奥卡西平联合左乙拉西坦对小儿癫痫认知功能、胶质纤维酸性蛋白的影响

目的分析奥卡西平联合左乙拉西坦对小儿癫痫认知功能、胶质纤维酸性蛋白的影响。方法选取2017年1月~2019年12月我院收治小儿癫痫患儿200例为研究对象,随机分为对照组和观察组,各100例。对照组给予奥卡西平治疗,研究组在对照组的基础上联合左乙拉西坦治疗,比较两组患儿的疗效、认知功能、胶质纤维酸性蛋白(GFAP)水平及不良反应发生情况。结果研究组总有效率高于对照组,差异有统计学意义(P<0.05);治疗后,研究组患儿认知功能评分高于对照组,GFAP水平低于对照组,差异有统计学意义(P<0.05);两组患儿不良反应发生率比较,差异无统计学意义(P>0.05)。结论奥卡西平联合左乙拉西坦治疗小儿癫痫,可提高疗效及患儿认知功能,降低GFAP水平,不良反应较少,安全性高,值得推广应用。     

卡马西平、左乙拉西坦对伴中央-颞区棘波的良性癫痫患儿认知功能的影响

目的:比较卡马西平、左乙拉西坦对伴中央-颞区棘波的良性癫痫患儿认知功能的影响。方法:选择诊断明确的伴中央-颞区棘波的良性癫痫患儿80例随机分为卡马西平和左乙拉西坦组,均治疗6个月。比较两组患儿治疗前后脑电图、P3潜伏期及认知功能的变化。结果:左乙拉西坦治疗组治疗后临床下痫样放电较卡马西平组减少,P3潜伏期缩短(均P<0.05)。治疗前后两组总智商(FIQ)差异无统计学意义(P>0.05)。左乙拉西坦治疗组儿童语言智商(VIQ)、操作智商(PIQ)较卡马西平组提高(P<0.05)。结论:左乙拉西坦对伴中央-颞区棘波的小儿良性癫痫患儿的认知功能有改善作用。     

丙戊酸钠联合左乙拉西坦治疗对癫痫患儿认知功能的影响

目的 分析丙戊酸钠联合左乙拉西坦治疗对癫痫患儿认知功能的影响.方法 选择2018年1月至2020年12月我院收治的癫痫患儿45例,随机分为观察组(23例)和对照组(22例).对照组单纯采用丙戊酸钠治疗,观察组此基础上采用左乙拉西坦治疗,对比两组的治疗效果、认知功能及不良反应发生率.结果 观察组治疗总有效率明显高于对照组...     

奥卡西平联合左乙拉西坦治疗卒中后癫痫的效果研究

目的 探讨奥卡西平联合左乙拉西坦治疗卒中后癫痫的长程脑电图特征。方法 收集2019年1月—2020年1月于齐齐哈尔医学院附属第二医院神经内科诊疗的卒中2周后且至少有2次间隔≥24 h的癫痫发作的患者60例。按照随机数字表法分为对照组（n=31）和联合组（n=29）。其中对照组给予奥卡西平治疗,联合组给予奥卡西平联合左乙拉西坦治疗,治疗后分析联合用药对卒中后癫痫脑电图、癫痫的影响。结果 治疗8个月后,两组患者的癫痫年发作次数和持续时间比较,联合组患者的癫痫年发作次数更短（P <0.05）。相较于对照组,联合组患者的癫痫发作持续时间显著缩短（P <0.05）;两组痫样放电均显著降低,并且联合组显著低于对照组（P <0.05）;两组累及导联数明显减少,联合组评分更高（P <0.05）。治疗总有效率比较,联合组（93.10%）高于对照组（67.74%）(P <0.05)。认知功能评分与治疗前比较,两组患者治疗后均显著提升,以联合组评分为著;联合组不良反应发生率（13.79%）高于对照组（9.68%）,差异无统计学意义（P> 0.05）。结论 奥卡西平联合左乙...     

不同抗癫痫新药对癫痫患儿血液系统的影响

目的探讨抗癫痫新药单药或联合用药对癫痫患儿血液系统指标的影响。方法观察并分析广东省人民医院2008年6月-2014年12月收治的70例癫痫患儿在抗癫痫新药单药或联合用药至少1年后血白细胞、血小板、血红蛋白含量的变化,以同期门诊20例健康体检儿童作为对照组。结果奥卡西平联合拉莫三嗪治疗癫痫患儿6个月及12个月均引起白细胞及血小板计数显著降低,与对照组相比差异有统计学意义(P0.05);奥卡西平联合左乙拉西坦治疗癫痫患儿6个月白细胞计数明显降低,与对照组比较差异有统计学意义(P0.05);左乙拉西坦联合托吡酯治疗癫痫患儿12个月白细胞计数明显降低,与对照组比较差异有统计学意义(P0.05);其他联合用药或单用抗癫痫新药对血液系统指标无明显影响(P0.05)。结论奥卡西平联合拉莫三嗪会引起癫痫患儿白细胞及血小板计数降低,奥卡西平联合左乙拉西坦及左乙拉西坦联合托吡酯治疗会引起癫痫患儿白细胞计数降低;其他抗癫痫新药联合用药或单用抗癫痫新药对血液系统指标无明显影响。     

不同抗癫痫药物对患儿血清尿酸的影响

目的为了解不同抗癫痫药物治疗癫痫患儿对其血清尿酸水平的影响。方法前瞻性对178例癫痫患儿采用尿酸酶-过氧化物酶偶联法检测了其服药前后血清尿酸水平,并与正常对照组对照。结果在平均服药(2.71±2.23)年后,丙戊酸钠组、左乙拉西坦组、丙戊酸钠联合左乙拉西坦组、丙戊酸钠联合奥卡西平组、丙戊酸钠联合拉莫三嗪组及多药组(丙戊酸钠、奥卡西平、左乙拉西坦、拉莫三嗪、妥泰)血清尿酸水平较服药前增高,差异有统计学意义(t值分别为5.45、4.93、3.43、2.44、4.47、3.77,均P<0.05),而奥卡西平联合左乙拉西坦组服药前后差异无统计学意义(t=1.53,P>0.05)。其中丙戊酸钠组、左乙拉西坦组、丙戊酸钠联合奥卡西平组,多药组血清尿酸水平高于正常对照组,差异有统计学意义(t值分别为3.50、2.94、3.21、2.59,均P<0.05)。结论不同抗癫痫药物对血清尿酸水平影响不同,提示临床医生注意定期监测服用抗癫痫药物患儿血清尿酸水平变化以便早期发现肾功能损伤。     

羚羊角颗粒联合左乙拉西坦治疗小儿癫痫的临床研究

目的 探讨羚羊角颗粒联合左乙拉西坦治疗小儿癫痫的临床效果.方法 112例小儿癫痫患儿随机分为两组各56例,对照组给予左乙拉西坦治疗,观察组给予羚羊角颗粒联合左乙拉西坦治疗,比较两组患儿的临床疗效、不良反应以及认知功能.结果 观察组的治疗总有效率为89.29％,显著高于对照组的73.21％(P<0.05).观察组的不良反...     

左乙拉西坦治疗小儿癫痫的临床疗效和安全性分析

目的观察分析左乙拉西坦治疗小儿癫痫的临床疗效和安全性。方法选取我院2014年1月至2016年1月收治的癫痫患儿200例,随机分为观察组和对照组各100例。对照组给予丙戊酸钠治疗,观察组给予左乙拉西坦治疗。观察两组患儿的治疗效果及不良反应发生情况。结果观察组患儿的临床治疗总有效率为95.0%,显著高于对照组的77.0%,差异具有统计学意义(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论采用左乙拉西坦治疗小儿癫痫,有利于缓解患儿的临床症状,提高治疗总有效率,不良反应发生率低,安全可靠。     

左乙拉西坦治疗小儿癫痫的临床疗效分析

目的:探讨分析左乙拉西坦治疗小儿癫痫的临床疗效。方法:选取我院2018年4月至2019年收治的小儿癫痫患儿52例作为本次研究对象,分为两组,其中2018年4月至2018年9月26例为对照组,给予奥卡西平治疗;2018年10月至2019年3月26例为观察组,给予左乙拉西坦治疗,比较两组患儿的临床疗效和不良反应发生情况。结果:两组的临床疗效相比,治疗后对照组治疗有效率80.77%(21/26)低于观察组92.31%(24/26);两组的不良反应发生情况相比,对照组不良反应发生率11.54%(3/26)高于观察组3.45%(1/26),均具显著差异和统计学意义(P0.05)。结论:左乙拉西坦应用于小儿癫痫的临床治疗,疗效显著,不良反应少,安全性较高,是治疗小儿癫痫的理想药物。     

左乙拉西坦联合托吡酯治疗儿童难治性癫痫综合征的临床效果

目的观察左乙拉西坦(Levetiracetam,LEV)联合托吡酯治疗儿童难治性癫痫综合征(Lennox-Gastaut,LGS)的临床效果。方法将诊断为LGS的患儿分为左乙拉西坦联合托吡酯治疗组和左乙拉西坦对照组,每组各20例。治疗组患儿给予左乙拉西坦联合托吡酯干预,对照组患儿给予左乙拉西坦单药干预,治疗8周后比较治疗组与对照组的临床疗效。比较LEV联合治疗组前后患儿头颅磁共振波谱、脑电图棘慢波指数的变化,同时采用中国修订版韦氏儿童智力量表(WISC-R)作为评定工具,对LEV联合治疗组治疗前后对儿童进行智力测试及评定。结果左乙拉西坦联合托吡酯治疗组临床有效率为90%,左乙拉西坦对照组临床有效率为60%,两组病例统计学比较有显著性差异(P0.01)。治疗组患儿头颅磁共振波谱NAA(N-乙酰天门冬氨酸)峰值升高,脑电图棘慢波指数较治疗前明显减少,患儿认知功能明显改善,差异有统计学意义(P0.01)。结论LEV联合托吡酯治疗LGS综合征疗效好,值得临床广泛运用。     

丙硫氧嘧啶联合甲巯咪唑治疗对甲亢患者甲状腺功能及肝功能的影响

目的 探讨丙硫氧嘧啶联合甲巯咪唑治疗对甲亢患者甲状腺功能及肝功能的影响.方法 选取甲亢患者100例,随机分为两组各51例.对照组给予丙硫氧嘧啶治疗,观察组给予丙硫氧嘧啶联合甲巯咪唑治疗.比较两组的甲状腺功能及肝功能.结果 治疗3个月后,观察组的TSH水平显著高于对照组,TT3、FT3、FT4水平均显著低于对照组(P<0...     

PDCA循环在缩短肺功能患者等候时间中的作用

目的：探讨PDCA在缩短肺功能患者等候时间中的作用。方法：通过调取2018年3月19~4月19日肺功能工作量与2017年同期对比，查找患者等候时间长的原因。结果：通过完善绩效考核体系、设定基础工作量、加强科室内部协调等措施，有效缩短了患者等候时间，提高了工作效率。结论：通过PDCA循环，不仅缩短了患者等候时间和呼吸科平均住院日，还提高了患者满意度，使科室内部合作更加协调与紧密。     

Self-Reports of Hand Function in Persons with Diabetes

ABSTRACT

The purpose of this study was to examine the reliability and validity of three self-reports of hand function for persons with diabetes. Thirty-six people with type II diabetes completed self-report questionnaires of hand function including the Hand Function Disability Scale (HFDS), Michigan Hand Outcomes Questionnaire (MHQ), and Dreiser's Functional Hand Index (DFI) at two points in time to assess test–retest reliability. To determine validity, participants were also administered performance-based tests of hand strength, dexterity, and joint motion using the Keital Function Test, and Hand Mobility in Scleroderma Test. Test–retest reliability intraclass correlation coefficients for test–retest reliability ranged from 0.89 to 0.96 for the HFDS; 0.58 to 0.94 for the MHQ; and 0.90 for the DFI. Spearman Rho correlations showed fair correlations between the HFDS and applied hand strength. Fair correlations were also found between the scores on the MHQ and hand strength and joint motion, while scores on the DFI did not correlate with hand strength, dexterity, or joint motion. Overall, the HFDS and the MHQ appear to be reliable and valid measures of hand function in persons with diabetes and may help occupational therapists determine the level of difficulty with daily tasks and monitor outcomes of therapy in persons with diabetes.     

Sexual Function in Men with Traumatic Brain Injury

Traumatic brain injury has been linked with higher incidence of sexual problems. As there have been few published reports regarding sexual functioning in men with traumatic brain injury in Latin America, this study sought to compare sexual measures in men with traumatic brain injury with healthy controls. The hypotheses that males with TBI would experience significantly lower indices of sexual functioning compared to unaffected individuals and that increased age and injury severity would predict lower sexual functioning among participants with TBI were tested. Seventy-one Spanish-speaking Colombian men with a history of moderate to severe TBI who were at least 6 months post-injury, and 71 healthy controls participated by completing the Sexual Desire Inventory, International Index of Erectile Function, Index of Premature Ejaculation, Sexual Quality of Life Questionnaire, Index of Sexual Satisfaction. SPSS 22 was used to analyze the results. When compared to matched controls, males with TBI had significantly lower overall and dyadic sexual desire, sexual satisfaction and sexual quality of life. Erectile functioning, ejaculation control, satisfaction with ejaculation control were reported to by lower in the TBI group than in the control group. Almost 44% of participants with TBI had moderate to severe erectile dysfunction, whereas nearly 10% of the control group had the same.     

Cognitive Function in Adults with Enduring Anorexia Nervosa

Anorexia Nervosa (AN) is a severe and often enduring disorder characterized by restriction of food intake, low body weight, fear of weight gain, and distorted body image. Investigations on cognition performance in AN patients have yielded conflicting results. Using an established and sensitive computerized cognitive test battery, we aimed to assess core aspects of cognitive function, including attention span, information processing, reasoning, working and episodic memory, in AN patients and controls. Patients were recruited from the Danish Prospective Longitudinal all-comer inclusion study in Eating Disorders (PROLED). Included were 26 individuals with AN and 36 healthy volunteers (HV). All were tested with CogTrack (an online cognitive assessment system) at baseline, and AN patients were tested again at a follow-up time point after weight increase (n = 13). At baseline, AN patients showed faster reaction times in the attention tasks, as well as increased accuracy in grammatical reasoning compared to HV. There were no differences in cognitive function between AN patients and HV in the other cognitive domains measured (sustained attention, working and episodic memory, speed of retrieval, and speed of grammatical reasoning). No differences were visible in the AN sample between baseline and follow-up. Performance did not correlate with any clinical variables in the AN sample. These findings supplement results from other studies suggesting increased concentration and reasoning accuracy in patients suffering from AN, who showed increased performance in cognitive tasks despite their illness.     

Pulmonary Function Testing in Children with the Airflometer

Use of the airflometer (AFM) as an inexpensive apparatus for routine screening of pulmonary function has been hindered by the lack of established norms of AFM readings for young children. Using both the airflometer and the vitalograph, lung function was measured in 828 children, aged five to 11 years, randomly selected from six schools. Results indicate that girls aged five, 8–11 years have lower Forced Vital Capacity (FVC), Forced Expiratory Volume in one second (FEV₁, and AFM scores than boys. High correlations were observed between AFM units and FEV₁ (0.93), between height and FEV₁ (0.88), and between FVC (0.89) and AFM units (0.84). Regression equations are given to enable prediction of AFM from height and from age for boys and girls. Tables indicate scores that should be followed with further pulmonary function testing. A protocol is outlined to enable the airflometer to be used as a first level screening device.     

Exocrine Pancreatic Function in Girls with Anorexia Nervosa

Objectives: To assess pancreatic exocrine function in patients with anorexia nervosa using a breath test with ¹³C-labeled mixed triglycerides (MTG-BT) and to determine the relationship between the test results and selected biochemical and hormonal parameters. Material and methods: Anthropometric measurements, biochemical and hormonal parameters (serum leptin, soluble leptin receptor (sLR), acylated and desacylated ghrelin, free leptin index (FLI)), and MTG-BT were performed in a group of 31 girls with the restrictive type of AN, as well as 38 healthy girls (C). Results: The average cumulative dose of ¹³C-triglycerides recovered with exhaled air (%CD) was similar in both study groups, while the average time from ¹³C-triglycerides administration to peak ¹³CO₂ excretion in expired air (time to peak (TTP)) was significantly longer in patients with AN compared to C. In both groups, %CD correlated negatively with FLI. TTP correlated negatively with sLR and FLI in the AN and with serum insulin and HOMA-IR values in the C. Conclusions: In girls with AN, the pancreatic efficiency of lipase secretion was found to be normal, while the kinetics of this enzyme secretion were disturbed. These changes may result from disorders in the functioning of the adipose–insular and islet–acinar axes.     

Brunnstrom技术联合针灸对脑卒中软瘫期患者神经功能及认知功能的影响

目的探讨Brunnstrom技术联合针灸对脑卒中软瘫期患者神经功能及认知功能的影响。方法选择2017年6月至2019年6月我院收治的脑卒中软瘫期患者118例,随机分为观察组(59例)和对照组(59例)。对照组采用针灸治疗,观察组在对照组基础上联合Brunnstrom技术治疗。对比两组患者治疗前后的NIHSS评分与MMSE评分。结果治疗后,观察组的NIHSS评分为(8.16±2.41)分,明显低于对照组的(12.80±3.14)分(P<0.05);观察组的MMSE评分为(27.23±2.55)分,明显高于对照组的(24.14±3.74)分(P<0.05)。结论Brunnstrom技术联合针灸对脑卒中软瘫期患者的临床效果显著,可有效改善患者的神经功能,提高其认知功能。     

BiPAP对重叠综合征患者心功能及血管内皮功能的作用机制研究

目的探析BiPAP呼吸机治疗重叠综合征患者对其血管内皮功能及心功能的作用机制。方法选取2013年7月至2014年7月我院收治的94例重叠综合征患者为研究对象,按治疗方法的不同分为实验组和对照组各47例,对照组实施常规疗法,实验组在常规疗法的基础上实施BiPAP无创呼吸机疗法。比较两组患者的临床总有效率、心功能以及血管内皮功能变化情况。结果实验组的临床总有效率为85.1%,显著高于对照组的59.6%,差异具有统计学意义(P<0.05);两组患者治疗后的脑钠肽水平、左心室Tei指数、右心室Tei指数等心功能指标以及血管内皮素-1、一氧化氮、凝血酶-Ⅲ等血管内皮功能指标均有改善,且实验组改善程度显著优于对照组,差异具有统计学意义(P<0.05)。结论采用BiPAP无创呼吸机治疗重叠综合征患者,对纠正二氧化碳潴留及缺氧情况有效,可显著改善患者的血管内皮功能及心功能,临床效果确切,值得推广。     

缺血性脑卒中偏瘫患者采用运动控制训练仪进行康复训练对其平衡功能和下肢功能的作用效果分析

目的 探讨缺血性脑卒中偏瘫患者采用运动控制训练仪进行康复训练,对其平衡功能和下肢功能的治疗效果.方法 选取2017年12月-2018年10月在大连港医院进行康复治疗的58例缺血性脑卒中偏瘫患者,随机分为对照组和观察组各29例,对照组采用常规康复训练,观察组主要使用运动控制训练仪进行康复治疗,比较两组治疗8周后的平衡功能和下肢功能.结果 治疗后,观察组的下肢功能、平衡功能、躯干控制能力评分及起立-步行测试均优于对照组,差异均具有统计学意义(P<0.05).结论 运动控制训练仪能够有效改善缺血性脑卒中偏瘫患者的下肢功能和平衡功能,值得在有条件的医疗机构推广使用,以改善脑卒中偏瘫患者的预后.