老年人自理能力、健康机遇控制与年龄态度的关系

目的考察老年人健康机遇控制在生活自理能力和年龄态度关系中的中介作用。方法选取广州市社区老年人333人,男144人,女189人,年龄65~91岁,平均(72±6)岁,采用日常生活能力量表(ADL)、费城老年中心信心量表(PGC)的年龄态度分量表、多维度健康状况心理控制源量表(MHLC)分别测量日常生活能力、年龄态度和健康心理控制源。结果自理能力、年龄态度、机遇控制得分两两之间相关(r=-0.219~0.247)。自理能力机遇控制分别对年龄态度有负向预测作用(β=-0.219,P<0.001;β=-0.120,P<0.05)。Bootstrap中介效应检验结果显示,95%可信区间分别为-0.028~-0.001。结论老年人自理能力、机遇控制、年龄态度密切相关,机遇控制在自理能力和年龄态度间起部分中介作用。     

河南省某大学学生性态度与童年逆境和人格的关系

目的探讨马基雅维利主义人格(马氏人格)和贪婪倾向在童年逆境与大学生性态度之间的中介作用。方法使用童年环境量表(ECS)、马氏人格量表(MPS)、贪婪倾向特质量表(DGS)和青少年性态度量表(SAS)对1 186名本科在校生进行测量。结果童年逆境(r=0.17,P 0.01)、马氏人格(r=0.19,P 0.01)和贪婪倾向(r=0.07,P 0.05)均与性态度正相关;童年逆境与马氏人格正相关(r=0.35,P 0.01),与贪婪倾向负相关(r=-0.06,P 0.05);马氏人格和贪婪倾向的中介作用均显著(相对中介效应分别为50%,10%);童年逆境可以通过马氏人格和贪婪倾向的链式中介来预测性态度(相对中介效应为10%)。结论童年逆境既可以直接影响性态度,并可以通过马氏人格和贪婪倾向间接影响性态度。     

自我价值感和抑郁对老年人主观年龄和主观幸福感的链式中介作用

目的探讨自我价值感和抑郁在老年人主观年龄和主观幸福感(SWB)之间的链式中介作用。方法采用主观年龄量表(ADS)、自我价值感量表(GSWS)、老年人抑郁量表(GDS-11)和纽芬兰纪念大学幸福度量表(MUNSH)对219名60岁及以上的老年人进行问卷调查。结果老年人的实际年龄显著高于主观年龄的感觉年龄、外表年龄、行为年龄和兴趣年龄4个因子(P<0.01);受教育年限≤9年的老年人主观年龄4个因子显著高于受教育年限>9年(P<0.05);经常参加休闲活动的老年人主观年龄4个因子显著低于偶尔参加休闲活动者(P<0.05);主观年龄年轻组SWB显著高于主观年龄中等组和年老组(F=44.63,P<0.01);老年人主观年龄、自我价值感与SWB呈显著正相关(P<0.01),而抑郁与SWB呈显著负相关(P<0.01);回归分析显示,老年人主观年龄(β=0.19,P<0.01)、自我价值感(β=0.21,P<0.01)和抑郁(β=-0.38,P<0.01)对SWB具有一定的预测作用;中介效应分析显示,老年人自我价值感和抑郁在主观年龄对SWB的影响中具有部分中介效应(β=0.31,P<0.01),中介效应占总效应的0.62%。结论降低主观年龄、提高自我价值感有助于推进老年人成功老龄化,提升老年人的SWB。     

社区老年人衰弱与认知功能的关系:心理弹性的中介机制

目的探讨社区老年人衰弱与认知功能之间的关系,并探讨心理弹性在其中的中介作用。方法采用Tilburg衰弱量表、心理弹性量表简版、简易精神状态评估量表和自编一般情况调查问卷对827例社区老年人进行调查。结果社区老年人衰弱发生率为30.11%,认知功能下降发生率为21.04%。衰弱与心理弹性(r=-0.45,P<0.01)、认知功能(r=-0.34,P<0.01)呈负相关,心理弹性与认知功能呈正相关(r=0.39,P<0.01)。模型拟合结果显示,心理弹性在衰弱与认知功能之间起中介作用(β=-0.13,P<0.01)。结论社区老年人的衰弱对认知功能有直接预测作用,且受心理弹性的中介效应调节,今后可采取措施降低老年人衰弱程度,提升其心理弹性水平,以减少认知功能衰退发生率,促进老年人的健康老龄化。     

离退休老年人焦虑与应对方式的关系

目的探讨离退休老年人焦虑与应对方式之间的关系。方法采用焦虑自评量表、应对方式量表对132名离退休老年人进行调查。结果离退休老年人的焦虑程度在年龄和家庭属性上存在显著差异(F=7.276,P<0.01;t=3.816,P<0.05),在文化程度和性别上不存在显著差异(F=3.943,P>0.05;t=1.145,P>0.05);离退休老年人的应对方式在性别和年龄上不存在显著差异,在文化程度上存在显著差异(F=18.641,P<0.001等);正常与焦虑离退休老年人在应对方式的6个因子上存在显著差异;相关分析表明,解决问题与焦虑呈显著负相关(r=-0.324,P<0.01),自责、退避、幻想与焦虑呈显著的正相关(r=0.418、0.363、0.196,P=0.012、0.027、0.044)。结论焦虑与应对方式之间存在着密切的关系。     

老年高血压病患者血压变异性相关因素的研究

目的通过筛选老年高血压病(EH)患者24h收缩压变异性(24hSBPV)和24h舒张压变异性(24hDBPV)的独立相关因素,来寻找控制其血压变异性(BPV)的方法。方法对1557名老年EH患者进行问卷调查、体格检查、实验室检查和24h动态血压检测,运用多元回归分析方法确定1557老年EH患者24hSBPV和24hDBPV的独立相关因素。结果老年EH患者24hSBPV的独立相关因素有24hSBP(β=0.052,P<0.001)、苯磺酸氨氯地平片(β=-0.471,P<0.01)、载脂蛋白AⅠ(β=0.009,P<0.001)、载脂蛋白B100(β=0.017,P<0.01)、甘油三酯(β=0.199,P<0.05)、年龄(β=0.080,P<0.001)、性别(β=-0.652,P<0.01)、尿酸(β=0.003,P<0.01);24hDBPV的独立相关因素有24hDBP(β=0.045,P<0.001)、硝苯地平控释片(β=-0.710,P<0.001)、苯磺酸氨氯地平片(β=-0.421,P<0.01)、年龄(β=0.061,P<0.001)、体重指数(β=0.080,P<0.001)、载脂蛋白AⅠ(β=0.004,P<0.01)、载脂蛋白B100(β=0.007,P<0.01)。结论降低血压水平,控制动脉粥样硬化的危险因素(如血脂异常、高尿酸血症、肥胖等),可能是控制老年EH患者血压变异性增大的有效措施。     

社区老年人抗逆力在社会支持与正负情绪间的中介效应

目的 探讨抗逆力在社会支持与正负性情绪间的中介效应。方法 应用抗逆力量表,领悟社会支持量表,正负性情绪量表对唐山市某社区751例社区老年人进行问卷调查。结果 社区老年人抗逆力与社会支持、正负性情绪呈相关关系(均P<0.001);社会支持与正负性情绪呈相关关系(P<0.001);抗逆力在社会支持对正负情绪的预测中起部分中介作用,中介效应占总效应的比例分别为14.16%,R²=0.287;12.62%,R²=0.253。结论 增加社会支持,有利于提高社区老年人抗逆力水平,对社区老年人正负情绪有保护作用。     

营养不良在社区老年人抑郁和衰弱之间的中介作用

目的探讨营养不良在社区老年人抑郁和衰弱之间的中介作用。方法采用多阶段分层抽样方法,采用自制的一般资料问卷、老年抑郁量表(GDS-5)、微型营养评价精简法(MNA-SF)及Fried身体表型衰弱量表,对济南市社区936名老年人进行调查。结果社区老年人衰弱和衰弱前期发生率为3.8%和52.8%,抑郁和营养不良风险率为10.4%与11.5%。Logistic回归分析表明老年人抑郁增加营养不良(OR=21.632,P0.001)和衰弱(OR=3.149,P0.001)发生风险,营养不良增加了衰弱发生风险(OR=2.377,P=0.001),并减弱了抑郁与衰弱关系强度(OR=2.075,P=0.006),Z检验证实间接效应具有统计学意义(Z=3.234,P0.01)。结论营养不良在社区老年人抑郁和衰弱间起中介作用,改善社区抑郁老年人的营养状况有助于延缓衰弱的发生。     

抑郁在老年人收支水平与认知功能间的中介效应

目的 探索老年人抑郁在经济收入与认知功能间的中介作用及社交活动的调节作用.方法 采用蒙特利尔认知评估量表(北京版)、简版老年抑郁量表和自编的一般情况问卷对厦门市3230位老年人进行问卷调查.结果 在控制性别、年龄和教育年限后,收支水平对认知功能具有显著的正向预测作用(P<0.001);抑郁在收支水平与认知功能关系之间起...     

居家养老和机构养老的老年人孤独感和死亡态度对比

目的探讨不同养老方式下老年人孤独感和死亡态度的差异性及其相关性。方法采用加利福尼亚大学洛杉矶分校(UCLA)孤独量表和死亡态度描绘量表,对枣庄市320名老年人(居家养老组和机构养老组各160名)进行问卷调查。结果 1居家养老组孤独感明显高于机构养老组(t=13.054,P<0.001);2在死亡态度的五个维度中,两组死亡焦虑恐惧、趋近死亡接受和自然死亡接受上有显著差异(t=10.605,-7.017,-18.150,均P<0.001);3两组孤独感与死亡焦虑恐惧、死亡逃避、趋近死亡接受和自然死亡接受4个维度呈显著相关(r=0.526,0.356,-0.455,-0.371;均P<0.001)。结论机构养老的老年人孤独感更低,对死亡态度更乐观;孤独感可以预测老年人的死亡态度。     

肛门病不同术式对肛门控便能力的影响

目的探讨肛门病不同手术方式对肛门控便能力的影响。 方法回顾性分析聊城市第二人民医院肛肠科2014年03月至2016年3月间1 455例肛门疾病患者的手术方式与术后肛门控便能力的关系。 结果肛周脓肿术后总失禁率为19.6%,肛瘘为14.9%,混合痔为5.6%,肛裂为7.1%。肛周脓肿患者和肛瘘患者术后肛门控便能力比较,差异无统计学意义（Z值=-1.475,P>0.05）;Ⅲ、Ⅳ度环状脱垂痔的手术方式对术后肛门控便能力影响的比较,差异有统计学意义（Z值=-6.873,P<0.05）;肛周脓肿、肛瘘、肛裂其各自的手术方式对术后肛门控便能力影响的比较,差异无统计学意义（Z值=-1.469,Z值=-1.841,Z值=-0.307,P均>0.05）。 结论在选择合理手术方式的前提下,肛周脓肿可以采取一期根治性手术治疗;对于Ⅲ、Ⅳ度环状脱垂痔的吻合器痔上粘膜环切钉合术（PPH）值得临床推广。     

北京市社区老年人衰弱状况及其相关因素分析

目的了解北京市社区老年人的衰弱状况及其影响因素,为采取相应措施延缓老年人衰弱进程提供科学依据。方法2015年11月至2016年1月采用分层整群抽样方法,选取北京市东城区(原北京市崇文区)龙潭街道办事处所管辖社区的60岁及以上老年人为研究对象,以面对面询问的方式进行入户调查,应用衰弱指数(FI)评价老年人的衰弱状况,采用多元线性回归分析影响老年人衰弱的相关因素。结果共调查1557名老年人,老年人FI值中位数(四分位间距)为0.09(0.08),其中男性为0.08(0.07)、女性为0.10(0.08),女性FI值明显高于男性(Z=5.376,P=0.000),随增龄老年人FI值增大(H=329.698,P=0.000);多元线性回归结果显示,女性、增龄、生理失能越严重、过去1年住过院、近3年住过院、对目前生活状态不满意的老年人FI值相对高(β’=0.082、0.236、0.336、0.065、0.089、0.193,均P<0.05),而文化程度越高、家庭和睦、可支持和帮助的朋友数多、参加集体组织活动的频率高、定期体检及经常参加体育锻炼的老年人FI值相对低(β’=-0.049、-0.052、-0.089、-0.047、-0.045、-0.219,均P<0.05),且生理失能对FI值的影响最大,其次为年龄及是否经常参加体育锻炼。结论以FI的方法评价中国老年人的衰弱情况及特性与国外研究类似,对于评价中国老年人的衰弱情况也适用;老年人衰弱状况除与自身的生理与疾病等内在因素有关外,同时与社会、心理、行为等这些可干预因素均有关,应采取针对相关因素的综合性措施延缓老年人衰弱的进程。     

Sociodemographic characteristics,disability trajectory,and health care and long-term care utilization among middle-old and older adults in Taiwan

ObjectivesTo understand whether disability trajectories mediated the association between sociodemographic characteristics and later health care and long-term care services use.MethodsData were from the Taiwan Longitudinal Study on Aging Survey, 1996–2007 (N =3429). Latent class growth curves modeling and structural equation modeling were applied to examine the effect of disability trajectory as mediator on sociodemographic characteristics and on later services use.ResultsRespondents were identified in three trajectories: maintained disability (1.92%), progressive disability (10.56%), and functional independence trajectories (87.52%). The progressive disability trajectory partially and fully mediated the effects of age on later use of health care and long-term care services (the partially mediating effect on age and long-term care service use: β = 0.047, p < 0.001, for example). With the progressive disability trajectory in the model, higher education had a direct effect on greater use of long-term care services (β = 0.020, p =0.020), but through the mediating effect of the disability trajectory, education had an indirect effect on lower use of long-term care services(β = -0.025, p < 0.001). Education had fully mediating effects on the later use of inpatient (β = -0.016, p < 0.001) and emergency services (β= -0.012, p < 0.001).ConclusionsPreventing older adults from developing a fast-growing disability trajectory could be an effective way to decrease use of health care and long-term care services and related expenditures in late life.     

信息化随访干预措施对HBV感染患者依从性影响分析

目的通过信息化随访方式干预慢性乙型病毒性肝炎患者,对比分析其对患者疾病及用药依从性影响。方法收集2014年10月至2017年10月惠州市第六人民医院门诊及住院部诊断为慢性乙型病毒性肝炎、乙肝肝硬化患者,剔除不符合纳入条件患者,共纳入符合条件患者264例,有42例合并肝硬化。对纳入患者采取分层随机抽样方法进行分组,最终微信+电话随访组87例,电话随访组88例,对照组89例。随访并对比三组在2年后肝功能、肝硬化人数及停用恩替卡韦时间等不同差异。结果随访年后三组在失访人数上差异存在统计学意义,其中A组与B组2年后两组在ALT(Z=-3.218,P=0.02)、AST(Z=-2.749,P=0.03)、Alb(Z=1.746,P=0.04)、乙肝病毒DNA(Z=-3.231,P=0.02)指标差异具有统计学意义,而TBil、FIB-4指数、APRI、γ-GT指标差异无统计学意义。A组与C组2年后对比结果显示,两组在ALT(Z=-11.089,P<0.001)、AST(Z=-9.247,P=0.01)、TBil(Z=-7.623,P=0.01)、APRI(Z=-4.834,P=0.01)、γ-GT(Z=-2.867,P=0.03)、Alb(Z=3.187,P=0.02)、乙肝病毒DNA(Z=-10.078,P<0.001)指标差异具有统计学意义,而FIB-4指数指标差异无统计学意义。B组与C组2年后两组对比结果显示,两组在ALT(Z=-1.275,P=0.04)、AST(Z=-2.045,P=0.03)、TBil(Z=-3.762,P=0.02)、APRI(Z=-1.461,P=0.04)、γ-GT(Z=-2.254,P=0.03)、乙肝病毒DNA(Z=-1.782,P=0.04)指标差异具有统计学意义,而Alb、FIB-4指数指标差异无统计学意义。随访2年后A组肝硬化人数为12人,B组为16人,C组为24人。A组与B组(χ²=0.945,P=0.408)、B组与C组肝硬化人数(χ²=2.741,P=0.103)差异无统计学意义,而A、C两组肝硬化人数差异有统计学意义(χ²=6.843,P=0.013)。在2年时间内,A组有15例患者暂停使用恩替卡韦,B组有28例,C组有61例,三组停用恩替卡韦人数差异有统计学意义(χ²=25.061,P<0.001),通过Kaplan-meier分析,结果显示A组使用恩替卡韦时间长于B组(83.0%vs 68.5%,χ²=5.754,P=0.016)及C组(83.0%vs 33.7%,χ²=61.601,P<0.001),而B组使用时间长于C组(63.5%vs 33.7%,χ²=32.451,P<0.001)。结论通过对患者强化信息化干预,可以使患者服用抗乙肝病毒药物依从性提高,降低患者肝功能异常发生及肝硬化发病率。     

营养状况与老年女性慢性心力衰竭生存质量相关性研究

目的探讨老年女性慢性心力衰竭(CHF)患者生存质量与营养状况的相关性。方法选取老年女性CHF患者120例,按照心功能分级(NYHA)分为Ⅱ级组34例、Ⅲ级组54例、Ⅳ级组32例,另选取老年女性健康体检者30例为对照组。收集各组血清血红蛋白、淋巴细胞绝对值,进行微型营养评定量表(MNA)和明尼苏达心力衰竭生存质量量表(MLHFQ)评分。结果Ⅱ级组、Ⅲ级组、Ⅳ级组患者存在营养不良风险和营养不良的总发生率明显高于对照组(67.7%,81.5%,100.0%vs 33.3%,P<0.01)。Ⅱ级组、Ⅲ级组、Ⅳ级组白蛋白和MNA评分及Ⅲ级组、Ⅳ级组血红蛋白水平明显低于对照组,外周水肿深度明显高于对照组(P<0.05)。Ⅳ级组外周水肿深度明显高于Ⅱ级组及Ⅲ级组,血红蛋白和MNA评分明显低于Ⅱ级组及Ⅲ级组(P<0.05)。MNA评分和外周水肿深度与MLHFQ评分相关(P<0.01)。MLHFQ评分与住院天数呈正相关(r=0.327,P<0.01)。结论老年女性CHF患者营养不良问题普遍存在。MNA评分和外周水肿深度对预测老年女性CHF患者生存质量有重要意义。     

Low bone mass is an infrequent feature of the adult growth hormone deficiency syndrome in middle-age adults and the elderly

Low bone mass is considered a characteristic feature of adult GH deficiency (GHD). Although low bone mass is universally observed in cohorts of GHD adults of young age, the situation is less clear with regard to cohorts of GHD middle-age adults or the elderly. We have examined the relationship between bone mineral density (BMD) and age in 125 severely GHD adults using dual-energy x-ray absorptiometry. This relationship was further examined with a calculated measure of volumetric BMD, bone mineral apparent density (BMAD). A significant positive correlation was observed between age and BMD (Z scores) at the lumbar spine (r = 0.39, P < 0.0001), femoral neck (r = 0.47, P < 0.0001), total hip (r = 0.47, P < 0.0001), and ultradistal (r = 0.46, P < 0.0001) and distal radius (r = 0.52, P < 0.0001). Young adults were observed to have reduced bone mass, whereas the elderly GHD patients had normal Z scores. After division of the cohort into age ranges (<30, 30-45, 45-60, and >60 yr), BMD Z scores at all five skeletal sites increased significantly across the age groups from youngest to oldest (P < 0.001). When BMD was assessed using absolute values (g/cm(2)), in contrast to the decline in BMD observed with aging in a normal population, BMD at the total hip and ultradistal and distal radius increased across the age strata of GHD adults (P = 0.003, P = 0.004, and P = 0.002, respectively), and a trend toward an increase in lumbar spine and femoral neck BMD was also observed. No significant change in BMAD was observed across the four age groups. The percentage of patients observed to have BMD Z scores of less than -2.0 at the lumbar spine was 30, 11, 11, and 14% in the four age groups, respectively. At the femoral neck, the corresponding percentages were 36, 6, 7, and 0%, respectively. In summary, we have shown that the effect of severe GHD on BMD is dependent on age. Low bone mass was observed in the young patients; however, patients over the age of 60 yr demonstrated a mean BMD Z score above that of the reference population and significantly greater BMD (g/cm(2)) when compared with young GHD adults. Few patients were observed to have BMD Z scores below -2.0 except patients aged less than 30 yr, which, in part, was explained by their shorter stature. Thus, significantly reduced bone mass is not a frequent observation in adults with GHD.     

Epidemiology of hypertension among a population of school children in Sousse, Tunisia

BACKGROUND: Pediatric hypertension is a field of increasing interest and importance. Early identification of children at risk for hypertension is important to prevent the serious, long-term complications associated with the condition. In Tunisia, there are no data available on the cardiovascular disease risk profile, such as hypertension, in the population of children. OBJECTIVE: To establish the prevalence of hypertension, the percentile distribution of blood pressure and the inter-relationships between hypertension and other cardiovascular disease risk factors among school children. METHODS: An epidemiological survey was conducted based on a representative sample of 1569 urban school children in Sousse, Tunisia. RESULTS: The prevalence of arterial hypertension was 9.6%, with no significant difference between boys (9.2%) and girls (9.9%). The prevalence of systolic and diastolic hypertension was 6.4% and 4.5%, respectively. In both boys and girls, systolic pressure had a highly significant positive correlation with height (boys: r=0.33, P<0.001; girls: r=0.08, P=0.02), weight (boys: r=0.47, P < or = 0.001; girls: r=0.35, P<0.001) and triglyceride concentrations (boys: r=0.13, P<0.001; girls: r=0.10, P=0.006). Among boys, a positive correlation was found between systolic blood pressure and age (r=0.12, P=0.001) and, among girls, a negative correlation was found (r=-0.12, P=0.001). CONCLUSION: This information will be used to help launch a regional program of heart health promotion in schools.     

FibroTouch、FibroScan及ARFI在原发性胆汁性胆管炎相关肝纤维化中的诊断价值

目的评估FibroTouch与FibroScan、声辐射力脉冲成像(ARFI)对原发性胆汁性胆管炎(PBC)患者肝纤维化程度的诊断效能。方法回顾性纳入2014年9月—2018年10月在首都医科大学附属北京友谊医院行肝穿刺活检明确诊断为PBC的患者。采用METAVIR评分系统评估肝纤维化和炎症程度。在肝活检1周内分别应用瞬时弹性成像(FibroTouch和FibroScan)和ARFI技术检测肝脏硬度值(LS);以病理结果作为金标准,采用受试者工作特征曲线下面积(AUC)比较3种超声弹性成像技术对PBC肝纤维化的诊断价值,并分析其影响因素;采用Youden指数计算不同程度肝纤维化的诊断界值。多组间比较采用Kruskal-Wallis H检验,进一步两两比较采用Bonferroni法校正P值。采用Spearman进行相关性分析,采用多重线性回归模型进行多因素分析。结果研究共纳入68例PBC患者,其中肝纤维化F0、F1、F2、F3和F4分别为13、15、18、12和10例。FibroTouch获得的LS(FT-LS)、FibroScan获得的LS(FS-LS)和ARFI获得的LS(ARFI-LS)与肝纤维化程度均呈强正相关(r值分别为0.798、0.782和0.742,P值均<0.001)。FT-LS诊断F≥2、F≥3、F=4 AUC分别为0.922、0.881、0.926,对应的cut-off值分别为10.5、15.8和17.5 kPa;FS-LS诊断F≥2、F≥3、F=4 AUC分别为0.918、0.878、0.939,对应的cut-off值分别为10.1、12.9和18.2 kPa;ARFI-LS诊断F≥2、F≥3、F=4 AUC分别为0.904、0.869、0.928,对应的cut-off值分别为1.45、1.83和2.08 m/s。3种超声成像技术对各期纤维化程度的诊断差异无统计学意义(P>0.05)。多因素分析结果显示,FT-LS的影响因素有肝纤维化程度(β=0.399,P<0.001)、TBil水平(β=0.466,P<0.001)和PTA(β=-0.195,P=0.020);FS-LS的影响因素有肝纤维化程度(β=0.370,P<0.001)、AST(β=0.450,P<0.001)、PTA(β=-0.303,P=0.001)和ALP(β=-0.187,P=0.042);而ARFI-LS的影响因素有肝纤维化程度(β=0.489,P<0.001)、AST(β=0.467,P<0.001)和PLT(β=-0.188,P=0.028)。结论FibroTouch与FibroScan和ARFI在诊断PBC肝纤维化程度的效能相似,特别是对显著纤维化(F≥2)和肝硬化(F=4)具有较高的诊断效能,可作为诊断PBC患者肝纤维化程度的可靠手段。     

Routine Invasive Strategy in Elderly Patients with Non-ST Elevation Acute Coronary Syndrome: An Updated Systematic Review and Meta-analysis of Randomized Trials

Invasive treatment with coronary angiography is preferred approach for patients with non-ST elevation acute coronary syndrome (NSTE-ACS) compared to medical therapy alone. The results from the randomized clinical trials (RCT) that compared the invasive treatment strategy vs. conservative approach in the elderly (≥75 years) with NSTE-ACS has been inconsistent. To compare invasive and conservative strategies in the elderly (>75 years) with NSTE-ACS. We searched PubMed, Cochrane CENTRAL Register and ClinicalTrials.gov (inception through July 10, 2021) for RCTs comparing invasive and conservative strategies in the elderly with NSTE-ACS. We used random-effects model to calculate risk ratio (RR) with 95% confidence interval(CI). A total of 6 RCT including 2,323 patients were included in the meta-analysis. The median follow-up duration was 13.5 months. When invasive approach was compared to conservative strategy, it showed no difference in all-cause mortality in patients aged ≥75 years with NSTE-ACS (RR of 0.85; 95% CI 0.70–1.04; P = 0.12; I2 = 0%). There was significant reduction in MI (RR 0.59; 95% CI 0.49 0.71; P < 0.001; I2 = 0%) and unplanned revascularization (RR 0.30, 95% CI 0.17-0.53, P <0.001, I2 = 0%). Invasive strategy was associated with higher risk of major bleeding when compared to conservative treatment (RR 2.12, 95% CI 1.21-3.74, P = 0.009, I2 = 0%). Comparison of both strategies showed no significant difference in stroke (RR 0.75; 95% CI 0.38-1.46, P = 0.40; I2 = 0%). This updated meta-analysis suggests that in elderly patients (>75 years) with NSTE-ACS, a routine invasive strategy is associated with a reduction in MI and revascularization, while increasing the risk of major bleeding, but without difference in all-cause mortality and stroke.