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1.
目的 探讨气囊面罩结合气管插管通气对急救心肺复苏结局及预后的影响。方法 选取2015年1月—2017年5月在重庆医科大学附属大学城医院接受急救心肺复苏患者102例,采用随机数字表法将分为观察组和对照组,每组51例。对照组给予气管插管通气治疗,观察组给予气囊面罩结合气管插管通气治疗。比较两组患者治疗前后的pH、氧分压(PO2)、二氧化碳分压(PCO2)水平变化;记录两组患者治疗后气道开放、呼吸恢复、心跳恢复及意识改善时间;比较两组患者治疗后生命体征指标恢复情况、复苏成功率、最终存活率及满意度情况。结果 治疗前,两组患者的pH、PO2、PCO2比较无统计学意义(P >0.05)。治疗后,两组患者的pH、PO2均有所升高,但是观察组pH(7.29±0.12)mmHg低于对照组(7.53±0.22)mmHg(P <0.05),观察组PO2(89.34±7.69)mmHg高于对照组(71.56±6.98)mmHg (P <0.05);两组患者的PCO2均有所降低,但是观察组的PCO2(37.43±5.25)mmHg低于对照组(44.32±6.51)mmHg (P <0.05)。观察组气道开放、呼吸恢复、心跳恢复及意识改善时间都短于对照组(P <0.05)。观察组血氧饱和度(85.32±11.76)%高于对照组(43.54±9.12)% (P <0.05),平均动脉(72.32±9.56)mmHg高于对照组(36.78±7.32)mmHg (P <0.05)。观察组复苏成功率(52.94% VS 25.49%)、最终存活率均高于对照组(33.33% VS 11.76%) (P <0.05)。观察组总满意率高于对照组(86.27% VS 62.75%) (P <0.05)。结论 采用气囊面罩与气管插管通气结合进行急救心肺复苏,能有效改善患者的pH、PO2、PCO2,促进患者的各项生命体征的恢复,缩短患者气道开放、呼吸恢复、心跳恢复及意识改善时间,提高复苏成功率及最终存活率,从而提高患者的满意度。治疗效果显著,值得推广使用。  相似文献   

2.
目的 探讨右美托咪定(Dex)对脓毒症小鼠认知功能及热休克蛋白70(HSP70)表达的影响,为其脑保护机制的研究提供参考。方法 将80只C57BL/6小鼠随机分为对照组(CON组)、单纯Dex组(Dex组)、脓毒血症组(LPS组)和Dex +脓毒血症组(D + L组),每组20只。首先,Dex组和D + L组腹腔注射Dex 25 μg/kg,CON组和LPS组腹腔注射等剂量的生理盐水;30 min后LPS组和D + L组腹腔注射5 mg/kg脂多糖(LPS)复制脓毒血症模型,CON组和Dex组腹腔注射等剂量的生理盐水。采用Morris水迷宫实验评估小鼠学习记忆能力,酶联免疫吸附试验检测血清肿瘤坏死因子-α(TNF-α)和白细胞介素-1β(IL-1β)水平,化学比色法检测海马组织过氧化物歧化酶(SOD)活性和谷胱甘肽(GSH)、丙二醛(MDA)水平,苏木精-伊红染色观察海马CA1区病理变化,免疫组织化学染色和实时荧光定量聚合酶链反应检测海马HSP70蛋白、mRNA表达。结果 各组小鼠第1、2、3、4、5天逃避潜伏期比较,经重复测量设计的方差分析,结果 ①不同时间点的逃避潜伏期比较,差异有统计学意义(P <0.05);②各组小鼠的逃避潜伏期比较,差异有统计学意义(P <0.05),LPS组较CON组延长,D + L组较LPS组缩短;③各组小鼠逃避潜伏期变化趋势比较,差异有统计学意义(P <0.05)。各组小鼠游泳速度比较,差异无统计学意义(P >0.05)。LPS组目标象限停留时间短于CON组(P <0.05),D + L组长于LPS组(P <0.05);LPS组穿越平台次数少于CON组(P <0.05);D + L组多于LPS组(P <0.05)。LPS组血清TNF-α、IL-1β水平较CON组升高(P <0.05),D + L组较LPS组降低(P <0.05)。LPS组GSH、SOD水平较CON组降低(P <0.05),MDA水平较CON组升高(P <0.05),D + L组GSH、SOD水平较LPS组升高(P <0.05),MDA水平较LPS组下降(P <0.05)。LPS组HSP70蛋白阳性表达率较CON组升高(P <0.05),D + L组较LPS组升高(P <0.05),Dex组与CON组比较,差异无统计学意义(P >0.05)。LPS组HSP70 mRNA相对表达量较CON组升高(P <0.05),D + L组较LPS组升高(P <0.05);Dex组与CON组比较,差异无统计学意义(P >0.05)。结论 Dex能够降低脓毒症小鼠体内炎症和氧化应激水平,改善认知功能,其机制可能与上调HSP70表达有关。  相似文献   

3.
目的 探究盐酸纳美芬对大脑中动脉缺血再灌注(MCAO/R)模型大鼠的神经保护作用。方法 将36只大鼠随机分为假手术组、模型组、盐酸纳美芬组,各12只。盐酸纳美芬组大鼠复制MCAO/R模型前10 min尾静脉注射20 μg/kg盐酸纳美芬注射液,假手术组和模型组注射等体积生理盐水。随后除假手术组外,其余两组采用线栓法复制MCAO/R模型。采用Longa评分标准评估大鼠神经功能,酶联免疫吸附试验(ELISA)检测脑组织超氧化物歧化酶(SOD)活性、丙二醛(MDA)含量,苏木精-伊红(HE)染色和TUNEL染色观察脑组织病理变化和细胞凋亡情况,Western blotting检测脑组织Caspase-3、Bcl-2、Bax蛋白的表达。结果 假手术组大鼠神经功能评分低于模型组和盐酸纳美芬组(P <0.05);盐酸纳美芬组大鼠神经功能评分低于模型组(P <0.05)。模型组、盐酸纳美芬组SOD活性低于假手术组(P <0.05),MDA含量高于假手术组(P <0.05);与模型组比较,盐酸纳美芬组SOD活性升高(P <0.05),MDA含量降低(P <0.05)。HE染色结果显示,假手术组细胞轮廓清晰,排列有序;模型组细胞破损,数量减少,炎症浸润严重;盐酸纳美芬组细胞数量较多,轮廓清晰,炎症浸润减少。模型组、盐酸纳美芬组凋亡细胞数多于假手术组(P <0.05);盐酸纳美芬组凋亡细胞数少于模型组(P <0.05)。模型组、盐酸纳美芬组Caspase-3、Bax蛋白相对表达量高于假手术组(P <0.05),Bcl-2蛋白相对表达量低于假手术组(P <0.05);与模型组相比,盐酸纳美芬组Caspase-3、Bax蛋白相对表达量降低(P <0.05),Bcl-2蛋白相对表达量升高(P <0.05)。结论 盐酸纳美芬可以降低MCAO/R大鼠脑组织氧化应激水平,减少神经细胞凋亡,具有良好的神经保护作用,其作用机制与调节Caspase-3/Bcl-1/Bax通路有关。  相似文献   

4.
目的 探讨不同剂量咪达唑仑对术前中重度焦虑的结直肠癌老年患者术后早期认知功能的影响。方法 选择南方医科大学顺德医院择期行结直肠癌根治术的80例老年患者,术前评估为中重度焦虑,随机分为空白对照组(C组)和不同剂量咪达唑仑组(M1组、M2组、M3组),每组20例。患者麻醉诱导时,C组不注射咪达唑仑,M1组、M2组、M3组分别静脉注射0.05 mg/kg、0.10 mg/kg、0.15 mg/kg咪达唑仑。观察并记录4组患者的血流动力学变化、Riker镇静-躁动评分(SAS)、苏醒时间、拔除气管导管时间和视觉模拟评分(VAS)。记录4组患者术前1 d、术后第1天、术后第7天的简易智力状态检查量表(MMSE)和术后早期认知功能障碍的发生率。检测并记录4组患者于麻醉前、术后第1天、术后第7天的血清白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)及中枢神经特异性蛋白(S-100β)水平。结果 4组患者不同时间点的平均动脉压(MAP)、心率(HR)有差异(P <0.05),4组的MAP、HR无差异(P >0.05),4组的MAP、HR变化趋势无差异(P >0.05)。M3组患者苏醒时间长于其他组(P <0.05),M1和M2组患者的拔管时间短于C组和M3组(P <0.05),C组患者VAS评分高于其他组(P <0.05),躁动发生率亦高于其他组(P <0.05)。4组患者不同时间点的MMSE评分有差异(P <0.05),4组的MMSE评分有差异(P <0.05),4组MMSE评分变化趋势有差异(P <0.05)。根据MMSE评估结果,术后第1天C组和M1组患者术后早期认知功能障碍的发生率高于M2组和M3组(P <0.05)。术后第7天,C组仍有25%患者术后认知功能障碍,高于其他组(P <0.05)。4组患者不同时间点的IL-1β水平无差异(P >0.05),4组的IL-1β水平无差异(P >0.05),4组IL-1β水平变化趋势无差异(P >0.05)。4组患者不同时间点的IL-6、S-100β水平有差异(P <0.05),4组的IL-6、S-100β水平有差异(P <0.05),4组的IL-6、S-100β水平变化趋势有差异(P <0.05)。结论 术前中重度焦虑的老年结直肠癌患者使用0.10 mg/kg咪达唑仑进行麻醉诱导,安全可靠,苏醒质量好,炎症反应减轻,术后早期认知功能得到改善。  相似文献   

5.
目的 探讨环泊酚对老年患者胸腔镜肺癌根治术中血流动力学和术后苏醒质量的影响。方法 选取2019年7月—2022年7月在南京医科大学附属脑科医院胸科院区行胸腔镜肺癌根治术的108例老年患者,采用随机数字表法将患者分为观察组和对照组,每组54例。观察组给予环泊酚麻醉,对照组给予丙泊酚麻醉,观察两组麻醉诱导前(T0)、诱导后5 min(T1)、拔管即刻(T2)和拔管后5 min(T3)时心率(HR)、平均动脉压(MAP)、收缩压(SBP)和舒张压(DBP),以及术后苏醒时间、定向力恢复时间、不良反应等,同时分析手术前后应激、炎症因子差异。结果 两组患者T0、T1、T2、T3的HR、MAP、SBP、DBP比较,结果 ①不同时间点的HR、MAP、SBP、DBP比较,差异均有统计学意义(F =4.412、4.603、5.003和4.954,均P <0.05);②两组患者HR、MAP、SBP、DBP比较,差异均有统计学意义(F =5.154、4.102、4.987和5.884,均P <0.05);③两组患者HR、MAP、SBP、DBP变化趋势比较,差异均有统计学意义(F =4.412、4.603、5.003和4.954,均P <0.05)。观察组术后苏醒时间、定向力恢复时间短于对照组(P <0.05)。两组患者苏醒期躁动发生率比较,差异无统计学意义(P >0.05)。观察组手术前后去甲肾上腺素、肾上腺素、肿瘤坏死因子-α和白细胞介素-6的差值低于对照组(P <0.05)。观察组呼吸抑制、恶心呕吐发生率低于对照组(P <0.05)。两组患者心动过缓、呛咳、体动发生率比较,差异均无统计学意义(P >0.05)。结论 环泊酚在老年患者胸腔镜肺癌根治术中有较好的麻醉效果,与丙泊酚比较,对血流动力学无明显影响;具有术后苏醒质量好、应激炎症水平低、不良反应少等优点。  相似文献   

6.
目的 观察短时间吸入不同浓度七氟醚对幼鼠空间学习记忆能力及海马神经细胞凋亡的影响。方法 选择80只SD幼鼠,均为1月龄,采取随机数字表法将幼鼠分为对照组(单纯吸氧2 h)、1%七氟醚组(吸入1%七氟醚2 h)、2%七氟醚组(吸入2%七氟醚2 h)与3%七氟醚组(吸入3%七氟醚2 h),每组20只。吸入结束12 h后,各组取5只开展Morris水迷宫实验,5只取海马组织行苏木精-伊红染色,5只通过流式细胞分析仪进行细胞凋亡测定,5只通过激光共聚焦显微镜进行神经元细胞游离钙离子浓度测定。结果 2%七氟醚组、3%七氟醚组平台象限停留时间较对照组缩短(P <0.05),穿台次数较对照组减少(P <0.05)。2%七氟醚组、3%七氟醚组凋亡神经元数目较对照组增加(P <0.05)。2%七氟醚组、3%七氟醚组早期凋亡率、晚期凋亡率较对照组增加(P <0.05)。2%七氟醚组、3%七氟醚组荧光强度较对照组增加(P <0.05),钙离子浓度较对照组升高(P <0.05)。结论 短时间内吸入1%七氟醚并不会对幼鼠空间学习记忆能力造成影响,短时间吸入2%或者3%七氟醚可降低其空间学习记忆能力,促进海马神经细胞凋亡,提高细胞钙离子浓度可能为触发凋亡的机制。  相似文献   

7.
目的 观察白藜芦醇(RES)对过氧化氢H2O2诱导的小鼠精原细胞(Gc-1 spg)氧化应激损伤的作用。方法 H2O2复制Gc-1 spg细胞氧化应激损伤模型,设置空白组、H2O2组(800 μmol/L)、H2O2 +5 μmol/L RES组、H2O2 +10 μmol/L RES组和H2O2+15 μmol/L RES组。检测超氧化物歧化酶(SOD)、丙二醛(MDA)、乳酸脱氢酶(LDH)和谷胱甘肽过氧化物酶(GSH-Px)水平,CCK-8法检测细胞活力,JC-1试剂盒检测线粒体膜电位,Mito Tracker?? Green FM试剂盒检测活细胞线粒体水平,Hoechst 33342染色检测细胞核凋亡率,Western blotting检测凋亡蛋白Bax、Bcl-2和Caspase-3表达。结果 浓度为800 μmol/L H2O2处理Gc-1 spg细胞6 h时达到实验要求(P <0.05)。与空白组比较,各H2O2组细胞活力降低(P <0.05),与H2O2组比较,H2O2 +5 μmol/L RES组、H2O2+10 μmol/L RES组、H2O2 +15 μmol/L RES组细胞活力升高(P <0.05)。与空白组比较,各H2O2组的GSH-Px和SOD水平降低(P <0.05),LDH和MDA水平升高(P <0.05);与H2O2组比较,H2O2 +5 μmol/L RES组、H2O2+10 μmol/L RES组、H2O2 +15 μmol/L RES组GSH-PX和SOD水平降低(P <0.05),LDH和MDA水平升高(P <0.05)。与空白组比较,H2O2组细胞的红/绿荧光比值降低,提示线粒体膜电位降低(P <0.05);与H2O2组比较,H2O2+5 μmol/L RES组、H2O2 +10 μmol/L RES组、H2O2 +15 μmol/L RES组JC-1红/绿荧光比值升高(P <0.05)。与空白组比较,H2O2组细胞线粒体数明显减少(P <0.05);与H2O2组比较,H2O2 +5 μmol/L RES组、H2O2+10 μmol/L RES组、H2O2 +15 μmol/L RES组细胞荧光强度升高(P <0.05)。与空白组比较,H2O2组大量细胞核皱缩、碎裂,染色程度明显增强,细胞凋亡严重;与H2O2组比较,H2O2 +5 μmol/L RES组、H2O2+10 μmol/L RES组、H2O2 +15 μmol/L RES组细胞凋亡率降低(P <0.05)。与空白组比较,H2O2组凋亡蛋白Bax和Caspase-3相对表达量增加(P <0.05),Bcl-2相对表达量减少(P <0.05);与H2O2组比较,H2O2 +5 μmol/L RES组、H2O2 +10 μmol/L RES组、H2O2 +15 μmol/L RES组Bax和Caspase-3相对表达量降低(P <0.05),Bcl-2相对表达量增加(P <0.05)。结论 RES对H2O2诱导的Gc-1 spg细胞氧化应激损伤具有保护作用,这种保护作用与RES浓度有关。  相似文献   

8.
目的 探讨前锯肌平面阻滞对胸腔镜肺癌根治术患者物质能量代谢和胰岛素抵抗的影响。方法 选取2018年6月—2020年6月在日照市人民医院全身麻醉下行胸腔镜肺癌根治手术的60例患者。采用随机数字表法分为对照组和阻滞组,每组30例。对照组行全身麻醉,阻滞组先在超声引导下行前锯肌平面阻滞,后行全身麻醉。记录两组患者入手术室后5 min(T0)、麻醉诱导前(T1)、手术切皮时(T2)、手术结束时(T3)平均血压(BP)和心率(HR)。记录两组患者术后6 h(T4)、12 h(T5)、24 h(T6)、48 h(T7)时静止状态及咳嗽状态下行视觉模拟量表评分。两组患者T0、T3、T6、T7时检测C反应蛋白、静息能量消耗、呼吸商、甘油三酯、血糖、胰岛素。采用间接测热法测定静息能量消耗和呼吸商,稳态模型评价胰岛素抵抗指数,全自动生化分析仪测定甘油三酯水平,酶联免疫吸附试验试剂盒检测C反应蛋白。结果 两组性别比例、年龄、体质量指数、美国麻醉医生协会分级、手术时间和术中出血量比较,差异均无统计学意义(P >0.05)。阻滞组术中瑞芬太尼用量较对照组少,自主呼吸恢复时间、拔管时间较对照组短(P <0.05)。两组患者T0、T1、T2、T3时BP比较,结果 ①不同时间点BP比较,差异有统计学意义(P <0.05);②两组BP比较,差异无统计学意义(P >0.05);③两组BP变化趋势比较,差异有统计学意义(P <0.05)。两组T0、T1、T2、T3时HR比较,结果 ①不同时间点HR比较,差异有统计学意义(P <0.05);②两组HR比较,差异有统计学意义(P <0.05),阻滞组T2、T3时较对照组低(P <0.05);③两组HR变化趋势比较,差异有统计学意义(P <0.05)。两组T4、T5、T6、T7时静息状态下VAS比较,结果 ①不同时间点VAS比较,差异有统计学意义(P <0.05);②两组VAS比较,差异有统计学意义(P <0.05),阻滞组T4、T5时较对照组低(P <0.05);③两组VAS变化趋势比较,差异无统计学意义(P >0.05)。两组T4、T5、T6、T7时咳嗽状态下VAS比较,结果 ①不同时间点VAS比较,差异有统计学意义(P <0.05);②两组VAS比较,差异有统计学意义(P <0.05),阻滞组T4、T5时较对照组低(P <0.05);③两组VAS变化趋势比较,差异有统计学意义(P <0.05)。两组患者T0、T3、T6、T7时C反应蛋白、REE、RQ、甘油三酯、IRI比较,结果 ①不同时间点C反应蛋白、REE、RQ、甘油三酯、IRI比较,差异均有统计学意义(P <0.05);②两组C反应蛋白、REE、RQ、甘油三酯、IRI比较,差异均有统计学意义(P <0.05);③两组C反应蛋白、REE、RQ、甘油三酯、IRI变化趋势比较,差异均有统计学意义(P <0.05)。结论 前锯肌平面阻滞可减轻胸腔镜肺癌根治术患者炎症反应,改善物质代谢和静息能量消耗,减轻胰岛素抵抗。  相似文献   

9.
目的 探讨特发性肺纤维化(IPF)患者血清热休克蛋白47(HSP47)和血管内皮生长因子(VEGF)的动态变化及其临床意义。方法 选取2017年1月—2019年8月天津市胸科医院收治的加重期IPF患者、稳定期IPF患者及同期该院体检的健康者共141例为研究对象,分别纳入加重期组、稳定期组及健康对照组,每组47例。采用酶联免疫吸附试验检测各组血清HSP47、VEGF水平及肺功能,采用高分辨率CT(HRCT)评分法评价各组肺纤维化程度,分析血清HSP47、VEGF、肺功能及HRCT评分之间的相关性。结果 加重期组、稳定期组及健康对照组的血清HSP47、VEGF水平比较,差异有统计学意义(P <0.05),加重期组血清HSP47、VEGF水平高于稳定期组,稳定期组高于健康对照组;加重期组动脉血二氧化碳分压(PaCO2HRCT评分高于稳定期组(P <0.05);加重期组动脉血氧分压(PaO2)水平低于稳定期组(P <0.05)。加重期组第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、第1秒用力呼气容积占用力肺活量比值(FEV1%)、一氧化碳弥散量占预计值百分比(DLCO%pred)低于稳定期组。Pearson相关性分析显示,HSP47与FEV1、FVC、FEV1%、DLCO%pred、PaO2呈负相关(r =-0.735、-0.579、-0.612、-0.642和-0.636,均P <0.05),与PaCO2HRCT评分呈正相关(r =0.683和0.517,均P <0.05);VEGF与FEV1、FVC、FEV1%、DLCO%pred、PaO2呈负相关(r =-0.757、-0.583、-0.644、-0.656和-0.663,均P <0.05),与PaCO2HRCT评分呈正相关(r =0.597和0.525,均P <0.05);HSP47与VEGF呈正相关(r =0.685,P<0.05)。结论 IPF患者血清HSP47、VEGF水平随着病情的加重而升高,检测血清HSP47、VEGF水平有利于辅助评估IPF患者的病情。  相似文献   

10.
目的 探究不同月经稀发程度多囊卵巢综合征(PCOS)患者血清抗米勒管激素(AMH)、卵泡刺激素(FSH)、促黄体生成素(LH)、雌二醇(E2)水平变化及其临床意义。方法 选取2018年1月—2022年5月安徽医科大学附属滁州医院收治的240例PCOS患者,根据患者月经不同稀发程度分为A组(月经周期36~90 d)150例、B组(月经周期91~180 d)56例和C组(月经周期> 180 d)34例。比较3组基线资料、代谢指标[胰岛素抵抗指数(HOMA-IR)、总胆固醇(TC)、甘油三酯(TG)、血尿酸(UA)]、性激素指标[AMH、FSH、LH、E2、睾酮(T)、泌乳素(PRL)、游离雄激素指数(FAI)],采用Spearman相关性分析评价PCOS患者月经稀发程度与代谢和性激素指标的相关性。结果 A组体质量指数(BMI)低于B组和C组(P <0.05),B组BMI低于C组(P <0.05);3组年龄、腰臀比、多毛占比比较,差异均无统计学意义(P >0.05)。A组HOMA-IR、TG、UA均低于B组和C组(P <0.05),B组HOMA-IR、TG、UA均低于C组(P <0.05);3组TC比较,差异无统计学意义(P >0.05)。A组LH、T、FAI均低于B组和C组(P <0.05),B组LH、T、FAI均低于C组(P <0.05);3组AMH、FSH、E2、PRL比较,差异无统计学意义(P >0.05)。Spearman相关分析结果显示,PCOS患者月经稀发程度与HOMA-IR、TG、UA、LH、T和FAI均呈正相关(rs =0.764、0.560、0.558、0.650、0.512和0.678,P <0.05)。结论 PCOS患者月经稀发程度与糖脂代谢和性激素水平密切相关,月经稀发程度越严重,糖脂代谢及性激素异常程度越高。  相似文献   

11.
Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P < 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (>0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P <0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P < 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.  相似文献   

12.
Objective: To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods: SD rats served as both donors and recipients. 4℃ sodium lactate Ringer's was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava (IVC) inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results: Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion: This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.  相似文献   

13.
Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P< 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P< 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.  相似文献   

14.
目的:评价使用安心颗粒对急诊经皮冠状动脉介入术(PPCI)术后生活质量的影响.方法:将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组(术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次)和对照组(仅接受基础药物治疗).所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表(MIDAS)、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果:入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异(P>0.05);出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低(P<0.05);组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低(P<0.05).两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血(P>0.05).两组发生轻度血小板减少症的患者数比较无差异(P>0.05).结论:PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.  相似文献   

15.
Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P<0.01);the MAP decreased(P<0.01)and the HR increased drastically(P<0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.  相似文献   

16.
Objective:To investigate the gene expression of osteoprotegerin(OPG) and osteoclast differentiation factor(ODF) in the bone tissue of patients with hip fracture due to osteoporosis. Methods:OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers(over 50 years old) with hip fracture(Observer Group) and 30 cases of hip facture sufferers with no osteoporosis(Control group) were analyzed with the Semi-Quantitative RT-PCR method. Results:The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion:Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.  相似文献   

17.
Objective:To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas(SPTP). Methods:Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin(HE) staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results:Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin(9/9 cases), AAT(9/9 cases), NSE(9/9 cases), ACT(7/9 cases), CK20(2/9 cases), CgA(1/9 cases), S-100(3/gcases), PR(4/gcases), Syn(3/9 cases) and CD56(5/9cases), negative in CEA and ER. Conclusion:SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.  相似文献   

18.
Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.  相似文献   

19.
Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.  相似文献   

20.
Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.  相似文献   

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