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排序方式: 共有115条查询结果,搜索用时 9 毫秒
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One-Year Follow-up of Duodenal Ulcers after 1-Wk Triple Therapy for Helicobacter pylori 总被引:1,自引:0,他引:1
Joseph J. Y. Sung M.D. S.C. Sydney Chung M.D. Thomas K. VV. Ling Ph.D. Man Yee Yung R.N. Augustin F. B. Cheng M.D. Shorland W. Hosking M.D. Arthur K. C. Li M.D. 《The American journal of gastroenterology》1994,89(2):199-202
Objective : to study the ulcer recurrence rate of Helicobacter pylori-positive duodenal ulcers at 1 yr after eradication of the bacteria by triple therapy. Method : Patients with H. pylori-positive duodenal ulcers were randomized to receive either triple therapy for 1 wk plus omeprazole for 4 wk (THple+OMP) (n = 78), or omeprazole alone (OMP) for 4 wk (N = 77). Patients were followed up every 3 months for symptom enquiry. At 1 yr, all asymptomatic patients were invited to attend for gastroscopy. Results : At 8 wk, 16 patients in the OMP group and four in the Triple+OMP group had an ulcer. During the 1-yr period, 12 patients in the OMP group and no patient in the Triple+OMP group developed symptomatic ulcers. At follow-up endoscopy at 1 yr, another 10 ulcers were detected in the OMP group and two in the Triple+OMP group. Fifteen patients in the OMP group and 13 in the Triple+OMP group were lost to follow-up. In total, ulcers were de-tected in 39 of 61 (64%) assessahle patients in the OMP group, and in six of 65 (97o) assessahle patients in the Triple+OMP group after I yr (χ2 test: p < 0.001). Of the patients whose H, pytori were successfully eradicated hy Triple+OMP at 8 wk, 90% remained H. pylori negative at 1 yr. Conclusion : Triple therapy for 1 wk eradicates H, pylori infection and significantly reduces duodenal ulcer relapses. 相似文献
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Contador José Pérez-Millan Agnès Guillen Nuria Tort-Merino Adrià Balasa Mircea Falgàs Neus Olives Jaume Castellví Magdalena Borrego-Écija Sergi Bosch Beatriz Fernández-Villullas Guadalupe Ramos-Campoy Oscar Antonell Anna Bargalló Nuria Sanchez-Valle Raquel Sala-Llonch Roser Lladó Albert 《Journal of neurology》2022,269(5):2573-2583
Journal of Neurology - MRI atrophy predicts cognitive status in AD. However, this relationship has not been investigated in early-onset AD (EOAD, < 65 years) patients... 相似文献
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Morgun VV 《航天医学与医学工程》1997,(5)
在进行职业训练时,对受训者的心理变化趋势进行监视是必要的。航天员心理因素的发展水平可通过心理测试来检测,以便能对其重要的心理指标进行评价,并给出综合评价。文中列出应进行测试的心理指标,并根据大量的样本统计给出了经验加权因子。测试结果的积累可以预测航天员将来飞行任务中处理复杂问题的能力,并能帮助改进训练过程及暴露缺点。 相似文献
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H Havanka-Kanniainen E Hokkanen VV Myllylä 《Cephalalgia : an international journal of headache》1985,5(1):39-43
The efficacy of nimodipine in the prophylaxis of migraine was assessed in a double-blind, placebo-controlled, cross-over study carried out on 33 patients, 20 of whom suffered from classic and 13 from common migraine. Four patients dropped out, but not as a result of the side effects of the drug. The duration of drug treatment was 8 weeks. The dosage used was 30 mg four times daily. Nimodipine proved to be better than placebo, the number of migraine attacks and severity of headache showing a significant reduction. The drug was well tolerated and no marked side effects were noted. The results suggest that nimodipine is a useful new prophylactic drug for migraine, but further studies are needed before its final value can be evaluated. 相似文献
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Wang M Hays T Balasa V Bagatell R Gruppo R Grabowski EF Valentino LA Tsao-Wu G Manco-Johnson MJ;Pediatric Coagulation Consortium 《Journal of pediatric hematology/oncology》2003,25(5):379-386
PURPOSE: To compare results of low-dose tissue plasminogen activator (TPA) in children with arterial and venous thrombi relative to standard published dosing. METHODS: Subjects consisted of all consecutive children with objectively confirmed thrombi for whom TPA thrombolysis was clinically ordered by the authors. Initial dosing used published standard dose (0.1-0.5 mg/kg per hour). With experience, a low-dose regimen (0.01-0.06 mg/kg per hour) was given in an attempt to derive a minimal effective dose. RESULTS: Thirty-five children were treated with TPA. Either standard or low-dose infusions of TPA resulted in complete thrombolysis of 28 of 29 (97%) acute thrombi, while all 6 chronic thrombi had a partial response. In contrast to the recommended adult-derived dosages of 0.1 to 0.5 mg/kg per hour, the authors found that initial doses of less than 0.01 mg/kg per hour were effective in 12 of 17 patients with acute thrombosis. Neonates required 0.06 mg/kg per hour. Route of administration (local or systemic) did not affect efficacy. Major bleeding occurred in only one extremely preterm infant. Minor bleeding, primarily oozing at intravenous sites, occurred in 27% of children during TPA infusions. Prophylactic unfractionated or low-molecular-weight heparin was infused concomitant with TPA in 42% of the children and did not increase the risk of bleeding. CONCLUSIONS: TPA in very low doses appears to be safe and effective for thrombolysis of acute thromboses in most children, given appropriate patient selection. 相似文献