共查询到20条相似文献,搜索用时 15 毫秒
1.
We have investigated if ketoprofen 0.5 mg kg-1 i.v. provided as good
analgesia with less adverse effects compared with ketoprofen 2.0 mg kg- 1
i.v. in 107 children, aged 1-7 yr, after adenoidectomy, in a randomized,
double-blind, parallel group study design. A standard anaesthetic method
was used and all children received fentanyl 1 microgram kg-1 i.v. during
induction. Children in group 2.0 received ketoprofen 2.0 mg kg-1 and
children in group 0.5, 0.5 mg kg-1 i.v. during induction. If the child was
in pain, fentanyl 1 microgram kg-1 was given i.v. as rescue analgesia. We
found that ketoprofen provided good analgesia and only 49% of children
required fentanyl in the post- anaesthesia care unit. There were no
differences between the groups in the number of fentanyl doses, pain scores
or frequency of adverse reactions. No serious adverse reactions occurred.
相似文献
2.
We have investigated if a low dose of ketoprofen (0.3 mg kg-1) i.v.,
provided as good analgesia with less adverse effects than higher doses (1.0
and 3.0 mg kg-1) in 220 children, aged 1-7 yr, undergoing adenoidectomy, in
a prospective, randomized, double-blind, placebo- controlled, parallel
group study. The postoperative analgesic effect was notable even after the
lowest dose of ketoprofen. However, the higher doses seemed to provide
better analgesia with no increase in adverse events or intraoperative
bleeding. None of the children experienced postoperative bleeding which
would have required intervention or delayed discharge from hospital. This
study confirms the efficacy and safety of intraoperative ketoprofen in
children during adenoidectomy.
相似文献
3.
In this study, we investigated the feasibility of pain treatment using ketoprofen 25 mg tablets (5 mg x kg(-1) x day(-1)) at home in children after daycase adenoidectomy. We also determined the adverse events and the incidence of postoperative bleeding during the first week after surgery. Initially, we studied 611 children aged 1-9 years. The study design was prospective, longitudinal, and open. The final data consisted of 555 (91%) children, and 522 children who received ketoprofen at home. The parents administered four (1-10, median with 10th and 90th percentiles) ketoprofen tablets to their children during the first week. A total of 20% of the parents experienced problems in administering tablets, and problems were three times more common in children under 48 months compared to older children. The main problems were swallowing difficulties and the unpleasant taste of the tablet. Neither serious adverse events, nor clinically significant bleeding occurred. Ketoprofen at the dose of 5 mg x kg(-1) x day(-1) proved to be a safe analgesic in children for short-term use after adenoidectomy. 相似文献
4.
Comparison of intravenous and oral ketoprofen for postoperative pain after adenoidectomy in children
One hundred children, aged 19 yr, undergoing adenoidectomywere randomized to receive ketoprofen 1 mg kg1either i.v. with an oral placebo (n=40) or ketoprofen 1 mg kg1orally with an i.v. placebo (n=40), or both oral and i.v. placebo(n=20). The study design was prospective and double blind withparallel groups. The pain was assessed at rest and during swallowingusing the Maunuksela pain scale (0=no pain, 10=worst possiblepain) after surgery for 3 h. Fentanyl 0.5 µg kg1i.v. was given for rescue analgesia. Children in the i.v. groupneeded significantly less doses (1, 13; median and 10th/90thpercentiles) of rescue analgesic compared with the oral group(2, 13; P=0.024). Of those who needed rescue analgesic,three out of 30 children in the i.v. group required three ormore doses of fentanyl compared with 10 out of 28 children inthe oral group. There were no differences between the groupswith respect to pain scores, operation times, perioperativebleeding or frequency of adverse events. Br J Anaesth 2000; 85: 2247
* Corresponding author 相似文献
5.
Because nonsteroidal anti-inflammatory drugs, such as ketoprofen, prolong bleeding time, their preoperative administration may both prolong operation time and delay discharge. Therefore, charts of 335 children who had undergone adenoidectomy were evaluated to determine the effect of ketoprofen on operation time (OPERTIME) and length of hospital stay (ACTUAL LOS). The study was conducted in three phases (I-III) which differed from each other in the dose of i.v. ketoprofen, 0.3-3 mg x kg(-1). All phases were conducted with parallel groups using a prospective, randomized, and double blind design; moreover, phases I and III were placebo-controlled. OPERTIMEs were similar between Placebo groups and Ketoprofen groups. The dose of ketoprofen did not affect OPERTIME or ACTUAL LOS. In phase I, ACTUAL LOS was significantly longer in the Placebo group (251 +/- 46 min, mean +/- SD) compared to the Ketoprofen group (225 +/- 44 min, P=0.006). In conclusion, preincisional ketoprofen did not prolong OPERTIME or delay discharge in children undergoing adenoidectomy. 相似文献
6.
Murat I 《Annales fran?aises d'anesthèsie et de rèanimation》2007,26(5):472-3; discussion 474-6
7.
Postoperative pain after adenoidectomy in children 总被引:4,自引:4,他引:0
We have investigated if pain intensity or analgesic requirements in
hospital predicted pain intensity, pain duration or analgesic requirements
at home in 611 children, aged 1-7 yr, after day-case adenoidectomy. We also
investigated if ketoprofen 0.3-3.0 mg kg-1, administered pre-emptively i.v.
during operation, modified pain at home. In hospital, a prospective,
randomized, double-blind, placebo- controlled study design was performed. A
standard anaesthetic technique was used in all children and fentanyl i.v.
was available for rescue analgesia. After discharge, the study design was
open, experimental, prospective and longitudinal. On return home, children
were prescribed ketoprofen tablets 5 mg kg-1 day-1. Parents were asked to
complete an analgesia diary; non-responders were contacted by telephone.
The response rate was 91%. The number of doses of fentanyl given in
hospital correlated with pain intensity at home (P < 0.001). There were
no other correlations and no pre-emptive effect of ketoprofen.
相似文献
8.
Pain management after adenoidectomy with ketoprofen: comparison of rectal and intravenous routes 总被引:2,自引:1,他引:1
We compared the efficacy of rectally and intravenously administeredketoprofen for pain management after day-case adenoidectomy.Patients (123 children aged 19 yr) were allocatedrandomly to receive on induction of anaesthesia ketoprofen 25 mgrectally with an i.v. placebo, ketoprofen 25 mg i.v. witha rectal placebo, or placebo both i.v. and rectally. The methodof anaesthesia and the operative technique were standardized.Postoperative pain was assessed at rest and during swallowingusing the Maunuksela pain scale (0=no pain, 10=worst possiblepain). Fentanyl 0.5 µg kg1 was givenas rescue analgesia. There was no significant difference betweenthe two ketoprofen groups in their requirement for rescue analgesics.However, both the proportion of children needing rescue analgesics[55 of 84 children (65%) vs. 33 of 39 children (84%); difference19%, 95% confidence interval 434%, P=0.029] and the numberof rescue analgesic doses [mean 1.2 (SD 1.2) vs. 2.2 (1.4);mean difference 0.9, 95% confidence interval 0.41.4,P=0.001] were significantly lower among children receiving ketoprofenthan in children receiving placebo. Adverse events, durationof operation, perioperative bleeding, pain scores and time ofdischarge were similar in the three groups. Br J Anaesth 2000; 85: 83640 相似文献
9.
10.
11.
12.
Postoperative agitation is a common problem after sevoflurane anesthesia in children. In the present study, we evaluated if tropisetron or clonidine could reduce the incidence of postoperative agitation after day case adenoidectomy in small children. We included 75 unpremedicated children aged 1-7 yr who were randomly assigned to receive either placebo, tropisetron (0.1 mg/kg) or clonidine (1.5 microg/kg) after anesthesia induction. Anesthesia was induced and maintained with sevoflurane. Patients also received alfentanil (20 microg/kg) and diclofenac (1 mg/kg). Postoperative pain was treated with IV oxycodone (0.05 mg/kg). Time to achieve discharge criteria was recorded. Modified pain/discomfort scale was used assess the postoperative behavior. The incidence of postoperative agitation was significantly less (32%, 8/25 patients) in the tropisetron group compared with placebo (62%, 16/26 patients), P < 0.05). Clonidine could not prevent agitation (incidence 54%, 13/24). No adverse effects were noted during the study. Discharge times were similar between the groups (between 80 and 99 min on average). In conclusion, tropisetron 0.1 mg/kg significantly reduced the incidence of postoperative agitation after sevoflurane anesthesia. Clonidine 1.5 microg/kg did not differ from placebo with respect to postoperative agitation. 相似文献
13.
Recovery after halothane anaesthesia induced with thiopental, propofol-alfentanil or halothane for day-case adenoidectomy in small children 总被引:1,自引:0,他引:1
Viitanen H Annila P Rorarius M Paloheimo M Baer G 《British journal of anaesthesia》1998,81(6):960-962
We studied recovery from halothane anaesthesia in 93 children, aged 1-3 yr,
undergoing day-case adenoidectomy. Children were allocated randomly to
receive thiopental 5 mg kg-1 (group TH), alfentanil 10 micrograms kg- 1 and
propofol 3 mg kg-1 (group PAH) or 5% halothane (group HH) for induction of
anaesthesia. In group TH, tracheal intubation was facilitated with
succinylcholine (suxamethonium) 1.5 mg kg-1. In groups PAH and HH, tracheal
intubation was performed without neuromuscular block, and succinylcholine
was used only if required. Anaesthesia was maintained with 1-3% halothane
during spontaneous respiration. Times to achieving predetermined recovery
end-points were recorded. Quality of recovery was assessed using a score of
1-9 (best to worst) for sedation, crying, restlessness and agitation. A
postoperative questionnaire was used to determine the well-being of the
child at home, 24 h after operation. Emergence from anaesthesia (response
to non- painful stimuli) occurred earlier in group HH (mean 9 (SD 6) min)
than in groups PAH (13 (6) min, P < 0.01) and TH (18 (14) min, P <
0.01). Sitting up, walking and home readiness were achieved earlier in
groups PAH and HH than in group TH (P < 0.05 for each variable).
Children in group TH were more sedated during the first 30 min after
anaesthesia than those in the two other groups (P < 0.05) while
emergence-related delirium was more common in group HH than in group TH (P
< 0.01). Well- being at home was similar in all groups. We conclude that
induction of halothane anaesthesia with propofol-alfentanil or halothane
provided more rapid recovery and earlier discharge than that with
thiopental.
相似文献
14.
BACKGROUND: Different parenteral routes of administration of NSAIDs such as ketoprofen have not been properly compared in children. This study was designed to compare the analgesic efficacy of intravenous and intramuscular ketoprofen for pain management in children after day-case adenoidectomy. METHODS: A total of 120 children, aged 1-9 years, who were scheduled to undergo adenoidectomy, were randomized to receive ketoprofen 2 mg/kg either intravenously with intramuscular placebo (n = 40) or ketoprofen 2 mg/kg intramuscularly with intravenous placebo (n = 40), or both intravenous and intramuscular placebo (n = 40) at induction of anesthesia. The study design was prospective and double-blind with parallel groups. Pain was assessed at rest and during swallowing using the Maunuksela pain scale during 3 h after surgery, and fentanyl i.v. was given for rescue analgesia. RESULTS: Children in the Placebo group needed significantly more doses of fentanyl (72 doses) than either children in the intravenous group (47 doses) or children in the intramuscular group (51 doses) (P = 0.021). In addition, a higher proportion of children in the Placebo group than in the two ketoprofen groups (P = 0.03) demanded rescue analgesic. No difference in the need for rescue analgesia or in pain scores was found between the two ketoprofen groups. Children in the intravenous group had less pain than children in the Placebo group. The difference was significant during swallowing at 1 h after surgery (P = 0.046) and for the worst pain observed during swallowing for 3 h after surgery (P = 0.022). There were no differences between the three groups with respect to operation times, amount of perioperative bleeding, or rate or extent of adverse events. CONCLUSION: The efficacy of intravenous and intramuscular ketoprofen was similar, and they both differed from placebo. 相似文献
15.
We compared the effects of rectally administered diclofenac (12.5 mg) with paracetamol (125 mg) on pre- and postoperative behaviour and the need for supplementary analgesia in 44 children scheduled for adenoidectomy (with or without myringotomy). The study drugs were given in combination with diazepam (0.5 mg.kg-1) about 20 min before the children were taken to the operating theatre. On arrival there, the children who had received diclofenac were significantly quieter (< 0.05), easier to handle (p < 0.01) and cried less (p < 0.05) than those in the paracetamol group. During recovery, children in the diclofenac group needed fewer supplementary doses of intravenous pethidine than those receiving paracetamol (p < 0.001). There were no obvious differences between the groups in intra-operative bleeding (as estimated by the surgeon), or in measured blood loss. No postoperative complications became evident. The pre-operative rectal administration of diclofenac for pain relief after adenotomy is safe and effective. 相似文献
16.
Annila P.; Rorarius M.; Reinikainen P.; Oikkonen M.; Baer G. 《British journal of anaesthesia》1998,80(6):756-760
We studied the effect of anticholinergics on the incidence of cardiac
arrhythmias during paediatric anaesthesia. ASA I-II children (n = 77)
undergoing adenoidectomy were randomly allocated to three groups.
Intravenous atropine 0.02 mg kg-1 was given in group A (n = 25),
glycopyrrolate 0.004 mg kg-1 in group G (n = 27) and physiological saline
in group P (n = 25) 3 min before the induction of anaesthesia. The children
breathed spontaneously under halothane anaesthesia with 66% nitrous oxide
in oxygen after induction with thiopentone and succinylcholine.
Perioperative monitoring of the ECG (Holter recordings) and oxygen
saturation was carried out. Ventricular tachycardia occurred in 16.0%,
18.5% and 12.0% of the children in groups A, G and P respectively (ns). The
incidence of ventricular arrhythmias (ventricular tachycardia, ventricular
bigeminy, ventricular premature beats > 10) was 20.0% in group A, 44.4%
in group G and 36.0% in group P (ns). Bradycardia (< 70 beats min-1) was
observed in 0.0%, 14.8% and 24.0% of patients in groups A, G and P
respectively (A vs P, P < 0.05). The use of anticholinergics did not
influence the incidence of ventricular arrhythmias during halothane
anaesthesia in children. Bradycardia was more common in the placebo group
than in the atropine group.
相似文献
17.
18.
BACKGROUND: No pharmacokinetic data are available with respect to the plasma concentration of ketoprofen during intravenous infusion in children. METHODS: We present here the pharmacokinetics of ketoprofen after a 10-min intravenous infusion of 1 mg/kg followed by a 24-h infusion of 4 mg/kg in 18 children aged 7 months to 16 years. Venous blood samples were collected at 5 min, 1, 2, 4, 24 h following the loading dose, and then 1, 2 and 4 h after the end of the infusion. A validated HPLC method was used to measure plasma levels of ketoprofen. RESULTS: The steady state plasma concentration of ketoprofen was 2.0 microg/mL (range 1.3-2.7 microg/mL). The clearance of ketoprofen was 0.09 L x h(-1) x kg(-1) (range 0.06-0.13 L x h(-1) x kg(-1)). The distribution volume was 0.16 L/kg (range 0.12-0.21 L/kg). The terminal half-life was 1.3 h (range 0.8-1.7 h). CONCLUSION: The pharmacokinetics of ketopofen in children is similar to that reported in adults. Our results indicate that ketoprofen is a feasible drug for continuous intravenous infusion in acute pain treatment in children. 相似文献
19.
Dexmedetomidine is a highly specific and selective alpha‐2‐adrenergic agonist with sedative, anxiolytic, and organ protective effects. Its clinical applications in children include premedication, prevention of emergence delirium, as part of multimodal anesthetic regimen and sedation in the pediatric intensive care unit. Its role in neuroprotection in children undergoing anesthesia should be explored. In this review, various uses of dexmedetomidine are discussed in detail. 相似文献
20.
《Acta anaesthesiologica Scandinavica》1998,42(S112):133-140