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1.
M. Harza C. Baston A. Preda V. Olaru G. Ismail L. Domnisor D. Daia I. Mitroi M.O. Baston I. Sinescu 《Transplantation proceedings》2014,46(10):3459-3462
BackgroundUrological complications such as ureteral strictures and ureteral leakage can affect the outcome of kidney transplantation by increasing morbidity and mortality, including graft loss. Controversy still exists regarding the role of stents in renal transplantation. The aim of this study was to evaluate the role of ureteral stenting in kidney transplantation.MethodsWe performed a retrospective study on a series of 798 consecutive renal transplants performed in our center between January 1, 2004, and December 31, 2011. Ureteral stents were used in 152 cases (19.1%) of the total (stent group) and were removed 2 weeks postoperatively. Donor and recipient age, sex, type of ureteroneocystostomy, stent and non-stent patients, cold and warm ischemia time, and urological complications were analyzed.ResultsThe overall incidence of urological complications was 7.8% (62 cases). Ureteral stenosis (3.1%) and ureteral leakage (2.4%) were the most common complications; 39.7% (25 cases) of complications were recorded in the first month after transplantation. Major urological complication rate was 3.3% in the stent group compared with 8.8% in the non-stent group (P = .04). However, stent use was associated with the increase of urinary tract infections rate in the stent group (51.3%) compared with the non-stent group (17.9%) (P = .03).ConclusionsIn our study, the use of ureteral stents significantly decreased urological complications in kidney transplant recipients but increased the risk for development of urinary tract infections. 相似文献
2.
G. Kövér T. Harza Éva Szőcs T. Bálint Éva Tarján 《International urology and nephrology》1969,1(3):289-296
Acetylcholine (1 mg/min) was infused in 1 ml of physiological saline into the renal artery of dogs.
1) While arterial blood pressure was not significantly affected, renal vascular resistance decreased and renal blood flow
increased by about 35%.
2) The increase in renal blood flow was not associated with an increase in CPAH, whereas EPAH diminished.
3) Ccreat and Ecreat decreased, while sodium and water excretion did not change significantly.
4) While in the control experiments the RBF measured on basis of the uptake of86Rb was only 7% lower than the directly estimated renal blood flow (RBFdir), the difference between the two values during the infusion of ACh increased to 40%.
5) The changes in response to ACh infusion have been accounted for by the opening of shunts and the inhibition of ionic transport
across the tubular epithelium. 相似文献
3.
Kovács G Zimmer M Bankó E Harza I Antal A Vidnyánszky Z 《Cerebral cortex (New York, N.Y. : 1991)》2006,16(5):742-753
The existence of facial aftereffects suggests that shape-selective mechanisms at the higher stages of visual object coding -- similarly to the early processing of low-level visual features -- are adaptively recalibrated. Our goal was to uncover the ERP correlates of shape-selective adaptation and to test whether it is also involved in the visual processing of human body parts. We found that prolonged adaptation to female hands -- similarly to adaptation to female faces -- biased the judgements about the subsequently presented hand test stimuli: they were perceived more masculine than in the control conditions. We also showed that these hand aftereffects are size and orientation invariant. However, no aftereffects were found when the adaptor and test stimuli belonged to different categories (i.e. face adaptor and hand test, or vice versa), suggesting that the underlying adaptation mechanisms are category-specific. In accordance with the behavioral results, both adaptation to faces and hands resulted in a strong and category-specific modulation -- reduced amplitude and increased latency -- of the N170 component of ERP responses. Our findings suggest that shape-selective adaptation is a general mechanism of visual object processing and its neural effects are primarily reflected in the N170 component of the ERP responses. 相似文献
4.
Adaptation processes in human early visual cortical areas are sensitive to the exposure time of the adaptor stimulus. Here we investigated the effect of adaptation duration at the higher, shape-specific stages of visual processing using facial adaptation. It was found that long-term (5s) adaptation evokes facial aftereffects consisting of a position invariant as well as a position-specific component. As a result of adaptation to a female face, test faces were judged more masculine when they were displayed in the same location as the female adaptor face, as compared to that when they were presented in the opposite visual hemifield. However, aftereffects evoked by short-term (500 ms) adaptation were found to be entirely position invariant. In accordance with these behavioral results, we found that the adaptation effects, measured on the amplitude of the N170 ERP component consisted of a position-specific component only after long-term, but not after short-term adaptation conditions. These results suggest that both short and long exposure to a face stimulus leads to adaptation of position invariant face-selective processes, whereas adaptation of position-specific neural mechanisms of face processing requires long-term adaptation. Our findings imply that manipulating adaptation duration provides an opportunity to specifically adapt different neural processes of shape-specific coding and to investigate their stimulus selectivity. 相似文献
5.
Hársing L. Bartha J. Harza T. Kövér G. 《Pflügers Archiv : European journal of physiology》1969,308(1):47-56
Zusammenfassung An isolierten, perfundierten Hundenieren wurden Experimente zur Untersuchung der Nierendurchblutung und PAH-Extraktion in osmotischer Diurese und unter Ureterverschluß durchgeführt. Die Bestimmung der Nierendurchströmung erfolgte simultan aufgrund des vernösen Abflusses (direkter RBF-Wert) und nach der Rb-Methode (Rb-RBF), die der regionalen Nierendurchströmung aufgrund des Rb-Gehaltes in der Rinde sowie im äußeren und inneren Mark. Während des freien Harnabflusses betrug der direkte RBF-Wert durchschnittlich 413 ml/min/100 g, der Rb-RBF-Wert durchschnittlich 310 ml/min/100 g, der Quotient der Rinden-Rb-Blutströmung und der totalen Nierendurchblutung im Durchschnitt 0,64 und die PAH-Extraktion durchschnittlich 0,63. Unter Ureterverschluß sank der direkte RBF-Wert auf durchschnittlich 307, der Rb-RBF-Wert auf durchschnittlich 181 ml/min/100 g, der Quotient der Rinden-Rb-Blutströmung und totalen Nierendurchblutung auf durchschnittlich 0,51, die PAH-Extraktion im Durchschnitt auf 0,52.Die auch schon bei den Kontrollperioden nachweisbare Differenz zwischen dem direkten und dem Rb-RBF-Wert wird im Einklang mit der entsprechend niedrigeren PAH-Extraktion auf die in der isolierten Niere auch bereits bei freiem Harnabfluß bestehenden offenen AV-Shunts zurückgeführt. Während bei der Niere in situ die Steigerung des postcapillaren Widerstands unter Ureterverschluß durch die Öffnung von AV-Shunts kompensiert werden kann, nimmt durch das Fehlen dieses Kompensationsmechanismus in der isolierten Niere unter Ureterverschluß der totale Nierenwiderstand zu und sowohl die capillare als auch die totale Durchblutung der Niere ab. 相似文献
6.
C. Baston M. Harza A. Preda I. Gener I. Manea S. Voinea V. Olaru B. Badescu I. Sinescu 《Transplantation proceedings》2014
Background
The incidence of urologic complications after kidney transplantation remains high despite improvements in diagnosis and operative techniques. Urinary tract reconstruction is usually done by ureteroneocystostomy (UCNS), and several techniques are available. In this study, we evaluated the outcomes of 2 different UCNS techniques performed in our department, the transvesical Leadbetter-Politano (L-P) and the extravesical Lich-Gregoire (L-G) technique.Material and Methods
We evaluated the outcomes of 2 different UCNS techniques, L-P versus L-G, performed in our department between July 1, 2006, and December 31, 2011. During this period, we performed 524 consecutive renal transplantations—264 cases using the L-P technique (50.3%) and 260 cases with L-G technique (49.7%). Renal grafts were obtained from cadaveric donors in 146 cases (27.86%) and from living-related donors in 378 cases (72.14%). Recipient mean age was 35.64 years and the male to female ratio was 1.63:1.Results
Urologic complications after kidney transplantation occurred in 22 cases in the L-P UCNS group (8.33%). The most common complications were ureteral stenosis (3.41%) and leakage (2.65%). Other complications recorded were lymphoceles (1.89%) and hematoma with secondary ureteral obstruction (0.38%). Compared with the L-P UCNS technique, the L-G technique was associated with fewer overall complications (6.15% vs 8.33%; P = .06), a lesser rate of ureteral stenosis (2.31% vs 3.41%; P = .08), and a similar rate of leakage. However, statistical analysis revealed no differences between the 2 techniques (P = .06). In addition, we did not note any differences in graft and patient survival between the 2 groups.Conclusions
In our study, the extravesical L-G technique has a lower complication rate compared with transvesical L-P procedure, but without statistical differences. Furthermore, the L-G technique is easier and faster to perform, it avoids a separate cystotomy, and requires a shorter ureteral length. In conclusion, we recommend L-G technique as technique of choice in kidney transplantation. 相似文献7.
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9.
Gener Ismail Gabriel Mircescu Alecse Valerian Ditoiu Beatrice Dorina Tacu Roxana Jurubita Mihai Harza 《International urology and nephrology》2014,46(4):787-792
Purpose
The venous thromboembolic events (VTE) incidence is high in nephrotic syndrome (NS). We aimed to assess prospectively the risk of VTE in a large cohort of NS patients and to identify predictive factors for VTE, especially haemostasis-related parameters.Methods
This is the prospective, observational study conducted in 256 adults with idiopathic NS. VTE were the study outcome. Clinical data, proteinuria, albuminuria, haemostasis and fibrinolysis parameters, and D-dimers were evaluated every 6 months.Results
Median follow-up time was 24 [IQR 12–72] months. VTE cumulative and rate incidence were 11 % and 4.4 per 100 patient-years. Baseline higher proteinuria, lower serum albumin, low antithrombin III activity, and, surprisingly, high ionized calcium were VTE independent predictors. Proteinuria and serum albumin cut-offs, and positive and negative predictive values (PPV and NPV) for VTE were 9.0 g/24 h (30 % PPV and 90 % NPV) and 1.5 g/dL (69 % PPV and 93 % NPV).Conclusions
The rate of VTE incidence of 4.4 per 100 patient-years found in this prospective study confirms the idiopathic nephrotic syndrome as a thromboembolism-generating condition. Severe and unremitting proteinuria and hypoalbuminemia, low antithrombin III activity, and, surprisingly, high ionized calcium are independent VTE predictors. 相似文献10.
Jenö Bartha Tibor Harza und László Hársing 《Pflügers Archiv : European journal of physiology》1966,288(4):315-321
Zusammenfassung Auf Grund der Ablagerung und intrarenalen Verteilung von 86Rb bestimmten wir die durch die Niere, und zwar durch die Rinden- und Marksubstanz strömende Blutmenge in der osmotischen Diurese und unter stop flow-Bedingungen.In osmotischer Diurese wird die Niere von 383 ml/min/100 g, die Rindensubstanz von 445 ml/min/100 g, das äußere Mark von 357 ml/min/100 g, das innere Mark von 152 ml/min/100 g Blut durchströmt. Das durch 100 g Niere strömende Blut verteilt sich folgendermaßen: Rinde 298 ml/min (76,2%), äußeres Mark 82 ml/min (19,9%), inneres Mark 15,2 ml/min (3,9%). Bei stop flow stellten wir die Blutdurchströmung der Niere mit 223 ml/min/100 g, die der Rinde mit 286 ml/min/100 g, die des äußeren Marks mit 146 ml/min/100 g, die des inneren Marks mit 42 ml/min/100 g fest. Von dem durch 100 g Niere strömenden Blut gelangen 192 ml/min (84,1%) in die Rindensubstanz, 33,6 ml/min (14,1%) in die äußere und 4,2 ml/min (1,8%) in die innere Marksubstanz.Zwischen den in situ und den in isolierten Nieren ermittelten Blutdurchströmungswerten besteht kein Unterschied. 相似文献