首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   27349篇
  免费   2700篇
  国内免费   1949篇
耳鼻咽喉   169篇
儿科学   380篇
妇产科学   383篇
基础医学   3328篇
口腔科学   495篇
临床医学   3696篇
内科学   4456篇
皮肤病学   259篇
神经病学   1578篇
特种医学   1003篇
外国民族医学   21篇
外科学   2731篇
综合类   4172篇
现状与发展   5篇
一般理论   1篇
预防医学   2034篇
眼科学   655篇
药学   2801篇
  23篇
中国医学   1466篇
肿瘤学   2342篇
  2024年   171篇
  2023年   517篇
  2022年   1177篇
  2021年   1524篇
  2020年   1135篇
  2019年   999篇
  2018年   1031篇
  2017年   951篇
  2016年   847篇
  2015年   1272篇
  2014年   1508篇
  2013年   1381篇
  2012年   1985篇
  2011年   2188篇
  2010年   1277篇
  2009年   1009篇
  2008年   1393篇
  2007年   1322篇
  2006年   1299篇
  2005年   1294篇
  2004年   905篇
  2003年   725篇
  2002年   706篇
  2001年   567篇
  2000年   610篇
  1999年   712篇
  1998年   447篇
  1997年   439篇
  1996年   330篇
  1995年   295篇
  1994年   227篇
  1993年   176篇
  1992年   229篇
  1991年   189篇
  1990年   156篇
  1989年   171篇
  1988年   150篇
  1987年   134篇
  1986年   113篇
  1985年   108篇
  1984年   52篇
  1983年   37篇
  1982年   30篇
  1981年   30篇
  1980年   24篇
  1979年   19篇
  1978年   19篇
  1977年   13篇
  1976年   17篇
  1970年   10篇
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
2.
3.
BACKGROUND: The ubiquitin-proteasome system (UPS) is thought to be functionally active in atherosclerosis (AS) lesions. Aspirin was found to be a potent inhibitor of the UPS in some tumour studies; however, its effect on AS remains to be demonstrated in vivo. METHODS: New Zealand rabbits were placed on a normal diet (N) or on a normal diet with aspirin (NI) or on an atherogenic diet without (H) or with aspirin (HI) for 12 weeks. Proteasome activity, concentrations of plasma lipids and levels of peroxidation were determined. Ubiquitin/ubiquitin-conjugates (Ub), IkappaBalpha, phosphorylated IkappaB (pIkappaBalpha) and p65 were investigated by Western blotting or immunochemistry. RESULTS: Concentrations of plasma lipids and peroxidation levels were higher in H or HI vs. N or NI. Histological analysis showed that atheroma was increased in H. Ub and IkappaBalpha were mainly localised in subendothelium and media vascular smooth muscle cells. Western blots revealed that Ub, IkappaBalpha, and pIkappaBalpha were increased, whereas p65 was lower in HI vs. H. The activity of the 20S proteasome was functionally active in H vs. N, NI or HI, while the 26S proteasome was not affected in any of the groups. CONCLUSIONS: Aspirin can attenuate the pathogenesis of atheroma formation, the degradation of IkappaBalpha and pIkappaBalpha, and lower the expression of p65, indicating that its therapeutic effects on AS may be via inhibition of the UPS.  相似文献   
4.
多发性肌炎的动物模型及雷公藤多甙对其疗效的研究   总被引:4,自引:0,他引:4  
目的 寻找一种多发性肌炎的良好动物模型及其有效的治疗药物。  方法 给动物注射同种大鼠的肌匀浆 ,观察其活动状态 ;通过肌肉组织染色及ELISA法 ,研究肌肉的病理学变化 ,同时给动物喂服雷公藤多甙观察药物疗效。  结果 部分动物表现肌无力和肌萎缩 ,大多数肌肉组织学检查示肌纤维炎性变 ;免疫组化检查可见肌膜、肌内膜和肌束膜中有IgG沉积。动物服雷公藤多甙后肌肉病变明显减轻 ,其疗效与强的松相似。  结论 用同种大鼠肌匀浆免疫动物可诱导出多发性肌炎的动物模型 ;雷公藤多甙能有效地治疗多发性肌炎。  相似文献   
5.
Y R Zhao  D F Zhang  C Q Pan 《中华内科杂志》1992,31(11):686-8, 730
Viral markers were studied in 79 cases of viral hepatitis with hepatic failure. The results were shown as follows: 8 cases were positive for anti-HAV IgM (10.12%); 76 cases positive for HBsAg or anti-HBc IgM (96.20%) and 41 cases positive for anti-HCV antibodies (51.89%). Among those with anti-HCV positive, 35 cases were co-infected with HBV, 5 cases with HAV and/or HCV, only one was infected with HCV alone 2 cases were HD-Ag positive (2.52%) and one not identified (1.27%). With the reference of clinical findings, patients co-infected with HBV/HCV or anti-HBc IgM positive were more critical and usually entail higher mortality. In cases with HCV co-infections, the positive HBV replication markers seems to be reduced. Hepatic failure without HBV replicative markers had a high rate of hepatic coma as well as poor outcome.  相似文献   
6.
7.
OBJECTIVE: We sought to assess the efficacy of facial translocation in the management of tumors of the skull base and paranasal sinuses. STUDY DESIGN AND SETTING: From July 1993 to December 1999, 75 patients, aged 3 to 102 years old, underwent facial translocation. Thirty-three (44%) patients also underwent a combined neurosurgical procedure. Nineteen (25%) had previous surgery. These patients were followed up to 6 years. RESULTS: There were 21 benign and 54 malignant tumors. There were no perioperative deaths. The morbidity rate was 31%. Of the 54 patients with malignant tumors, the actuarial 3-year survival rate was 59%, whereas the local control rate was 54%. CONCLUSION: The facial translocation technique offers favorable exposure of the critical zones of the anterior and middle cranial base, thus facilitating extensive resection and reconstruction. SIGNIFICANCE: This study demonstrates that facial translocation is one of the best surgical approaches to the skull base.  相似文献   
8.
We study 40 patients, 55 +/- 7 years old with acute myocardial infarction treated early by thrombolytic therapy (20 STK and 20 rt-PA). All patients were angiographically studied in the following conditions: 1) baseline, before initiating therapy. 2) Three hours after treatment. 3) Twenty four hours later. 4) Before discharge. The infarct related artery was patent 24 hours after treatment in 31 patients (78%); five of them were patent before treatment, and we observed an early reperfusion in 20 patients (57%) and late reperfusion in 6 patients (17%). The number of patients with angiographic evidence of intraluminal thrombus decreased progressively through conditions while the grade TIMI of coronary perfusion increased in the absence of reocclusion. Final regional wall motion of infarct related myocardial zones and their degree of recovery were significantly higher in recanalized patients, as compared with non-reperfused patients. Similarly, left ventricular functional recovery was higher in patients with antegrade of collateral flow to the infarct area, as compared with totally occluded patients.  相似文献   
9.
In an Italian hospital, we observed that hand hygiene was performed in 638 (19.6%) of 3,253 opportunities, whereas gloves were worn in 538 (44.2%) 1,218 of opportunities. We observed an inverse correlation between the intensity of care and the rate of hand hygiene compliance (R2=0.057; P<.001), but no such association was observed for the rate of glove use compliance (R2=0.014; P=.078). Rates of compliance with hand hygiene and glove use recommendations follow different behavioral patterns.  相似文献   
10.
重症肌无力患者泼尼松治疗前后免疫学指标的变化   总被引:3,自引:0,他引:3  
探讨泼尼松治疗重症肌无力(MG)免疫学机制。对382例MG患者在漏尼松中剂量冲击,小剂量维持疗法治疗前后,检测酰胆碱受体抗炎(AchRab),突触前膜抗体(PsMab),单个核细胞亚群(PBMC),肿瘤坏死因子(TNF),可溶性白介素-2受体(SIL-2R),β2-微球蛋白(β2-m),以及红细胞免疫功能的变化。结果表明:MG患者在泼尼松治疗前后多项免疫指标有显著性的变化。为泼尼松治疗MG提供了评定疗效的免疫学指标,进一步阐明了MG发病的免疫学机制。  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号