全文获取类型
| 收费全文 | 17399篇 |
| 免费 | 1030篇 |
| 国内免费 | 59篇 |
专业分类
| 耳鼻咽喉 | 229篇 |
| 儿科学 | 357篇 |
| 妇产科学 | 292篇 |
| 基础医学 | 2507篇 |
| 口腔科学 | 446篇 |
| 临床医学 | 1632篇 |
| 内科学 | 3558篇 |
| 皮肤病学 | 520篇 |
| 神经病学 | 1728篇 |
| 特种医学 | 1090篇 |
| 外国民族医学 | 2篇 |
| 外科学 | 2635篇 |
| 综合类 | 79篇 |
| 一般理论 | 4篇 |
| 预防医学 | 752篇 |
| 眼科学 | 413篇 |
| 药学 | 1109篇 |
| 中国医学 | 26篇 |
| 肿瘤学 | 1109篇 |
出版年
| 2023年 | 107篇 |
| 2022年 | 244篇 |
| 2021年 | 550篇 |
| 2020年 | 272篇 |
| 2019年 | 378篇 |
| 2018年 | 468篇 |
| 2017年 | 379篇 |
| 2016年 | 581篇 |
| 2015年 | 596篇 |
| 2014年 | 711篇 |
| 2013年 | 830篇 |
| 2012年 | 1261篇 |
| 2011年 | 1155篇 |
| 2010年 | 707篇 |
| 2009年 | 650篇 |
| 2008年 | 989篇 |
| 2007年 | 948篇 |
| 2006年 | 882篇 |
| 2005年 | 786篇 |
| 2004年 | 675篇 |
| 2003年 | 635篇 |
| 2002年 | 593篇 |
| 2001年 | 381篇 |
| 2000年 | 337篇 |
| 1999年 | 364篇 |
| 1998年 | 149篇 |
| 1997年 | 139篇 |
| 1996年 | 59篇 |
| 1995年 | 86篇 |
| 1994年 | 57篇 |
| 1993年 | 52篇 |
| 1992年 | 160篇 |
| 1991年 | 161篇 |
| 1990年 | 142篇 |
| 1989年 | 140篇 |
| 1988年 | 103篇 |
| 1987年 | 122篇 |
| 1986年 | 96篇 |
| 1985年 | 104篇 |
| 1984年 | 80篇 |
| 1983年 | 90篇 |
| 1982年 | 52篇 |
| 1981年 | 49篇 |
| 1979年 | 78篇 |
| 1977年 | 45篇 |
| 1975年 | 46篇 |
| 1974年 | 50篇 |
| 1973年 | 60篇 |
| 1971年 | 46篇 |
| 1969年 | 46篇 |
排序方式： 共有10000条查询结果，搜索用时 171 毫秒
1.
Michels Guido Horn Rudolf Helfen Andreas Hagendorff Andreas Jung Christian Hoffmann Beatrice Jaspers Natalie Kinkel Horst Greim Clemens-Alexander Knebel Fabian Bauersachs Johann Busch Hans-Jörg Kiefl Daniel Spiel Alexander O. Marx Gernot Dietrich Christoph F. 《Der Anaesthesist》2022,71(4):307-310
Die Anaesthesiologie - 相似文献
2.
3.
4.
5.
Distinct genetic alterations and luminal molecular subtype in nested variant of urothelial carcinoma
6.
Stefan Scholz Florian Koerber Kinga Meszaros Rosa Maya Fassbender Bernhard Ultsch Robert R. Welte Wolfgang Greiner 《Vaccine》2019,37(12):1692-1701
Introduction
Invasive meningococcal disease (IMD) is a severe disease mainly affecting infants and young children. The most common serogroup causing IMD in Germany is the serogroup type B Neisseria meningitidis (MenB). The aim of the present study is to estimate the economic burden of MenB-related IMD in Germany.Method
A bottom-up, model-based costing approach has been used to calculate the diagnose- and age-specific yearly lifetime costs of a hypothetical cohort of MenB-related IMD cases. Direct costs contain the treatment cost for the acute phase of the disease, long-term sequelae, costs for rehabilitation, and public health response. Indirect costs are calculated for the human-capital approach and the friction-cost approach considering productivity losses of patients or parents for the acute phase and long-term sequelae. Publicly available databases from the Federal Statistical Office, the SOEP panel data set, literature, and expert opinion were used as data sources. All future costs beyond the reference year of 2015 were discounted at 3%.Results
The total costs for the hypothetical cohort (343 patients) from a societal perspective are €19.6 million (€57,100/IMD case) using the friction-cost approach and €58.8 million (€171,000/IMD case) using the human-capital approach. Direct costs amount to €18.6 million or €54,300 €/case. Sequelae are responsible for 81% of the direct costs/case.Discussion
The elevated costs/MenB-related IMD case reflect the severity of the disease. The total costs are sensitive to the productivity-loss estimation approach applied. MenB is an uncommon but severe disease; The costs/case reflect the severity of the disease and is within the same magnitude as for human papilloma virus infections. The available literature on sequelae is due to the uncommonness limited and heterogeneous. 相似文献7.
Stress Testing Versus CT Angiography in Patients With Diabetes and Suspected Coronary Artery Disease
Abhinav Sharma Adrian Coles Nishant K. Sekaran Neha J. Pagidipati Michael T. Lu Daniel B. Mark Kerry L. Lee Hussein R. Al-Khalidi Udo Hoffmann Pamela S. Douglas 《Journal of the American College of Cardiology》2019,73(8):893-902
Background
The optimal noninvasive test (NIT) for patients with diabetes and stable symptoms of coronary artery disease (CAD) is unknown.Objectives
The purpose of this study was to assess whether a diagnostic strategy based on coronary computed tomographic angiography (CTA) is superior to functional stress testing in reducing adverse cardiovascular (CV) outcomes (CV death or myocardial infarction [MI]) among symptomatic patients with diabetes.Methods
PROMISE (Prospective Multicenter Imaging Study for Evaluation of Chest Pain) was a randomized trial evaluating an initial strategy of CTA versus functional testing in stable outpatients with symptoms suggestive of CAD. The study compared CV outcomes in patients with diabetes (n = 1,908 [21%]) and without diabetes (n = 7,058 [79%]) based on their randomization to CTA or functional testing.Results
Patients with diabetes (vs. without) were similar in age (median 61 years vs. 60 years) and sex (female 54% vs. 52%) but had a greater burden of CV comorbidities. Patients with diabetes who underwent CTA had a lower risk of CV death/MI compared with functional stress testing (CTA: 1.1% [10 of 936] vs. stress testing: 2.6% [25 of 972]; adjusted hazard ratio: 0.38; 95% confidence interval: 0.18 to 0.79; p = 0.01). There was no significant difference in nondiabetic patients (CTA: 1.4% [50 of 3,564] vs. stress testing: 1.3% [45 of 3,494]; adjusted hazard ratio: 1.03; 95% confidence interval: 0.69 to 1.54; p = 0.887; interaction term for diabetes p value = 0.02).Conclusions
In diabetic patients presenting with stable chest pain, a CTA strategy resulted in fewer adverse CV outcomes than a functional testing strategy. CTA may be considered as the initial diagnostic strategy in this subgroup. (PROspective Multicenter Imaging Study for Evaluation of Chest Pain [PROMISE]; NCT01174550) 相似文献8.
9.
10.