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Sexuality and Disability - This article focuses on the stories of women living with HIV concerning sexuality and well-being. Their stories counter the dominant perception of women's sexuality... 相似文献
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Victor Palomar-Asenjo Ma Soledad Boleas-Aguirre Noelia Sánchez-Ferrándiz Nicolas Perez Fernandez 《Otology & neurotology》2006,27(7):945-950
OBJECTIVES: To determine whether an association exists between the parameters of the caloric and rotatory chair tests in patients with unilateral Ménière's disease. METHODS: Patients with unilateral Ménière's disease (n = 100) were subjected to the caloric and the rotatory chair test (sinusoidal harmonic acceleration and impulsive tests) on the same day. Canal paresis and directional preponderance were assessed in the caloric test, and different variables were measured in the rotatory chair test based on the existence of abnormal parameters in the vestibulo-ocular reflex at two or three consecutive frequencies of those tested and on the time constant of the vestibulo-ocular reflex. STUDY DESIGN AND SETTING: A prospective study was conducted at a University hospital. RESULTS: An abnormal result in the caloric test was obtained from 73% of the patients. In the rotatory chair test, the most frequent abnormal findings involved increases in the normal phase lead at 2 consecutive frequencies tested (23%). There was a stronger association between an abnormal result in phase, gain, and/or symmetry at three adjacent frequencies and a pathological result in the caloric test. CONCLUSION: Very few of the criteria used to define the caloric and rotatory chair tests seem to be associated. This confirms previous knowledge that both tests examine vestibulo-ocular reflex by different ways. Only when vestibular dysfunction is severe enough (manifested by the finding of an abnormal result in at least three consecutive frequencies in the rotatory chair test), the caloric test is also found to be abnormal. 相似文献
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Vanesa Martín Ana María Sanchez‐Sanchez Noelia Puente‐Moncada Marina Gomez‐Lobo Marco Antonio Alvarez‐Vega Isaac Antolín Carmen Rodriguez 《Journal of pineal research》2014,57(3):308-316
Glioblastoma‐initiating cells (GICs) represent a stem cell‐like subpopulation within malignant glioblastomas responsible for tumor development, progression, therapeutic resistance, and tumor relapse. Thus, eradication of this subpopulation is essential to achieve stable, long‐lasting remission. We have previously reported that melatonin decreases cell proliferation of glioblastoma cells both in vitro and in vivo and synergistically increases effectiveness of drugs in glioblastoma cells and also in GICs. In this study, we evaluated the effect of the indolamine alone in GICs and found that melatonin treatment reduces GICs proliferation and induces a decrease in self‐renewal and clonogenic ability accompanied by a reduction in the expression of stem cell markers. Moreover, our results also indicate that melatonin treatment, by modulating stem cell properties, induces cell death with ultrastructural features of autophagy. Thus, data reported here reinforce the therapeutic potential of melatonin as a treatment of malignant glioblastoma both by inhibiting tumor bulk proliferation or killing GICs, and simultaneously enhancing the effect of chemotherapy. 相似文献
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Joan Carles March Cerdá María Ángeles Prieto Rodríguez Alina Danet Amets Suess Paloma Ruiz Román Noelia García Toyos 《Atencion primaria / Sociedad Espa?ola de Medicina de Familia y Comunitaria》2012,44(9):527-531
ObjectiveTo find out the opinions of health professionals on adolescent alcohol drinking and their evaluation of the existing legal regulation measures.MethodologyDesign: Qualitative and exploratory study, based on semi-structured interviews.Setting: Four cities representing four different regions in Spain: Palma de Mallorca, Granada, Barcelona and Pamplona.Participants: A total of 36 physicians and nurses from four Spanish regions, working in Primary Care and Emergency Care, selected by intentiones samples.Measurements: A total of 36 deep interviews, analysed using the software Nudist Vivo 4.0.ResultsHealth professionals accept their important role in preventing and intervening in adolescent alcohol drinking. Generally, they consider it as a public health problem. Prevention is associated with Primary Care, while the Emergency Departments act in specific situations of alohol abuse. Adolescents infrequently visit Primary Care, thus prevention must centre on education system and constant coordination between health professional and parents. Health personnel do not have sufficient knowledge on legal regulations. They consider educational measures as more efficient than sanctions.ConclusionsSpecific professional training is required in order to guarantee the coordination between the health and education systems and the family. 相似文献
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Abdominal Radiology - 相似文献
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Eliana Noelia Alonso María Julia Ferronato Norberto Ariel Gandini María Eugenia Fermento Diego Javier Obiol Alejandro López Romero 《Nutrition and cancer》2017,69(1):29-43
D-Fraction is protein-bound β-1,6 and β-1,3 glucans (proteoglucan) extracted from the edible and medicinal mushroom Grifola frondosa (Maitake). The antitumoral effect of D-Fraction has long been exclusively attributed to their immunostimulatory capacity. However, in recent years increasing evidence showed that D-Fraction directly affects the viability of canine and human tumor cells, independent of the immune system. Previously, we have reported that D-Fraction modulates the expression of genes associated with cell proliferation, cell death, migration, invasion, and metastasis in MCF7 human breast cancer cells. Therefore, the purpose of the current study is to investigate if this modulation of gene expression by Maitake D-Fraction really modulates tumor progression. In the present work, we demonstrate for the first time that Maitake D-Fraction is able to act directly on mammary tumor cells, modulating different cellular processes involved in the development and progression of cancer. We demonstrate that D-Fraction decreases cell viability, increases cell adhesion, and reduces the migration and invasion of mammary tumor cells, generating a less aggressive cell behavior. In concordance with these results, we also demonstrate that D-Fraction decreases tumor burden and the number of lung metastases in a murine model of breast cancer. 相似文献