番茄红素微囊的制备及稳定性考察

目的:制备番茄红素微囊,并对其稳定性进行考察.方法:用单凝聚法制备微囊,并用正交实验优化制备工艺.用分光光度法测定番茄红素的含量.结果:番茄红素微囊的最佳制备工艺为囊心囊材质量比0.2∶1,温度50℃,转速400r·min-1.在不同的影响因素条件下,微囊的稳定性明显优于原料(P<0.05).结论:番茄红素微囊的制备工艺简单,重现性好,且外观形态良好,微囊化是提高番茄红素稳定性的有效途径.     

喷雾干燥法制备莪术油微囊

目的 研究喷雾干燥法制备莪术油微囊的最佳处方及工艺。方法 以阿拉伯胶和麦芽糊精为囊材,喷雾干燥法制备莪术油微囊,以包封率为考察指标,探讨囊材配比、助乳化剂用量、固形物含量、微囊心材比等对微囊化的影响,并对喷雾干燥工艺进行正交试验考察。结果 阿拉伯胶和麦芽糊精的最佳配比为4：1,司盘-80 1 mL,固形物含量为40 %,微囊心材比为4 mL：10 g;喷雾干燥工艺条件为：进风温度160 ℃,进料速度2.5 mL&;#8226;min-1,吸气功率100%,制得的微囊囊形较好,平均粒径为5.2 μm,包封率可达到94.2 %,且微囊稳定性好。结论 根据该实验条件制得的微囊囊形圆整、表面致密,包封率较高,稳定性好。     

阴道用替硝唑缓释微囊的制备及其体外释放度考察

目的：制备替硝唑缓释微囊，考察其在体外的释放度。方法：以明胶、阿拉伯胶为囊材，采用复凝聚法制备替硝唑缓释微囊，正交试验优化制备工艺，采用紫外分光光度法测定含量。以100mL，pH4．5的乳酸溶液为释放介质，温度（37&#177;0．5）℃，转速50r&#183;min^-1测定其体外释放度。结果：替硝唑缓释微囊的最佳制备工艺为囊心囊材质量比为1：1，温度50℃，甲醛用量为2mL&#183;120mL）^-1。（甲醛用量／系统体积），体外缓释时间为240min。结论：替硝唑缓释微囊的制备工艺简单、成囊性和重复性好，替硝唑微囊具有明显的缓释效果。     

生姜油微囊的制备及其质量评价

目的:制备生姜油微囊并对其进行质量评价。方法:以辛烯基琥珀酸淀粉钠为囊材,采用喷雾干燥法制备生姜油微囊。以囊材与囊芯的混合温度、囊材与囊芯质量比、搅拌速度为考察因素,包封率为评价指标,采用正交试验优化生姜油微囊的制备工艺,并对其载药量、包封率、外观、粒径分布及光、热、湿稳定性(以碘价、过氧化值为指标)进行评价。结果:生姜油微囊的最优制备工艺为囊材与囊芯的混合温度60℃、囊材与囊芯质量比10∶1、搅拌速度12 000 r/min。最优工艺所制生姜油微囊的平均载药量为17.97%(n=3)、平均包封率为73.57%(n=3),生姜油微囊形态圆整光滑、无粘连、粒径分布均匀,平均粒径为(6.30±0.27)μm,在光、热、湿条件下生姜油微囊碘价、过氧化值变化较小。结论:优化后的生姜油微囊制备工艺简单、重复性好,生姜油微囊的包封率及载药量高,且稳定性较好。     

正交法研究盐酸克林霉素-乙基纤维素微囊的处方工艺

目的 制备盐酸克林霉素微囊,选择最优处方工艺。方法 以乙基纤维素为囊材,采用液中干燥法制备盐酸克林霉素微囊。采用四因素三水平正交实验设计考察药物与囊材的比例、油水相比例、表面活性剂用量、抗粘剂用量对微囊粒径、载药量和包封率的影响。结果 确定处方药物与囊材的比例为3：2,油水相比例为3：1,司盘用量为0．5％．滑石粉与囊材的质量比为1：1为最佳处方工艺。结论 本法处方合理,制备工艺可行,有良好的应用前景。     

荨麻提取物微囊制备工艺的研究

目的：研究荨麻提取物微囊的制备工艺。方法：采用正交设计法对荨麻提取物微囊的制备工艺进行研究。结果：当囊材与囊心的重量比为0．75：0．5，成囊温度为70℃，搅拌速度为600rpm，包囊率、含量、收率较高。结论：该法工艺简单、可靠。     

双嘧达莫缓释微囊的制备与体外评价

目的:研究以明胶和阿拉伯胶为囊材,将双嘧达莫微囊化的制备工艺。方法:以微囊的药物包封率为制备工艺优化指标,利用复凝聚法,通过正交实验得出微囊的最佳制备工艺条件。结果:囊材与囊心物的质量比2∶1,搅拌转速140r·min-1,固化时间3h、成囊pH4.0、成囊温度为50℃为最佳工艺条件。结论:以最佳制备工艺条件制备含药微囊,重复性好,工艺稳定,同时体外溶出实验表明,该微囊具有较好的缓释作用。     

裂叶荨麻提取物微囊的制备工艺

目的：研究裂叶荨麻提取物微囊的制备工艺。方法：采用正交设计法对裂叶荨麻提取物微囊的制备工艺进行研究。结果：当囊心、囊材比为0．5：1．25，成囊温度为70℃，搅拌速度为800r·min^-1时，含量及产量较高。结论：该工艺简单，可靠。     

京尼平苷微囊的制备及体外评价

目的:优选制备京尼平苷微囊的工艺条件.方法:明胶为材料,采用单凝聚法,以包封率为评价指标,利用均匀设计法优选最佳的微囊制备条件.结果:囊心囊材比为1∶12,温度45℃,转速为500 r·min-1.结论:微囊制备工艺稳定、粒径分布及溶出符合要求.     

正交法研究双嘧达莫微囊的制备工艺

目的 :研究双嘧达莫微囊的制备工艺。方法 :用正交设计法对双嘧达莫微囊的制备工艺进行研究。结果 :用单凝聚法制备双嘧达莫微囊 ,其包裹率与囊心囊材比有显著性差异 (P<0.05) ,而搅拌速度能影响微囊的粒径 ,当囊心囊材比为1∶4、成囊温度50℃、搅拌速度为400r/min时 ,包裹率最高 ,囊径最小。结论 :该法工艺简单、可靠     

克拉霉素微囊的制备及其质量评价

目的:制备克拉霉素微囊并对其质量进行评价。方法:以乙基纤维素为囊材,采用乳化-溶剂挥发法制备克拉霉素微囊,并对微囊粒径、包封率和载药量、体外释药性进行考察。结果:所制微囊粒径分布均匀,粒径33.0～38.0μm,包封率在87%以上,载药量大于45%,6h时累积释药量达75%。结论:该制剂制备方法简便易行,质量评价合格。     

维生素D_3微囊的制备及含量测定

目的:制备维生素D3微囊并建立其含量测定方法。方法:采用复凝聚法制备微囊;以高效液相色谱法测定维生素D3含量。结果:所制微囊粒径分布均匀,平均粒径(103.9±26.2)μm,包封率(90.8±2.68)%;维生素D3检测浓度的线性范围为0.1～1.0μg.mL-1(r=0.9993),平均回收率为98.65%,45min溶出度为75%以上。结论:该法成功制得维生素D3微囊,所建立的含量测定方法简便可行。     

正交实验设计优化岩白菜素微囊的制备工艺

目的优化岩白菜素微囊的制备工艺,并对制备的岩白菜素微囊进行质量评价。方法以明胶为囊材,单凝聚法制备岩白菜素微囊,通过正交实验设计优化其制备工艺,并对包封率、载药量、平均粒径、体外溶出率进行研究。结果明胶制备岩白菜素微囊的最佳工艺条件为:明胶质量分数为6%,囊心囊材质量比为1∶2,搅拌速度为750r·min^-1。此最佳工艺制备的岩白菜素微囊包封率为75.90%,载药量为23.09%,体外溶出度测定30min为28.6%,12h累计释放达到90%以上。结论以最佳工艺条件制备岩白菜素微囊工艺稳定,包封率高,同时体外释放实验表明,该微囊具有较好的缓释作用。     

Effect of processing parameters on the formation of spherical multinuclear microcapsules encapsulating peppermint oil by coacervation

The gelatin/gum arabic multinuclear microcapsules encapsulating peppermint oil were prepared by coacervation. The effect of various processing parameters, including the core/wall ratio, wall material concentration, pH value, as well as stirring speed on the morphology, particle size distribution, yield and loading was investigated. When the wall material concentration or the core/wall ratio increased, the morphology of multinuclear microcapsules changed from spherical to irregular and the average particle size increased, the optimal wall material concentration and the core/wall ratio were 1% and 2:1, respectively. The multinuclear spherical microcapsules with desired mean particle size can be manufactured by modulating the pH value and stirring speed. The ideal preparation conditions were pH 3.7 at 400 rpm of stirring speed. The yield of multinuclear microcapsules encapsulating peppermint oil by coacervation was approximately 90% and the processing parameters had very slight influence on the yield. When transglutaminase was used as the cross-linker instead of formaldehyde, morphology, mean particle size, yield and loading remained the same as that hardening with formaldehyde, but the particle size distribution became narrower.     

Effect of processing parameters on the formation of spherical multinuclear microcapsules encapsulating peppermint oil by coacervation

The gelatin/gum arabic multinuclear microcapsules encapsulating peppermint oil were prepared by coacervation. The effect of various processing parameters, including the core/wall ratio, wall material concentration, pH value, as well as stirring speed on the morphology, particle size distribution, yield and loading was investigated. When the wall material concentration or the core/wall ratio increased, the morphology of multinuclear microcapsules changed from spherical to irregular and the average particle size increased, the optimal wall material concentration and the core/wall ratio were 1% and 2:1, respectively. The multinuclear spherical microcapsules with desired mean particle size can be manufactured by modulating the pH value and stirring speed. The ideal preparation conditions were pH 3.7 at 400?rpm of stirring speed. The yield of multinuclear microcapsules encapsulating peppermint oil by coacervation was ～90% and the processing parameters had very slight influence on the yield. When transglutaminase was used as the cross-linker instead of formaldehyde, morphology, mean particle size, yield and loading remained the same as that hardening with formaldehyde, but the particle size distribution became narrower.     

萘普生微囊的制备及其质量考察

目的:制备萘普生微囊并考察其制剂质量。方法:以明胶和阿拉伯胶为囊材,采用复凝聚法将萘普生制成微囊;以阿拉伯胶浓度(A)、萘普生与阿拉伯胶的质量比例(B)和成囊温度(C)为考察因素,包封率为指标设计正交试验优化成囊的最佳制备工艺,并对优化工艺所制得微囊的粒径、包封率、载药量、体外释放性进行考察。结果:最佳工艺条件为A2%、B1:1、C50℃;所制微囊的平均囊径48.92μm,包封率(77.03±1.43)%,载药量(35.31±1.02)%,微囊在48h时体外累积溶出百分率达到91.32%。结论:所制萘普生微囊工艺重现性好、稳定,并具有良好的缓释作用。     

醋酸布舍瑞林缓释纳米粒灭菌粉末的处方工艺研究及质量评价

目的:优化醋酸布舍瑞林缓释纳米粒(BA-PLGA-NP)灭菌粉末的处方,并评价其质量。方法:先对影响处方工艺的因素进行单因素试验,再在此基础上以包封率为考察指标,投药量、PLGA浓度、内水相-油相的体积比、超声功率为主要考察因素进行正交试验筛选最佳处方;同时考察其在4℃及-20℃条件下放置3个月的稳定性。结果:最佳处方为投药量0.5mg·mL-1、PLGA2.0%、内水相-油相体积比1∶10、超声功率40W;所制制剂粒径呈单峰分布,平均粒径为127～132nm,Zeta电位为-64.8～-67.3mV,包封率为(63.37±0.29)%。制剂在考察期内各指标均无明显变化。结论:该优化处方质量稳定,可行性较强。     

Development and characterization of different low methoxy pectin microcapsules by an emulsion-interface reaction technique

In the controlled release area, biodegradable microcapsules are one of the most useful devices to deliver materials in an effective, prolonged and safe manner. A new charged film microcapsular carrier system, using three different pectins, is described. The study utilized pectin microcapsules prepared by two encapsulation mechanisms of interfacial reaction explored through interaction of charged droplet-oil-anionic surfactant-calcium or oil-cationic surfactant with negatively charged pectin. A method for drug encapsulation was developed based on the type of pectin, surfactants and emulsification technique. Both types of surfactant, anionic sodium dodecyl sulphate (SDS) and cationic benzalkonium chloride (BzACl) promoted polymer film formation on the oil droplet surfaces, probably through cross-linking and electrostatic interaction, respectively. Microcapsules consisting of pectin as shell and hydrophobic oil as core were characterized. The resulting microcapsules were relatively small particles (d< 3 microm), had high total particle number, specific surface area and drug encapsulation efficiency. They also demonstrated good stability with minimum particle aggregation. Correlation between physicochemical and drug release kinetic parameters were investigated with regard to the effect of pectin macromolecular structure and nature of surfactant used as a counterion in the manufacturing of microcapsules. The release rate of the encapsulated material (prednisolone) in three microcapsules can be controlled by manipulating the conformational flexibility of pectins in the presence of different counterions. As a result, biodegradable pectin microcapsules offer a novel approach for developing sustained release drug delivery systems that have potential for colonic drug delivery.     

内含脂质体的聚电解质微囊作为药物载体的制备与表征

目的:通过层层自组装技术(LBL)制备内含有脂质体的聚电解质微囊,并对其结构及其对药物的自沉积作用和释放性能进行研究.方法:利用共沉淀法制备碳酸钙模板,在其表面层层组装可生物降解的壳聚糖和海藻酸钠,去除碳酸钙模板后,得到内含脂质体的聚电解质微囊.通过透射电镜(TEM),扫描电镜(SEM)等对微囊的结构、自沉积作用及释放性能进行表征.结果:TEM和SEM显示本实验成功得到了内含脂质体的聚电解质微囊;随着多柔比星给药浓度的增高,载体的囊内药物浓度呈非线性增加,在给药浓度为1 mg·ml-1的条件下,微囊内的最高药物浓度达520.1 mg·ml-1;48 h内,微囊在不同pH(5.0,6.5,7.4)的PBS中的累积释放百分率分别达到59.2%,54.3%,44.8%.结论:内含脂质体的聚电解质微囊具有良好的自沉积作用和释放能力,作为新型的药物载体具有较好的应用前景.