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排序方式: 共有641条查询结果,搜索用时 15 毫秒
1.
Autoimmune hepatitis type 1 and primary biliary cirrhosis have distinct bone marrow cytokine production 总被引:3,自引:0,他引:3
Zachou K Rigopoulou EI Tsikrikoni A Alexandrakis MG Passam F Kyriakou DS Stathakis NE Dalekos GN 《Journal of autoimmunity》2005,25(4):389-288
We have recently reported differences in the hematopoiesis between autoimmune hepatitis type 1 (AIH-1) and primary biliary cirrhosis (PBC). In view of the notion that cytokines are regulators of hematopoiesis, we investigated in our tertiary center the cytokine production in the bone marrow (BM) of the same consecutive cohort of patients (13 AIH-1, 13 PBC, 10 healthy and 7 patients with cirrhosis due to chronic hepatitis B). Interferon-gamma (IFN-gamma), interleukin-4 (IL-4), interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta (TGF-beta) were determined in the supernatants of long-term BM cultures by ELISAs. IL-4, TNF-alpha and TGF-beta were found significantly increased in the BM of PBC patients compared to AIH-1 and both control groups. AIH-1 patients had significantly higher BM IL-10 compared to PBC patients and higher IL-10, IL-4 and TNF-alpha compared to controls. BM IFN-gamma was significantly higher in PBC and AIH-1 patients compared to controls. In AIH-1 patients, IL-10 was positively correlated with CD34+, CD34+/CD38- and CD34+/CD38+ cell proportions. In conclusion, the BM cytokine microenvironment of PBC and AIH-1 patients differs significantly compared to that of healthy individuals and cirrhotic patients of non-autoimmune etiology. Differences were also found between patients with PBC and AH-1. The implication of BM in the pathogenesis of autoimmune liver diseases is possible and needs further investigation. 相似文献
2.
Trukeschitz Birgit Hajji Assma Batchelder Laurie Saloniki Eirini Linnosmaa Ismo Malley Juliette 《Quality of life research》2021,30(7):1975-1984
Quality of Life Research - The Adult Social Care Outcomes Toolkit for informal carers (ASCOT-Carer) can be used to assess long-term care-related quality of life (LTC-QoL) of adult informal carers... 相似文献
3.
Eirini Mamalaki Sokratis Charisis Costas A. Anastasiou Eva Ntanasi Kyriaki Georgiadi Vassilis Balomenos Mary H. Kosmidis Efthimios Dardiotis Georgios Hadjigeorgiou Paraskevi Sakka Nikolaos Scarmeas Mary Yannakoulia 《Nutrients》2022,14(14)
The aim of the current study was to investigate whether a Total Lifestyle Index (TLI), including adherence to the Mediterranean diet, sleep duration, physical activity and engagement in activities of daily living, is associated with cognitive health over time and dementia risk, in a representative cohort of older people. A total of 1018 non-demented community-dwelling older adults ≥65 years old (60% women) from the HELIAD study were included. A comprehensive neurological and neuropsychological assessment was conducted at baseline and at the 3-year follow-up evaluating cognitive functioning, and a dementia diagnosis was set. Diet, physical activity, sleep duration and engagement in activities of daily living were assessed using standard, validated questionnaires at baseline. Sixty-one participants developed dementia at follow-up; participants who developed dementia were older and had fewer years of education compared with participants with normal cognition. With the exception of sleep duration, participants with normal cognition at follow-up scored higher in the individual lifestyle factors compared to those who developed dementia. Regarding TLI, values were lower for participants with dementia compared with those with normal cognition. Each additional unit of the TLI was associated with 0.5% of a standard deviation less decline per year of the Global Cognition score, whereas for each additional unit of the TLI, the risk for dementia was reduced by 0.2% per year (p < 0.05). Our results suggest that greater adherence to a healthy lifestyle pattern is associated with a slower decline of cognitive function and reduced dementia risk. 相似文献
4.
Imatinib mesylate is considered the standard first-line systemic treatment for patients with chronic myeloid leukaemia (CML) and gastrointestinal stromal tumour (GIST) by targeting BCR-ABL and c-KIT tyrosine kinases, respectively. Indeed, imatinib has substantially changed the clinical management and improved the prognosis of both diseases. Treatment with imatinib is generally well tolerated, and the risk for severe adverse effects is low, generally occurring during the early phase of treatment and correlating with imatinib dose, phase of disease and patient’s characteristics. This article summarises recent data on safety profile of imatinib for the treatment of CML and GIST, including long-term side effects. Prolonged treatment with imatinib in both diseases demonstrates excellent tolerability. There are few significant concerns and those that have emerged, like cardiotoxicity, have far turned out to be exaggerated. 相似文献
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Vlahoyiannis Angelos Karali Eirini Giannaki Christoforos D. Karioti Aggeliki Pappas Aggelos Lavdas Eleftherios Karatzaferi Christina Sakkas Giorgos K. 《Sleep & breathing》2022,26(1):149-156
Sleep and Breathing - To compare physical, psychological, and physiological adaptations between rotating and morning shift health workers using objective and subjective approaches. Forty nurses... 相似文献
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9.
Dimopoulos MA Kastritis E Delimpasi S Katodritou E Hatzimichael E Kyrtsonis MC Repousis P Tsirogianni M Kartasis Z Parcharidou A Michael M Michalis E Tsatalas C Stefanoudaki E Hatjiharissi E Gika D Symeonidis A Terpos E Zervas K;Greek Myeloma Study Group 《European journal of haematology》2012,89(1):10-15
10.
Voskaridou E Ladis V Kattamis A Hassapopoulou E Economou M Kourakli A Maragkos K Kontogianni K Lafioniatis S Vrettou E Koutsouka F Papadakis A Mihos A Eftihiadis E Farmaki K Papageorgiou O Tapaki G Maili P Theohari M Drosou M Kartasis Z Aggelaki M Basileiadi A Adamopoulos I Lafiatis I Galanopoulos A Xanthopoulidis G Dimitriadou E Mprimi A Stamatopoulou M Haile ED Tsironi M Anastasiadis A Kalmanti M Papadopoulou M Panori E Dimoxenou P Tsirka A Georgakopoulos D Drandrakis P Dionisopoulou D 《Annals of hematology》2012,91(9):1451-1458
Haemoglobinopathies are the most common hereditary disorders in Greece. Although there is a successful national prevention program, established 35 years ago, there is lack of an official registry and collection of epidemiological data for haemoglobinopathies. This paper reports the results of the first National Registry for Haemoglobinopathies in Greece (NRHG), recently organized by the Greek Society of Haematology. NRHG records all patients affected by thalassaemia major (TM), thalassaemia intermedia (TI), "H" Haemoglobinopathy (HH) and sickle cell disease (SCD). Moreover, data about the annual rate of new affected births along with deaths, between 2000 and 2010, are reported. A total of 4,506 patients are registered all over the country while the number of affected newborns was significantly decreased during the last 3 years. Main causes for still having affected births are: (1) lack of medical care due to financial reasons or low educational level; (2) unawareness of time limitations for prenatal diagnosis (PD); due either to obstetricians' malpractice or to delayed demand of medical care of couples at risk; and (3) religious, social or bioethical reasons. Cardiac and liver disorders consist main causes for deaths while life expectancy of patients lengthened after 2005 (p < 0.01). The NRHG of patients affected by haemoglobinopathies in Greece provides useful data about the haemoglobinopathies in the Greek population and confirms the efficacy of the National Thalassaemia Prevention Program on impressively decreasing the incidence of TM and sickle cell syndromes. 相似文献