厄贝沙坦分散片联合硝苯地平控释片治疗高血压的疗效观察

目的探讨厄贝沙坦分散片联合硝苯地平控释片治疗高血压的疗效。方法采用随机对照试验,将116例确诊为原发性高血压的患者随机分为治疗组56例、对照组60例,治疗组给予厄贝沙坦分散片联合硝苯地平控释片治疗,对照组给予硝苯地平控释片治疗,两组均治疗8周,治疗结束后检测患者血压恢复情况。结果治疗8周后,总有效率治疗组96．4％、对照组83．3％,两组总有效率比较,差异具有统计学意义（P〈0．05）;治疗组与对照组患者的血压下降程度比较,差异具有统计学意义（P〈0.05）。结论厄贝沙坦分散片联合硝苯地平控释片治疗原发性高血压疗效显著。     

硝苯地平控释片与依那普利联合应用方案治疗原发性高血压的临床疗效观察

目的:探讨硝苯地平控释片与依那普利联合应用方案治疗原发性高血压的临床疗效。方法:选取96例原发性高血压患者为研究,随机分为治疗组,对照组1及对照组2,每组各32例患者,治疗组患者采用硝苯地平控释片与依那普利联合方案进行治疗,对照组1患者单服硝苯地平控释片,对照组2患者单服依那普利进行治疗,将三组患者的临床疗效进行统计及比较。结果:治疗组32例患者,显效14例,有效16例,无效2例,总有效率为93.75%;对照组1的32例患者,显效11例,有效13例,无效8例,总有效率为75%;对照组2的32例患者,显效10,有效15,无效7例,总有效率为78.13%。三组患者治疗效果比较,治疗组患者的总有效率明显高于对照组1和对照组2,差异具有统计学意义(P<0.05)。结论:硝苯地平控释片与依那普利联合应用方案治疗原发性高血压临床疗效好,能有效降低血压,值得临床推广应用。     

缬沙坦与硝苯地平控释片联合治疗原发性高血压的临床疗效观察

目的:探究在原发性高血压治疗时,采用缬沙坦与硝苯地平控释片联合治疗的效果.方法:针对360例原发性高血压患者实施分组,分组后对照组患者采用硝苯地平控释片治疗,观察组患者使用缬沙坦与硝苯地平控释片联合治疗;此后观察并比较两组治疗效果.结果:观察组患者治疗的总有效率为94.44％,对照组治疗的总有效率为80.55％,两组比较明显为观察组较高,且P＜0.05则说明差异明显.结论:缬沙坦与硝苯地平控释片联合治疗原发性高血压的临床疗效观察发现,其能够有效降低患者血压,提高临床治疗的效果,因此值得在原发性高血压治疗时推广使用.     

缬沙坦联合硝苯地平控释片治疗原发性高血压的效果研究

目的分析缬沙坦与硝苯地平控释片两药联合应用于原发性高血压的临床治疗中的疗效。方法选取2016年2月至2019年1月,我院接收的原发性高血压患者60例,随机将其分为A、B两组,各组30例,A组单独采用缬沙坦实施治疗,B组采用缬沙坦与硝苯地平控释片治联合治疗,对A、B两组患者的临床的治疗结果进行对比。结果治疗后,B组者临床治疗的总有效率为96.67%,A组为80.00%,B组总有效率明显高于A组,P 0.05;且B组患者不良反应率3.33%明显低于A组的23.33%,P 0.05,两组对比差异显著。结论采用缬沙坦与硝苯地平控释片联合对原发性高血压患者进行治疗疗效明显,患者血压控制效果较好,且安全性高,值得推广。     

贝那普利联合硝苯地平控释片治疗原发性高血压的临床分析

目的 探讨贝那普利联合硝苯地平控释片治疗原发性高血压的临床效果.方法 选取106例原发性高血压患者为研究对象,随机分为对照组和治疗组,每组53例.对照组患者给予硝苯地平控释片治疗,治疗组患者给予贝那普利联合硝苯地平控释片治疗.2组疗程均为8周,对比分析2组的治疗效果.结果 经过8周的治疗,对照组总有效率为79.2%,治疗组总有效率为94.3%,2组差异有统计学意义(P﹤0.05).治疗组在治疗后收缩压(SBP)和舒张压(DBP)的下降情况都要比对照组明显,2组差异有统计学意义(P﹤0.05).结论 采用贝那普利联合硝苯地平控释片治疗原发性高血压,能够取得更好的临床治疗效果.     

硝苯地平控释片联合福辛普利治疗原发性高血压疗效观察

目的：观察硝苯地平控释片联合福辛普利治疗原发性高血压的疗效,并与苯磺酸氨氯地平联合福辛普利的疗效进行比较。方法：选取72例原发性高血压患者,随机分为两组,治疗组36例,给予硝苯地平控释片联合福辛普利治疗,对照组36例,给予苯磺酸氨氯地平联合福辛普利治疗,共用药8周。结果：治疗组总有效率为94.3%,对照组为66.5%（P〈0.05）。结论：硝苯地平控释片联合福辛普利可更有效地降低收缩压和舒张压,疗效优于苯磺酸氨氯地平联合福辛普利。     

硝苯地平缓释片配伍氯沙坦钾片治疗血液透析患者高血压65例疗效观察

目的:观察比较硝苯地平缓释片联合氯沙坦钾片治疗血液透析患者高血压的临床效果。方法:将195例血液透析高血压患者均分为联合用药组、硝苯地平缓释片组及氯沙坦钾组,其中联合用药组口服给予硝苯地平缓释片及氯沙坦钾片,观察比较三组患者的症状体征及治疗前后收缩压和舒张压的变化。结果:治疗后,三组患者的症状体征及收缩压和舒张压均有所改善,联合用药组、硝苯地平缓释片组及氯沙坦钾组的总有效率分别为96.9%、87.7%、86.2%,联合用药组对于舒张压和收缩压的降低程度和临床有效率均显著优于单独用药的两个组(P<0.05)。结论:硝苯地平缓释片联合氯沙坦钾片治疗血液透高血压患者的临床疗效优于单独用药。     

缬沙坦与硝苯地平控释片治疗老年原发性高血压的临床观察

目的:观察缬沙坦与硝苯地平控释片治疗老年性原发性高血压的疗效。方法:选择80例原发性高血压患者,随机分为观察组40例和对照组40例,对照组给予缬沙坦,观察组给予缬沙坦联合硝苯地平控释片,观察两组治疗前后血压变化。结果:观察组总有效率为95%,优于对照组的80%,差异有统计学意义(P<0.05)。结论:缬沙坦与硝苯地平控释片治疗原发性高血压疗效确切。     

辛伐他汀联合硝苯地平控释片对原发性高血压的协同降压作用

目的评价辛伐他汀联用硝苯地平控释片治疗原发性高血压的临床疗效与安全性。方法 120例原发性高血压患者随机分为2组：治疗组给予硝苯地平控释片30mg/d,辛伐他汀20mg/d。对照组给予硝苯地平控释片30mg/d。12周后观察2组血压,血脂变化。结果治疗组总有效率为96.2%,对照组总有效率为81%,2组比效差异有统计学意义（P〈0.05）。2组24h、日间、夜间动态血压比较差异均有统计学意义（P〈0.05）;治疗组血脂异常患者与对照组血脂异常患者治疗前后相比总胆固醇、甘油三脂、低密度脂蛋白下降有显著性差异（P〈0.05）。结论辛伐他汀与硝苯地平控释片联用有明显的协同降压作用,尤其适用于高血压伴高脂血症患者。     

硝苯地平加玉米须治疗原发性高血压临床观察

目的观察硝苯地平控释片加玉米须治疗高血压临床疗效。方法 102例原发性高血压患者随机分成治疗组和对照组,每组各51例。治疗组用硝苯地平控释片加玉米须治疗;对照组单纯用硝苯地平控释片治疗。观察临床疗效,治疗组的治愈率(56.86%)、总有效率(92.15%)均显著高于对照组的治愈率(33.33%)、总有效率(70.58%)(P0.01)结论硝苯地平控释片加玉米须治疗原发性高血压疗效明显优于单用硝苯地平控释片者。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.