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V. P. Mikhailov L. D. Smirnov G. V. Kurygin N. N. Zolotov 《Bulletin of experimental biology and medicine》1992,113(2):175-177
Department of Pathophysiology, Yaroslavl' State Medical Institute. All-Union Research Center for Safety of Biologically Active Substances, Kupavna, Moscow Region. (Presented by Academician of the Academy of Medical Sciences of the USSR A. G. Chuchalin.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 113, No. 2, pp. 139–141, February, 1992. 相似文献
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Calciphylaxis – a topical overview 总被引:3,自引:0,他引:3
G Arseculeratne† AT Evans‡ SM Morley† 《Journal of the European Academy of Dermatology and Venereology》2006,20(5):493-502
'Calciphylaxis', a calcification syndrome associated with ischaemic cutaneous necrosis, is acquired naturally in humans in disease states. It is a life and limb-threatening complication, usually observed in patients with renal disease and secondary hyperparathyroidism, but known to occur in the absence of renal or parathyroid disease. The reported mortality rate, which ranges from 60-80%, relates to wound infection, sepsis and organ failure. It is a small-vessel vasculopathy, which is estimated to occur in about 4% of haemodialysis patients. Clinically, violaceous, reticulate areas of cutaneous necrosis and eschar may be evident, particularly in the extremities. In addition to the clinical picture, a raised calcium phosphorous product, an elevated parathyroid hormone level, radiographic evidence of vessel and soft-tissue calcification and the finding of mural calcification affecting small arteries and arterioles on histopathology help to confirm the diagnosis of this entity which generally has a poor prognosis. A high index of suspicion and an active multidisciplinary management approach, with rigorous attention to wound care and prevention of sepsis, are vital in the management of these patients. In this overview, we discuss the pathophysiology, clinical features and associations, risk factors, diagnosis and management issues relating to calciphylaxis. 相似文献
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Oncology Research Center, Russian Academy of Medical Sciences, Moscow. Translated from Meditsinskaya Tekhnika, No. 6, pp.
9–10, November–December, 1992. 相似文献
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Mutations in the retinal guanylate cyclase (RETGC-1) gene in dominant cone-rod dystrophy 总被引:3,自引:0,他引:3
Kelsell RE; Gregory-Evans K; Payne AM; Perrault I; Kaplan J; Yang RB; Garbers DL; Bird AC; Moore AT; Hunt DM 《Human molecular genetics》1998,7(7):1179-1184
The dominant cone-rod dystrophy gene CORD6 has previously been mapped to
within an 8 cM interval on chromosome 17p12-p13. The retinal- specific
guanylate cyclase gene (RETGC-1), which maps to within this genetic
interval and previously was implicated in Leber's congenital amaurosis, was
screened for mutations within this family and in a panel of small families
and individuals with various cone and cone- rod dystrophy phenotypes. A
missense mutation (E837D) was identified in affected members of the CORD6
family, as well as a second missense mutation (R838C) in three other
families with dominant cone-rod dystrophy. RETGC-1 is only the fourth gene
to be implicated in cone-rod dystrophy and this is the first report of
dominant mutations in this gene.
相似文献
9.
V. V. Mikhailov M. A. Gordeeva A. G. Rusanova 《Bulletin of experimental biology and medicine》1991,111(3):301-302
Department of Pathological Physiology, N. A. Semashko Moscow Medical Stomatologic Institute. (Presented by Academician of the Academy of Medical Sciences of the USSR A. D. Ado.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 111, No. 3, pp. 246–297, March, 1991. 相似文献
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Theoretical substantiation and practical experience of vibromechanical dilatation of a tubular organ
S. A. Regirer N. A. Chigogidze L. B. Vanina K. G. Vasil'ev S. S. Mikhailov 《Biomedical engineering》1998,32(1):29-34
Conclusions
Bakulev Research Center for Cardiovascular Surgery, Russian Academy of Medical Sciences, Moscow. Institute of Mechanics, Moscow
State University. Translated from Meditsinskaya Tekhnika, No. 1, pp. 27–32, January–February, 1998. 相似文献
1. | Force applied to the tubular organ walls in the place of contact with the flexible rotating shaft of the dilatation catheter is normal to the wall surface and does not exceed physiological value (except for very stiff walls). |
2. | Power consumption measurement allows estimation of only tangential forces. |
3. | Vibromechanical dilatation is a promising technique for treating stenoses of tubular organs. |