The effect of superficial venous surgery on generic health-related quality of life.

BACKGROUND: Superficial venous surgery (SVS) is associated with a significant improvement in disease-specific health related quality of life (HR-QoL) but the effect on generic HR-QoL remains uncertain. The aim of this study was to determine the effect of SVS on responses to the Short Form [SF]-36, the most widely used generic HR-QoL instrument. METHOD: Two hundred and three patients undergoing SVS completed the SF-36 pre-operatively and 24 months post-operatively. Scores for the 8 SF-36 domains [physical (PF) and social functioning (SF), role limitation due to physical (RP) and emotional (RE) problems, mental health (MH), vitality (V), pain (P), and general health perception (HP)] were calculated and normalised using UK standard data. RESULTS: Pre-operatively, patients scored significantly lower (worse) than the general UK population in PF, RP and P. Surgery was associated with a significant improvement in PF and P (45.3 vs. 42.5 and 48.9 vs. 43.8 postop vs. preop, p<0.001, WSR) at 2 years. CONCLUSION: SVS leads to a statistically and clinically significant improvement in the physical components of the SF-36. These data will allow the clinical benefits of SVS to be compared with other interventions so helping informing decisions about how venous surgery should be prioritised appropriately within the NHS.     

腹腔镜胆囊切除术中气腹后中心静脉压的变化

目的观察腹腔镜下胆囊切除术中气腹后中心静脉压的变化情况,探讨其临床意义。方法无其他因素影响中心静脉压的30例病例行腹腔镜下胆囊切除术,观察二氧化碳气腹前、中、后中心静脉压的变化情况。结果二氧化碳气腹后中心静脉压明显升高,但仍在正常范围内,停止气腹后,中心静脉压快速恢复至术前水平。结论行腹腔镜下胆囊切除术时,二氧化碳气腹后的中心静脉压增加对循环系统功能影响不明显,仍在机体代偿范围,无常规检测的必要。     

Comparison of long-term quality of life after laparoscopic and open cholecystectomy

Background: Although many studies have compared open and laparoscopic procedures, showing many advantages in favor of the laparoscopic technique during the early postoperative period, only a limited number of reports in the literature compare the two techniques during the later follow-up period with regard to quality of life. This study aimed to compare the effects of these two cholecystectomy techniques on the quality of life and clinical outcome of the patients during long-term follow-up evaluation. Methods: This study evaluated 200 patients who underwent cholecystectomy operations with either technique between 1993 and 1999 in our department. There were 100 patients in each group. Both groups were similar with respect to age, gender, body mass indexes, American Society of Anesthesiology (ASA) scores, and indications for surgery. The Medical Outcome Study Short Form 36 Health survey (SF-36), which includes 36 items, was used for evaluating the quality-of-life index. In addition to this, a system-specific instrument for gastrointestinal diseases was used to investigate clinical outcome. Results: The mean administration time for the questionnaire was 46.8 ± 18.7 months in the laparoscopic cholecystectomy (LC) group and 41.5 ± 16 months in the open cholecystectomy (OC) group. Statistically significant differences were noted in the scores for all eight SF = 36 health status domains in favor of laparospopic surgery. No statistically significant difference was found for abdominal pain, location of the pain, referral to a doctor for the pain, accompanying symptoms, relieving factors for the pain, distention, and dyspeptic complaints, usage of antacid therapy, weight changes, changes in bowel habit, need for a special diet, or sexual functions between the two groups. Conclusions: The gastrointestinal clinical symptoms were similar in the two groups during the long-term follow-up evaluation, but laparoscopic cholecystectomy was found to be significantly superior to the open technique with respect to the quality of life over the long term.     

Improvement in quality of life measures after laparoscopic antireflux surgery

OBJECTIVE: To determine if patients with gastroesophageal reflux "well controlled medically" had a different quality of life from those with residual symptoms receiving aggressive medical therapy, and to determine whether laparoscopic antireflux surgery significantly altered quality of life in patients with gastroesophageal reflux. SUMMARY BACKGROUND DATA: Clinical determinants of outcome may not adequately reflect the full impact of therapy. The medical outcomes study short form (SF-36) is a well-validated questionnaire that assays eight specific health concepts in three general fields. It may provide a more sensitive tool for judging the success of antireflux therapy. METHODS: A total of 345 patients undergoing laparoscopic antireflux surgery completed at least one questionnaire during the study period. Preoperative questionnaires were completed by 290 patients, 223 completed a questionnaire 6 weeks after surgery, and 50 completed the same questionnaire 1 year after surgery. A subgroup of 70 patients was divided before surgery into two groups on the basis of their response to standard medical therapy. RESULTS: Preoperative scores were extremely low. All eight SF-36 health categories improved significantly 6 weeks and 1 year after surgery. In the 70-patient subgroup, 53 patients (76%) underwent laparoscopic antireflux surgery because of symptoms refractory to medical therapy and 17 patients (24%) reported that their symptoms were well controlled but elected to have surgery because they wished to be medication-free. The preoperative quality of life scores of these two patient groups were equivalent in all but one category. Postoperative scores were significantly improved in all categories and indistinguishable between the two groups. CONCLUSIONS: Laparoscopic antireflux surgery is an effective therapy for patients with gastroesophageal reflux and may be more effective than medical therapy at improving quality of life.     

Zeus手术机器人胆囊切除术与常规腹腔镜胆囊切除术的对比研究

目的探讨Zeus手术机器人用于胆囊切除术的价值。方法将40例择期胆囊切除术患者分为Zeus手术机器人胆囊切除组(A组)和腹腔镜胆囊切除组(B组),每组20例。结果A组擦镜次数(1.1±1.0)次和调整术野时间(2.2±0.7)min显著少于B组(4.5±1.5)次,(7.5±1.2)min。A组解剖动作次数(337±86)次和操作失误率(10%)少于B组(389±94)次,(25%)。A组手术时间(104.9±20.5)min和系统建立时间(29.5±9.8)min显著长于B组(78.6±17.1)min,(12.6±2.5)min。两组术中出血量(35.6±25.2)ml∶(31.8±16.4)ml和术后住院天数(2.8±0.8)d:(2.8±0.7)d相近,均无术后并发症,各有1例中转开腹手术。结论手术机器人胆囊切除术与腹腔镜手术相比,手术时间长,但术野控制能力好,动作精确性和稳定性更大。     

Assessing long term quality of life in geriatric patients after elective laparoscopic cholecystectomy

IntroductionWhile cholecystectomy is shown to be safe in older patients, few existent studies investigate associated quality of life. This study examines quality of life in symptomatic geriatric patients after elective laparoscopic cholecystectomy.MethodsPatients ≥65 years of age who underwent elective laparoscopic cholecystectomy at a tertiary care center were administered the 12-Item Short Form Survey (SF-12) and a gastrointestinal survey pre-operatively and post-operatively (within 6 and 18 months of surgery). Quality of life characteristics were compared amongst visit type in univariate and multivariate settings, with a mixed-model regression.ResultsOur sample included 30 patients. Pain frequency (p = 0.004) and pain severity (p = 0.013) scores improved with each subsequent visit type. SF-12 mental health aggregate score improved overall from pre-operative to long term follow-up (p = 0.0403).DiscussionOur findings suggest that health-related quality of life in geriatric patients improves after elective laparoscopic cholecystectomy in the short and long term.SummaryQuality of life was assessed in symptomatic geriatric patients undergoing elective laparoscopic cholecystectomy. Pain frequency, pain severity, and the SF-12 mental health aggregate scores improved overall from pre-operative to post-operative visit types.     

Deep venous thrombosis after laparoscopic cholecystectomy and prevention with nadroparin

Background: Postoperative thromboembolic disease has been suggested to occur with higher frequency during laparoscopic cholecystectomy than during other laparoscopic procedures or conventional cholecystectomy. The aim of this prospective study was to evaluate the occurrence of deep vein thrombosis (DVT) in laparoscopic cholecystectomy patients, whether they were treated with low-molecular-weight heparins or not. Methods: All 238 laparoscopic cholecystectomy patients included in the study underwent pre- and postoperative venous duplex scanning of both legs. Subcutaneous Nadroparin was administred to 105 patients. The remaining 133 patients did not receive pharmacologic prophylaxis. The different risk factors for thromboembolic disease were distributed evenly between the two groups, except for the duration of general anesthesia. Results: No patient had postoperative clinical manifestations of DVT or pulmonary embolism. In five patients, DVT was detected at duplex scan approximately 10 days after surgery. Four DVTs were found among the 133 patients who did not receive Nadroparin (1.68%). In the group with pharmacologic prevention, one patient manifested a DVT (0.42%), giving a total DVT incidence of 2.10% after laparoscopic cholecystectomy. The difference between the two groups was not significant (p = 0.27), but the results seem to indicate a tendency toward a lower incidence in the Nadroparine group. Conclusions: In the light of the study results, it seems advisable to use thromboembolic prophylaxis during laparoscopic cholecystectomy.     

腹腔镜胆囊切除术与开腹胆囊切除术的比较

按顺序抽取腹腔镜胆囊切除术(LC)病历110份，开腹胆囊切除术(OC)病历136份，笔者就两组病例的手术时间、切口长度、出血量及住院天数等资料进行回顾性分析和比较，结果显示：LC组在手术时间、切口长度、出血量及住院天数均短于或少于OC组。提示：LC优于OC，值得在基层推广与普及。     

Gastrointestinal quality of life in patients with symptomatic or asymptomatic cholelithiasis before and after laparoscopic cholecystectomy

Background: There is an ongoing need, from both the medical and the economic perspective, for a more accurate definition of the influence of symptomatic or asymptomatic gallstone disease on gastrointestinal symptomatology, as well as on the health of the individual in general. Methods: Using the Gastrointestinal Quality of Life Index (GIQLI), 37 symptomatic and 30 asymptomatic gallstone patients were evaluated at admission to the hospital and again 4 months after undergoing an uneventful laparoscopic cholecystectomy (LC). Results: Postoperatively, significant increases in the total GIQLI score were noted in both the symptomatic group (113.42 ± 21.9 vs 80.32 ± 19.1 preoperatively; p < 0.05) and the asymptomatic group (96.37 ± 14.26 vs 113.30 ± 15.22; p < 0.05). For the subgroups of items, the core symptoms and the physical, psychological, and disease-specific items improved significantly in both groups in the postoperative period (p < 0.05 for all comparisons), but only the symptomatic group achieved a significant improvement in the subgroup of social items (p < 0.05). Negative correlations were found in both the symptomatic and asymptomatic groups between the preoperative GIQLI scores and the improvement seen after LC (r = -0.70 and r = -0.49, respectively). Conclusion: Gallstone disease has a profoundly negative impact on quality of life, especially in symptomatic patients with a history of biliary colic attacks and/or the complications of the disease. Although the condition is not equally distressing for the asymptomatic group of patients without such a history, uncomplicated LC improves the quality of life significantly in both groups. Gallstone patients with lower GIQLI scores are more likely to benefit from LC.     

腹腔镜直肠癌切除术后生活质量评价

目的评价腹腔镜直肠癌切除术后生活质量情况。方法对我院45例直肠癌切除手术患者进行前瞻性研究,其中腹腔镜手术组23例,传统开腹手术组22例,分别在手术前、术后1个月、6个月和12个月回访填写QLQ-CR38评分量表,比较两组患者的生活质量变化。结果两组患者基本资料和术前评分具有可比性,差异无统计学意义;两组患者在胃肠道症状、化疗副反应、排便问题和造口相关问题评分差异无统计学意义(P0.05),术后1个月腹腔镜组在身体形象、未来期望和体重减轻评分具有优势(P0.05),术后6个月和12个月评分差距缩小。结论腹腔镜直肠癌手术在术后短期生活质量改善具有优势,值得推广。     

腹腔镜胆囊切除术后肝功能变化的原因

目的:探讨腹腔镜胆囊切除术后肝功能变化的原因。方法:将胆囊结石62例患者随机分为2组,A组32例,常规应用电刀切除胆囊,胆囊床普遍电凝处理;B组(对照组)30例,应用弯剪刀分离切除胆囊,钛夹钳闭止血。术后1、3、5、7d抽血测TBIL、ALT、AST、GGT、ALP含量。结果:A组术后第1天TBIL、ALT、AST明显升高,B组无升高,两组差异有显著性(P<0.01),A组术后第3天ALT、AST虽有下降,但仍高出正常值范围,差异仍有显著性(P<0.01),GGT、ALP两组均无明显升高。结论:电热损伤局部肝组织和肝外胆管的热电效应是术后肝功能变化的主要原因。     

Low incidence of deep venous thrombosis after laparoscopic cholecystectomy

The effects of the increased intraabdominal pressure that occurs during laparoscopic cholecystectomy and the effects of the reverse Trendelenburg position adopted for the procedure on deep venous thrombosis (DVT) were investigated prospectively. Thirty patients who underwent laparoscopic and 13 who underwent open cholecystectomy for symptomatic cholelithiasis were investigated for postoperative DVT. Lower extremity venous blood flow was examined by color Doppler ultrasonography before and after operations. Thrombus formation was not found in the femoral, popliteal, or iliac veins of any of the patients who underwent either open or laparoscopic cholecystectomy. None of the patients in either group displayed signs of DVT or pulmonary embolus. We concluded that the incidence of DVT does not increase with laparoscopic cholecystectomy.     

Long term quality of life after laparoscopic antireflux surgery for the elderly

Background

Studies have previously shown laparoscopic antireflux surgery is a safe and effective treatment for GERD even in elderly patients. The aim of the current study was to evaluate patients receiving laparoscopic antireflux surgery before and after 65 years of age and to assess their surgical outcomes and improvements in long term quality of life.

Methods

Patients were given a standardized symptoms questionnaire and the Short-Form 36 Health Survey for quality-of-life evaluation before and after laparoscopic total fundoplication.

Results

Forty-nine patients older than 65 years of age were defined as the elderly group (EG) whereas the remaining 262 younger than 65 years of age were defined as the young group (YG).There were 114 (36.6%) patients who filled out the SF36 questionnaire (98 in the younger group, rate: 37.4%; 16 in the elderly group, rate: 32.6%) pre- and post-operatively. There was no significant difference between the two age groups regarding preoperative PCS ( 45.6 ± 7.8 in YG vs. 44.2 ± 8.2 in EG; P = 0.51) and MCS ( 48.1 ± 10.7 in YG vs. 46.9 ± 9.2 in EG; P = 0.67). There was no significant difference between the two age groups regarding postoperative PCS (49.8 ± 11.9 in YG and 48.2 ± 9.5 in EG ; P = 0.61 and MCS (48.4 ± 10.7 in YG vs. 50.1 ± 6.9 in EG; P = 0.54).

Conclusions

In conclusion, laparoscopic total fundoplication is a safe and effective surgical treatment for gastroesophageal reflux disease generally warranting low morbidity and mortality rates and a significant improvement of symptoms comparable. An improved long-term quality of life is warranted even in the elderly.

     

Multivariate comparison of complications after laparoscopic cholecystectomy and open cholecystectomy.

OBJECTIVE: To answer the question whether laparoscopic cholecystectomy (LC) or open cholecystectomy (OC) is safer in terms of complications, the authors evaluated complications relating to 1440 cholecystectomies performed by the same surgeons in a retrospective study. SUMMARY BACKGROUND DATA: A definite pronouncement on whether LC truly is superior to OC is not possible because prospective trials are burdened with problems of recruitment. METHODS: After the introduction of LC at the authors' institution in April 1991 and until October 1993, 94.6% (700/740) of all patients admitted for operation because of symptomatic gallstone disease could be treated laparoscopically. The clinical records of the last 700 patients who underwent OC before the introduction of LC were re-evaluated with regard to both overall complications and the grade of complication (severity grade 1-4). A comparison of the incidence of complications relating to the two surgical methods, age, sex, common bile duct stones, acute cholecystitis, concomitant illness, Apache score, and length of operation was calculated by multivariate analysis using the logistic regression model. RESULTS: The total rate of complications in the OC group was 7.7%, with five postoperative deaths, compared with 1.9% and one postoperative death in the LC group. Multivariate analysis for OC revealed that both old age (p = 0.014) and the existence of common bile duct stones (p = 0.02) had independent prognostic influences in increasing the overall complication rate, whereas only old age (p = 0.019) influenced the overall complication rate after LC. Multivariate analysis of all cholecystectomies (n = 1440) showed that the overall complication rate was influenced independently by OC as a detrimental factor. CONCLUSIONS: As this analysis emphasizes, LC can be performed safely with an overall complication rate that is distinctly lower than that of OC. For selective surgery, LC is undoubtedly superior to OC and can probably be seen as a new "gold standard" for cholecystectomies.     

Health-related quality of life three years after coronary surgery: A comparison with the general population

Objectives. To assess health-related quality of life (HRQOL) in patients three years after coronary artery bypass grafting (CABG) compared to the general Norwegian population, with emphasis on age and gender-differences. Design. A cross-sectional postal survey of patients who underwent CABG in 2000. HRQOL was assessed using the Short Form 36 (SF-36). Subgroup analyses were performed according to age (<70 versus ≥70 years) and gender. Results. Of 233 eligible patients 203 responded (mean age 67.6 years, 17% females). Patients reported better scores on bodily pain than the general population (p?=?0.008), but did not differ on other subscales of SF-36. Younger patients tended to score lower, older patients higher than the general population on HRQOL. Female patients reported lower HRQOL than the general female population and reported significantly lower scores than male patients on 3 of 8 subscales. Conclusions. Three years after CABG the HRQOL is comparable to the general Norwegian population even in older patients. The older patients reported less pain than the general population.     

Single-incision laparoscopic cholecystectomy in children: a retrospective comparison with traditional laparoscopic cholecystectomy

Purpose

The natural progression of minimal access surgery is to perform the same technical operation with minimal or no evidence of scarring. In children, small case series of single-incision laparoscopic cholecystectomy suggests that the operation is feasible; however, no comparison has been made to traditional, multiport laparoscopic cholecystectomy in patient safety, outcomes, and cost.

Methods

A retrospective review of consecutive single-incision laparoscopic cholecystectomies in children was performed from January 2009 to November 2010. Demographics and outcome measures were recorded, including operative time, operative costs, length of stay, need for intravenous analgesia, and operative complications. A concurrent group of pediatric patients undergoing traditional, multiport laparoscopic cholecystectomy was used for comparison.

Results

A total of 69 pediatric laparoscopic cholecystectomies were performed from January 2009 to October 2010. Forty-two patients with a mean age of 14.7 years (range, 5.9-18.9 years) underwent attempted single-incision laparoscopic cholecystectomy, and 27 patients with a mean age of 15 years (range, 2.8-19.4 years) underwent multiport laparoscopic cholecystectomy. Mean operative time (68 vs 64.5 minutes; P, not significant [NS]), length of stay (1.45 vs 1.19 days; P, NS), and doses of intravenous analgesia (1.7 vs 2; P, NS) were not significantly different for patients undergoing single-incision or multiport laparoscopic cholecystectomy, respectively. Two patients (5%) undergoing the single-incision approach required 1 additional port be placed to complete the operation. In addition, there was no significant difference in operative costs between the single-incision and multiport approach ($7766 vs $8383; P, NS).

Conclusion

Single-incision laparoscopic cholecystectomy is safe and effective in the pediatric population. It can be performed with the same technical exposure and outcomes as multiport laparoscopy, with the added benefit of little to no scarring and no increase in cost.     

A comparison of the incidence of nausea after laparoscopic cholecystectomy and diagnostic laparoscopy

Thirty-four patients undergoing gynecologic diagnostic laparoscopy and 30 patients undergoing laparoscopic cholecystectomies were followed prospectively for nausea and vomiting 24 hours postoperatively. Diagnostic laparoscopy patients had a significantly higher incidence of nausea and vomiting than laparoscopic cholecystectomy patients with similar anesthetic techniques, duration of surgery, and population parameters. All patients had their stomach contents suctioned after induction. While both procedures involve bowel manipulation, patient position and organ manipulation differ: diagnostic laparoscopy involves the Trendelenburg position and laparoscopic cholecystectomy involves the reverse Trendelenburg; diagnostic laparoscopy involves the uterus, ovaries, and fallopian tubes while laparoscopic cholecystectomy involves mainly the gall-bladder and its appendages. These factors may contribute to the differences found in this study.