全文获取类型
收费全文 | 2626篇 |
免费 | 165篇 |
国内免费 | 29篇 |
专业分类
耳鼻咽喉 | 16篇 |
儿科学 | 79篇 |
妇产科学 | 43篇 |
基础医学 | 293篇 |
口腔科学 | 115篇 |
临床医学 | 199篇 |
内科学 | 629篇 |
皮肤病学 | 62篇 |
神经病学 | 136篇 |
特种医学 | 61篇 |
外国民族医学 | 2篇 |
外科学 | 461篇 |
综合类 | 64篇 |
一般理论 | 1篇 |
预防医学 | 109篇 |
眼科学 | 148篇 |
药学 | 218篇 |
中国医学 | 24篇 |
肿瘤学 | 160篇 |
出版年
2024年 | 3篇 |
2023年 | 37篇 |
2022年 | 101篇 |
2021年 | 158篇 |
2020年 | 91篇 |
2019年 | 128篇 |
2018年 | 125篇 |
2017年 | 88篇 |
2016年 | 73篇 |
2015年 | 86篇 |
2014年 | 135篇 |
2013年 | 148篇 |
2012年 | 221篇 |
2011年 | 209篇 |
2010年 | 112篇 |
2009年 | 85篇 |
2008年 | 130篇 |
2007年 | 146篇 |
2006年 | 128篇 |
2005年 | 107篇 |
2004年 | 130篇 |
2003年 | 109篇 |
2002年 | 88篇 |
2001年 | 16篇 |
2000年 | 30篇 |
1999年 | 17篇 |
1998年 | 9篇 |
1997年 | 2篇 |
1996年 | 7篇 |
1995年 | 6篇 |
1994年 | 8篇 |
1993年 | 4篇 |
1992年 | 4篇 |
1991年 | 8篇 |
1990年 | 10篇 |
1989年 | 8篇 |
1988年 | 5篇 |
1987年 | 9篇 |
1986年 | 14篇 |
1985年 | 4篇 |
1984年 | 3篇 |
1983年 | 4篇 |
1982年 | 3篇 |
1981年 | 3篇 |
1979年 | 1篇 |
1978年 | 3篇 |
1977年 | 1篇 |
1974年 | 1篇 |
1971年 | 1篇 |
1966年 | 1篇 |
排序方式: 共有2820条查询结果,搜索用时 31 毫秒
1.
2.
3.
Despite recent advances in surgical technique using laparoscopic and robotic approaches for the management of early organ-confined prostate cancer, most contemporary reports demonstrate significant rates of erectile dysfunction comparable to standard open approaches. Controversy remains related to many of the pre-and postoperative management strategies, including agents to enhance nerve recovery, erectogenic drugs, antioxidants, vasoactive injectables, vacuum erection devices and nerve grafting procedures. Additionally, the optimal timing of these interventions and their duration, dose, frequency and outcome thresholds remain ill-defined. In our paper, we provide a comprehensive literature review involving both the basic and clinical data surrounding rehabilitative approaches. 相似文献
4.
5.
Human papillomavirus infection in Egyptian esophageal carcinoma: correlation with p53, p21, mdm2, C-erbB2 and impact on survival 总被引:1,自引:0,他引:1
The etiological role of human papillomavirus (HPV) in esophageal carcinoma (EC) in relation to p53, mdm2, p21(waf), c-erbB2 and the overall survival (OS) rate was investigated. Tumor and normal tissues from 50 EC were evaluated by polymerase chain reaction and InnoLiPA for HPV. Single strand conformation polymorphism/sequencing were used to detect p53 gene mutations. Immunohistochemistry was performed to determine p53, mdm2, p21(waf)and c-erbB2 expression. Human papillomavirus was detected in 54% of tumors and in 24% of normal tissues. p53, mdm2 and c-erbB2 overexpression was detected in 68%, 70% and 60% of tumors and in 14%, 16% and 10% of normal samples, whereas loss of p21(waf) was evident in 64% of tumors. p53 mutations were detected in 20% of cases. Exon 8 and 5 showed the highest mutation rate (40% each), followed by exons 6 and 7 (10% each). There was a significant correlation between HPV and p53, mdm2, c-erbB2 overexpression. The OS was significantly associated with overexpression of p53 and loss of p21(waf). Human papillomavirus infection is frequent in Egyptian EC. Both p53-dependent and p53-independent pathways seem to be involved in HPV-associated EC. mdm2 and c-erbB2 are possible targets for HPV in the p53-independent pathway. However, only advanced stage and aberrant expression of p53 and p21(waf) are independent prognostic markers. 相似文献
6.
Haseeb Khan Ahmad Saleh Al Deeb Khalaf Al Moutaery Mohammad Tariq 《Experimental and toxicologic pathology》2003,55(2-3):181-186
A direct association between aging and drug-induced dyskinesia has been reported by several investigators. Iminiodipropionitrile (IDPN), a prototype nitrile compound produces a motor syndrome in rodents, which resembles neuroleptic drug induced dyskinesia. In this investigation attempt has been made to study the effect of age on IDPN induced vestibular hair cell degeneration and resulting dyskinetic syndrome. Male Wistar rats aged 3, 6 and 12 weeks received IDPN in the doses of 0, 200 and 400 mg/kg, intraperitoneally for 3 consecutive days. IDPN-induced dyskinesia was assessed using a behavioral testing battery on days 3, 4, 5, 6, 7, 14, 21 and 28. The rats were sacrificed on day 28; temporal bones were excised for vestibular histopathology and sera were collected for measuring the indices of oxidative stress (glutathione and conjugated dienes). IDPN in the dose of 200 mg/kg produced dyskinesia in 12 weeks old rats, but failed to do so in 3 and 6 weeks old rats. The high dose of IDPN (400 mg/kg) caused dyskinesia in all age groups, however, its onset and severity were age-dependent. Older rats showed an early onset and significantly high incidence of dyskinesia as compared to younger rats. The susceptibility of rats to IDPN-induced behavioral deficits was proportional to oxidative stress and degeneration of sensory hair cells in the crista ampullaris. 相似文献
7.
Modelling and simulation methods can play an important role in guiding public health responses to infectious diseases and emerging health threats by projecting the plausible outcomes of decisions and interventions. The 2003 SARS epidemic marked a new chapter in disease modelling in Canada as it triggered a national discussion on the utility and uptake of modelling research in local and pandemic outbreaks. However, integration and application of model-based outcomes in public health requires knowledge translation and contextualization. We reviewed the history and performance of Pan-InfORM (Pandemic Influenza Outbreak Research Modelling), which created a national infrastructure in Canada with a mandate to develop innovative knowledge translation methodologies to inform policy makers through modelling frameworks that bridge the gaps between theory, policy, and practice. This review demonstrates the importance of a collaborative infrastructure as a “Community of Practice” to guide public health responses, especially in the context of emerging diseases with substantial uncertainty, such as the COVID-19 pandemic. Dedicated resources to modelling and knowledge translation activities can help create synergistic strategies at the global scale and optimize public health responses to protect at-risk populations and quell socioeconomic and health burden. 相似文献
8.
9.
10.
Mostafa Kamalpour Atae Rezaei Aghdam Jason Watson Amina Tariq Laurie Buys Rebekah Eden Syed Rehan 《Health & social care in the community》2021,29(2):328-343
The aim of this paper is twofold. Firstly, to investigate the potential benefits of online health communities (OHCs) for informal caregivers by conducting a systematic literature review. Secondly, to identify the relationship between the potential benefits of OHCs and resilience factors of older adults. Performing a thematic analysis, we identified the potential benefits of OHCs for informal caregivers of older adults, including two salient themes: (a) caregivers sharing and receiving social support and (b) self and moral empowerment of caregivers. Then, we uncovered how these potential benefits can support resilience of older adults. Our findings show that sharing and receiving of social support by informal caregivers, and self and moral empowerment of informal caregivers in OHCs, can support four resilience factors among older adults, including self-care, independence, altruism and external connections. This review enables a better understanding of OHCs and Gerontology, and our outcomes also challenge the way healthcare and aged-care service providers view caregivers and older adults. Furthermore, the identified gap and opportunities would provide avenues for further research in OHCs. 相似文献