Treatment effects of occipitomental anchorage appliance of maxillary protraction combined with chincup traction in children with Class III malocclusion.

BACKGROUND/PURPOSE: Little information related to the treatment effects of the occipitomental anchorage (OMA) appliance of maxillary (Mx) protraction combined with chincup traction is available. The aim of this study was to investigate the treatment effects of the OMA orthopedic appliance on patients with Class III malocclusion. METHODS: Pretreatment and post-treatment cephalometric records of 20 consecutively treated patients with Class III malocclusions were evaluated and compared with a matched sample of untreated Class III control subjects. RESULTS: The OMA appliance is effective for correcting skeletal Class III malocclusion in growing children. The treatment effects of this orthopedic appliance were considered to be from both skeletal and dentoalveolar changes. The skeletal effects were mainly obtained by stimulating forward growth of the Mx complex with negligible rotation of the Mx plane and restraining forward advancement of the mandible (Mn) with backward and downward rotation of the Mn plane. The observed dentoalveolar effects were mostly due to the labial tipping movement of the Mx incisors. CONCLUSION: Our results suggest that the OMA orthopedic appliance can correct the mesial jaw relationship and negative incisal over jet. This appliance is effective for correcting skeletal Class III malocclusion with both midface deficiency and Mn prognathism in growing children.     

Craniofacial skeletal dysplasia of opposite-sex dizygotic twins

Craniofacial skeletal dysplasia can lead to different skeletal malocclusions. Both environmental factors and heredity contribute to the formation of malocclusions. There are strong familial tendencies in the development of Angle's Class II and III malocclusions. Cases such as opposite-typed (Class II and III) malocclusions with skeletal and dentoalveolar discordance in siblings or dizygotic (DZ) twins have seldom been reported. We describe the rare case of a pair of opposite-sex DZ twins with completely different skeletal malocclusions, and discuss the clinical considerations for treatment. The patients were twins aged 13 years and 4 months. The girl had mandibular prognathism and a Class III dentoskeletal relationship, whereas the boy had skeletal Class II with mandibular retrusion. Several morphological traits have been implicated with hormonal effect. However, there was no evidence of whether the masculinization effect had any impact on jaw size in the female fetus or whether this effect lasted into adolescence. We suggest that, although DZ twins share the same growth environment, genetic or other unknown extrinsic factors can result in discordance of characteristics of the craniofacial skeleton, dentition, and occlusion.     

Thin-plate spline graphical analysis of the mandible in mandibular prognathism.

The chin cup has been used to treat skeletal mandibular prognathism in growing patients for 200 years. The pull on the orthopedic-force chin cup is oriented along a line from the mandibular symphysis to the mandibular condyle. Various levels of success have been reported with this restraining device. The vertical chin cup produces strong vertical compression stress on the maxillary molar regions when the direction of traction is 20 degrees more vertical than the chin-condyle line. This treatment strategy may prevent relapse due to counter-clockwise rotation of the mandible. In this report, we describe a new strategy for using chin-cup therapy involving thin-plate spline (TPS) analysis of lateral cephalometric roentgenograms to visualize transformation of the mandible. The actual sites of mandibular skeletal change are not detectable with conventional cephalometric analysis. A case of mandibular prognathism treated with a chin cup and a case of dental Class III malocclusion without orthodontic treatment are described. The case analysis illustrates that specific patterns of mandibular transformation are associated with Class III malocclusion with or without orthopedic therapy, and that visualization of these deformations is feasible using TPS graphical analysis.     

Morphometric analysis of mandibular growth in skeletal Class III malocclusion.

BACKGROUND: The craniofacial growth patterns of untreated individuals with skeletal Class III malocclusion have rarely been systemically investigated. This study used morphometric techniques to investigate the growth characteristics of the mandible in individuals with skeletal Class III malocclusion. METHODS: Lateral cephalometric head films of 294 individuals with untreated skeletal Class III malocclusion (134 males, 160 females) were selected and divided into five triennial age groups (T1-T5) and by gender to identify the morphologic characteristics and sexual dimorphism in changes of mandibular growth. Procrustes, thin-plate spline, and finite element analyses were performed for localization of differences in shape and size changes. Maximum and minimum principal axes were drawn to express the directions of shape changes. RESULTS: From T1 (age 6-8 years) to T4 (age 15-17 years), the distribution of localized size and shape changes of the mandible was very similar between the two genders. From T1 to T2 (age 9-11 years), significant lengthening of the condylar region was noted (23.4-39.7%). From T2 to T3 (age 12-14 years), the greatest size and shape change occurred at the condylar head (27.4-34.9%). From T3 to T4, the greatest size and shape changes occurred in the symphyseal region (23.6-42.1%). From T4 to T5 (age>or=18 years), significant sexual dimorphism was found in the distribution and amount of localized size and shape changes. Females displayed little growth increments during T4. Despite differences in the remodeling process, the whole mandibular configurations of both genders exhibited similarly significant upward and forward deformation from T4 to T5. CONCLUSION: We conclude that thin-plate spline analysis and the finite element morphometric method are efficient for the localization and quantification of size and shape changes that occur during mandibular growth. Plots of maximum and minimum principal directions can provide useful information about the trends of growth changes.     

Evaluation of the changes in midfacial configuration after face mask therapy in skeletal Class III growing patients by morphometric analysis techniques.

BACKGROUND AND PURPOSE: The prevalence of Angle Class III malocclusion is relatively high in Taiwan. For children who suffer from maxillary retrognathia, face mask therapy is a promising treatment modality. The purpose of this study was to evaluate the changes in midfacial configuration after face mask therapy in skeletal Class III growing patients by morphometric analysis techniques. METHODS: Thirty children who had been treated with face masks were compared with a group of 30 gender-matched, age-matched, observation period-matched, and craniofacial configuration-matched subjects with untreated Class III malocclusions. Average geometries, scaled to an equivalent size, were generated by means of Procrustes analysis. Graphical analysis, utilizing thin-plate spline analysis and strain tensor methods, was performed for localization of differences in shape and size changes. Maximum and minimum principal extensions were drawn to express the directions of shape change. RESULTS: Maxillary protraction-induced changes resulted from a combination of both orthopedic and dental effects. A significant increase in size (7.7% to 9.9%) was noted at the supero-anterior region of the midfacial configuration (rhinion-orbitale-midpalatal point-anterior nasal spine) when subjected to an extraoral traction force; 7.7% to 12.1% of increase in size and 14.4% to 33.4% of change in shape were found at the anterior portion of the maxillary alveolar bone. The directions and amount of principal strain tensors could express the magnitudes and directions of morphological changes within the midfacial complex in an efficient way. CONCLUSIONS: We conclude that morphometric analysis techniques can be used to evaluate the changes in midfacial configuration after face mask therapy and can provide a valuable supplement for conventional cephalometric analysis.     

Management of the suspicious cytologic cervical smear to the final diagnosis and therapy

The diagnostic procedures dictated by suspicious cytologic reports are described. Mass screening by cytologic techniques has yielded 2–2.5 % of Papanicoloau Class III smears. Of this group 45.1% will be patients with mild or moderate dysplasia and the remainder will have severe dysplasia, carcinoma in situ, and early invasive carcinoma. A reliable diagnosis can be obtained only by histologic examination of serial sections of the cervical cone or of the cervix after hysterectomy. Cervical conization of every patient with a suspicious cytologic smear might expose 45 % of the patients so treated to an unnecessary surgical procedure and would impose a great burden on the gynecologist and the pathologist. By employing colposcopy with selective spot biopsy, or fractional curettage for precise identification of patients with early cervical neoplasia, the number of the conizations can be reduced without increasing the false-negative detection rate.     

Surgical treatment for Perthes disease at risk.

The treatment of Perthes disease has remained controversial ever since the disorder was first described in 1910. It is generally accepted that surgical treatment is favorable if the patients are at risk clinically or radiologically. From March 1983 to March 1988, 13 patients suffering from severe Perthes disease were treated surgically at the National Taiwan University Hospital. There were 12 boys and one girl with an average age of eight years and eight months (ranging from five years and 10 months to 12 years and one month). They were all at risk either clinically or radiologically. All patients suffered from hip pain, limping and limited range of motion, except one who was pain-free. All femoral heads were classified as Catterall group III or IV, and had at least two radiologic risk signs. After nonsurgical treatment for an average duration of 13 months, including bed rest, traction and bracing as inpatients or outpatients, operations, including varus derotational osteotomy of the femur in three, Salter innominate osteotomy in one, combined surgery in three and triple innominate osteotomy in six patients, were performed. After following up for 36 months, we determined that surgical containment for Perthes disease can achieve satisfactory results. In our preliminary report, triple innominate osteotomy was one of the relatively simple and effective procedures.     

Schwangerschaftsbetreuung bei Skelettdysplasien

Several medical fields should be involved in the care for pregnancies on risk of genetic disorders with malformations. This holds true especially for skeletal dysplasias. They comprise a large heterogeneous group of rare genetic conditions characterized by impaired skeletal development with a clinical spectrum from very severe to mild. Diagnostic relying on specific prenatal ultrasound procedures is in several cases complemented by DNA-analysis. Achondroplasia will be taken as example to illustrate how information processing may assist genetic counseling and provide support to help affected families. In a very recent effort the care for rare diseases is being organized by implementation of network structures involving medical colleagues, diagnostic and research laboratories as well as self support groups.     

Mandibular metastasis in a patient with endometrial cancer

Gynecologic cancers metastatic to bone are a rare entity, and a metastasis to the mandible at initial presentation is even more infrequently seen. We present a case of a 71-year-old woman with stage IV endometrial cancer with a metastasis to the mandible, with no other sites of distal spread apparent. The endometrial tumor was a FIGO grade III adenocarcinoma. The pathologic evaluation of the mandibular lesion revealed poorly differentiated adenocarcinoma with focal squamous differentiation. She was treated with a total abdominal hysterectomy and bilateral salpingo-oophorectomy, radiation therapy to the mandible, and chemotherapy consisting of Taxol and carboplatin for six cycles. She had a complete response, but 10 months after the original diagnosis developed spinal cord compression and progressive disease in the pelvis. Patients in good clinical condition with a single bone metastasis should be treated aggressively, as survival can be extended.     

The effect of maternal Class III obesity on neonatal outcomes: a retrospective matched cohort study

Objectives: To compare outcomes of neonates born from women with Class III obesity with those whose mothers were of normal body weight. Methods: A retrospective cohort study of live-born singleton infants was undertaken. Maternal prepregnancy body mass index (BMI) defined matched normal and Class III obese cohorts. Multivariable regression models were used to determine adjusted relative odds ratios (aOR) and 95% confidence intervals (CI) for selected adverse neonatal outcomes. Results: Newborns exposed to maternal Class III obesity had greater risks of fetal overgrowth and low cord artery pH. Class III obesity was protective against small for gestational age and low birthweight. There was no difference in the risk of preterm delivery, meconium in the amniotic fluid or breastfeeding initiation. Conclusions: The new knowledge generated by this study provides further information on unique challenges faced by newborns of women with Class III obesity, suggesting more specialized care in the intrapartum and neonatal periods may be beneficial.     

The vascular architecture and innervation of the cerebral arteries in Leiothrix lutea.

The vascular architecture and innervation of the cerebral arteries in the robin-billed leiothrix, Leiothrix lutea, were studied using catecholamine fluorescence, acetylcholinesterase active staining, and immunohistochemical techniques. The cerebral arteries in Leiothrix lutea consisted of the cerebral carotid and the basilar systems. The cerebral carotid artery can be divided into the anterior and posterior rami. Due to poor development of the posterior ramus, the posterior cerebral artery originated from the anterior ramus, and an anterior communicating artery between the cerebroethmoidal arteries formed the circle of Willis. The cerebral carotid system was supplied with aminergic nerve fibers (Amn), cholinergic nerve fibers (Chn) and peptides [substance P (SP), neurokinin A (NKA), calcitonin gene related peptide (CGRP) and vasoactive intestinal polypeptide (VIP)]-like immunoreactive (LI) nerve fibers in all regions. These nerve fibers were abundant in the cerebral carotid system, but were few and scattered in the basilar system. Only neuropeptide Y (NPY)-LI nerve fibers were recognized in moderate numbers in the cerebral carotid system, but were not found in the basilar system. Innervation of the small blood vessels of the cerebral parenchyma differed from that of the cerebral superficial arteries, SP-, NKA-, CGRP- and VIP-LI nerve fibers showed a dense distribution, but Amn and NPY-LI nerve fibers showed a sparse distribution, and almost no Chn was observed. Double staining in the cerebral arteries for SP-, NKA- and CGRP-LI nerve fibers demonstrated exactly the same distribution. This suggests that SP, NKA and CGRP co-exist in the same fiber.(ABSTRACT TRUNCATED AT 250 WORDS)     

Antenatal diagnosis of meconium peritonitis in dichorionic twins: a case report

BACKGROUND: Meconium peritonitis (MP) is a chemical peritonitis, and little is known about its natural history. Below we report MP in both fetuses from a twin pregnancy, with identical clinical ultrasonographic findings but a delay in presentation. CASE: A 31-year-old woman with a twin pregnancy was referred to our institution due to fetal bowel dilatation and ascites. Serial ultrasonography demonstrated gradual but dynamic changes. Both infants were delivered at 29 weeks'gestation. The larger infant had type II MP and experienced more postoperative complications and longer ventilatory care, parenteral nutrition and hospital stay than the smaller one, who had type III MP. CONCLUSION: The type of MP at birth may be more important than birth weight in terms of neonatal morbidity. This case increases our understanding of the natural history and prognosis of MP.     

An Unusual Complication After Vaginal Hysterectomy

BackgroundUterovaginal prolapse is a common problem in older women, with significant economic and health implications. For the patient no longer desiring fertility or unwilling to undergo conservative management, the definitive treatment is a vaginal hysterectomy with simultaneous repair of anterior or posterior compartment defects if present.CaseA 66-year-old postmenopausal woman with procidentia, cystocele, rectocele, and latent stress incontinence underwent vaginal hysterectomy, anterior and posterior colporrhaphy, and placement of a modified mid-urethral sling. Perioperatively she sustained a fracture of the pubic ramus that was not explained by perioperative events or her medical history.ConclusionUnusual and unexpected complications can occur after routine vaginal surgery in the older, postmenopausal population.     

The paradox of obstetric "near misses": converting maternal mortality into morbidity

OBJECTIVE: To systematically review evidence of obstetric near-misses and their consequences. DATA SOURCES: PUBMED, OVID, and references of retrieved articles were used. METHODS OF STUDY SELECTION: Only 13 original articles describe the occurrence of obstetric/maternal near-miss morbidity to date. All were included in this review, in addition to other articles related to the epidemiology and consequences of severe acute maternal morbidity. TABULATION, INTEGRATION, AND RESULTS: Serious forms of maternal morbidity occur in about 1% of women in the United States compared to 3.01 to 9.05% in some developing settings. Worldwide, the leading causes of near-miss morbidity are hemorrhage and pregnancy-related hypertension or eclampsia/pre-eclampsia. These complications can have lasting effects, and their sequelae may result in maternal illness, injury and disability. Based on severity, we have provided three phenotypes of obstetric near-misses: Class I (near-miss with healthy infant); Class II (near-miss with feto-infant morbidity); Class III (near-miss with fetal/infant death). CONCLUSION: Obstetric near-misses should be considered as potentially chronic illnesses that warrant follow-up care because the theoretical cycle of near-miss (as postulated in this paper) can only be interrupted by the resolution of residual issues or the mother's death. Some may consider near-miss events to be obstetric successes because ultimately the mother's life was spared, but the consequences of these complications can be overwhelming and enduring.     

Recent developments in pelvic organ prolapse

Pelvic organ prolapse is a common worldwide problem. Recent advances in our understanding of its pathophysiology, along with progress made in the evaluation and treatment of pelvic support defects, are discussed. Although the pathophysiology of this condition is still not completely understood, genetic factors and environmental factors are involved. Understanding these factors better will help us to approach treatment of pelvic organ prolapse in a more logical manner. Multiple surgical techniques are available for pelvic relaxation, with a wide range of success rates ranging from 77 to 97% for various procedures. New techniques need to be studied further before being incorporated into routine practice. Better standardization of evaluation methods can help in such clinical studies.     

Prospective cohort study of pregnancy complications and birth outcomes in women with asthma

Introduction

Classification of variants of unknown significance (VUS) in the breast cancer genes BRCA1 and BRCA2 changes with accumulating evidence for clinical relevance. In most cases down-staging towards neutral variants without clinical significance is possible.

Methods

We searched the database of the German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC) for changes in classification of genetic variants as an update to our earlier publication on genetic variants in the Centre of Dresden. Changes between 2015 and 2017 were recorded.

Results

In the group of variants of unclassified significance (VUS, Class 3, uncertain), only changes of classification towards neutral genetic variants were noted. In BRCA1, 25% of the Class 3 variants (n = 2/8) changed to Class 2 (likely benign) and Class 1 (benign). In BRCA2, in 50% of the Class 3 variants (n = 16/32), a change to Class 2 (n = 10/16) or Class 1 (n = 6/16) was observed. No change in classification was noted in Class 4 (likely pathogenic) and Class 5 (pathogenic) genetic variants in both genes. No up-staging from Class 1, Class 2 or Class 3 to more clinical significance was observed.

Conclusion

All variants with a change in classification in our cohort were down-staged towards no clinical significance by a panel of experts of the German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC). Prevention in families with Class 3 variants should be based on pedigree based risks and should not be guided by the presence of a VUS.

     

Surgical treatment of subluxation and dislocation of the hips in cerebral palsy patients.

BACKGROUND AND PURPOSE: Progressive subluxation and dislocation of the hip are major complications in patients with cerebral palsy (CP), causing functional deterioration and difficulties in personal hygiene. Treatment of these problems is difficult and complicated. The purpose of this study was to describe the surgical results and long-term follow-up in a group of CP patients. METHODS: Twenty-three CP patients with subluxated (15 hips) or dislocated hips (12 hips) underwent corrective surgery between 1985 and 1993. This included 11 quadriplegic, eight diplegic, and four hemiplegic patients. Before surgery, four patients were bed-ridden, eight were sitters, six were house-ambulators, and five were community-ambulators. The average age at surgery was 8 years and 5 months. The surgical procedures consisted of femoral varus derotational osteotomy in 21 patients (25 hips), selected soft tissue release in 18 patients (22 hips), and pelvic osteotomy in 18 patients (20 hips). The center-edge angle, acetabular index, and neck-shaft angle were used as parameters to evaluate preoperative and postoperative radiographic changes. RESULTS: After an average follow-up of 4.8 years, 19 patients (22 hips) had gained hip stability, and also had improved functional status. The four bed-ridden patients all became sitters; six of the eight sitters became house-ambulators and one became a community-ambulator; all six house-ambulators became community-ambulators, and the five community-ambulators had functional improvement. Complications included nonunion at the femoral osteotomy site in one hip, redislocation in two hips, and resubluxation in one hip. CONCLUSIONS: We conclude that subluxated or dislocated hips in patients with CP can be effectively treated with aggressive correction, which may include soft tissue release, femoral derotational osteotomy, and pelvic osteotomy for improvement of hip range of motion and functional status.     

What physicians should know about the regulation of Obstetric and Gynecologic Medical Devices

This article provides background and discusses the purposes of the Medical Device Amendments to the federal Food, Drug, and Cosmetic Act of 1976, which gave the Food and Drug Administration (FDA) the responsibility of protecting the public from unsafe and ineffective medical devices. The FDA is authorized to ensure that devices are safe and effective both before and during marketing, and must classify all medical devices for human use into 1 of 3 regulatory categories based on the extent of control necessary to assure their safety and effectiveness: Class I, General Controls; Class II, Performance Standards, and Class III, Premarket Approval. Panels of experts including 1 nonvoting representative each of industry and consumers will continue until all devices are classified. Device manufacturers are required to register and list their products, and there is a premarket notification requirement applicable to manufacturers of all postamendment devices. Under certain circumstances the FDA is authorized to ban devices, order manufacturers, importers, or distributors to repair or replace devices presenting unreasonable health risks, or restrict the sale, distribution, or use of a device. The FDA promulgates regulations requiring conformity with good manufacturing practice regulations and can regulate color additives and develop performance standards for Class II devices. The development of a device and collection of data necessary to demonstrate safety and effectiveness may occur simultaneously, in which case a Product Development Protocol must be submitted to the FDA. Devices intended solely for investigational use and custom devices may be exempt from some requirements. In most cases the amendments preempt state and local requirements. Imported devices must comply with FDA regulations. The Office of Small Manufacturers Assistance has been established to assist small manufacturers in complying with the act. Greater cooperation with medical practitioners would be highly desirable in the regulation of medical devices.     

Radiographic assessment of skeletal maturation stages for orthodontic patients: hand-wrist bones or cervical vertebrae?

BACKGROUND/PURPOSE: The skeletal maturation status of a growing patient can influence the selection of orthodontic treatment procedures. Either lateral cephalometric or hand-wrist radiography can be used to assess skeletal development. In this study, we examined the correlation between the maturation stages of cervical vertebrae and hand-wrist bones in Taiwanese individuals. METHODS: The study group consisted of 330 male and 379 female subjects ranging in age from 8 to 18 years. A total of 709 hand-wrist and 709 lateral cephalometric radiographs were analyzed. Hand-wrist maturation stages were assessed using National Taiwan University Hospital Skeletal Maturation Index (NTUH-SMI). Cervical vertebral maturation stages were determined by the latest Cervical Vertebral Maturation Stage (CVMS) Index. Spearman's rank correlation was used to correlate the respective maturation stages assessed from the hand-wrist bones and the cervical vertebrae. RESULTS: The values of Spearman's rank correlation were 0.910 for males and 0.937 for females, respectively. These data confirmed a strong and significant correlation between CVMS and NTUH-SMI systems (p less than 0.001). After comparison of the mean ages of subjects in different stages of CVMS and NTU-SMI systems, we found that CVMS I corresponded to NTUH-SMI stages 1 and 2, CVMS II to NTUH-SMI stage 3, CVMS III to NTUHSMI stage 4, CVMS IV to NTUH-SMI stage 5, CVMS V to NTUH-SMI stages 6, 7 and 8, and CVMS VI to NTUH-SMI stage 9. CONCLUSION: Our results indicate that cervical vertebral maturation stages can be used to replace hand-wrist bone maturation stages for evaluation of skeletal maturity in Taiwanese individuals.