全文获取类型
收费全文 | 999篇 |
免费 | 80篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 21篇 |
儿科学 | 21篇 |
妇产科学 | 36篇 |
基础医学 | 132篇 |
口腔科学 | 44篇 |
临床医学 | 101篇 |
内科学 | 232篇 |
皮肤病学 | 8篇 |
神经病学 | 104篇 |
特种医学 | 21篇 |
外科学 | 154篇 |
综合类 | 2篇 |
预防医学 | 45篇 |
眼科学 | 40篇 |
药学 | 27篇 |
肿瘤学 | 92篇 |
出版年
2024年 | 1篇 |
2023年 | 10篇 |
2022年 | 18篇 |
2021年 | 50篇 |
2020年 | 18篇 |
2019年 | 28篇 |
2018年 | 40篇 |
2017年 | 34篇 |
2016年 | 45篇 |
2015年 | 41篇 |
2014年 | 65篇 |
2013年 | 59篇 |
2012年 | 95篇 |
2011年 | 89篇 |
2010年 | 47篇 |
2009年 | 36篇 |
2008年 | 48篇 |
2007年 | 52篇 |
2006年 | 57篇 |
2005年 | 50篇 |
2004年 | 39篇 |
2003年 | 41篇 |
2002年 | 38篇 |
2001年 | 13篇 |
2000年 | 8篇 |
1999年 | 14篇 |
1998年 | 6篇 |
1997年 | 2篇 |
1996年 | 2篇 |
1995年 | 1篇 |
1994年 | 2篇 |
1993年 | 3篇 |
1992年 | 4篇 |
1991年 | 3篇 |
1990年 | 3篇 |
1989年 | 4篇 |
1988年 | 1篇 |
1987年 | 3篇 |
1986年 | 2篇 |
1985年 | 3篇 |
1983年 | 1篇 |
1980年 | 1篇 |
1979年 | 3篇 |
排序方式: 共有1080条查询结果,搜索用时 15 毫秒
1.
2.
Blood flowing through a prosthetic heart valve can be damaged by flow-induced shear forces. Fluid dynamics variables and geometric factors play an important role in the evaluation of shear-stress-related blood damage. Central-flow prosthetic valves have been considered as an optimal replacement for mechanical and biological valves. Recently it was shown that shear stress distribution along the surface of a polyurethane cusp reaches values that can damage the blood elements. A mathematical model correlating the effects of shear stresses on blood corpuscles with clinical findings was employed in vitro. The model can be applied to the effects of blood-surface interaction and is of clinical relevance. 相似文献
3.
Elad D Yas-Natan E Aroch I Shamir MH Kleinbart S Hadash D Chaffer M Greenberg K Shlosberg A 《Journal of clinical microbiology》2004,42(11):5406-5408
Clinical signs of botulism were observed in a group of eight cats, four of which died, after being fed pelican carrion. Clostridium botulinum type C was isolated from one cat. The microorganism and its toxin were found in the pelican. This is apparently the first report of natural botulism in cats. 相似文献
4.
D Elad I Aizenberg M Shamir F Soriano S Shlomovitz 《Journal of clinical microbiology》1992,30(5):1167-1169
Corynebacterium group D2 was isolated from two dogs with urinary tract infections. The isolates were resistant in vitro to all tested antibacterial drugs except vancomycin. One dog was successfully treated with this antibiotic, while the other died before treatment could be initiated. 相似文献
5.
6.
Thaísa Agrizzi Verediano Hrcia Stampini Duarte Martino Maria Cristina Dias Paes Elad Tako 《Nutrients》2021,13(4)
Intestinal health relies on the association between the mucosal immune system, intestinal barrier and gut microbiota. Bioactive components that affect the gut microbiota composition, epithelial physical barrier and intestinal morphology were previously studied. The current systematic review evaluated evidence of anthocyanin effects and the ability to improve gut microbiota composition, their metabolites and parameters of the physical barrier; this was conducted in order to answer the question: “Does food source or extract of anthocyanin promote changes on intestinal parameters?”. The data analysis was conducted following the PRISMA guidelines with the search performed at PubMed, Cochrane and Scopus databases for experimental studies, and the risk of bias was assessed by the SYRCLE tool. Twenty-seven studies performed in animal models were included, and evaluated for limitations in heterogeneity, methodologies, absence of information regarding allocation process and investigators’ blinding. The data were analyzed, and the anthocyanin supplementation demonstrated positive effects on intestinal health. The main results identified were an increase of Bacteroidetes and a decrease of Firmicutes, an increase of short chain fatty acids production, a decrease of intestinal pH and intestinal permeability, an increase of the number of goblet cells and tight junction proteins and villi improvement in length or height. Thus, the anthocyanin supplementation has a potential effect to improve the intestinal health. PROSPERO (CRD42020204835). 相似文献
7.
Embryo transfer (ET) is the last stage of extracorporal fertilization during which the embryo is placed in the uterine cavity with a medium-filled catheter 2–3 days after in vitro fertilization. While fertilization in the laboratory occurs at very high rates (>:90%), the overall success of the procedure (i.e., take home baby) is still very low (<25%) and assumed to be mainly due to implantation failure. A computational model was developed to simulate ET within the uterine cavity by a fluid-filled catheter inserted into a two-dimensional channel with oscillating walls. The results showed that the speed at which the embryos are injected from the catheter dominates the procedure and controls the velocity of their transport within the uterine cavity. ET at excessively high injection speeds may lead to ectopic pregnancies, while uterine peristalsis affects transverse dispersion only during injection at low injection speeds. The presence of the catheter within the uterus does not affect flow patterns downstream of its tip. The potential risks to implantation failure due to mechanical factors involved in the ET processes are discussed. © 2003 Biomedical Engineering Society.
PAC2003: 8719-j, 8710+e 相似文献
8.
Neoadjuvant chemotherapy does not increase postoperative complication rate after resection of colorectal liver metastases. 总被引:2,自引:0,他引:2
S Yedibela L Elad A Wein A Dimmler S Merkel W Hohenberger T Meyer 《European journal of surgical oncology》2005,31(2):141-146
BACKGROUND: This paper discusses, whether neoadjuvant chemotherapy has an impact on the rate of postoperative complications after primary resection of liver metastases from colorectal carcinoma. METHODS: Of 183 patients 64 were studied. The patients were subdivided into two matched groups of 32 patients each-prior neoadjuvant chemotherapy (CT-group) vs. (control-group, primary resection). RESULTS: There were no postoperative complications in 24 patients of the control group (75%) and 26 patients of the CT-group (81%). Following prior chemotherapy, no major complications such as liver failure were observed, even after extended resections. CONCLUSION: Neoadjuvant chemotherapy prior to surgical resection of colorectal liver metastases does not result in an increase of postoperative morbidity and mortality. 相似文献
9.
Naveenchandra Suryadevara Andrea R. Shiakolas Laura A. VanBlargan Elad Binshtein Rita E. Chen James Brett Case Kevin J. Kramer Erica C. Armstrong Luke Myers Andrew Trivette Christopher Gainza Rachel S. Nargi Christopher N. Selverian Edgar Davidson Benjamin J. Doranz Summer M. Diaz Laura S. Handal Robert H. Carnahan Michael S. Diamond Ivelin S. Georgiev James E. Crowe Jr. 《The Journal of clinical investigation》2022,132(11)
The protective human antibody response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) focuses on the spike (S) protein, which decorates the virion surface and mediates cell binding and entry. Most SARS-CoV-2 protective antibodies target the receptor-binding domain or a single dominant epitope (“supersite”) on the N-terminal domain (NTD). Using the single B cell technology called linking B cell receptor to antigen specificity through sequencing (LIBRA-Seq), we isolated a large panel of NTD-reactive and SARS-CoV-2–neutralizing antibodies from an individual who had recovered from COVID-19. We found that neutralizing antibodies against the NTD supersite were commonly encoded by the IGHV1-24 gene, forming a genetic cluster representing a public B cell clonotype. However, we also discovered a rare human antibody, COV2-3434, that recognizes a site of vulnerability on the SARS-CoV-2 S protein in the trimer interface (TI) and possesses a distinct class of functional activity. COV2-3434 disrupted the integrity of S protein trimers, inhibited the cell-to-cell spread of the virus in culture, and conferred protection in human angiotensin-converting enzyme 2–transgenic (ACE2-transgenic) mice against the SARS-CoV-2 challenge. This study provides insight into antibody targeting of the S protein TI region, suggesting this region may be a site of virus vulnerability. 相似文献
10.