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Oral Diseases (2011) 17 , 720–726 Background: Tobacco‐related oral squamous cell carcinoma (OSCC) is one of the most common cancers involving Indian males. We assessed the association of IL4 promoter –589 T>C, –33 T>C, and IL6–174 G>C functional genetic polymorphisms with tobacco‐related OSCC in Asian Indians. Patients and Methods: The IL4 and IL6 promoter polymorphisms were assessed in 140 patients with OSCC and 120 normal subjects by PCR–RFLP technique, and significance of the data was determined using chi‐square test. Results: The frequency of TC, CC genotype, and C allele at IL4 promoter sites –589 and –33 were higher in patients when compared with controls. Consequently, TC/CC genotypes and C allele at both sites appeared as susceptible. However, IL6–174 G>C single‐nucleotide polymorphisms (SNP) appeared to be protective in patients with OSCC. Of eight haplotypes, five were associated with two‐ to seven‐fold increased risk of tobacco‐related OSCC. These SNPs further showed heterogeneity among different ethnic population, but their distribution in Asian Indians stand closer to other Asian populations. Conclusions: In this study, IL4–589 CC, –33 CC genotype, and *C allele at both sites appeared to be susceptible, while IL6–174 CC genotype and *C allele appeared to be protective in patients with OSCC; hence, these SNPs may be a potential prognostic markers for tobacco‐related OSCC in Asian Indians. 相似文献
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The effect of dietary fats such as butter, lard, cottonseed oil, and hydrogenated cottonseed oil on the fatty acid composition of enamel and dentin lipids of rabbit molars was studied. The enamel and dentin of molars of all of the rabbits contained a variety of fatty acids, palmitic, stearic, oliec, linoleic, and eicosapentaenoic being the major ones. Enamal lipids were more unsaturated than dentinal lipids in all of the groups. A significant difference was noticed in the fatty acid composition of both the enamel and dentin between these four groups of rabbits. Linoleic acid content was highest in both the enamel and dentin lipids of rabbits fed cottonseed oil. There was no marked difference in the saturated-unsaturated fatty acid ratio in both the enamel and dentin among rabbits fed cottonseed oil, lard, and butter. It is concluded that tooth lipids are responsive to diets and are in direct equilibrium with dietary components. 相似文献
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Bhatnagar S Das UM Chandan GD Prashanth ST Gowda L Shiggaon N 《Journal of the Indian Society of Pedodontics and Preventive Dentistry》2011,29(4):336-338
Most foreign bodies pass through the gastrointestinal tract uneventfully. The majority of the reported literature describes the management of ingested blunt objects. However, ingestion of sharp objects can still occur with a higher rate of perforation corresponding to treatment dilemmas. We report a case of inadvertently ingested sharp foreign body by a special child, which was retrieved by endoscopic guided forceps. Urgent endoscopic assessment and retrieval of recently ingested sharp dental foreign body is indicated and routine use of preventive measures such as rubber dam, gauze throat screens or floss ligatures is suggested. 相似文献
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