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1.
TSUTOMU NOMURA KAZUHIDE HIGUCHI HIDENORI YU SHIN-ICHI SASAKI SHUJI KIMURA HIROYUKI ITOH MICHIYO TANIGUCHI TETSUO ARAKAWA KOKI KAWAI 《Journal of gastroenterology and hepatology》2006,21(1):54-58
Background and Aim: Although pretreatment with a sedative drug is effective in relieving pain during esophagogastroduodenoscopy (EGD), such drugs can cause significant side‐effects. The aim of this study was to examine the effect of slow‐wave photic stimulation on discomfort and/or pain felt during EGD. Methods: Forty consecutive patients (25 men and 15 women) who underwent diagnostic EGD in our hospital were included in the study. Twenty patients received photic stimulation for 25 min, and underwent electroencephalographic recording, in addition to the usual premedications. Twenty control patients received the same treatment but without photic stimulation. All patients evaluated the discomfort/pain felt during endoscopy against a five‐grade scale in comparison with what they had experienced in their previous examination. Results: Patients with an improved discomfort/pain score were 18/20 and 3/20 in the treated and control groups, respectively. Overall comparison of pain scores between both groups was significant (P < 0.0001). The proportion of slow‐wave activity recorded in patients’ electroencephalograms significantly increased in the treated group compared to control values (36.6 ± 6.8% vs 29.1 ± 3.4%, P < 0.001). There was a close correlation between the degree of discomfort/pain felt during endoscopy and the proportion of slow‐wave activity (P < 0.001). Conclusion: Slow‐wave photic stimulation shows promise as a treatment for relieving the discomfort and/or pain felt by patients undergoing EGD. 相似文献
2.
In order to clarify the distinction between three antigens included in the 4c complex, correlation coefficients, gene frequencies, haplotype frequencies and linkage disequilibrium parameters are given for HL-A5, Te50 = W5 and Te58 = W18 in three different ethnic groups.
Te58 = W18 is shown to be an allele of the second segregant series by data from family studies by correlation coefficients, by the lack of triplets, and by the goodness of fit according to the Hardy-Weinberg law. 相似文献
Te58 = W18 is shown to be an allele of the second segregant series by data from family studies by correlation coefficients, by the lack of triplets, and by the goodness of fit according to the Hardy-Weinberg law. 相似文献
3.
Changes in Cell Characteristics Due to Culture Conditions in Cell Lines From Human Small Cell Lung Cancer 总被引:8,自引:0,他引:8
TERASAKI TAKEO; SHISMOSATO YUKIO; NAKAJIMA TAKASHI; TSUMURAYA MASARU; MORINAGA SHOJIROH; HIROHASHI SETSUO; YAMAGUCHI KEN; KATO KANEFUSA; ICHINOSR HIROSHI; NAGATSU TOSHIHARU 《Japanese journal of clinical oncology》1986,16(3):203-212
Eight cultured cell lines were established from human smallcell lung cancers. Every cell line showed the morphologicaland biochemical characteristics of small cell cancer. Changesin cell characteristics were observed in many of these celllines when culture conditions were changed: "oat cell type"changed to "intermediate cell type" and vice versa when serum-freemedium was changed to serum-supplemented medium; a deficiencyof vitamin A in the medium caused a change to squamous cellsand vice versa; and a tumor promoter (teleocidin B) enhancedthe adherence of these cells to the surface of plastic culturedishes. These findings provide evidence that many small celllung cancer cell lines can change their morphology with changesin the environment of the cells. 相似文献
4.
SEIICHI KATO AKIRA OZAWA HIDENORI SHIBUYA HIROSHI NAKAGAWA HIROSHI NAGANUMA 《Pediatrics international》1993,35(1):53-56
The case of a 13 year old boy with an inflammatory esophagogastric polyp and ulcerative colitis is described. Endoscopy revealed a typical polyp and gastric fold complex at the esophagogastric junction and a hiatal hernia. Histology of a biopsy specimen confirmed an inflammatory polyp covered by hyperplastic squamous and gastric foveolar epithelium. Continuous 24 hour esophageal manometry suggested gastroesophageal reflux, which may be related to the pathogenesis of the lesion. Follow-up endoscopy showed marked regression of the polyp with medication for reflux eosphagitis. This clinical entity is rare in childhood and adolescence, and the manifestations may not be readily recognized. Therefore, endoscopic biopsy is important in children with esophageal polyps. However, polypectomy is unnecessary except when malignancy is suspected or when symptoms persist. 相似文献
5.
SEIICHI KATO NAOTAKA FUJITA HIDENORI SHIBUYA HIROSHI NAKAGAWA 《Pediatrics international》1993,35(2):151-153
In a case with chronic pancreatitis and pseudocysts related to muscular cytochrome—c oxidase deficiency, endoscopic ultrasonography (EUS) was performed to morphologically examine the pancreas for features that may have been missed by abdominal computed tomography and pancreatography. Conventional abdominal sonography had failed to show valuable diagnostic information of chronic pancreatitis in this case. EUS demonstrated several new findings. Parenchymal atrophy was remarkable, especially in the pancreatic tail, and a dilated pancreatic main or branch duct was clearly found in the region. Moreover, pancreatic stones in the main duct were also distinctly proved. EUS may become a useful new diagnostic method in pediatric gastroenterology, especially when sufficient findings are not obtained by conventional imaging techniques. However, an ultrasonographic endoscope with a shorter rigid portion and smaller caliber should be developed for pediatric patients. 相似文献
6.
HIDEO TAMAI M.D. KEIJI IGAKI M.D. TAKAFUMI TSUJI M.D. EISHO KYO M.D. KUNIHIKO KOSUGA M.D. AKIYOSHI KAWASHIMA M.D. SHIGEO MATSUI M.D. HIDENORI KOMORI M.D. SEIICHIRO MOTOHARA M.D. HIROMU UEHATA M.D. EIJI TAKEUCHI M.D. † 《Journal of interventional cardiology》1999,12(6):443-450
Although biocompatibility of biodegradable stents is controversial, stents made of high molecular weight poly- l -lactic acid (PLLA) are thought to be the most promising. We investigated the biocompatibility of PLLA stents histologically and angiographically in porcine coronary arteries. The Igaki-Tamai stent is made of PLLA monofilaments (molecular mass 183 kD) with a zigzag helical coil design. Fourteen PLLA stents in 6 pigs and 9 Palmaz-Schatz half stents in 9 pigs were implanted in 15 normocholesterolemic pigs. Stents were mounted on a delivery catheter, and were implanted percutaneously into coronary arteries. Coronary angiography was performed before and immediately after stenting, at 2 and 6 weeks in five PLLA pigs and nine Palmaz-Schatz pigs. Histological studies were performed in PLLA pigs: 2 pigs at 2 weeks, 3 pigs at 6 weeks, and 1 pig at 16 weeks with hematoxylin-eosin and elastica van Giesons stains. All PLLA stents were successfully delivered. No stent thrombosis was detected in either group. There were no significant differences in minimal lumen diameter (MLD) or percent diameter stenosis between the PLLA and Palmaz-Schatz stent groups immediately after implantation, or at 2 or 6 weeks after implantation. Histological studies at 2, 6, and 16 weeks revealed no inflammation and minimal neointimal coverage on the PLLA stent struts. The PLLA stent maintained its structure for up to 16 weeks. These results suggest sufficient biocompatibility and strength of PLLA biodegradable stents in porcine coronary arteries. Clinical trial is now underway to validate the safety and usefulness of PLLA stents in humans. 相似文献
7.
‘Atypical adenomatous hyperplasia’ in liver cirrhosis: low-grade hepatocellular carcinoma or borderline lesion? 总被引:7,自引:0,他引:7
Y. NAKANUMA T. TERADA S. TERASAKI K. UEDA A. NONOMURA E. KAWAHARA O. MATSUI 《Histopathology》1990,17(1):27-35
Adenomatous hyperplasia, defined as a sizable parenchymal nodule in cirrhosis, was examined morphologically. Ninety-seven nodules of adenomatous hyperplasia were obtained from 47 cirrhotic livers and were divided into 'ordinary' (44 nodules) and 'atypical' (53 nodules) types. The former consisted of hepatocytes similar to those of the surrounding liver, and showed regularly distributed portal tracts. The latter type was composed of hepatocytes showing nuclear atypia, relative to the surrounding liver, and showed irregular or sparse portal tracts. Atypical nodules were histologically heterogeneous, possessing areas of normo-trabecular, compact, pseudoglandular and/or scirrhous patterns. Several cytological changes, such as clear cell change, small or large cell change and fatty change, were intermingled variably within a given nodule. Atypical nodules showed expansive and/or replacing growth into the surrounding liver. Atypical hepatocytes also infiltrated into the fibrous septa and portal tracts. Foci of overt hepatocellular carcinoma were found in 11 of the 53 atypical nodules. These findings suggest that ordinary adenomatous hyperplasia may be a large-sized regenerative nodule, while atypical adenomatous hyperplasia may be a hepatocellular neoplasm, a peculiar form of low-grade hepatocellular carcinoma or borderline lesion, in which overt hepatocellular carcinoma is likely to evolve through multiple steps. 相似文献
8.
TAKAFUMI TSUJI M.D. HIDEO TAMAI M.D. KEIJI IGAKI M.D. † EISHO KYO M.D. KUNIHIKO KOSUGA M.D. TATSUHIKO HATA M.D. MASAHARU OKADA M.D. TAKUJI NAKAMURA M.D. HIDENORI KOMORI M.D. SEIICHIRO MOTOHARA M.D. HIROMU UEHATA M.D. 《Journal of interventional cardiology》2000,13(6):439-445
The metallic stent has become the most common device to reduce acute occlusion and late restenosis after balloon angioplasty, but the long-term effects of metallic stents in human coronary arteries are still unknown. To overcome several problems of conventional stenting, there have been many attempts to manufacture stents made of biodegradable materials. Although some studies have noted various degrees of inflammatory responses after biodegradable stent implantation, stents made of poly-1-lactic acid (PLLA) showed high biocompatibility with minimal inflammatory response and neointimal formation in porcine coronary arteries. A clinical study of PLLA self-expanding stent implantation is underway in Japan. The initial and 6-month results are favorable and suggest the feasibility, safety, and efficacy of the PLLA biodegradable stent in humans. However, long-term follow-up with larger numbers of patients will be required to validate the long-term efficacy of PLLA stents. 相似文献
9.
Intraoperative transesophageal echocardiography for inferior vena caval tumor thrombus in renal cell carcinoma 总被引:1,自引:0,他引:1
TAKEHIRO OIKAWA TORU SHIMAZUI AKIRA JOHRAKU SHINICHI KIHARA SADAMU TSUKAMOTO NAOTO MIYANAGA KAZUNORI HATTORI KOJI KAWAI KATSUNORI UCHIDA HITOSHI TAKESHIMA SHIGEYUKI SAITO HIDENORI TOYOOKA HIDEYUKI AKAZA 《International journal of urology》2004,11(4):189-192
BACKGROUND: We investigated the advantages of intraoperative transesophageal echocardiography (TEE) during inferior vena caval tumor thrombectomy in renal cell carcinoma (RCC). METHODS: Five patients with RCC that extended into the inferior vena cava (IVC) underwent radical nephrectomy. To remove the tumor thrombus in the IVC, an inflated Fogarty balloon catheter was used to pull the thrombus below the level of the hepatic veins with real-time TEE monitoring. RESULTS: In all cases, TEE monitoring during surgery provided an accurate and excellent view of the IVC thrombus. TEE was particularly helpful for the thrombectomy to minimize hepatic mobilization by using occlusion balloon catheter in two patients whose thrombus extended to the intrahepatic IVC. CONCLUSIONS: Intraoperative real-time TEE monitoring is a safe, minimally invasive technique that can provide accurate information regarding the presence and extent of IVC involvement, guidance for placement of a vena caval clamp, confirmation of complete removal of the IVC thrombus and intervention using catheters to assist in thrombectomy. 相似文献
10.