全文获取类型
收费全文 | 198篇 |
免费 | 7篇 |
国内免费 | 2篇 |
专业分类
儿科学 | 13篇 |
妇产科学 | 19篇 |
基础医学 | 18篇 |
口腔科学 | 5篇 |
临床医学 | 14篇 |
内科学 | 35篇 |
皮肤病学 | 4篇 |
神经病学 | 7篇 |
特种医学 | 1篇 |
外科学 | 16篇 |
综合类 | 2篇 |
预防医学 | 20篇 |
药学 | 16篇 |
中国医学 | 2篇 |
肿瘤学 | 35篇 |
出版年
2023年 | 3篇 |
2022年 | 6篇 |
2021年 | 8篇 |
2020年 | 5篇 |
2019年 | 7篇 |
2018年 | 5篇 |
2017年 | 6篇 |
2016年 | 8篇 |
2015年 | 6篇 |
2014年 | 7篇 |
2013年 | 7篇 |
2012年 | 16篇 |
2011年 | 9篇 |
2010年 | 12篇 |
2009年 | 5篇 |
2008年 | 9篇 |
2007年 | 12篇 |
2006年 | 15篇 |
2005年 | 14篇 |
2004年 | 15篇 |
2003年 | 10篇 |
2002年 | 7篇 |
1998年 | 3篇 |
1997年 | 6篇 |
1996年 | 2篇 |
1995年 | 2篇 |
1994年 | 1篇 |
1989年 | 1篇 |
排序方式: 共有207条查询结果,搜索用时 0 毫秒
1.
Wanitchaya Kittikraisak Podjanee Phadungkiatwatana Darunee Ditsungnoen Surasak Kaoiean Louis Macareo Kamonthip Rungrojcharoenkit Nattinee Srisantiroj Tawee Chotpitayasunondh Fatimah S. Dawood Joshua A. Mott Kim A. Lindblade 《Vaccine》2021,39(1):18-25
BackgroundWe compared cord blood antibody titers in unvaccinated pregnant women to those vaccinated with seasonal influenza vaccine during the 2nd and the 3rd trimesters.MethodsPregnant women had cord blood collected at delivery for hemagglutination inhibition assay against vaccine reference viruses: A/California/07/2009 (H1N1)pdm09, A/Switzerland/9715293/2013 (H3N2), and B/Phuket/3073/2013 (Yamagata lineage). Geometric mean titer (GMT) ratios were calculated comparing vaccinated versus unvaccinated pregnant women, and women vaccinated in the 2nd and the 3rd trimesters. Proportions of women achieving defined titers were compared using the χ2 test.ResultsOf 307 women, 190 (62%) were unvaccinated. Fifty and 67 were vaccinated during the 2nd and the 3rd trimesters, respectively. Median enrollment age was 29 years (interquartile range 24–34). Sixteen (5%) women had pre-existing conditions, but none were immunocompromised. GMT ratios comparing vaccinated and unvaccinated women were 5.90 (95% confidence interval [CI] 5.06–6.96) for influenza A/California, 5.39 (95% CI 4.18–6.08) for influenza A/Switzerland, and 5.05 (95% CI 4.43–5.85) for influenza B/Phuket. Similarly, the GMT ratios comparing the 3rd and the 2nd trimester vaccinated women were 2.90 (95% CI 2.54–3.39), 2.82 (95% CI 2.56–3.13), and 2.83 (95% CI 2.56–3.14), respectively. The proportions of women with defined titers for the three vaccine reference viruses did not differ between 2nd and 3rd trimester vaccinated women (titers ≥40: 68–92% versus 70–93%; ≥110: 32% versus 33–63%; and ≥330: 4–10% versus 3–21%).ConclusionsPregnant women vaccinated against influenza had more placental transfer of influenza antibodies to their infants than unvaccinated women. Placental transfer of antibodies was higher among those vaccinated in the 3rd trimester than in the 2nd trimester. There was no difference in the proportions of women achieving antibody titers corresponding to protection against influenza in children. Findings support the current World Health Organization’s recommendation that pregnant women may be vaccinated in either 2nd or 3rd trimester of pregnancy. 相似文献
2.
3.
Peters J Farrenkopf R Clausmeyer S Zimmer J Kantachuvesiri S Sharp MG Mullins JJ 《Circulation research》2002,90(10):1135-1141
Intracardiac renin is considered to be involved in the pathogenesis of cardiac hypertrophy, fibrosis, and myocardial infarction. Cardiac renin is predominantly derived from the circulation, because preprorenin is not expressed locally and uptake of renin has been demonstrated. One mechanism of internalization recently described involves the mannose-6-phosphate receptor and requires glycosylation of renin. Based on previous observations, we considered the existence of another pathway of uptake, not requiring glycosylation and predominantly involving prorenin. This hypothesis and its functional consequences were investigated in vitro and in vivo. We demonstrate that isolated adult cardiomyocytes internalize unglycosylated prorenin, which is followed by the generation of angiotensins. We further show that transgenic rats, expressing the ren-2(d) renin gene in an inducible manner, exhibit markedly enhanced levels of unglycosylated renin within intracellular compartments in the heart as a consequence of the induction of hepatic transgene expression and the rise of circulating unglycosylated prorenin levels. Because in this model severe cardiac damage occurs as a consequence of the rise of circulating prorenin levels, internalization of prorenin into cardiac cells is likely to play a key role in this process. 相似文献
4.
5.
6.
7.
8.
Prevalence of and Predictive Factor for Abdominal Aortic Calcification in Thai Chronic Kidney Disease Patients 下载免费PDF全文
Dusit Lumlertgul Surasak Kantachuvesiri Somboon Apichaiyingyurd Worapot Treamtrakanpon Manoch Rattanasompattikul Pongsathorn Gojaseni Prasert Thanakitcharu Thananda Trakarnvanich Ussanee Poonvivatchaikarn Kriengsak Vareesangthip the Impact‐CKD investigators 《Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy》2017,21(6):611-619
Presence and severity of cardiovascular calcifications strongly predict cardiovascular morbidity and mortality in patients with CKD. This multicenter, cross‐sectional study primarily aimed to determine prevalence of abdominal aortic calcification (AAC) detected by plain lateral abdominal radiograph, and secondarily aimed to assess predictive factors for AAC. Patients (N = 1500), aged 18–70 years, with CKD stages 3–5D for ≥3 months prior to evaluation, were enrolled at 24 study centers in Thailand; 54.3% were non‐dialysis patients. The prevalence of AAC was 70.6% and 70.8% in non‐dialysis and dialysis patients, respectively. Patient's advanced age and widening pulse pressure were identified as predictive factors for AAC ≥ 5 in non‐dialysis patients, while patient's age, history of coronary heart disease or diabetes, longer dialysis vintage, and increasing corrected serum calcium or high‐sensitivity C‐reactive protein were identified as such in dialysis patients. With additional regression having covariates in binary, corrected serum calcium ≥9.5 mg/dL gave an OR 1.974 (95% CI: 1.324–2.943) for AAC ≥ 5 among the dialysis patients. AAC in diabetes subgroup (N = 692) was additionally evaluated and found that it was prevalent at 84.7% with increased phosphorus as predictive factor (OR, 1.178; 95% CI: 1.032–1.344) and 1,25 (OH)2 vitamin D as protective factor (OR, 0.983; 95% CI, 0.970–0.996). The prevalence of AAC in the Thai CKD population is lower than that reported in the literature, and yet the burden is prominent in patients coexisting with diabetes. Variable relationships identified in this study may guide preventive measures against cardiovascular complications in CKD patients. 相似文献
9.
Surasak Puvabanditsin Eugene Garrow Nachu Chinnakaruppan Mayoor Bhatt Erik Brandsma 《Pediatric surgery international》2009,25(5):441-443
Calcified intraluminal meconium is a rare finding in newborn infants. It is often associated with communication between the
urinary and gastrointestinal tracts. Intra-abdominal calcifications are unusual radiographic findings in the newborn and can
easily be misinterpreted as meconium peritonitis. We report on a newborn infant with anorectal malformation, meconium balls,
intraluminal calcifications, colpocephaly, and agenesis of the corpus callosum, a rare association. 相似文献
10.