收费全文 | 1392565篇 |
免费 | 115862篇 |
国内免费 | 6468篇 |
耳鼻咽喉 | 17383篇 |
儿科学 | 44722篇 |
妇产科学 | 37867篇 |
基础医学 | 190055篇 |
口腔科学 | 37179篇 |
临床医学 | 127372篇 |
内科学 | 289140篇 |
皮肤病学 | 32813篇 |
神经病学 | 115458篇 |
特种医学 | 57275篇 |
外国民族医学 | 275篇 |
外科学 | 218382篇 |
综合类 | 32191篇 |
现状与发展 | 2篇 |
一般理论 | 477篇 |
预防医学 | 111103篇 |
眼科学 | 29032篇 |
药学 | 97082篇 |
5篇 | |
中国医学 | 2281篇 |
肿瘤学 | 74801篇 |
2018年 | 14786篇 |
2017年 | 11636篇 |
2016年 | 13867篇 |
2015年 | 15589篇 |
2014年 | 21851篇 |
2013年 | 32246篇 |
2012年 | 40297篇 |
2011年 | 43207篇 |
2010年 | 26754篇 |
2009年 | 25911篇 |
2008年 | 40118篇 |
2007年 | 42713篇 |
2006年 | 43762篇 |
2005年 | 42340篇 |
2004年 | 40394篇 |
2003年 | 39255篇 |
2002年 | 36929篇 |
2001年 | 66436篇 |
2000年 | 68183篇 |
1999年 | 56970篇 |
1998年 | 17320篇 |
1997年 | 15511篇 |
1996年 | 16380篇 |
1995年 | 16560篇 |
1994年 | 15407篇 |
1993年 | 14427篇 |
1992年 | 47296篇 |
1991年 | 45938篇 |
1990年 | 44147篇 |
1989年 | 41981篇 |
1988年 | 38896篇 |
1987年 | 38205篇 |
1986年 | 35987篇 |
1985年 | 34758篇 |
1984年 | 26542篇 |
1983年 | 22291篇 |
1982年 | 14050篇 |
1981年 | 12630篇 |
1980年 | 11857篇 |
1979年 | 23641篇 |
1978年 | 17157篇 |
1977年 | 14455篇 |
1976年 | 13229篇 |
1975年 | 13756篇 |
1974年 | 16144篇 |
1973年 | 15427篇 |
1972年 | 14200篇 |
1971年 | 13056篇 |
1970年 | 11892篇 |
1969年 | 11109篇 |
Introduction
Physician communication impacts patient outcomes. However, communication skills, especially around difficult conversations, remain suboptimal, and there is no clear way to determine the validity of entrustment decisions. The aims of this study were to 1) describe the development of a simulation-based mastery learning (SBML) curriculum for breaking bad news (BBN) conversation skills and 2) set a defensible minimum passing standard (MPS) to ensure uniform skill acquisition among learners.Innovation
An SBML BBN curriculum was developed for fourth-year medical students. An assessment tool was created to evaluate the acquisition of skills involved in a BBN conversation. Pilot testing was completed to confirm improvement in skill acquisition and set the MPS.Outcomes
A BBN assessment tool containing a 15-item checklist and six scaled items was developed. Students' checklist performance improved significantly at post-test compared to baseline (mean 65.33%, SD = 12.09% vs mean 88.67%, SD = 9.45%, P < 0.001). Students were also significantly more likely to have at least a score of 4 (on a five-point scale) for the six scaled questions at post-test. The MPS was set at 80%, requiring a score of 12 items on the checklist and at least 4 of 5 for each scaled item. Using the MPS, 30% of students would require additional training after post-testing.Comments
We developed a SBML curriculum with a comprehensive assessment of BBN skills and a defensible competency standard. Future efforts will expand the mastery model to larger cohorts and assess the impact of rigorous education on patient care outcomes. 相似文献Areas covered: the principal pharmacogenetic and non-genetic differences in the pharmacology of tamoxifen and endoxifen are evaluated. To this end, references from PubMed, Embase or Web of Science, among others, were reviewed As non-genetic factors, important differences and similarities such age, or adherence to tamoxifen therapy are comprehensively illustrated. Additionally, since CYP2D6 genotypes are considered the main limitation of tamoxifen, many studies have investigated the association between the worsened clinical outcomes in patients with non-functional CYP2D6 genotypes. In this review, an overview of the research on this field is presented. Also, a summary describing the literature about individualizing tamoxifen therapy with endoxifen concentrations and its limitations is listed.
Expert opinion: z-endoxifen hydrochloride is only investigated in the metastatic setting, still more research is required before its place in therapeutics is known. Similarly, monitoring tamoxifen efficacy based on endoxifen concentrations might not be overall recommended due to the limited evidence available. 相似文献