lengthy incubation. Since the time course of
ordered transition of HOS responses will vary more than the total HOS
response in semen of different aetiologies, the importance of HOS response
subtypes and response evaluation time should be taken into consideration
when applying HOS test.
相似文献
6.
Yersinia pestis, the etiologic agent of plague is a highly invasive organism being able to invade non-phagocytic epithelial cells. Its plasminogen activator (Pla), encoded by the pPCP1 plasmid plays a pivotal role in internalisation of bacteria by HeLa cells. The aim of this study was to analyse the intracellular signalling processes and cytoskeletal rearrangement events associated with invasion. Wortmannin caused a 50% decrease of invasiveness at 50nM concentration pointing to the involvement of phosphatidyl-inosinol-4 kinase (PtINs4). Pre-treatment with staurosporin, a potent inhibitor of protein kinases (PKs) and with genistein, a specific tyrosine kinase inhibitor decreased the number of internalised bacteria about seven-fold and two-fold, respectively, indicating the involvement of PKs including tyrosine kinases in Pla-mediated internalisation. Cytochalasin D, an actin polymerisation inhibitor, C3 exoenzyme of Clostridium botulinum, a specific inhibitor of small GTPase Rho, and NDGA, a 5-lipoxygenase inhibitor also involved in Rho activation strongly reduced the number of internalised bacteria revealing the role of cytoskeletal events in the invasion process. All the tested inhibitors changed the invasion but not the adhesion pattern of the Pla producing recombinant strain. Actin rearrangement could also be visualised also with rhodamin-phalloidin staining. 相似文献
7.
This study investigated the relationship between theory of mind (ToM) deficits and visual perception in patients with schizophrenia (N=52; 17 remitted and unmedicated) compared with healthy controls (N=30). ToM was assessed with the Eyes Test, which asked participants to choose which of 4 words best described the mental state of a person whose eyes were depicted in a photograph. Visual perception was evaluated with form and motion coherence threshold measurements. Results revealed that patients with schizophrenia (both remitted and nonremitted) showed deficits on the Eyes Test and the motion coherence task. ToM dysfunctions were associated with higher motion coherence thresholds and more severe negative symptoms. This suggests that ToM deficits are related to motion perception dysfunctions, which indicates a possible role of motion-sensitive areas in the pathophysiology of schizophrenia. 相似文献
8.
I Patty S Benedek G Deák T Jávor P Kenéz F Morón L Nagy L Simon F Tárnok G Mózsik 《International journal of tissue reactions》1983,5(3):301-307
The effects of vitamin A were studied on the basal and maximal gastric secretory responses of 12 patients; and on healing in 60 patients with chronic gastric ulcer. The effect of vitamin A on ulcer healing was evaluated by a multiclinical, multicentre, randomized, prospective study in which the patients were divided into three groups. In group A the patients were treated with antacids only; in group B the patients were given antacids plus vitamin A (in doses of 3 X 50.000 U orally); and in group C the patients received antacids, vitamin A plus cyproheptadine (in doses of 3 X 4 mg orally). The treatment lasted four weeks. At the beginning and the end of treatment endoscopies were performed and ulcer sizes were measured planimetrically. Various other parameters such as ulcer index, antacid consumption and laboratory parameters were also evaluated during the four-week treatment. It was observed that: (i) vitamin A (given in doses of 100.000 U i.m.) decreased neither basal nor maximal gastric secretory responses; (ii) the number of patients with completely healed gastric ulcer was significantly higher (P less than 0.05) in groups B and C than in group A; (iii) the extent of ulcer reduction was significantly higher (P less than 0.01) in groups B and C than in group A; (iv) no significant changes were observed in ulcer index and antacid consumption during the four-week treatment in the different groups of patients; (v) the reduction of ulcer size was significantly greater (P less than 0.01) in the group treated with antacids plus vitamin A than in the group treated with antacids only, at two weeks of treatment.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
9.
Horváth G Kékesi G Dobos I Szikszay M Klimscha W Benedek G 《European journal of pharmacology》1999,368(2-3):197-204
Agmatine, an endogenous ligand, interacts both with the alpha2-adrenoceptors and with the imidazoline binding sites. The effect of intrathecally administered agmatine on carrageenan-induced thermal hyperalgesia was investigated by means of a paw-withdrawal test in rats. The effect of agmatine on morphine-induced anti-hyperalgesia was also studied. Intrathecal agmatine in doses larger than 250 microg caused a decrease in the pain threshold, with vocalization and agitation lasting for several hours in all animals. Agmatine alone at 1-100 microg did not give rise to any change in the thermal withdrawal threshold in the contralateral non-inflamed paw. Agmatine pretreatment was found to dose-dependently attenuate the thermal hyperalgesia induced by intraplantar carrageenan. The effect of 100 microg agmatine was completely lost by 60 min, whereas the effect of 50 microg was of similar magnitude but exhibited a longer duration. Agmatine posttreatment had a slighter effect. Agmatine pretreatment (100 microg) together with 1 microg morphine (subeffective dose) has significantly higher anti-hyperalgesic effect then the individual compounds by themselves. These are the first data demonstrating the behavioral and anti-hyperalgesic effects of intrathecal agmatine. The results reveal important interactions between intrathecal agmatine and opioids in thermal hyperalgesia. 相似文献
10.
Why laparoscopic cholecystectomy today? 总被引:1,自引:0,他引:1
Jozsef Sandor Andras Sandor Andras Zaborszky Sandor Megyaszai György Benedek Zoltan Szeberin 《Surgery today》1996,26(7):556-560
Traditional open cholecystectomy became the gold standard of surgical treatment for symptomatic gallstone disease during the last century. In spite of its good results, clinicians have been trying to establish effective nonsurgical methods of eliminating gallstones. Although oral, percutaneous, or retrograde litholysis can be used effectively for cholesterol stones, these represent only 10% of all gallstones. Moreover, intracorporeal lithotripsy is an invasive method, and while extracorporeal shock wave lithotripsy is a promising procedure, even after careful selection, only 70%–80% of the patients become stone-free within 1 year. In fact, none of the methods which leave the gallbladder intact are free of complications, and they are followed by 50% stone recurrence within 5 years. Since 1987, laparoscopic cholecystectomy has become the procedure of choice as it is safe and only minimally invasive. We believe that the laparoscopic technique is a promising way to the surgery of the future. 相似文献