Palatal evaluation and treatment in 22q11.2 deletion syndrome

Palatal involvement occurs commonly in patients with 22q11.2 Deletion Syndrome (22qDS), and includes palatal clefting and velopharyngeal dysfunction in the absence of overt or submucous clefts. The reported incidence and distribution of palatal abnormalities vary in the literature. The aim of this article is to revisit the incidence and presenting features of palatal abnormalities in a large cohort of patients with 22qDS, summarize the surgical treatments performed in this cohort, and provide an overview of surgical treatment protocols and management guidelines for palatal abnormalities in this syndrome. Charts of 1,121 patients seen through the 22q and You Center at the Children's Hospital of Philadelphia were reviewed for palatal status, demographic factors, deletion size, and corrective surgical procedures. Statistical analysis was performed using Pearson's chi‐squared test to identify differences between gender, deletion size, and palatal abnormality. Of the patients with complete evaluations, 67% were found to have a palatal abnormality. The most common finding was velopharyngeal dysfunction in 55.2% of patients, and in 33.3% of patients, this occurred in the absence of palatal clefting. There was no significant difference in the incidence of palatal abnormalities by gender; however, a difference was noted among race (p < 0.01) and deletion sizes (p < 0.01). For example, Caucasian and Asian patients presented with a much higher prevalence of palatal abnormalities, and conversely those with nested deletions presented with a much lower rate of palatal defects. Overall, 26.9% of patients underwent palatal surgery, and the most common indication was velopharyngeal dysfunction. Palatal abnormalities are a hallmark feature of 22q11.2 Deletion Syndrome; understanding the incidence, presenting features, and treatment protocols are essential for practitioners counseling and treating families affected with this disorder.     

Effect on bone healing of bone morphogenetic protein placed in combination with endosseous implants: a pilot study in beagle dogs

Although dental implants have become an effective treatment modality for the replacement of missing teeth, their predictability relies on successful osseointegration during the healing period. The purpose of this pilot study was to evaluate the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on early bone formation within the perforations of dental implants in beagle dogs. Histologic sections were evaluated for the extent of new bone formation within a 1-mm diameter of through-and-through perforations. Data indicated that significantly more bone formation occurred with rhBMP-2-treated sites within the implant perforation (P < 0.01) compared to sites treated with the vehicle alone. This pilot study indicates that rhBMP-2 increases the rate and extent of bone formation in combination with dental implants.     

Shrink-free ceramic

An all-ceramic crown employing the Cerestore system utilizes a unique shrink-free alumina ceramic as its substrate. This core renders the restoration exceptional fit and strength. A ceramic layering technique employed with the aluminous porcelain veneers offers the capability of constructing a full crown restoration incorporating the optical properties present in a natural tooth.     

Oral surgery program university of california, san francisco.

The two cases presented here demonstrate a successful therapeutic modality with resection followed by immediate reconstruction with bone grafts. At least one of the cases presented seems to indicate that the tumor is relatively less aggressive than the simple ameloblastoma. The histopathology of the two cases suggests that this odontogenic tumor has a wider histologic variation than originally described by Pindborg.     

A study of CdS nanoparticle surface states by potential-modulated sub-bandgap spectroscopy

The potential modulation spectrum of CdS Q-dots deposited on an optically transparent electrode has been investigated. A peak at 580 nm, that corresponded to bleaching of a sub-bandgap absorption, was observed. It was established that the peak was related to electron injection into the conduction band of the CdS Q-dots. The mechanism by which the absorption of surface states may be monitored using potential-modulated absorption spectroscopy is outlined.