全文获取类型
收费全文 | 614篇 |
免费 | 48篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 16篇 |
妇产科学 | 11篇 |
基础医学 | 78篇 |
口腔科学 | 1篇 |
临床医学 | 26篇 |
内科学 | 150篇 |
皮肤病学 | 6篇 |
神经病学 | 35篇 |
特种医学 | 16篇 |
外科学 | 207篇 |
综合类 | 5篇 |
预防医学 | 33篇 |
药学 | 22篇 |
中国医学 | 1篇 |
肿瘤学 | 55篇 |
出版年
2023年 | 4篇 |
2022年 | 17篇 |
2021年 | 20篇 |
2020年 | 17篇 |
2019年 | 20篇 |
2018年 | 30篇 |
2017年 | 26篇 |
2016年 | 16篇 |
2015年 | 23篇 |
2014年 | 42篇 |
2013年 | 35篇 |
2012年 | 63篇 |
2011年 | 49篇 |
2010年 | 41篇 |
2009年 | 41篇 |
2008年 | 37篇 |
2007年 | 36篇 |
2006年 | 41篇 |
2005年 | 25篇 |
2004年 | 31篇 |
2003年 | 19篇 |
2002年 | 22篇 |
2001年 | 2篇 |
2000年 | 2篇 |
1999年 | 1篇 |
1997年 | 1篇 |
1996年 | 1篇 |
1994年 | 1篇 |
1993年 | 1篇 |
1991年 | 1篇 |
排序方式: 共有665条查询结果,搜索用时 15 毫秒
1.
Wassim Daher Lydie Pelinski Sylvie Klieber Freddy Sadoun Viviane Meunier Martine Bourrié Christophe Biot Fran?ois Guillou Gérard Fabre Jacques Brocard Laurent Fraisse Jean-Pierre Maffrand Jamal Khalife Daniel Dive 《Drug metabolism and disposition》2006,34(4):667-682
Ferroquine (SSR97193) has been shown to be a promising antimalarial, both on laboratory clones and on field isolates. So far, no resistance was documented in Plasmodium falciparum. In the present work, the metabolic pathway of ferroquine, based on experiments using animal and human hepatic models, is proposed. Ferroquine is metabolized mainly via an oxidative pathway into the major metabolite mono-N-demethyl ferroquine and then into di-N,N-demethyl ferroquine. Some other minor metabolic pathways were also identified. Cytochrome P450 isoforms 2C9, 2C19, and 3A4 and, possibly in some patients, isoform 2D6, are mainly involved in ferroquine oxidation. The metabolites were synthesized and tested against the 3D7 (chloroquine-sensitive) and W2 (chloroquine-resistant) P. falciparum strains. According to the results, the activity of the two main metabolites decreased compared with that of ferroquine; however, the activity of the mono-N-demethyl derivative is significantly higher than that of chloroquine on both strains, and the di-N-demethyl derivative remains more active than chloroquine on the chloroquine-resistant strain. These results further support the potential use of ferroquine against human malaria. 相似文献
2.
3.
4.
Luis A. Kluth Malte Rieken Evanguelos Xylinas Matthew Kent Michael Rink Morgan Rouprêt Nasim Sharifi Asha Jamzadeh Wassim Kassouf Dharam Kaushik Stephen A. Boorjian Florian Roghmann Joachim Noldus Alexandra Masson-Lecomte Dimitri Vordos Masaomi Ikeda Kazumasa Matsumoto Masayuki Hagiwara Eiji Kikuchi Yves Fradet Jonathan Izawa Ricardo Rendon Adrian Fairey Yair Lotan Alexander Bachmann Marc Zerbib Margit Fisch Douglas S. Scherr Andrew Vickers Shahrokh F. Shariat 《European urology》2014
Background
The impact of gender on the staging and prognosis of urothelial carcinoma of the bladder (UCB) is insufficiently understood.Objective
To assess gender-specific differences in pathologic factors and survival of UCB patients treated with radical cystectomy (RC).Design, setting, and participants
Data from 8102 patients treated with RC (6497 men [80%] and 1605 women [20%]) for UCB between 1971 and 2012 were analyzed.Outcome measurements and statistical analysis
Multivariable competing-risk regression analyses were performed to evaluate the relationship of gender on disease recurrence (DR) and cancer-specific mortality (CSM). We also tested the interaction of gender and tumor stage, nodal status, and lymphovascular invasion (LVI).Results and limitations
Female patients were older at the time of RC (p = 0.033) and had higher rates of pathologic stage T3/T4 disease (p < 0.001). In univariable, but not in multivariable analysis, female gender was associated with a higher risk of DR (p = 0.022 and p = 0.11, respectively). Female gender was an independent predictor for CSM (p = 0.004). We did not find a significant interaction between gender and stage, nodal metastasis, or LVI (all p values >0.05).Conclusions
We found female gender to be associated with a higher risk of CSM following RC. However, these findings do not appear to be explained by gender differences in pathologic stage, nodal status, or LVI. This gender disparity may be due to differences in care and/or the biology of UCB. 相似文献5.
Hoi-Poh Tee Crispin Corte Hamdan Al-Ghamdi Emilia Prakoso John Darke Raman Chettiar Wassim Rahman Scott Davison Sean P Griffin Warwick S Selby Arthur J Kaffes 《World journal of gastroenterology : WJG》2010,16(31):3905-3910
AIM: To study the significance of cap-fitted colonoscopy in improving cecal intubation time and polyp detection rate. METHODS: This study was a prospective randomized controlled trial conducted from March 2008 to February 2009 in a tertiary referral hospital at Sydney. The primary end point was cecal intubation time and the secondary endpoint was polyp detection rate. Consecutive cases of total colonoscopy over a 1-year period were recruited. Randomization into either standard colonoscopy (SC) or cap-assist... 相似文献
6.
Wassim Shatila Zvonimir Krajcer 《Catheterization and cardiovascular interventions》2019,93(4):E261-E261
- Baseline risk scores for TAVI patients, including STS and EuroSCORE, might not predict long‐term outcomes.
- Including postprocedural data might improve risk stratification.
- The ACEF‐7 risk score includes the lowest creatinine clearance in the first 7 postprocedural days and appears to be a good predictor of worse long‐term outcomes.
7.
8.
9.
10.
Wassim Shatila MD Zvonimir Krajcer MD 《Catheterization and cardiovascular interventions》2018,91(7):1318-1319
- In patients with peripheral artery disease, high on‐treatment platelet reactivity (HoTPR) might be associated with worse outcomes for those taking clopidogrel, but not for those taking aspirin.
- Certain genetic polymorphisms might account for HoTPR.
- Current literature supports the importance of antiplatelet therapy in treating patients with PAD with clopidogrel, aspirin, or both.