全文获取类型
收费全文 | 544篇 |
免费 | 32篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 17篇 |
儿科学 | 19篇 |
妇产科学 | 20篇 |
基础医学 | 55篇 |
口腔科学 | 54篇 |
临床医学 | 25篇 |
内科学 | 149篇 |
皮肤病学 | 3篇 |
神经病学 | 54篇 |
特种医学 | 3篇 |
外科学 | 53篇 |
综合类 | 1篇 |
预防医学 | 47篇 |
眼科学 | 9篇 |
药学 | 38篇 |
中国医学 | 7篇 |
肿瘤学 | 23篇 |
出版年
2023年 | 4篇 |
2022年 | 3篇 |
2021年 | 16篇 |
2020年 | 8篇 |
2019年 | 7篇 |
2018年 | 17篇 |
2017年 | 13篇 |
2016年 | 19篇 |
2015年 | 13篇 |
2014年 | 21篇 |
2013年 | 31篇 |
2012年 | 40篇 |
2011年 | 57篇 |
2010年 | 24篇 |
2009年 | 14篇 |
2008年 | 36篇 |
2007年 | 49篇 |
2006年 | 49篇 |
2005年 | 45篇 |
2004年 | 32篇 |
2003年 | 27篇 |
2002年 | 23篇 |
2001年 | 9篇 |
2000年 | 5篇 |
1999年 | 2篇 |
1998年 | 1篇 |
1997年 | 1篇 |
1996年 | 1篇 |
1992年 | 2篇 |
1991年 | 1篇 |
1990年 | 2篇 |
1988年 | 1篇 |
1985年 | 1篇 |
1982年 | 1篇 |
1914年 | 1篇 |
1907年 | 1篇 |
排序方式: 共有577条查询结果,搜索用时 15 毫秒
1.
Jorge Guardado Carlos Cotrim Otília Sim?es Sofia Almeida Mário Ialá Luís Lopes Hélder Pereira Manuel Carrageta 《Revista portuguesa de cardiologia》2006,25(4):409-415
INTRODUCTION: Transesophageal echocardiography (TEE) has become increasingly useful in the study of patients with suspected pulmonary thromboembolism. OBJECTIVE: The aim of this study was to prospectively evaluate the usefulness of TEE in the study of the distal part of the left pulmonary artery (LPA) as well as the influence of this procedure on total echocardiographic exam duration. METHODOLOGY: A prospective study in two groups of consecutive patients referred for TEE with a one- year interval between evaluation of Group A: 33 patients, 17 male, mean age 54 +/- 24 years, and Group B: 42 patients, 20 male, mean age 48 +/- 27 years (p = NS). The procedure was considered long when it took more than 3 min to evaluate the distal part of the LPA. RESULTS: In group A we were able to visualize the distal part of the LPA in 24 patients (73%) without significant prolongation of total exam duration in 16 patients (48% of group A). In one of the patients with suspected pulmonary thromboembolism thrombi were only observed in the distal part of the LPA. In group B we were able to visualize the distal part of the LPA in 36 patients (86%) without significant prolongation of total exam duration in 26 patients (61% of group B). CONCLUSIONS: 1. Visualization of the distal part of the LPA was possible in more patients, and with TEE time prolongation in less patients, in group B. These differences can be accounted for by the training of the operator in this technique. 2. The importance of visualization of this part of the LPA in guiding treatment in the subset of patients with pulmonary thromboembolism confirms the usefulness of this specific procedure. 相似文献
2.
Carlos Cotrim Otília Sim?es M J Loureiro Pedro Cordeiro Rita Miranda Cecília Silva Teresa Avillez Manuel Carrageta 《Revista portuguesa de cardiologia》2006,25(5):529-533
We describe the case of a pregnant woman with idiopathic pulmonary arterial hypertension, a responder in right heart catheterization, followed since the first trimester in outpatient consultations, admitted to hospital at 23 weeks gestation. She was treated with inhaled iloprost until delivery (at 34 weeks gestation) and continuous infusion of iloprost throughout the perioperative period and following days. This line of therapy has proved efficacious in previous cases. The authors present echocardiographic images that document acute changes in ventricular synchrony during inhalation of iloprost. 相似文献
3.
6-Methyl-2,4-heptandione (1) was coupled with diazonium salts of sulfanilamide (2) and 4-aminobenzoic acid (3). Resulting new hydrazones, namely 4-methyl-2-oxovaleraldehyde p-substituted phenylhydrazones 4 and 5, were refluxed with various hydrazines to synthesize the title compounds 6-15. Their structure elucidation was made on the basis of their analytical and spectroscopic data. The antibacterial activity was evaluated. Some of the compounds tested exerted moderate to potent antibacterial activity against Staphylococcus aureus, Staphylococcus epidermidis and Streptococcus pyogenes. 相似文献
4.
Abdominal Stab Wounds in Children: an 18-Year Experience 总被引:1,自引:0,他引:1
Hayrettin ?ztürk Abdurrahman Onen Selcuk Ot?u Ali hsan Dokucu Yusuf Yamur Senol Gedik 《European Journal of Trauma》2002,28(2):85-89
Objective: Evaluation of the diagnosis, management, and the role of selective treatment in children with abdominal stab wounds.
Patients and Methods: 59 children (56 male and three female) were included in the study. The patients' median age was 11.8 years (range, 5–14 years).
Time between injury and admission was about 3 h. Laparotomy was performed in 44 patients (74%). Solid organ injury was detected
in 32 of these patients (73%) and could not be observed in twelve (27%). 15 patients (26%) were treated conservatively, and
only one (6.6%) underwent laparotomy during the follow-up. The stomach was the most frequently injured organ (ten patients),
followed by the intestines (nine patients). Types of surgical treatment were as follows: primary suture in 28 patients, resection-anastomosis
in three, and osteotomy in two.
Results: Some prognostic factors such as presence of abdominal organ evisceration and pneumoperitoneum were not significantly correlated
with intraabdominal organ injury, whereas some other risk factors such as acute abdomen on admission (p < 0.002) or abdominal
clinical and hemodynamic findings (p < 0.001) showed significant correlation with intraabdominal organ injury. The relative
risk (odds ratio) of developing an intraabdominal organ injury was > 2 for patients with signs of an acute abdomen on admission.
Postoperative complications were observed in five patients with organ injuries. None of our patients died.
Conclusions: Conservative treatment can be safely performed in most children with abdominal stab injuries. Signs of major internal hemorrhage
or generalized peritonitis are an absolute indication for emergency operation for abdominal stab wounds. Peritoneal penetrations,
free air on the abdominal X-ray, and omental or intestinal evisceration are poor indicators of significant organ injuries,
and patients presenting these signs shold be closely followed up for developing acute abdominal symptoms.
Received: November 2, 2001; revision accepted: February 15, 2002 相似文献
5.
Gontijo AM Marcondes JP Elias FN de Oliveira ML de Lima RO Salvadori DM de Camargo JL 《Environmental and molecular mutagenesis》2002,40(3):190-199
In order to determine if patients with a history of previous urothelial cell carcinoma (UCC) but with current normal urinary cytology have DNA damage in urothelial cells, the single-cell gel electrophoresis (comet) assay was conducted with cells obtained by urinary bladder washings from 44 patients (28 with a history of previous UCC). Increased DNA damage was observed in cytologically "normal" urothelial cells of patients with a history of UCC when compared with referents with no similar history and after correcting the data for smoking status and age (P < 0.018). Increased DNA damage also correlated with the highest tumor grade, irrespective of time or course of the disease after clinical intervention (Kendall tau correlation, 0.37, P = 0.016). Moreover, aneuploidy, as assessed by DNA content ratio (DCR; 75th/25th percentile of total DNA fluorescence of 50 comets/patient) was unaltered by smoking status, but increased with UCC grade: 1.39 +/- 0.12 (median +/- 95% confidence interval; referents); 1.43 +/- 0.11 (Grade I UCC; P = 0.264, against referents); 1.49 +/- 0.16 (Grade II UCC; P = 0.057); 1.57 +/- 0.16 (Grade III UCC; P = 0.003). Micronucleated urothelial cells (MNC) were also scored on Giemsa-stained routine cytological smears and were found not to correlate with DNA damage or DCR. MNC frequencies were higher for patients with a history of UCC and/or smoking than referents with neither history, but there was no statistical difference between groups. Taken together, these results suggest that the normal-appearing urothelium of patients resected for UCC still harbor genetically unstable cells. 相似文献
6.
Dokucu AI Ozdemir E Oztürk H Otçu S Onen A Ciğdem K Kaya M Bükte Y Yücesan S 《International urology and nephrology》2000,32(1):3-8
We analysed the inter-relationships of the cause and the type of trauma, the presence of pelvic fracture, the associated intraabdominal
organ injuries,and the morbidity and mortality rates in 154 patients presenting and being treated for UGT between 1983 and
1997.The cause of injury was blunt in 77% of cases and penetrating in 13%. The most frequently injured organs were kidney
followed by urethra and bladder. Bowels, liver and spleen were the most frequently associated injured organs. Moreover, bladder
injuries were strongly associated with bowel injuries (p < 0.0001). Hemodynamically normal 49 children with minor or major kidney injuries were managed conservatively. Hemodynamically
non-stable 11 patients were explored.The majority of urogenital injuries can be managed conservatively evenwhen associated
with intraabdominal organ injuries. Solid genitourinary organ injuries may accompany more frequently to intraperitoneal solidorgan
injury. Whereas, non-solid genitourinary organ injuries may more frequently associated with injuries of intraperitoneal hollow
viscus.
This revised version was published online in August 2006 with corrections to the Cover Date. 相似文献
7.
Impact of simultaneous glutamate dehydrogenase and toxin A/B rapid immunoassay on Clostridium difficile diagnosis and treatment in hospitalized patients with antibiotic‐associated diarrhea in a university hospital of Brazil
下载免费PDF全文
![点击此处可从《Journal of gastroenterology and hepatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
8.
Clinical Rheumatology - Explore the perspective of patients and professionals regarding non-radiographic axial spondyloarthritis (nr-axSpA) and to define the patient’s journey from diagnosis... 相似文献
9.
Morphofunctional characteristics of the right ventricle in Chagas' dilated cardiomyopathy 总被引:1,自引:0,他引:1
Right ventricular involvement is a typical characteristic of Chagas' disease, and it has been described especially in the early stages of the disease. However, the role of right ventricular dysfunction in cardiac failure due to Chagas' cardiomyopathy has not been well established. Seventy-four patients with positive serology tests for Trypanosoma cruzi and Chagas' dilated cardiomyopathy characterized by left ventricular dilatation and systolic dysfunction were studied. Clinical history, physical exam, ECG, chest X-ray and Doppler echocardiogram with color flow mapping were obtained in all. Mean age was 47.5+/-12.9 and 51 were males (69%). Sixty-five patients (88%) were in NYHA functional classes I and II. Mild systolic dysfunction was present in 35 (47%) while in 18 (24%), dysfunction was moderate and in 21 (28%) it was severe. In 43 patients (58%), only the left ventricle was involved by echocardiographic criteria; the remaining 31 patients (42%) showed biventricular involvement. No patient had isolated involvement of the right ventricle. Greater dilation of the right ventricle was associated with larger diastolic (p<0.002) and systolic (p<0.001) diameters of the left ventricle. Systolic pulmonary artery pressure was obtained non-invasively in 54 patients. Pulmonary hypertension was associated with right ventricular dilation (p<0.005) and with systolic dysfunction of the left ventricle (p<0.001). In this group of patients with Chagas' dilated cardiomyopathy, right ventricular dysfunction was present when there was associated and significant involvement of the left ventricle and with higher levels of pulmonary pressure. 相似文献
10.
P.A. Caro Aponte C.A. Otálora J.C. Guzmán L.F. Turner J.P. Alcázar E.L. Mayorga 《Neurología (Barcelona, Spain)》2021,36(3):191-200
Parkinson's disease (PD) is characterised by motor alterations, which are commonly treated with L-DOPA. However, long-term L-DOPA use may cause dyskinesia. Although the pathogenic mechanism of L-DOPA-induced dyskinesia is unclear, the condition has been associated with alterations in dopamine receptors, among which D2 receptors (D2R) have received little attention. This study aims to: (i) develop and standardise an experimental model of L-DOPA-induced dyskinesia in rats with hemiparkinsonism; and (ii) evaluate the correlation between D2R expression and presence of abnormal involuntary movements (AIM). We allocated 21 male Wistar rats into 3 groups: intact controls, lesioned rats (with neurotoxin 6-OHDA), and dyskinetic rats (injected with L-DOPA for 19 days). Sensorimotor impairment was assessed with behavioural tests. Dyskinetic rats gradually developed AIMs during the treatment period; front leg AIMs were more severe and locomotor AIMs less severe (P < .05). All AIMs were significantly evident from day 5 and persisted until the last day of injection. D2R density was greater in the striatum and the medial anterior brain of the lesioned and dyskinetic rats than in those of controls. Our results suggest an association between D2R expression and locomotor AIMs. We conclude that RD2 is involved in L-DOPA-induced dyskinesia. 相似文献