全文获取类型
收费全文 | 1015篇 |
免费 | 36篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 36篇 |
妇产科学 | 30篇 |
基础医学 | 87篇 |
口腔科学 | 32篇 |
临床医学 | 82篇 |
内科学 | 302篇 |
皮肤病学 | 21篇 |
神经病学 | 74篇 |
特种医学 | 20篇 |
外科学 | 186篇 |
综合类 | 3篇 |
预防医学 | 9篇 |
眼科学 | 5篇 |
药学 | 70篇 |
肿瘤学 | 93篇 |
出版年
2023年 | 12篇 |
2022年 | 6篇 |
2021年 | 15篇 |
2020年 | 7篇 |
2019年 | 15篇 |
2018年 | 23篇 |
2017年 | 14篇 |
2016年 | 25篇 |
2015年 | 24篇 |
2014年 | 35篇 |
2013年 | 51篇 |
2012年 | 75篇 |
2011年 | 72篇 |
2010年 | 44篇 |
2009年 | 35篇 |
2008年 | 57篇 |
2007年 | 65篇 |
2006年 | 49篇 |
2005年 | 58篇 |
2004年 | 63篇 |
2003年 | 48篇 |
2002年 | 37篇 |
2001年 | 27篇 |
2000年 | 23篇 |
1999年 | 11篇 |
1998年 | 9篇 |
1997年 | 10篇 |
1996年 | 6篇 |
1995年 | 14篇 |
1994年 | 8篇 |
1993年 | 4篇 |
1992年 | 14篇 |
1991年 | 13篇 |
1990年 | 7篇 |
1989年 | 10篇 |
1988年 | 7篇 |
1987年 | 13篇 |
1986年 | 7篇 |
1985年 | 6篇 |
1984年 | 3篇 |
1983年 | 2篇 |
1982年 | 2篇 |
1981年 | 3篇 |
1979年 | 4篇 |
1974年 | 2篇 |
1973年 | 2篇 |
1972年 | 3篇 |
1967年 | 2篇 |
1905年 | 1篇 |
1894年 | 1篇 |
排序方式: 共有1055条查询结果,搜索用时 0 毫秒
1.
L Savelli P de Iaco T Ghi L Bovicelli F Rosati B Cacciatore 《Ultrasound in obstetrics & gynecology》2004,23(3):284-288
OBJECTIVE: To describe the sonographic features of peritoneal pseudocysts (PPCs) in order to determine the particular aspects that distinguish them from true ovarian cysts. METHODS: Thirty-one women with PPCs were investigated using transvaginal sonography immediately before surgery. The diameters of the cysts were measured, and the shape, margins, content, location, presence of septa and echogenic portions were analyzed. RESULTS: The PPCs were monolateral in 20 (65%) and bilateral in 11 (35%) women. A well-defined cystic structure was found in only six (19%) women, while in the other 25 (81%) women the PPCs showed blurred, undefined margins and a bizarre morphology, giving them a star-like tubular or lumpy shape. The ipsilateral ovary was identified in 26 (84%) cases either external to the cyst or entrapped within it like a 'spider in a web'. Septa were present in 25 (81%) cases and were often mobile, resembling a 'flapping sail' when touched by the endovaginal probe. CONCLUSION: Despite having a gross morphology resembling that of a true ovarian cyst, PPCs present some characteristic sonographic findings that allow a correct differential diagnosis in the vast majority of cases. 相似文献
2.
Free anterolateral thigh flap versus free forearm flap: Functional results in oral reconstruction. 总被引:1,自引:0,他引:1
F Farace V E E Fois Andrea Manconi A Puddu F Stomeo A Tullio F Meloni G Pisanu C Rubino 《Journal of plastic, reconstructive & aesthetic surgery》2007,60(6):583-587
Nowadays, microsurgery performed for oral reconstruction of cancer patients, has become the standard treatment in restoring oral functions. The free radial forearm flap (FRFF) is still apparently the first reconstructive choice in oral cavity cancers. Recently the anterolateral thigh flap (ALTF) seemed to challenge the superiority of FRFF. The lack of functional data on which to base this recent supposition is the reason for this new research. Twenty reconstructed patients were enrolled for this study. Speech, swallowing, and donor site complications were studied to assess differences between the two techniques. Results show that difference in function between ALTF and FRFF groups is statistically insignificant. Donor site risks and complications seem to be the only variables among groups. These variables may be used as indicators when making a surgical choice. 相似文献
3.
Anna Di Landro Lorenzo Marchesi Luigi Naldi Teresio Motta Tullio Cainelli 《Pediatric dermatology》1997,14(6):449-452
Abstract: Hypopigmented mycosis fungoides is a variant of mycosis fungoides characterized by the presence of hypopigmented patches as the sole manifestation of the disease. It has been described aimost always in young black or dark-skinned patients. The only white patient described was a 64-year-oid woman who not oniy had hypopigmented lesions, but also nodular lesions with lymphadenopathy. We describe hypopigmented lesions arising in a white boy 12 years of age, born in northern Italy, without any foreign ancestors. The microscopic alterations, with epidermotropism, the immunoiogic markers, the negativity of T-cell receptor gene rearrangement, and the good response to PUVA therapy correspond to the main findings in black patients with this disease. Long-term follow-up of these patients is important to obtain better knowledge of the natural history of the disorder, Hypopigmented mycosis fungoides must now be included in the differential diagnosis of hypopigmented macular lesions not only in black or dark-skinned patients but also in white patients. 相似文献
4.
Bovicelli L Ghi T Pilu G Farina A Savelli L Simonazzi G Calzolari E Ferlini A Santini D Valeri B 《Human reproduction (Oxford, England)》2004,19(5):1231-1234
A complete mole coexisting with dichorionic twins was diagnosed by the combined use of sonography and chorionic villus sampling at 10 weeks gestation. The pregnancy resulted in the death of one fetus at 31 weeks from presumed feto-maternal haemorrhage, while the other fetus survived in good condition. A summary of the available literature, combined with this report, reveals a total of seven pregnancies with twins and a coexistent complete mole. Only two out of 14 fetuses survived. Maternal complications included one case of pre-eclampsia and one persistent trophoblastic tumour. Accurate diagnosis of complete mole is possible by genetic analysis of chorionic villi obtained with standard transabdominal sampling. Twins with a coexistent complete mole will usually undergo miscarriage. However, fetal survival is possible and the maternal risks seem limited. A concomitance between gestational trophoblastic disease and the occurrence of feto-maternal haemorrhage is observed. 相似文献
5.
Patients' use of a newly prescribed inhaler was evaluated on the basis of pulmonary function test (PFT) results and the number of steps of an 11-step inhaler sequence that were completed correctly. Adult male outpatients with mild to moderate chronic obstructive pulmonary disease were assigned to a counseled (n = 10) or noncounseled (n = 9) group. Patient characteristics were similar in both groups. The counseled group was instructed by a pharmacist on the correct use of the inhaler; the noncounseled group was not. Counseled patients had a significantly higher mean percentage change in forced expiratory volume in one second (FEV1) after inhaler use than did the noncounseled group. The mean number of steps missed was significantly greater for the noncounseled group, and there was a significant negative correlation between the number of steps missed and the percentage change in FEV1. Evaluation of the 11-step inhaler sequence identified three steps ("shake the inhaler," "use one puff at a time," and "shake between puffs") that correlated with PFT results and appeared to contribute to improved bronchodilation. Of the five patients who achieved adequate response, only four (all in the counseled group) performed these steps correctly. Instruction with demonstration and practice resulted in better patient understanding and performance of the correct steps for inhaler use, with improved bronchodilation as measured by PFTs. 相似文献
6.
SMC1 involvement in fragile site expression 总被引:2,自引:0,他引:2
Musio A Montagna C Mariani T Tilenni M Focarelli ML Brait L Indino E Benedetti PA Chessa L Albertini A Ried T Vezzoni P 《Human molecular genetics》2005,14(4):525-533
Common fragile sites have been involved in neoplastic transformation, although their molecular basis is still poorly understood. Here, we demonstrate that inhibition of the SMC1 by RNAi is sufficient to induce fragile site expression. By investigating normal, ATM- and ATR-deficient cell lines, we provide evidence that the contribution of SMC1 in preventing the collapse of stalled replication fork is an Atr-dependent pathway. Using a fluorescent antibody specific for gamma-H2AX, we show that very rare discrete nuclear foci appear 1 and 2 h after exposure to aphidicolin and/or RNAi-SMC1, but became more numerous and distinct after longer treatment times. In this context, fragile sites might be viewed as an in vitro phenomenon originating from double-strand breaks formed because of a stalled DNA replication that lasted too long to be managed by physiological rescue acting through the Atr/Smc1 axis. We propose that in vivo, following an extreme replication block, rare cells could escape checkpoint mechanisms and enter mitosis with a defect in genome assembly, eventually leading to neoplastic transformation. 相似文献
7.
Rundek T Di Tullio MR Sciacca RR Titova IV Mohr JP Homma S Sacco RL 《Stroke; a journal of cerebral circulation》1999,30(12):2683-2686
BACKGROUND AND PURPOSE: Aortic arch atheromas (AAs) have been shown to be a risk factor for ischemic stroke (IS) in the elderly because of their potential for cerebral embolization. However, the association between AAs and the presence of cerebral microemboli has not been clearly established. The aim of this study was to determine whether large AAs are associated with an increased frequency of high-intensity transient signals (HITS) in elderly patients with IS. METHODS: We performed bitemporal simultaneous HITS monitoring of both middle cerebral arteries in 62 consecutive elderly patients with acute IS (mean age 72.5+/-8.8 years, 65% men). In 16 patients, one or both temporal windows were inadequate; therefore, the analysis of HITS was performed in the remaining 46 patients. All patients underwent omniplane transesophageal echocardiography (TEE), and they had no significant extracranial or intracranial artery disease and no cardiac prosthetic valves. Large AA was defined as > or = 4 mm in thickness. Complex AA was defined as ulcerated or mobile, regardless of plaque thickness. HITS monitoring was performed within 24 hours of TEE and analyzed by an experienced neurologist-sonographer blinded to TEE findings. A 9-dB threshold was chosen to discriminate HITS from background Doppler signal. The HITS counts in the left and in the right middle cerebral arteries were added and reported as a total number of HITS in 30 minutes. RESULTS: HITS were detected in 14 (78%) of 18 patients with large AAs versus 8 (29%) of 28 patients with no or small AAs (odds ratio [OR] 8.8, 95% CI 2.2 to 34.8; P=0. 001). The association was also present in 27 patients with no other cardiac embolic sources, such as atrial fibrillation, patent foramen ovale, spontaneous echo contrast, and thrombus (7 of 10 patients with large AAs versus 3 of 17 patients with small or no AA; OR 10.9, 95% CI 1.7 to 68.5; P=0.013). Complex AAs were associated with a higher frequency of HITS than were noncomplex AAs (6 of 6 patients with complex AAs versus 15 of 39 patients with noncomplex AAs; OR 2. 6, 95% CI 1.7 to 3.9; P=0.005). CONCLUSIONS: HITS are significantly associated with large AAs in elderly stroke patients. This observation may support the causal role of large AAs in IS. 相似文献
8.
9.
Paolo Pedrazzoli Cinzia Tullio Giulio Cerea Salvatore Siena 《Journal of clinical oncology》2004,22(21):4428; author reply 4428-4428; author reply 4429
10.
Claire Petit Benjamin Lacas Jean-Pierre Pignon Quynh Thu Le Vincent Grégoire Cai Grau Allan Hackshaw Björn Zackrisson Mahesh K B Parmar Ju-Whei Lee Maria Grazia Ghi Giuseppe Sanguineti Stéphane Temam Maurice Cheugoua-Zanetsie Brian O'Sullivan Marshall R Posner Everett E Vokes Juan J Cruz Hernandez L.P. Zhong 《The lancet oncology》2021,22(5):727-736