连续间置空肠储袋代胃术的临床应用

目的：探讨连续间置空肠储袋代胃术在胃癌全胃切除术后消化道重建方面的优点,以减少全胃切除术后患者并发症的发生率。方法总结自2008年3月至2012年10月,抚顺市中心医院76例胃癌全胃切除术患者的临床资料,对比传统的Roux-en-Y消化道重建及Roux-en-Y＋空肠储袋消化道重建术式的并发症、Visick分级指数及营养指标等。结果应用连续间置空肠储袋代胃术行术后消化道重建的32例病例术后恢复良好,与另外两组消化患者比较,术后并发症发生率明显较低;术后1年的Visick分级指数及营养指标较好。结论全胃切除术后连续空肠储袋代胃可以有效地改善患者的营养状态,降低术后并发症的发生率,提高生活质量,是一种比较理想的消化道重建术式。     

全胃切除间置空肠改良空肠代胃术60例报告

目的探讨减少全胃切除术后并发症、提高患者生活质量的方法。方法对60例患者行全胃切除并淋巴结扩清后行间置空肠代胃术。结果本术式优点为:(1)抗返流作用强;(2)有类似胃腔的储存功能;(3)保持消化道的连续性;(4)可保留部分运动及消化功能。结论本术式术后并发症少,胆汁返流发生率低,患者生活质量明显提高。     

空肠间置代胃术在胃癌患者全胃切除中的临床效果

目的 观察根治性全胃切除后进行空肠间置代胃术与单纯Roux-en-Y吻合术对胃癌患者疗效的影响.方法 临床纳入进行根治性全胃切除的胃癌患者90例,根据全胃切除术后消化道重建方式的不同分为研究组与对照组,研究组进行空肠间置代胃术,对照组进行单纯Roux-en-Y吻合术.观察2组手术后血红蛋白浓度(Hb)、血浆前白蛋白(PA)、血浆总蛋白(TP)差异;采用Spitzer评分方法对术后患者生活质量进行评价;观察术后2组患者并发症发生率.结果 术后6个月,2组患者Hb、PA、TP水平差异无统计学意义(P>0.05);术后12个月,研究组Hb、PA、TP水平分别为(122.26±14.06)g/L、(325.48±11.62)mg/L、(64.05±3.54)g/L,对照组Hb、PA、TP水平分别为(133.65±18.26)g/L、(345.64±18.37)mg/L、(67.26±4.55)g/L,2组差异均有统计学意义(P<0.05).术后12个月对患者进行Spitzer评分:研究组活动情况、健康状况、总分分别为(1.42±0.62)、(1.13±0.64)、(1.36±0.62),对照组分别为(0.85±0.65)、(0.71±0.66)、(1.14±0.59),2组差异均有统计学意义(P<0.05).研究组术后并发症发生率为4.44%,远低于对照组的22.22%,差异有统计学意义(P<0.05).结论 胃癌患者采用根治性全胃切除空肠间置代胃术,能够有效提高术后肠道吸收功能,改善营养状况,并能在一定程度上提高患者的生活质量,值得推广.     

全胃切除连续间置空肠代胃消化道重建术

[目的]探讨连续间置空肠代胃消化道重建术在全胃切除后的应用价值.[方法]对2000年1月至2002年3月间26例全胃切除连续间置空肠代胃术的临床资料进行分析.[结果]全组病人无手术死亡和吻合口瘘发生.随访12个月至25个月,平均17.4个月.其中钡餐检查11例,代胃容量均在300ml以上,排空时间为30min～120 mm.术后6个月、12个月出现反流性食管炎分别为6例和2例.与术前相比,术后生活质量有所提高.[结论]连续间置空肠代胃术是全胃切除消化道重建的理想术式,手术操作简便省时,可取得较好的生活质量.     

胃癌全胃切除空肠间置代胃术临床评价

[目的]评价胃癌全胃切除术后连续性空肠间置代胃消化道重建术的临床应用.[方法]全胃切除后距屈氏韧带50cm处结肠后提起空肠,顶端与食管行端侧吻合(A),在A下方行空肠侧侧吻合(B),在B下方再行空肠侧侧吻合(C),在吻合口B、C降支空肠与十二指肠断端行端侧吻合(D),在D的下方降支空肠和B的下方升支空肠以7号丝线结扎.[结果]本术式有四个吻合口,借助管型吻合器吻合,不费时,手术时间平均3小时,不输血.全组36例患者均得到随访,患者均有食欲感,每日进餐4～6次,体重多恢复至术前水平或有增加,血红蛋白、血清蛋白均在正常范围,患者能从事家务及部分体力劳动,对术后生活质量感到满意.[结论]空肠间置代胃术使食物通过十二指肠符合生理;有效防止了反流性食管炎及倾倒综合征;无需切断空肠,手术省时、简捷安全,是胃癌全胃切除术后一种较为合理的消化道重建术式.     

肿瘤患者全胃切除连续间置空肠代胃消化道重建术观察

背景与目的:全胃切除术后患者易出现的低体重、反流性食管炎和严重的倾倒综合征等情况,严重地影响着患者的生活质量.积极探索一种理想的消化道重建方式,以减轻患者术后消化功能紊乱的症状,改善其生活质量是我们追求的目标.本研究旨在通过检测全胃切除术后患者体质量、血液指标、代胃容量变化,探讨连续间置空肠代胃消化道重建术在全胃切除后的应用价值.方法:对2000年1月-2010年3月间42例行全胃切除连续间置空肠代胃术的患者的临床资料进行分析.结果:全组患者无手术死亡和吻合口漏发生.随访12～24个月,平均17.4个月.术后6、12个月患者血红蛋白、外周血淋巴细胞数较术前有所提高.其中钡餐检查11例,代胃容量均在300mL以上,胃排空时间为30～120min.术后6、12个月分别有11例和4例患者出现反流性食管炎.与术前相比,患者术后生活质量有所提高.结论:全胃切除术采用连续间置空肠代胃消化道重建术,恢复食物经过十二指肠通道,对降低患者全胃切除术后的并发症和提高患者生活质量具有重要意义.     

胃癌全胃切除后SS和P型间置空肠代胃术31例报告

目的探讨胃癌行全胃切除术后空肠代胃术式的生理功能.方法回顾和分析1990年6月～2000年8月因胃癌手术31例.其中胃底贲门癌经胸腹联合切除8例,行间置空肠代胃(JI)SS型吻合3例,间置空肠代胃(JI)P型5例.胃体癌经腹切除者23例,其中SS型吻合13例,P型10例.两组随访6个月～5年,平均21个月.总结分析两种肖化道重建术式的临床资料.结果SS型和P型术后两组病人观察指标钡剂排空时间30～60分钟和80～120分钟分别为62.5%、66.7%和37.5%,33.3%;Visick分级指数Ⅰ～Ⅱ级分别为87.7%和86.7%;血浆总蛋白(BLA)分别为73.6±1.1%和74.4±1.3%;血红蛋白(HB)分别为15±1.3和15±1.5;PNI指数分别为54.15和56.1;SS型术后并发返流性食管炎的发生率12.5%.结论全胃切除术采用SS型和P型间置空肠代胃,恢复食物经过十二指肠通道,对降低全胃切除术后的并发症和提高生活质量具有重要的意义.     

全胃切除人工幽门Nakayama氏空肠代胃术13例报告

对１３例胃恶性肿瘤病员施行全胃切除人工幽门Ｎａｋａｙａｍａ氏空肠代胃术，通过２月至５年的随访，结果表明该术式能完全防止返流，认为是一种理想的代胃术。     

全胃切除、空肠翻转代胃消化道重建术的研究

目的探讨更加符合生理学要求的全胃切除消化道重建术式。方法对30例例胃癌患者行根治性全胃切除、翻转部分空肠代胃消化道重建术。结果30例患者术后未发生吻合口瘘及狭窄,无返流性食管炎、倾倒综合征和“无胃”综合征的发生。1年生存率为82．85（24／29）,2年生 率为65．5％（19／29）,3年生存率为52．6％（10／19）。82．8％（24／29）的患者术后6个月体重恢复或超过术前水平。结论根治性全胃切除,翻转部分肠代胃消化道重建术,是1种简捷易行,安全可靠的理想术式。     

根治性全胃切除，间置“O”环空肠代胃消化道重建术的临床研究

自１９９０年１月至１９９５年１月．作者为３１例胃体或累及胃体部的胃恶性肿瘤施行了根治性全胃切除，管状消化道吻合器食管－间置“０”环空肠（代胃）－十二指肠吻合消化道重建术。体会是：对胃体或侵及胃体部的癌，全胃切除术是有价值的。利用国产管状消化道吻合器行间置“０”环空肠代胃术具有以下优点：①重建的消化通路符合生理，食物正常通过十二指肠而具有较好的消化吸收功能；③代胃袋够大，能满足食物的贮存作用，避免了食糜排空过快；③避免了碱性的十二指肠液向食管返流；④在使用吻合器的情况下，手术简捷易行。为全胃切除消化道重建的理想术式。     

全胃切除消化道重建术式的比较

目的：探讨全胃切除后消化道重建的最佳术式。方法：对148例胃癌行全胃切除病例进行回顾性分析。结果：Roux-en-Y吻合术25例、空肠袋加Roux-en-Y吻合术30例、间置空肠代胃术23例、空肠袋加间置空肠代胃术22例、功能性间置空肠代胃术48例;功能性间置空肠代胃术术后并发症发生率10.4%,优于其他各组44%,26.7%,34.7%,22.7%,10.4%;Visick分级Ⅰ级Ⅱ级百分比为77.1%,优于其他各组48.0%,46.7%,52.2%,45.5%;在手术时间、术后生存率及体重变化方面无明显差异。结论：功能性间置空肠代胃术可以有效减少术后并发症的出现,且手术操作安全简便,在各方面都相对于另外四种术式更有优势。     

Functional jejunal interposition versus Roux-en-Y anastomosis after total gastrectomy for gastric cancer: A prospective randomized clinical trial

BackgroundNutritional status and quality of life deteriorate significantly after total gastrectomy for patients with gastric cancer. The numerous types of reconstruction proposed by medical researchers around the world have limited effect. This prospective, randomized clinical trial compared functional jejunal interposition with Roux-en-Y anastomosis to identify the optimal reconstruction procedure.MethodsThis was a multi-center, prospective, randomized control trial. The enrolled patients were randomly assigned into the functional jejunal interposition group and the Roux-en-Y group. All patients were followed up at regular intervals after surgery. The endpoints were postoperative nutritional status, quality of life, and long-term postoperative complications.ResultsA total of 113 patients were enrolled from August 2012 to September 2017. Until March 2018, the median follow-up period was 18 months. At 12 months after surgery, food intake per meal (P = 0.021), Prognosis Nutritional Index (P = 0.015), weight loss (P = 0.019), and Gastrointestinal Symptom Rating Scale score (P = 0.015) of the functional jejunal interposition group were significantly worse than those of the Roux-en-Y group. There was no significant difference in operative time, intraoperative blood loss, perioperative complications, time of first flatus and defecation after surgery, postoperative plasma nutritional parameters, Visick score, Eastern Cooperative Group physical condition score, and survival rate.ConclusionFor patients with long-term survival after total gastrectomy for gastric cancer, the Roux-en-Y anastomosis is a better choice compared with functional jejunal interposition.     

间置空肠代胃吻合术与Roux-en-Y代胃手术对患者术后生存质量的影响

目的：探讨间置空肠代胃吻合术（jejunal interposition pouch,JIP）与Roux-en-Y代胃手术对患者术后生存质量影响的差异性。方法：回顾性分析本院2006年至2011年收治的45例胃癌患者。按手术方式分为两组,即采用间置空肠代胃吻合术与Roux-en-Y代胃手术。记录其手术时间、住院天数、早期并发症与晚期并发症以及术后患者营养性指标,评估患者术后生存质量的差异性。结果：两组在手术时间、住院天数与早期并发症发生率之间的差异性无统计学意义（P＞0．05）,而间置空肠代胃吻合术后远期并发症的发生率明显低于Roux-en-Y术式,其术后1年的营养状况更是优于Roux-en-Y术式,差异具有统计学意义（P＜0．05）。结论：间置空肠代胃吻合术相对于Roux-en-Y术式可以明显降低患者术后远期并发症的发生,且可以提高患者术后生存质量,值得推广。     

胃癌全胃切除术后三种消化道重建方法对比研究

目的:探讨胃癌全胃切除术后理想的消化道重建方式。方法:对98例胃癌患者按全胃切除术后消化道重建方式的不同,分为Lahey+Braun式食管空肠端侧吻合术（Ⅰ组,n=34)、P型空肠袢食管空肠Roux-en-Y吻合术（Ⅱ组,n=28）及改良功能性空肠间置代胃术（Ⅲ组,n=36)。比较3种术式患者术后并发症发生率及营养指标。结果:Ⅱ组和Ⅲ组术后患者的营养状况均明显优于Ⅰ组,P<0．05;Ⅱ组和Ⅲ组术后并发症也明显少于Ⅰ组,P<0．05。Ⅱ组与Ⅲ组患者的营养指标变化和术后并发症相比,除体重外均无明显差异,P>0．05。结论:全胃切除后P型空肠袢Roux-en-Y吻合术和改良功能性空肠间置代胃重建方式较Lahey+Braun式食管空肠端侧吻合术为胃癌行全胃切除消化道重建较理想的术式,更有利于患者的营养恢复及减少术后并发症发生率。     

全胃切除间置回盲部回肠"p"字代胃术

的　探讨全胃切除消化道重建的理想术式。方法　全胃切除术后利用带蒂的回盲部回肠制成“P”字代胃 ,自体的回盲瓣代替幽门 ,间置于食管和十二指肠间 ,形成“新胃”。结果　 2 0例病人术后 6个月均恢复一日三餐 ,平均每日进食量 5 80 g( 45 0～ 6 2 0 g) ,体重恢复或超过术前 16例 ,占 88.9% ( 16 / 18) ;代胃容积平均 385ml( 30 0～ 45 0m1) ,代胃排空时间平均 145分钟 ( 12 4～ 186m1)。全组无胸骨后疼痛 ,无食物、消化液返流等现象 ,无倾倒综合征 ,无脂肪性腹泻。 1、3年生存率为 :87.5 % ( 14/ 16 )和 6 0 % ( 6 / 10 )。结论　间置回盲部回肠“P”字代胃术是全胃切除消化道重建的理想术式 ,值得推广应用。     

Surgical results of proximal gastrectomy for early-stage gastric cancer: jejunal interposition and gastric tube reconstruction

Background. The frequency of tumors in the upper one-third of the stomach has been increasing. The standard operation for proximal gastric cancer has been total or proximal gastrectomy. The aim of this study was to present the pathologic and surgical results of 30 patients with early-stage proximal gastric cancer managed by proximal gastrectomy. Methods. A consecutive series of 30 patients who underwent proximal gastrectomy for early-stage proximal gastric cancer was studied. Sixteen patients underwent jejunal interposition, while 14 underwent gastric tube reconstruction, which consisted of a direct anastomosis between the esophagus and the remnant of the tube-like stomach. Results. Twenty patients (67%) had no abdominal symptoms and the lesions were detected by screening gastric fiberscopy. The tumors were mostly located along the lesser curvature (73%), were grossly depressed type (IIc) (70%), and histologically well differentiated type (63%). The depth of wall invasion was the mucosa in 12 patients, submucosa in 15, and muscularis propria in 3; lymph node metastasis was absent in 28 patients (93%). When compared with patients with jejunal interposition, patients with gastric tube reconstruction had a shorter operation time (327 vs 165 min), less blood loss (508 vs 151 g), and shorter hospital stay after operation (31 vs 17 days). Endoscopy and 24-h pH monitoring showed no evidence of reflux esophagitis, except in 1 patient with gastric tube reconstruction, and no patient died of recurrence. Conclusions. Early-stage proximal gastric cancer can be successfully treated by proximal gastrectomy. Since gastric tube reconstruction is a simple, easy, and safe procedure, proximal gastrectomy followed by gastric tube reconstruction is recommended for patients with early-stage proximal gastric cancer. Received for publication on Jan. 5, 1999; accepted on Feb. 10, 1999     

全胃切除术后FJI消化道重建的临床研究

Objective To investigate the optimum reconstruction after total gastrectomy for malignant disease, especially the necessity of gastric substitute and duodenal passage. Methods Among the 459 total gastrectomy cases, 6 kinds of reconstructions had been used, including Braun, modified Braun I (mBraun I), modified Braun II (mBraun II), Roux-en-Y, “P” jejunal interposition (PJI) and functional jejunal interposition (FJI). Postoperative complains, body weight, food intake, serum nutritional paraments, complete blood count, half-emptying time of the gastric substitute, PNI, Visick index were evaluated one year after surgery. Results As compared with Braun group, the mBraun I, II and Roux-en-Y groups which had some kinds of gastric substitute showed less reflux esophagitis and higher serum total protein (P<0.01). As compared with mBraun I, II, Roux-en-Y, PJI and FJI groups which had duodenal passage showed better body weight, higher nutritional paraments and PNI (P<0.05). Conclusion It is essential to construct a gastric substitute and maintain the food chyme flowing through the duodenum after total gastrectomy, and the FJI is a better choice in this study.     

Clinical results of various reconstructions employed after total gastrectomy

Methods of restoring continuity after total gastrectomy, particularly those creating a "reservoir," have led to many publications over the last 20 years. These publications are herein reviewed in an attempt to answer questions regarding the clinical value of a jejunal "reservoir". The conclusion we reached from this review was that such a reconstruction does reduce unpleasant symptoms, aids weight maintenance, and is a valuable operative approach.