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LIVIA LUSTIG GUSTAVO F. DONCEL ESPERANZA BERENSZTEIN BERTA DENDUCHIS 《American journal of reproductive immunology (New York, N.Y. : 1989)》1987,14(4):123-128
ABSTRACT: Sixty-six percent of rats immunized with laminin isolated from a mouse Engelbreth-Holm-Swarm (EHS) sarcoma developed moderate lesions in the testis characterized by multiple foci of seminiferous tubules with different degrees of sloughing of the germinal epithelium or atrophy intermingled with normal histological areas. Interstitial mononuclear cell infiltrates were seen in the epididymis. By electron microscopy, pathological changes in the basement membranes of the seminiferous tubules, such as splitting and focal thickenings of knob-like projections toward the epithelium, were observed. Moreover, Sertoli cell cytoplasm showed dilated smooth endoplasmic reticulum and large vacuoles. By electron microscopy with the immunoper-oxidase technique, staining for in vivo-bound rat IgG was detected along the walls of the seminiferous tubules as a bright linear immunofluorescence and as a dense reaction product on the basal lamina. High titers of circulating antilaminin antibodies were detected by ELISA in all the rats immunized with laminin. As revealed by the skin test, a delayed type hypersensitivity reaction to laminin was observed in these rats. 相似文献
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BERTA UNGAR 《Internal medicine journal》1968,17(2):107-109
Antibody to gastric intrinsic factor was detected in the serum of five of 700 hospital patients (0·7%) aged over 50 years, but in none of 400 hospital patients aged below 50 years and in none of 500 blood donors aged below 60 years. Four of these five patients were further investigated : all four had latent pernicious anæmia and two of the patients had extremely low serum levels of vitamin B12 (30 and 60 pg. per millilitre). It is suggested that the presence of circulating intrinsic factor antibody in five of 700 hospital patients could indicate an overall incidence of latent pernicious anæmia in the vicinity of 1% in hospital patients aged over 50 years. 相似文献
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Intrinsic factor antibody was present in 54% and parietal cell antibody in 91% of 95 patients (26 men and 69 women) with Addisonian pernicious anæmia. The incidence of intrinsic factor antibody of 82% in 17 patients tested more than 10 years after diagnosis was significantly higher than the incidence of 47% in 78 patients tested within 10 years of diagnosis. The incidence of parietal cell antibody showed no significant variation with the duration of diagnosed pernicious anæmia. It is suggested that given sufficient time all patients with pernicious anæmia may develop detectable circulating antibody to intrinsic factor. 相似文献
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BALAZS BERTA M.D. ZOLTAN RUZSA M.D. Ph.D. GYORGY BARCZI M.D. DAVID BECKER M.D. Ph.D. LASZLO GELLER M.D. Ph.D. ZOLTAN JAMBRIK M.D. Ph.D. LEVENTE MOLNAR M.D. GYORGY SZABO M.D. BELA MERKELY M.D. D.Sc. F.E.S.C. F.A.C.C. 《Journal of interventional cardiology》2013,26(3):271-277