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T Karpathios C Golphinos P Psychou A Garoufi A Papadimitriou P Nicolaidou 《Archives of disease in childhood》1998,78(1):64-66
An indirect fluorescent antibody test for Bartonella
henselae, B quintana, and B
elizabethae was performed in all 18 children who presented to
our paediatric outpatient clinic with cat scratch disease over a six
year period. Serum samples were taken on admission, after 15 days, and
after six months. Diagnosis was confirmed in 15 patients (83%) and was
based on seroconversion or a fourfold change of the antibody titre to
B henselae in 12 patients and on a single high titre
(>128) in three patients. Lymphadenopathy was present in all patients,
erythema nodosum in one, osteomyelitis in one, hepatitis in one,
transverse myelitis in one, and liver or spleen granulomata, or both,
in three patients. Cat scratch disease developed in autumn or winter in
12 patients. All had a history of physical contact with a cat. Our
study shows that our clinical suspicion was accurate in the diagnosis
of cat scratch disease in a high percentage of patients presenting to a
hospital and that indirect fluorescent antibody testing for B
henselae is a useful diagnostic tool.
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Filippos K. Triposkiadis Javed Butler Georgios Karayannis Randall C. Starling Gerasimos Filippatos Kathy Wolski John Parissis Charalabos Parisis Dimitrios Rovithis Konstantinos Koutrakis John Skoularigis Christos-Konstantinos Antoniou Christina Chrysohoou Christos Pitsavos Christodoulos Stefanadis John Nastas Themistoklis Tsaknakis Lilian Mantziari Georgios Giannakoulas Haralambos Karvounis Andreas P. Kalogeropoulos Gregory Giamouzis 《International journal of cardiology》2014
Aims
The role of low-dose dopamine infusion in patients with acute decompensated heart failure (ADHF) remains controversial. We aim to evaluate the efficacy and safety of high- versus low-dose furosemide with or without low-dose dopamine infusion in this patient population.Methods and results
161 ADHF patients (78 years; 46% female; ejection fraction 31%) were randomized to 8-hour continuous infusions of: a) high-dose furosemide (HDF, n = 50, 20 mg/h), b) low-dose furosemide and low-dose dopamine (LDFD, n = 56, 5 mg/h and 5 μg kg− 1 min− 1 respectively), or c) low-dose furosemide (LDF, n = 55, furosemide 5 mg/h). The main outcomes were 60-day and one-year all-cause mortality (ACM) and hospitalization for HF (HHF). Dyspnea relief (Borg index), worsening renal function (WRF, rise in serum creatinine (sCr) ≥ 0.3 mg/dL), and length of stay (LOS) were also assessed. The urinary output at 2, 4, 6, 8, and 24 h was not significantly different in the three groups. Neither the ACM at day 60 (4.0%, 7.1%, and 7.2%; P = 0.74) or at one year (38.1%, 33.9% and 32.7%, P = 0.84) nor the HHF at day 60 (22.0%, 21.4%, and 14.5%, P = 0.55) or one year (60.0%, 50.0%, and 47%, P = 0.40) differed between HDF, LDFD, and LDF groups, respectively. No differences in the Borg index or LOS were noted. WRF was higher in the HDF than in LDFD and LDF groups at day 1 (24% vs. 11% vs. 7%, P < 0.0001) but not at sCr peak (44% vs. 38% vs. 29%, P = 0.27). No significant differences in adverse events were noted.Conclusions
In ADHF patients, there were no significant differences in the in-hospital and post-discharge outcomes between high- vs. low-dose furosemide infusion; the addition of low-dose dopamine infusion was not associated with any beneficial effects. 相似文献5.
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Tsolia M Kouppari G Zaphiropoulou A Gavrili S Tsirepa M Kafetzis D Karpathios T 《Microbial drug resistance (Larchmont, N.Y.)》1999,5(4):271-278
The prevalence and patterns of Streptococcus pneumoniae resistance to antibiotics was examined in 146 nasopharyngeal carrier strains obtained during April and May, 1997, from 382 healthy children attending eight day care centers (DCCs) in the area of Athens. Reduced susceptibility to at least one antibiotic was found in 32.6% as follows: penicillin 11.4% (intermediate), cefotaxime 0.8% (intermediate), trimethoprim-sulfamethoxazole 22.7%, erythromycin 13.6%, tetracycline 11.4%, chloramphenicol 8.3%. Most of the nonsusceptible to penicillin isolates belonged to serogroups 23, 9, and 19. Multidrug resistance was detected in 11.4% of S. pneumoniae isolates including five penicillin nonsusceptible serogroup 23 strains. More than half of the multidrug resistant strains were susceptible to penicillin and belonged to serogroups 6 (4), 23 (1), 19 (1), and 1(1). Strains that belonged to the same serogroup/serotype and had identical resistance patterns appeared to cluster in some DCCs. Antibiotic use in the previous month was associated with reduced susceptibility to penicillin (p = 0.007) and multidrug resistance (p = 0.012). In conclusion, a moderate prevalence of reduced susceptibility to penicillin in pneumococcal carrier strains was found in our community. Multidrug resistance was common and was often associated with susceptibility to penicillin. Several distinct patterns of resistance were observed, suggesting the spread of resistant clones to our country. 相似文献
7.
Themistoklis Tsatalas Giannis Giakas Giannis Spyropoulos Vassilis Paschalis Michalis G. Nikolaidis Dimitrios E. Tsaopoulos Anastasios A. Theodorou Athanasios Z. Jamurtas Yiannis Koutedakis 《European journal of applied physiology》2010,110(5):977-988
The purpose of the present study was to examine the effects of muscle damage on walking biomechanics at different speeds.
Seventeen young women completed a muscle damage protocol of 5 × 15 maximal eccentric actions of the knee extensors and flexors
of both legs at 60°/s. Lower body kinematics and swing-phase kinetics were assessed on a horizontal treadmill pre- and 48 h
post-muscle damaging exercise at four walking speeds. Evaluated muscle damage indices included isometric torque, delayed onset
muscle soreness, and serum creatine kinase. All muscle damage indices changed significantly after exercise, indicating muscle
injury. Kinematic results indicated that post-exercise knee joint was significantly more flexed (31–260%) during stance-phase
and knee range of motion was reduced at certain phases of the gait cycle at all speeds. Walking post-exercise at the two lower
speeds revealed a more extended knee joint (3.1–3.6%) during the swing-phase, but no differences were found between pre- and
post-exercise conditions at the two higher speeds. As speed increased, maximum dorsiflexion angle during stance-phase significantly
decreased pre-exercise (5.7–11.8%), but remained unaltered post-exercise across all speeds (p > 0.05). Moreover, post-exercise maximum hip extension decreased (3.6–18.8%), pelvic tilt increased (5.5–10.6%), and tempo-spatial
differences were found across all speeds (p < 0.05). Limited effects of muscle damage were observed regarding swing-phase kinetics. In conclusion, walking biomechanics
following muscle damage are affected differently at relatively higher walking speeds, especially with respect to knee and
ankle joint motion. The importance of speed in evaluating walking biomechanics following muscle damage is highlighted. 相似文献
8.
T Karpathios A Fretzayas C Kakavakis A Garoufi C Courtis D Christol 《Archives fran?aises de pédiatrie》1990,47(5):369-371
A case of cat-scratch disease in an 8 year-old girl is reported. The inoculation injury followed by regional lymphadenopathy was typical of Parinaud syndrome. This patient also had vertebral lesions on scintigraphy, x-rays and CT scan. While the oculoglandular localization spontaneously improved within a few weeks, osteomyelitic lesions remained grossly unchanged after almost 2 years of follow-up. 相似文献
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