全文获取类型
收费全文 | 2282篇 |
免费 | 128篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 11篇 |
儿科学 | 95篇 |
妇产科学 | 33篇 |
基础医学 | 421篇 |
口腔科学 | 41篇 |
临床医学 | 294篇 |
内科学 | 450篇 |
皮肤病学 | 45篇 |
神经病学 | 222篇 |
特种医学 | 73篇 |
外科学 | 174篇 |
综合类 | 12篇 |
预防医学 | 208篇 |
眼科学 | 28篇 |
药学 | 189篇 |
中国医学 | 3篇 |
肿瘤学 | 126篇 |
出版年
2023年 | 17篇 |
2022年 | 19篇 |
2021年 | 45篇 |
2020年 | 31篇 |
2019年 | 45篇 |
2018年 | 63篇 |
2017年 | 45篇 |
2016年 | 55篇 |
2015年 | 57篇 |
2014年 | 88篇 |
2013年 | 117篇 |
2012年 | 183篇 |
2011年 | 201篇 |
2010年 | 107篇 |
2009年 | 98篇 |
2008年 | 166篇 |
2007年 | 158篇 |
2006年 | 151篇 |
2005年 | 136篇 |
2004年 | 114篇 |
2003年 | 124篇 |
2002年 | 93篇 |
2001年 | 24篇 |
2000年 | 14篇 |
1999年 | 24篇 |
1998年 | 26篇 |
1997年 | 15篇 |
1996年 | 17篇 |
1995年 | 11篇 |
1994年 | 11篇 |
1993年 | 8篇 |
1992年 | 5篇 |
1991年 | 6篇 |
1990年 | 8篇 |
1989年 | 15篇 |
1988年 | 9篇 |
1987年 | 9篇 |
1986年 | 7篇 |
1985年 | 10篇 |
1984年 | 6篇 |
1982年 | 5篇 |
1980年 | 7篇 |
1979年 | 8篇 |
1977年 | 7篇 |
1976年 | 6篇 |
1974年 | 4篇 |
1973年 | 4篇 |
1972年 | 4篇 |
1971年 | 5篇 |
1967年 | 5篇 |
排序方式: 共有2425条查询结果,搜索用时 15 毫秒
1.
Methicillin‐resistant Staphylococcus aureus eradication in young infants should include the diaper area and treat housing contacts 下载免费PDF全文
2.
3.
4.
5.
Eric G Butchart Christa Gohlke-B?rwolf 《Journal of the American College of Cardiology》2004,44(5):1143-4; author reply 1144-5
6.
Patrick Terheyden Jürgen C. Becker Christa Lurz George J. Kahaly Eva‐B. Brcker 《Journal der Deutschen Dermatologischen Gesellschaft》2003,1(1):30-35
Background: Scleromyxoedema is a rare disease of unknown aetiology that is characterized by deposition of mucin and sclerotic induration of the skin; it is associated with paraproteinaemia. Patients suffer from progressive disability due to immobilization and cosmetic disfigurement. Treatment of scleromyxoedema is a therapeutic challenge. The antimalarial hydroxychloroquine has a rapid and reliable effect in reticular erythematous mucinosis. Patients and methods: Four consecutive patients (two women, two men; median age: 50 years) with scleromyxoedema, three of them with IgG λ paraprotein, were treated with hydroxychloroquine. Treatment was initiated with 600 mg p. o. for 10 days, followed by 400 mg for at least 4 weeks, and 200 mg thereafter. Results: Complete remission of skin manifestations was achieved in one patient, whereas three patients achieved a partial remission of 61+, 5 and 25 months' duration. Notably, three patients felt increased mobility and reduced firmness of skin during the first week of treatment, which was reflected in a rapid reduction in dermal thickness. In one patient, dysphagia was reverted as evidenced by normalization of oesophageal clearance. Paraproteinaemia was not influenced at all. Side effects included one case of electroretinogram abnormalities after 19 months of therapy and one case of leucopenia after 3 months. Conclusion: Hydroxychloroquine is an effective form of therapy for scleromyxoedema, leading to rapid and prolonged alleviation of symptoms. 相似文献
7.
Blossom Christa Maree Stephan Nora Breen Diana Caine 《Journal of the International Neuropsychological Society》2006,12(6):884-895
Prosopagnosia is currently viewed within the constraints of two competing theories of face recognition, one highlighting the analysis of features, the other focusing on configural processing of the whole face. This study investigated the role of feature analysis versus whole face configural processing in the recognition of facial expression. A prosopagnosic patient, SC made expression decisions from whole and incomplete (eyes-only and mouth-only) faces where features had been obscured. SC was impaired at recognizing some (e.g., anger, sadness, and fear), but not all (e.g., happiness) emotional expressions from the whole face. Analyses of his performance on incomplete faces indicated that his recognition of some expressions actually improved relative to his performance on the whole face condition. We argue that in SC interference from damaged configural processes seem to override an intact ability to utilize part-based or local feature cues. 相似文献
8.
9.
The peptide melittin, the main constituent of bee venom is a potent stimulus for the generation of an eosinophil chemotactic factor (ECF) from human polymorphonuclear neutrophils, rat mast cells and rat peritoneal cells depleted in mast cells. Optimal EFC induction required a sublytic activation of the cells. With each cell type the kinetics of ECF generation were similar in that after an early rise in activity a steep fall off occurred at later times of incubation suggesting a mechanism of inactivation. The induction of ECF by melittin is increased in the presence of calcium. The polar portion of the melittin molecule (aminoacids 20–26) is responsible for the generation of the chemotactic activity. Other peptides of honey bee venom such as the mast cell degranulating peptide (MCD) or apamine do not initiate ECF release. It appears that melittin leads to ECF induction via the phospholipase A2-arachidonic acid dependent pathway of cell activation. Our data suggests that the lipid mediator ECF can be obtained from phagocytes and mast cells thus indicating the interdependence of inflammatory reactions. 相似文献
10.
Hocher B Dembowski C Slowinski T Friese ST Schwarz A Siren AL Neumayer HH Thöne-Reineke C Bauer C Nafz B Ehrenreich H 《Journal of molecular medicine (Berlin, Germany)》2001,78(11):633-641
The renal endothelin (ET) system, particularly the ET type B receptor, has been implicated in the regulation of sodium excretion and glomerular filtration rate (GFR). We analyzed kidney morphology and function in a rat strain characterized by complete absence of a functional ETB receptor. Due to Hirschsprung's disease limiting lifetime in these rats, studies were performed in 23-day-old rats. Kidney size and morphology (glomerular and interstitial matrix content, glomerular size and cell density and intrarenal vascular morphology) were normal in ETB-deficient rats. There were also no evidence of altered kidney cell cycle regulation in these rats. GFR was significantly lower, by 72% (P<0.001), in homozygous ETB-deficient rats than in wild-type rats. Fractional sodium excretion was likewise markedly reduced by 84% in homozygous ETB-deficient rats (P<0.001 versus wild-type rats). Treatment with the specific epithelial sodium channel blocker amiloride led to a much higher increase in fractional sodium excretion in ETB-deficient rats (934.2+/-73% in ETB-deficient rats versus 297+/-20% in wild-type rats, expressed as percentage of corresponding placebo treated control; P<0.001). Mean arterial blood pressure was elevated by 7.9 mmHg in homozygous ETB-deficient rats (P<0.05 versus wild-type rats). Our study demonstrates that ETB-deficiency causes early onset kidney dysfunction characterized by a markedly reduced sodium excretion, decreased GFR, and slightly elevated blood pressure. The complete absence of the ETB receptor causes in the kidney--in contrast to the colon--a functional rather than a developmental, neural crest cell dependent disease, since kidney morphology was normal in ETB-deficient rats. The much higher increase in the fractional sodium excretion in ETB-deficient rats after pharmacological blockade of the epithelial sodium channel indicates that the decreased fractional sodium excretion in ETB-deficient rats is most probably due to a lack of the inhibitory property of the ETB receptor on the epithelial sodium channel activity. 相似文献