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RW Parks FRCS MAR Clarke MRCPath B Cranley MD FRCS 《International journal of clinical practice》1997,51(6):414-415
Adenomyoepithelioma is a rare disorder characterised by simultaneous proliferation of ductal epithelium and myoepithelial cells. It is more common in salivary glands or skin, and only rarely found in breast tissue. Adenomyoepithelioma of the breast was first described in 1970 by Hamperl.1 Since then, approximately 55 cases have been described in the literature; the largest review, by Tavassoli in 1991, reported 27 of these cases.2 Because of the small number of cases reported, the natural history of adenomyoepithelioma of the breast remains uncertain. We report a further case which was treated by local excision, and follow-up for two years has revealed no evidence of local recurrence or metastatic spread. 相似文献
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BÉATRICE BREMBILLA‐PERROT M.D. ANNE M. ZINSCH M.D. JEAN M. SELLAL M.D. PIERRE Y. ZINZIUS M.D. JÉRÔME SCHWARTZ M.D. DANIEL BEURRIER M.D. CHRISTIAN DE CHILLOU M.D. JEAN P. GODENIR M.D. JEAN P. LETHOR M.D. CÉCILE MARCHAL M.D. JEAN L. CLOEZ M.D. MAHESHWAR PAURIAH M.D. RADU NOSU M.D. MARIUS ANDRONACHE M.D. FRANÇOIS MARÇON M.D. 《Pacing and clinical electrophysiology : PACE》2013,36(7):803-810
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FERNANDO CABRERA BUENO M.D. Ph.D. JAVIER ALZUETA RODRÍGUEZ M.D. Ph.D. JOSÉ OLAGÜE DE ROS M.D. IGNACIO FERNÁNDEZ‐LOZANO M.D. Ph.D. JUAN JOSÉ GARCÍA GUERRERO M.D. JOAQUÍN FERNÁNDEZ DE LA CONCHA M.D. ANTONIO HERNÁNDEZ MADRID Ph.D. JOSE MARÍA TOLOSANA VIU M.D. JOAQUÍN OSCA ASENSI M.D. ALBERTO BARRERA CORDERO M.D. Ph.D. ELENA LLORENTE HERNANGÓMEZ 《Pacing and clinical electrophysiology : PACE》2013,36(8):963-969
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ELDON E GEISERT JR. DEBORAH J BIDANSET NOBEL DEL MAR JOHN A ROBSON 《International journal of developmental neuroscience》1996,14(3):257-267
The up-regulation of the keratan sulfate proteoglycan (ABAKAN) was examined using indirect immunohistochemical methods. Previous studies indicate that the keratan sulfate proteoglycan is associated with astrocytes in the optic nerve and in the developing rat brain. In model culture systems, this proteoglycan is capable of inhibiting the growth of neurites over laminin. To determine whether the proteoglycan is up-regulated specifically during reactive gliosis, stab wounds were made in the cerebral cortex of early postnatal rats, and the up-regulation of the proteoglycan was related to the developmentally regulated gliotic response to injury. Following a stab wound in the cortex of the late postnatal rat, reactive gliosis was consistently observed along with an up-regulation of ABAKAN. When the cortex was injured on postnatal day 2, there was a variable gliotic response and considerable variation in the regulation of proteoglycan expression. Biochemical analysis revealed that ABAKAN is a large proteoglycan with multiple keratan sulfate side-chains, at least one chondroitin sulfate side-chain and at least one additional carbohydrate chain with a terminal 3-sulfoglucuronic acid. Taken together, these data demonstrate that the boundary proteoglycan ABAKAN is also associated with reactive gliosis during early postnatal development. Copyright ©1996 ISDN. Published by Elsevier Science Ltd. 相似文献
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JORGE PEDRÓN‐TORRECILLA Ph.D. MIGUEL RODRIGO M.S. ANDREU M. CLIMENT Ph.D. ALEJANDRO LIBEROS M.S. ESTHER PÉREZ‐DAVID M.D. JAVIER BERMEJO M.D. ÁNGEL ARENAL M.D. JOSÉ MILLET Ph.D. FRANCISCO FERNÁNDEZ‐AVILÉS M.D. Ph.D. OMER BERENFELD Ph.D. FELIPE ATIENZA M.D. Ph.D. MARÍA S. GUILLEM Ph.D. 《Journal of cardiovascular electrophysiology》2016,27(4):435-442
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Fermín MAR‐AGUILAR Claudia M. LUNA‐AGUIRRE J. Claudio MORENO‐ROCHA Juan ARAIZA‐CHÁVEZ Victor TREVINO Cristina RODRÍGUEZ‐PADILLA Diana RESÉNDEZ‐PÉREZ 《Asia-Pacific Journal of Clinical Oncology》2013,9(1):53-59
Aims: To develop new biomarkers for early detection and to inform effective clinical management of breast cancer. Methods: Real‐time polymerase chain reaction was used to profile microRNA (miRNA) in tumor tissue from 50 breast cancer patients using non‐tumor breast tissue from each patient as a control. We have focussed on three miRNA; miR‐21, miR‐125b and miR‐191, all of which have been implicated in breast cancer with either proven or predicted target genes involved in critical cancer‐associated cellular pathways. Results: Upregulation of miR‐21 and miR‐191 and downregulation of miR‐125b, was found in breast cancer tissue. Combined expression analysis of miR‐125b/miR‐191 increased sensitivity to 100% and specificity to 94% while miR‐21/miR‐191 increased to 92% and 100%, respectively. Therefore, combination of two miRNA gives a better prediction than individual miRNA. Conclusions: We could differentiate between breast cancer and adjacent non‐tumor breast tissue as a control with a high degree of sensitivity and specificity in the Mexican population using a combined expression analysis of only two miRNA. These observations, although a proof of principle finding at this time, show that a combined expression profile of two miRNA (miR‐125b/miR‐191 and miR‐21/miR‐191) can discriminate between breast cancer and non‐tumor tissue with high specificity and sensitivity. 相似文献