高血压合并脑出血168例临床分析

目的:掌握高血压合并脑出血患者的临床特点,有效的预防脑出血的发生,提高治愈率,减小病死率。方法:对2003年至2006年在我院住院168例患高血压合并脑出血的患者进行临床分析。结果:高发年龄在50岁～70岁,平均年龄58.2岁,死亡69例,占41.09%。病死率与年龄成正比,脑出血急性期的高病死率与脑出血继续出血有关。结论:脑出血是高血压病最常见的并发症之一,并有高致残率和高病死率,避免脑出血的发生主要措施是防治高血压。     

高血压合并脑出血168例临床分析

目的掌握高血压合并脑出血病人的临床特点，有效的预防脑出血的发生，提高治愈率，减少病死率。方法将168例患高血压合并脑出血的病人进行临床分析。结果患病高发年龄在48-58岁，平均年龄57．7岁；死亡67例，占39．9％，病死率与年龄成正比。结论脑出血是高血压病最常见的并发症之一，并有高致残率和高死亡率，避免脑出血的发生主要措施是防治高血压病。     

高血压合并脑出血168例临床分析

目的掌握高血压合并脑出血病人的临床特点，有效的预防脑出血的发生，提高治愈率，减少病死率。方法将168例患高血压合并脑出血的病人进行临床分析。结果患病高发年龄在48-58岁，平均年龄57．7岁；死亡67例，占39．9％，病死率与年龄成正比。结论脑出血是高血压病最常见的并发症之一，并有高致残率和高死亡率，避免脑出血的发生主要措施是防治高血压病。     

高血压合并脑出血84例临床分析

目的:掌握高血压合并脑出血患者的临床特点,有效的预防脑出血的发生,提高治愈率,减少病死率、致残率。方法:将84例患高血压合并脑出血的患者进行临床分析。结果:患病年龄在34岁～77岁,平均年龄57.7岁;死亡33例,病死率为39.3%,病死率与年龄成正比。结论:脑出血是高血压病最常见的并发症之一,并有高致残率和高病死率,避免脑出血发生的主要措施是防治高血压病。     

118例高血压性脑出血的临床分析

目的 掌握高血压合并脑出血患者的临床特点,有效的预防脑出血的发生,提高治愈率,减少病死率.方法 将118例患高血压合并脑出血的患者的临床资料进行临床分析.结果 患病高发年龄40～70岁,平均61岁;死亡67例,占56.77%,病死率与年龄成正比.结论 脑出血是高血压病最常见的并发症之一,并有高致残率和高病死率,避免脑出血的发生主要措施是防治高血压病.     

高血压合并脑出血127例临床分析

目的:掌握高血压合并脑出血患者的临床特点,有效的预防脑出血的发生,提高治愈率,减少病死率。方法:将127例患高血压合并脑出血的患者进行回顾性临床分析。结果:患病高发年龄在48～58岁,平均年龄57.7岁;死亡28例,占22.1%,病死率与年龄成正比。结论:脑出血是高血压病最常见的并发症之一,并有高致残率和高死亡率,避免脑出血的发生主要措施是防治高血压病。     

高血压合并脑出血68例疗效分析

目的 掌握高血压合并脑出血患者的临床特点,提高治愈率,减少病死率.方法 回顾性分析68例患高血压合并脑出血的患者的临床资料.结果 患病高发年龄在42-63岁,平均年龄55岁;死亡12例,占17.65%,病死率与年龄成正比.结论 脑出血是高血压病最常见的并发症之一,致残率和死亡率高,预防脑出血发生的主要措施是早期有效地防治高血压病.     

高血压合并脑出血160例临床分析

目的 掌握高血压合并脑出血病人的临床特点,有效的预防脑出血的发生,提高治愈率,减少病死率.方法 将160例患高血压合并脑出血的病人进行临床分析.结果 患病高发年龄在48～58 岁,平均年龄57.9岁;死亡65例,占40.6%,病死率与年龄成正比.结论 脑出血是高血压病最常见的并发症之一,并有高致残率和高死亡率,避免脑出血发生的主要措施是防治高血压病.     

高血压合并脑出血160例临床分析

目的 掌握高血压合并脑出血病人的临床特点,有效的预防脑出血的发生,提高治愈率,减少病死率.方法 将160例患高血压合并脑出血的病人进行临床分析.结果 患病高发年龄在48～58 岁,平均年龄57.9岁;死亡65例,占40.6%,病死率与年龄成正比.结论 脑出血是高血压病最常见的并发症之一,并有高致残率和高死亡率,避免脑出血发生的主要措施是防治高血压病.     

高血压性脑出血90例临床分析

目的：分析高血压性脑出血患者的临床资料,总结高血压性脑出血的诱发因素、主要症状和体征、出血部位、治疗、转归,预防脑出血的发生,提高治愈率,减轻致残率和减少病死率。方法：回顾性分析90例高血压合并脑出血患者临床资料。结果：高血压引起脑出血高发年龄在45～67岁,具有高致残率、高致死率的特点。结论：高血压是脑出血最重要的独立危险因素,控制高血压对防治脑出血至关重要,只有控制高血压,才能降低高血压性脑出血的发病率。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.