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排序方式: 共有96条查询结果,搜索用时 7 毫秒
1.
Ruhul Quddus M Latkovich P Castellani WJ James Sung C Steinhoff MM Briggs RC Miranda RN 《Archives of pathology & laboratory medicine》2002,126(4):459-463
CONTEXT: Endometrioid carcinoma is often preceded by characteristic histopathologic lesions known as endometrial hyperplasia. Estrogen appears to be involved in the development of endometrioid carcinoma. Other mechanisms of endometrial carcinogenesis include mutations in p53 and PTEN tumor suppressor genes and overexpression of cyclin D1. However, the pattern of cyclin D1 expression is not well defined in normal, hyperplastic, neoplastic, and metaplastic endometrium. DESIGN: Cyclin D1 immunohistochemical analysis was used to evaluate 108 fixed, paraffin-embedded endometrial biopsy specimens and uterine resections obtained from 108 patients. Specimens included proliferative and secretory endometria, simple and complex hyperplastic lesions, and endometrioid adenocarcinoma. Normal and metaplastic surface epithelia were also evaluated independently of glandular morphologic features. RESULTS: Cyclin D1 was significantly overexpressed in glands with complex hyperplasia and endometrioid adenocarcinoma compared with proliferative or secretory endometrium and simple hyperplasia. Significant overexpression was also noted in papillary, syncytial, and squamous metaplasias compared with normal surface epithelium or epithelium with tubal metaplasia. CONCLUSION: Overexpression of cyclin D1 increases from normal endometrium to hyperplasia and carcinoma, suggesting that it may play a role in endometrial carcinogenesis. Overexpression of cyclin D1 in endometrial glands was independent from overexpression of cyclin D1 in surface metaplastic epithelium. 相似文献
2.
The 2001 Bethesda system (TBS 2001) eliminated the "satisfactory but limited by" category, benign cellular changes (BCC), and the designations "favor benign" (ASC-B) and "favor low grade" (ASC-L) for atypical squamous cells. We compared the unsatisfactory rate and atypical squamous cells:squamous intraepithelial lesions (ASC:SIL) ratio pre- and postimplementation of TBS 2001 to see if there was an increase in unsatisfactory specimens, ASC rate, and altered ASC:SIL ratio. Pap Tests (569,726) reviewed at the Cytopathology Laboratory of Women and Infants Hospital from 1998-2002 were included. TBS 1991 terminology was used through December 31, 2001. Conversion to TBS 2001 took place on January 1, 2002. The average ASC:SIL ratios pre- and postimplementation of TBS 2001 were 1.52:1 and 1.42:1, respectively. The rates of unsatisfactory specimens and ASC remained unchanged. Conversion to TBS 2001 did not adversely affect the ASC:SIL ratio or the detection rates of abnormalities of Pap tests. 相似文献
3.
Ruhul AM Fukuda H Nakajima K Takatorige T Tatara K 《Environmental health and preventive medicine》1999,4(2):65-70
Health is one of the basic requirements for improvement in the quality of life. Since Bangladesh became independent, a policy
for providing essential minimum health care to all has been actively pursued.
An overview of Public Health Services in Bangladesh is presented in terms of: (1) a profile of the country, (2) an overview
of public health, (3) medical care, and (4) environmental health. Under each of these headings observations are included on
recent trends based upon relevant data and information.
Finally the authors describe the importance of (1) promotion of health care and planning at the national, divisional, local,
and community levels, (2) promotion of medical services at all levels, and (3) effective decentralization of health services
to enhance the services of health facilities. 相似文献
4.
Kaela M. Varberg Khursheed Iqbal Masanaga Muto Mikaela E. Simon Regan L. Scott Keisuke Kozai Ruhul H. Choudhury John D. Aplin Rebecca Biswell Margaret Gibson Hiroaki Okae Takahiro Arima Jay L. Vivian Elin Grundberg Michael J. Soares 《Proceedings of the National Academy of Sciences of the United States of America》2021,118(10)
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Nanoscale CuO with diameters in the range of 7–8 nm has been synthesized via a two-step precipitation–calcination method using copper(ii) isonicotinate tetrahydrate as the precursor. The first step involves the room temperature stirring of an alkaline ethanolic solution of the precursor which gives a non-crystalline CuO species, while the second step involves the calcination of the product of the first step at 180 °C to form nanocrystalline CuO which has been characterized by PXRD, TEM, SEM, H2-TPR and Raman spectroscopy, etc. The CuO material has shown excellent catalytic activity in the oxidation of styrene using TBHP as the oxidizing agent leading to complete styrene conversion with more than 95% styrene oxide selectivity at the end of 6 h. The oxide catalyst can be reused for at least 6 successive runs without significant loss in activity.Nanoscale CuO with diameters in the range of 7–8 nm has been synthesized via a two-step precipitation–calcination method using copper(ii) isonicotinate tetrahydrate as the precursor. 相似文献
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8.
Amin MR Kamitani H Watanabe T Ishibashi M Ogawa T Funakoshi T Miyata H Ohama E 《Brain tumor pathology》2002,19(1):5-10
Deep-seated gliomas, including thalamic gliomas, have a poor prognosis because of difficulty of accessibility for surgery.
In addition, an infiltrative pattern of the tumor is related to a poor prognosis. In this study, the infiltrative/invasive
profile of the proliferating tumor cells of a right thalamic glioma was evaluated in an autopsied brain. A 71-year-old man
died from extensive infiltration of a right thalamic glioma. The distribution of the proliferating tumor cells at the right
thalamic tumor level was represented by the topographic map of MIB-1 labeling indices (LI) on the whole-brain coronal slice,
and this map was analyzed with pathological findings and postmortem T2-weighted magnetic resonance imaging (MRI). The highest
MIB-1 LI was 24% for the whole autopsy brain at the thalamic tumor level, whereas the MIB-1 LI was 21% for the biopsy sample
of the right thalamic glioma. Because this patient survived only 9 months after diagnosis of the tumor as anaplastic astrocytoma,
it was confirmed that 21% MIB-1 LI of the biopsy sample was relevant to his prognosis. The topographic map of MIB-1 LI showed
that the proliferating tumor cells of the right thalamic glioma invaded the ventricular walls and the contralateral thalamus
by the periventricular route, but there was no exophytic extension to the cortex. In conclusion, topographic analysis of the
proliferative potential detected by MIB-1 immunostaining provides information on the growth pattern of human glioma. 相似文献
9.
Cherian T Mulholland EK Carlin JB Ostensen H Amin R de Campo M Greenberg D Lagos R Lucero M Madhi SA O'Brien KL Obaro S Steinhoff MC 《Bulletin of the World Health Organization》2005,83(5):353-359
BACKGROUND: Although radiological pneumonia is used as an outcome measure in epidemiological studies, there is considerable variability in the interpretation of chest radiographs. A standardized method for identifying radiological pneumonia would facilitate comparison of the results of vaccine trials and epidemiological studies of pneumonia. METHODS: A WHO working group developed definitions for radiological pneumonia. Inter-observer variability in categorizing a set of 222 chest radiographic images was measured by comparing the readings made by 20 radiologists and clinicians with a reference reading. Intra-observer variability was measured by comparing the initial readings of a randomly chosen subset of 100 radiographs with repeat readings made 8-30 days later. FINDINGS: Of the 222 images, 208 were considered interpretable. The reference reading categorized 43% of these images as showing alveolar consolidation or pleural effusion (primary end-point pneumonia); the proportion thus categorized by each of the 20 readers ranged from 8% to 61%. Using the reference reading as the gold standard, 14 of the 20 readers had sensitivity and specificity of > 0.70 in identifying primary end-point pneumonia; 13 out of 20 readers had a kappa index of > 0.6 compared with the reference reading. For the 92 radiographs deemed to be interpretable among the 100 images used for intra-observer variability, 19 out of 20 readers had a kappa index of > 0.6. CONCLUSION: Using standardized definitions and training, it is possible to achieve agreement in identifying radiological pneumonia, thus facilitating the comparison of results of epidemiological studies that use radiological pneumonia as an outcome. 相似文献
10.