全文获取类型
收费全文 | 5031篇 |
免费 | 445篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 30篇 |
儿科学 | 162篇 |
妇产科学 | 184篇 |
基础医学 | 481篇 |
口腔科学 | 77篇 |
临床医学 | 959篇 |
内科学 | 942篇 |
皮肤病学 | 47篇 |
神经病学 | 486篇 |
特种医学 | 76篇 |
外科学 | 428篇 |
综合类 | 52篇 |
一般理论 | 7篇 |
预防医学 | 732篇 |
眼科学 | 50篇 |
药学 | 476篇 |
中国医学 | 7篇 |
肿瘤学 | 286篇 |
出版年
2023年 | 29篇 |
2022年 | 38篇 |
2021年 | 95篇 |
2020年 | 60篇 |
2019年 | 85篇 |
2018年 | 112篇 |
2017年 | 99篇 |
2016年 | 118篇 |
2015年 | 117篇 |
2014年 | 158篇 |
2013年 | 232篇 |
2012年 | 337篇 |
2011年 | 379篇 |
2010年 | 210篇 |
2009年 | 169篇 |
2008年 | 320篇 |
2007年 | 383篇 |
2006年 | 405篇 |
2005年 | 345篇 |
2004年 | 307篇 |
2003年 | 266篇 |
2002年 | 257篇 |
2001年 | 75篇 |
2000年 | 75篇 |
1999年 | 77篇 |
1998年 | 42篇 |
1997年 | 29篇 |
1996年 | 34篇 |
1995年 | 31篇 |
1994年 | 21篇 |
1993年 | 21篇 |
1992年 | 36篇 |
1991年 | 37篇 |
1990年 | 30篇 |
1989年 | 30篇 |
1988年 | 28篇 |
1987年 | 23篇 |
1986年 | 35篇 |
1985年 | 37篇 |
1984年 | 27篇 |
1983年 | 20篇 |
1982年 | 20篇 |
1979年 | 30篇 |
1978年 | 15篇 |
1977年 | 16篇 |
1976年 | 15篇 |
1975年 | 20篇 |
1974年 | 19篇 |
1973年 | 18篇 |
1972年 | 15篇 |
排序方式: 共有5482条查询结果,搜索用时 15 毫秒
1.
Brittney H. Cotta Margaret F. Meagher Aaron Bradshaw Stephen T. Ryan Gerant Rivera-Sanfeliz 《Expert review of anticancer therapy》2019,19(4):301-308
Introduction: Percutaneous renal mass biopsy has evolved over the last decade with improvements on previous pitfalls including low tissue yield, high non-diagnostic rates, and complications. As understanding of tumor biology and natural history of renal cortical neoplasms has improved, percutaneous renal mass biopsy is poised to have an expanding role in an area characterized by individualized management and refined risk stratification.
Areas covered: This review summarizes the evolution of renal mass biopsy to its current state with respect to outcomes, indications, and clinical guidelines.
Expert opinion: With improved understanding of differential biological potential of renal cortical neoplasms combined with technical improvements in diagnostic yield and accuracy, utilization of renal mass biopsy is becoming an important adjunct to patient care in a broad range of clinical scenarios, including active surveillance, thermal ablation, and use of primary systemic therapy in localized and advanced settings. 相似文献
2.
Leyi Wang Saraswathi Lanka Debbie Cassout Nohra E. Mateus‐Pinilla Ganwu Li William C. Wilson Dongwan Yoo Paul Shelton Richard L. Fredrickson 《Transboundary and Emerging Diseases》2019,66(5):1809-1820
First described in 1955 in New Jersey, epizootic haemorrhagic disease (EHD) causes a severe clinical disease in wild and domestic ruminants worldwide. Epizootic haemorrhagic disease outbreaks occur in deer populations each year from summer to late autumn. The etiological agent is EHD virus (EHDV) which is a double‐stranded segmented icosahedral RNA virus. EHD virus utilizes point mutations and reassortment strategies to maintain viral fitness during infection. In 2018, EHDV serotype 2 was predominantly detected in deer in Illinois. Whole genome sequencing was conducted for two 2018 EHDV2 isolates (IL41747 and IL42218) and the sequence analyses indicated that IL42218 was a reassortant between different serotypes whereas IL41747 was a genetically stable strain. Our data suggest that multiple strains contribute to outbreaks each year. 相似文献
3.
Sina Alexander Debbie M Nathan Melvyn G Korman 《Clinical gastroenterology and hepatology》2006,4(5):661; author reply 661-661; author reply 662
4.
John P Elliott Hugh S Miller Suzanne Coleman Debbie Rhea Diana Abril Karen Hallbauer Niki B Istwan Gary J Stanziano 《Journal of perinatology》2005,25(10):626-630
OBJECTIVE: To assess the impact of activity restriction (AR) on the incidence of preterm birth in women treated for preterm labor testing negative for fetal fibronectin (fFN). STUDY DESIGN: Women who were diagnosed with preterm labor and tocolyzed with magnesium sulfate were concurrently screened with fFN for the purpose of subsequent management. Included were consenting patients with negative fFN, gestational age 23 0/7-33 6/7 weeks, cervical dilation < or =3 cm, and minimal vaginal bleeding. Patients were randomized to AR or no AR. Primary study outcome was incidence of preterm delivery and interval from randomization to delivery. RESULTS: A total of 73 women with negative fFN were randomized (36 with AR, 37 without AR). The overall preterm birth rate was 40%, with 44.4% of patients with AR and 35.1% of patients without AR delivering preterm, p=0.478. CONCLUSION: Maternal AR did not impact pregnancy outcome. The incidence of preterm birth in symptomatic women testing fFN negative was higher than previously reported. 相似文献
5.
6.
7.
The results of a community-based survey on knowledge and beliefs about tuberculosis in non-working women are presented. The women in the sample showed a very good knowledge of the important aspects of tuberculosis: 90% were aware that it is a problem in their area; 97% knew that it affects the chest; 94% said that it could be fatal; 85% considered it to be infectious and 88% knew that the local clinic provided treatment. Their knowledge of symptoms was good overall but the study revealed misconceptions about the causes and transmission of tuberculosis; 16% indicated that they would not be keen to associate with people with tuberculosis owing to fear of infection. The design effect of cluster sampling was considered in the analysis. The highest design effects (i.e. the most clustering of responses) were found for responses to questions on the causes of tuberculosis and places where treatment could be obtained, possibly reflecting that these beliefs are influenced by neighbourhood contacts. Future tuberculosis education in this group needs to build on existing knowledge and awareness and should focus on changing attitudes such as misconceptions about transmission and the stigmatisation of the disease. Health workers face the challenge of changing behaviour in this community to ensure that people with symptoms present early for screening and that people diagnosed as having tuberculosis comply with treatment. 相似文献
8.
9.
10.
Diego A Preciado Louise Lawson Colm Madden David Myer Chris Ngo John K Bradshaw Daniel I Choo John H Greinwald 《Otology & neurotology》2005,26(4):610-615
OBJECTIVES: To determine whether a stepwise diagnostic paradigm is more diagnostically efficient and cost-effective than a simultaneous testing approach in the evaluation of idiopathic pediatric sensorineural hearing loss (SNHL). DESIGN: Prospective prevalence study. SETTING: Tertiary referral children's hospital. PATIENTS: Consecutive children (n = 150) presenting with idiopathic SNHL in the last 2 years. INTERVENTIONS: All children were evaluated with full diagnostic evaluations including GJB2 screens, temporal bone computed tomography scans, and laboratory investigations. MAIN OUTCOME MEASURES: 1) Diagnostic yields of GJB2 screens, imaging, and laboratory results per SNHL category; 2) Cost analysis comparing a sequential versus a simultaneous testing approach. RESULTS: Overall, 12.0% of patients had biallelic mutations in the GJB2 gene, whereas 30% of patients had an abnormality on temporal bone scan. Laboratory testing did not reveal the SNHL etiology in any patient. While maintaining diagnostic accuracy, significant cost savings were inferred by using a sequential diagnostic algorithm. Our data show children with severe to profound SNHL should first be tested with a GJB2 screen, as opposed to those with milder SNHL, who should undergo imaging as the initial testing step. In patients with initially positive GJB2 or imaging screens, logistic regression analysis significantly predicted negative results on further testing. CONCLUSIONS: A stepwise diagnostic paradigm tailored to the level of the hearing loss in children with bilateral SNHL is more diagnostically efficient and cost effective than the more commonly used full, simultaneous testing approach. Laboratory investigation should not be routine but based on clinical history. 相似文献