低血清胆固醇与女性抑郁症的自杀行为

目的　本文对女性抑郁症患者的血清胆固醇水平与自杀行为的关系进行了探讨。方法　对 116例样本进行血清胆固醇水平测定 ,其中抑郁症伴自杀行为的 40例 ,抑郁症不伴自杀行为的 3 6例 ,正常人 40例。结果　抑郁症伴有自杀行为组血清胆固醇水平明显低于无自杀行为组和正常对照组。血清胆固醇水平与自杀的严重程度呈明显相关。结论　我们认为低血清胆固醇水平可增加女性抑郁症自杀的风险。推测低血清胆固醇导致的自杀行为可能与中枢 5 羟色胺 ( 5 HT)功能降低有关。     

血清总胆固醇及其低、高密度脂蛋白胆固醇的水平下降与抑郁症患者自杀行为的关系

目的 本文对抑郁症患者的血清胆固醇(TC)及高密度脂蛋白胆固醇(HDI)及低密度脂蛋白胆固醇(LDL)的水平与自杀行为的关系进行了探讨。方法 对107例样本进行了上述测定，其中病例组67例，抑郁症伴自杀行为者33例，无自杀行为者34例，正常对照组40例。结果 抑郁症伴有自杀行为者TC及LDL明显低于无自杀行为者和正常对照组，而HDI与无自杀行为者和正常对照组无明显差异。TC及LDL水平与自杀的严重程度呈明显相关。结论 我们认为TC和LDL水平的降低可增加抑郁症患者自杀的风险。     

抑郁症自杀未遂患者血清脑源性神经营养因子水平的变化

目的探讨血清脑源性神经营养因子（BDNF）水平与抑郁症患者自杀行为的关系。方法采用酶联免疫分析实验测定抑郁症自杀未遂患者（36例）、无自杀行为患者（55例）及36名正常对照血清BDNF水平,对抑郁症患者以汉密尔顿抑郁量表（HAMD）评定抑郁症状,以自杀意念自评量表（SIOSS）评定自杀意念的强烈程度。结果抑郁症患者组血清BDNF水平低于正常对照组（P〈0．01）。自杀未遂组血清BDNF水平低于无自杀组及正常对照组（P〈0．01）。自杀未遂组HAMD总分和SIOSS总分高于无自杀组。抑郁症患者血清BDNF水平与SIOSS总分呈负相关。结论抑郁症患者存在血清BDNF降低,BDNF水平可能是自杀倾向行为的生物学标志。     

5-羟色胺和胆固醇水平对抑郁症患者再次自杀风险评估的研究

目的 探讨抑郁症患者血小板5-羟色胺（5-HT）和胆固醇水平与抑郁症患者再次自杀的关系.方法 对33例有自杀行为的抑郁症患者在接受治疗前测定血小板5-HT和胆固醇水平,评定汉密尔顿抑郁量表（HAMD-24）和Beck绝望量表（BHS）,然后进行2年的随访.结果 16例患者再次出现自杀行为,再次自杀组血小板5-HT及血清胆固醇水平显著低于无再次自杀组（P＜0.01）.5-HT和血清胆固醇水平与HAMD-24、BHS分及自杀次数、自杀严重程度均呈负相关（P＜0.01）,且5-HT与血清胆固醇水平呈正相关（P＜0.01）.多重回归分析显示血小板5-HT浓度、家族史是自杀次数的主要影响因素.结论 低血小板5-HT及血清胆固醇浓度是抑郁症自杀的危险因素,对抑郁症自杀行为可能具有一定的的预测作用.     

抑郁症患者的自杀意念与血清总胆固醇水平

对110例抑郁症患者的血清总胆固醇（STch)水平与自杀意念的关系进行了探讨。研究组中男性45例,女性65例;正常对照组82例。结果110例抑郁症患者STch均值明显低于对照组。STch水平与自杀意念、自杀行为呈明显的负相关。认为低STch水平可增加抑郁症患者自杀的危险性。     

抑郁症自杀未遂患者的临床特征

目的：探讨抑郁症自杀未遂患者的l临床特征。方法：采用自制的抑郁症自杀未遂调查表和Hamiltion抑郁量表(HAMD)，对符合中国精神疾病分类方案与诊断标准第2版修订本诊断标准的住院抑郁症自杀未遂患者67例进行调查，以同期住院无自杀行为的抑郁症患者145例为对照。结果：自杀未遂组HAMD总均分明显高于无自杀行为组，逐步回归分析发现绝望感对自杀的影响最大，其次是抑郁情绪、自卑感和自知力。结论：有自杀行为与无自杀行为的抑郁症在l临床症状方面存在一定差异。     

精神分裂症自杀未遂者脑源性神经营养因子研究

目的:探讨影响精神分裂症自杀未遂患者脑源性神经营养因子(BDNF)水平的相关因素。方法:采用横断面病例-对照研究设计。研究包括精神分裂症自杀未遂组20例,精神分裂症无自杀行为组28例,正常对照组30名。采用酶联免疫吸附试验法测定血清BDNF浓度。采用简明精神病评定量表(BPRS)和自杀意图自评量表(SIOSS)对患者组进行评定。比较各组BDNF水平及其与相关因素之间的关系。结果:三组间BDNF水平差异有统计学意义(F=32.395,P<0.01)。Post-hoc分析发现,精神分裂症自杀未遂组BDNF水平[(51.3±11.1)pg/ml]显著低于精神分裂症无自杀行为组[(67.7±20.8)pg/ml](P<0.05),而精神分裂症无自杀行为组BDNF水平也低于正常对照组[(111.3±39.0)pg/ml](P<0.01)。自杀未遂组的血清BDNF水平与自杀严重程度呈负相关(r=-0.836,P<0.01)。结论:精神分裂症自杀未遂患者BDNF水平低于精神分裂症无自杀行为患者和正常人群;BDNF可能是参与精神分裂症自杀病理生理机制的一种重要物质。     

有无自杀意念抑郁症患者血脂水平与P_(300)的相关性

<正>抑郁症(major depressive disorder,MDD)患者常具有自杀意念或自杀行为等表现,研究发现低血清胆固醇水平与自杀未遂或者自杀意念有关[1],也有研究发现MDD患者的自杀意念与甘油三酯水平呈负相关[2]。有研究推测低血清胆固醇水平引起神经细胞膜的微粘度及5-羟色胺(5-hydroxy tryptamine,5-HT)受体和转运体功能改变[3-4],导致5-HT水平或者活性降低,但由于缺乏直接测量中枢5-HT水平或者活性的方法,血清血脂水平与中枢5-HT水平或活性的关系仍不清楚。强度依赖的听觉诱发电位(loud-     

抑郁症患者自杀行为与血清脑源性神经营养因子水平的关系

目的:探讨血清脑源性神经营养因子(BDNF)水平与抑郁症患者自杀行为之间的关系.方法:采用酶联吸附反应方法对有自杀行为的21例抑郁症患者(自杀组)、无自杀行为的52例抑郁症患者(非自杀组)以及80例正常人(对照组)血清的BDNF进行检测,应用汉密尔顿抑郁量表(HAMD)对抑郁症患者的抑郁症状进行评定. 结果:抑郁症患者...     

血清胆固醇水平与精神分裂症自杀未遂

几项研究显示。低胆固醇水平与自杀有关，为在精神分裂患者中明确低血清胆固醇水平与自未遂史之间的关系，我们对１２４例患精神分裂症的自杀未遂者的血清胆固醇水平进行了调查和测定。     

抑郁症患者血清胆固醇、脂蛋白和载脂蛋白的水平及其意义

目的 探讨抑郁症患者血清水平及其临床意义。方法 采用酶法及免疫比浊法检测６６例抑郁症和３６名健康对照者的血清胆固醇（ＴＣ），甘油三脂（ＴＧ），高密度脂蛋白－胆固醇（ＨＤＬ－Ｃ）低密度脂蛋白－胆固醇（ＬＤＬ－Ｃ），载脂蛋白ＡＩ（ａｐｏＡＩ）和载脂蛋白Ｂ（ａｐｏＢ）水平，并比较其中内源性抑郁患者（３４例）与非内源性抑郁患者（３２例），有自杀行为者（２５例）与无自杀行为者（４１例）的血脂水平。结果 与对     

Serum cholesterol, suicidal behavior and impulsivity in cocaine-dependent patients

Relationships between serum cholesterol and suicidal behavior have been reported. As suicidal behavior is common in cocaine dependence, we looked for a relationship with serum cholesterol. To do this, we compared 57 cocaine-dependent patients who had attempted suicide with 111 cocaine-dependent patients who had never attempted suicide for their admission total serum cholesterol levels. We found that there were no significant differences between cocaine-dependent patients who had or had not attempted suicide in their total serum cholesterol levels. Also, there were no significant correlations between total serum cholesterol levels and scores on the Barratt Impulsivity Scale. Thus, admission total serum cholesterol does not appear to be clinically useful in the assessment of suicidal behavior in cocaine-dependent patients.     

No evidence for an association between serum cholesterol and the course of depression and suicidality

In a number of previous reports, an association of altered, in most cases lower, serum cholesterol levels with depression, suicidal ideation and current or past suicidal behavior has been suggested. In this investigation, the course of serum cholesterol concentrations was measured in depressed patients during treatment. Ninety-two inpatients with a major depressive episode were included. Serum lipid concentrations were assessed at admission, after 1 week and after 4 weeks of antidepressant treatment. Degrees of depression and suicidality were measured with the Hamilton Depression Rating Scale. Although there was a significant reduction in depression and suicidality scores, neither a significant change in serum cholesterol levels nor a correlation between cholesterol levels and clinical improvement was found. Further, there were no significant differences in lipid levels between patients with and without a history of attempted suicide. In patients who had used a violent method, there was a trend for lower total cholesterol levels compared to those who had poisoned themselves. The results of this study do not support the hypothesis of an association of serum cholesterol with the course of depression and suicidal ideation. Cholesterol levels do not appear to be an appropriate biological marker for suicidality during the first 4 weeks of treatment in patients with a major depressive episode.     

Suicidal behavior in depression: relationship to platelet serotonin transporter

OBJECTIVE: Suicidal behavior in depressed patients is associated with low central serotonin. Thus, platelet serotonin uptake in relation to suicidal behavior in depression was examined. METHODS: Depressed patients who had never attempted suicide (n = 23) were compared with depressed patients who had never attempted suicide (n = 26) and normal controls (n = 71) for platelet serotonin uptake. RESULTS: Depressed patients who had a lifetime history of a suicide attempt had a significantly greater apparent Michaelis constant (Km) of platelet serotonin uptake than either depressed patients who had never attempted suicide or controls. Patients rated high for current suicidal ideation at the index admission had significantly higher Km values than patients rated low. Also, patients who reattempted or committed suicide during a 5-year follow-up period had significantly higher Km values than controls. Among women patients who had attempted suicide there was a significant correlation between extrapunitive hostility scores and Km values. CONCLUSION: The serotonin transporter warrants further study in relation to suicidal behavior in depression.     

Low serum cholesterol is correlated to suicidality in a Korean sample

OBJECTIVE: The aim of this study was to examine further the association between low total serum cholesterol and suicidal behaviour. METHOD: We measured the serum cholesterol levels in 231 patients admitted to an emergency room following a suicide attempt, in 231 age-,sex- and diagnosis-matched non-suicidal psychiatric controls, and in 231 age- and sex-matched normal controls. The suicide attempt patients were divided into five grades according to the degree of injury. RESULTS: The mean total cholesterol level of the suicide attempt patients was significantly lower than that of the psychiatric and normal controls.When the suicide attempt patients and non-suicidal psychiatric controls were divided by diagnosis, this significant relationship held true for major depressive disorders and personality disorders, but not for schizophrenia and bipolar disorders. Cholesterol level and the severity of suicide attempt were inversely correlated. CONCLUSION: The results suggest that cholesterol level may serve as a marker for suicide risk. Possible explanations are discussed.     

Relation of serum cholesterol, lipid, serotonin and tryptophan levels to severity of depression and to suicide attempts

OBJECTIVE: To determine if there is a relation to low serum cholesterol, lipoprotein, serotonin or tryptophan levels in patients with depression who have recently attempted suicide. DESIGN: Biochemical and behavioural study. SETTING: Inpatient and outpatient treatment at the Instituto Mexicano de Psiquiatría. PARTICIPANTS: Thirty-three patients with a diagnosis of major depressive episode. Eighteen of these patients had attempted suicide in the month before the start of the study; 15 patients had never attempted suicide. OUTCOME MEASURES: Serum levels of total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides, serotonin (5-HT) and tryptophan. Scores on Hamilton Depression Rating Scale, Carroll Depression Rating Scale, Beck Hopelessness Scale and Beck Suicide Attempt Severity Scale. RESULTS: There were no significant differences between patients who had attempted suicide and those who had not in terms of serum cholesterol, HDL, LDL and triglyceride levels. Serum levels of 5-HT and tryptophan were significantly lower in patients with depression who had a recent suicide attempt than in those patients who had never attempted suicide. A comparison of patients not taking antidepressant medication found serum 5-HT levels to be more than 3 times lower in those patients with a recent suicide attempt than in patients with no history of suicide attempt. CONCLUSIONS: The study found no difference in lipid profiles between patients who had attempted suicide and those who had not. Low serum levels of 5-HT may increase the risk of suicide attempt in patients who are depressed.