首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   1438000篇
  免费   106947篇
  国内免费   4654篇
耳鼻咽喉   18122篇
儿科学   46262篇
妇产科学   38022篇
基础医学   210869篇
口腔科学   37980篇
临床医学   140106篇
内科学   279550篇
皮肤病学   27905篇
神经病学   121826篇
特种医学   51646篇
外国民族医学   370篇
外科学   198849篇
综合类   30407篇
现状与发展   2篇
一般理论   617篇
预防医学   123868篇
眼科学   31421篇
药学   106050篇
  7篇
中国医学   3319篇
肿瘤学   82403篇
  2021年   12570篇
  2019年   13264篇
  2018年   18223篇
  2017年   13737篇
  2016年   14841篇
  2015年   17167篇
  2014年   23635篇
  2013年   36480篇
  2012年   50499篇
  2011年   53605篇
  2010年   30913篇
  2009年   28643篇
  2008年   49145篇
  2007年   52065篇
  2006年   52057篇
  2005年   50730篇
  2004年   48314篇
  2003年   46096篇
  2002年   44498篇
  2001年   61831篇
  2000年   63344篇
  1999年   53306篇
  1998年   16010篇
  1997年   14433篇
  1996年   14049篇
  1995年   13400篇
  1994年   12417篇
  1993年   11678篇
  1992年   42200篇
  1991年   41334篇
  1990年   39980篇
  1989年   37873篇
  1988年   35086篇
  1987年   34170篇
  1986年   32628篇
  1985年   31219篇
  1984年   23735篇
  1983年   20268篇
  1982年   12690篇
  1981年   11151篇
  1979年   21190篇
  1978年   15314篇
  1977年   12521篇
  1976年   12236篇
  1975年   12462篇
  1974年   15119篇
  1973年   14724篇
  1972年   13542篇
  1971年   12541篇
  1970年   11615篇
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
5.
6.
Vestibular function laboratories utilize a multitude of diagnostic instruments to evaluate a dizzy patient. Caloric irrigators, oculomotor stimuli, and rotational chairs produce a stimulus whose accuracy is required for the patient response to be accurate. Careful attention to everything from cleanliness of equipment to threshold adjustments determine on a daily basis if patient data are going to be correct and useful. Instrumentation specifications that change with time such as speed and temperature must periodically be checked using calibrated instruments.  相似文献   
7.
8.
9.
Abstract

Objectives: This study examined word use as an indicator of interpersonal positive reframing in daily conversations of couples coping with breast cancer and as a predictor of stress.

Design: The Electronically Activated Recorder (EAR) and Linguistic Inquiry and Word Count (LIWC) were used to examine naturally occurring word use conceptually linked to positive reframing (positive emotion, negative emotion, and cognitive processing words).

Sample: Fifty-two couples coping with breast cancer.

Methods: Couples wore the EAR, a device participants wear, that audio-recorded over one weekend (>16,000 sound files), and completed self-reports of positive reframing (COPE) and stress (Perceived Stress Scale). LIWC, a software program, measured word use.

Findings: Both partners’ word use (i.e., positive emotion and cognitive processing words) was associated with their own reported positive reframing, and spouses’ word use was also indicative of patients’ positive reframing. Results also revealed that, in general, words indicating positive reframing predicted lower levels of stress.

Conclusions: Findings supported the hypothesis that partners—and particularly spouses of breast cancer patients—may assist each other’s coping by positively reframing the cancer experience and other negative experiences in conversation.  相似文献   
10.

Background

Rosacea is a chronic inflammatory skin condition whose etiology has been linked to mast cells and the antimicrobial peptide cathelicidin LL-37. Individuals with refractory disease have demonstrated clinical benefit with periodic injections of onabotulinum toxin, but the mechanism of action is unknown.

Objectives

To investigate the molecular mechanism by which botulinum toxin improves rosacea lesions.

Methods

Primary human and murine mast cells were pretreated with onabotulinum toxin A or B or control. Mast cell degranulation was evaluated by β-hexosaminidase activity. Expression of botulinum toxin receptor Sv2 was measured by qPCR. The presence of SNAP-25 and VAMP2 was established by immunofluorescence. In vivo rosacea model was established by intradermally injecting LL-37 with or without onabotulinum toxin A pretreatment. Mast cell degranulation was assessed in vivo by histologic counts. Rosacea biomarkers were analyzed by qPCR of mouse skin sections.

Results

Onabotulinum toxin A and B inhibited compound 48/80-induced degranulation of both human and murine mast cells. Expression of Sv2 was established in mouse mast cells. Onabotulinum toxin A and B increased cleaved SNAP-25 and decreased VAMP2 staining in mast cells respectively. In mice, injection of onabotulinum toxin A significantly reduced LL-37-induced skin erythema, mast cell degranulation, and mRNA expression of rosacea biomarkers.

Conclusions

These findings suggest that onabotulinum toxin reduces rosacea-associated skin inflammation by directly inhibiting mast cell degranulation. Periodic applications of onabotulinum toxin may be an effective therapy for refractory rosacea and deserves further study.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号