Low-fluence Q-switched Nd:YAG 1064-nm laser versus Q-switched Nd:YAG 532-nm laser in the treatment of hyperpigmented lips: a prospective,randomized, controlled,evaluator-blinded trial

Lasers in Medical Science - Lip hyperpigmentation is an esthetic problem. Clinical data from controlled comparative studies is insufficient to support the efficacy of laser treatments for...     

Q-开关Nd:YAG激光治疗外源性皮肤色素性病变124例

目的：观察Q-开关Nd：YAG激光治疗外源性皮肤色素性病变的临床效果。方法：用Q-开关Nd：YAG激光1064nm波长治疗黑色、灰色或蓝色皮肤色素性病变；532nm波长治疗红色色素性病变，共计124例。结果：此方法可明显去除外源性皮肤色素性病变，效果好、无瘢痕产生，但需多次治疗。结论：Q-开关Nd：YAG激光治疗外源性皮肤色素性病变安全有效。     

强脉冲光联合调Q激光治疗色素增生性皮肤病

目的探讨强脉冲光联合调Q激光疗法对面部色素增生性皮肤病的疗效及安全性。方法根据患者面部色素性疾病的特点,对225例FitzpatrickⅢ、Ⅳ型皮肤的色素细胞增生性皮肤病患者,采用560nm强脉冲光联合调Q532nm激光治疗,首先使用560nm强脉冲光,能量密度30～40J／cm2的光子嫩肤治疗,每月1次,3个月后观察疗效。对于改善不品著的脂溢性角化斑、咖啡斑及眼睑、口唇周围残留的雀斑等,再使用调Q532nm激光,施行局部针对性治疗,能量密度70J／cm2。于激光治疗后2个月,对皮损的改善和满意度进行评估并记录不良反应。结果90％患者的雀斑、咖啡斑、脂溢性角化斑的色素均有50％～70％不同程度的消退,同时毛细血管扩张、毛孔粗大、细小皱纹均达到了60％以上的程度的改善。主要并发症为暂时性红斑和水疱。结论560nm强脉冲光联合调Q激光治疗面部色素增生性皮肤病安全有效,同时能有效改善肤质。     

Laser transmission through membranes using the Q-switched Nd:YAG laser

BACKGROUND AND OBJECTIVE: Many laser centres utilise various transparent membranes during treatment sessions with Q-switched lasers to prevent or reduce tissue splatter, thereby reducing the aerosolised biohazard of cellular debris to operator and laser. STUDY DESIGN/MATERIALS AND METHODS: We performed a series of experiments with the Q-Switched Nd:YAG laser, a selection of 11 varieties of membrane and a power meter in order to ascertain which of the membranes was the most effective protector concerning transmission of laser energy. Other mechanical properties such as transparency, strength, ease of application, and flexibility were taken into account. RESULTS: Tegaderm (overall average 94% transmission), Cling Film (93%), Bioclusive (89%), Opsite (91%), and Microwave Cling Film (87%) all consistently performed well in pure transmission terms, whereas other membranes tested such as Acetate (74%), Grades of Melinex (75%, 72%, 75%), 2nd Skin (74%), and Perspex (68%) were unsuitable as protection. CONCLUSION: Cling Film proved to be the best all round membrane. We recommend its use for operator and laser protection against the tissue spatter produced from the Q-Switched Nd:YAG laser.     

Nd：YAG激光治疗外源性皮肤色素性疾病

目的观察NdYAG激光治疗外源性皮肤色素性疾病的疗效及并发症。方法用Q开关倍频Nd∶YAG激光治疗不同部位的外源性皮肤色素性疾病,用特定波长治疗不同颜色的纹身、纹眉及外伤性刺青等。结果共治疗406例,有效率达100％。结论NdYAG激光治疗如文眉、文身等外源性色素性疾病效果良好,对面积大、部位深的病变需多次治疗方可彻底治愈,较现有其它常规方法有更多的优点。     

A split-face study: comparison of picosecond alexandrite laser and Q-switched Nd:YAG laser in the treatment of melasma in Asians

To evaluate efficacy and safety of picosecond 755 nm alexandrite laser as compared to 1064 nm QS-Nd:YAG laser for melasma treatment in Asians. Twelve patients received 4 sessions of treatments at 1-month interval in a split-face manner. The right side of each patient’s face received 755 nm picosecond laser, and the other side received 1064 nm QS-Nd:YAG laser. Zoom handpiece of 755 nm picosecond laser at fluence of 0.88–1.18 J/cm² was applied. The treatment protocol used for 1064 nm QS-Nd:YAG laser was 8 mm spot size at fluence of 2.0 J/cm² initially followed by 6 mm spot size at fluence of 3.5 J/cm², and finishing with 4 mm spot size at 3.2 J/cm². For both 755 nm picosecond laser and 1064 nm QS-Nd:YAG laser, the endpoint was mild erythema and swelling without petechiae. Objective evaluation with visual analogue score was conducted by two independent physicians. Subject self-assessment for each patient was conducted as well. Statistical results showed that higher pigmentation clearance rate was achieved at the 755 nm picosecond laser side after the second treatment. At the 3 months follow-up, greater clearance was observed at the 755 nm picosecond laser side compared to the 1064 nm QS-Nd:YAG side. 755 nm alexandrite picosecond laser has been observed to achieve a faster and better clearance rate for melasma compared to 1064 nm QS-Nd:YAG laser. We conclude that the 755 nm picosecond laser could be a safe and effective modality for melasma treatment in Asians.     

调Q-开关钕∶钇-铝石榴子石激光治疗太田痣326例

目的观察调 Q-开关钕∶钇-铝石榴子石(Nd∶YAG)激光对太田痣的临床治疗效果.方法根据患者的不同年龄、性别以及太田痣色泽的深浅,选用不同的技术参数对326例患者进行治疗.结果调Q-开关Nd∶YAG激光治疗2～4次后, 221例疗效极显著,74例疗效显著,31例略有效果,总有效率达到90.5 %.治疗后多数患者创面皮肤出现程度不等的继发性色素沉着反应,通常经3个月左右逐渐自然消退.治疗后全部患者均无瘢痕形成.结论调Q-开关Nd∶YAG激光治疗太田痣疗效令人满意.     

长脉宽Nd:YAG激光治疗皮肤血管性病变的临床研究

目的 探讨波长为1064nm的长脉宽Nd:YAG激光治疗皮肤血管性疾病的疗效.方法 采用长脉宽Nd:YAG激光治疗鲜红斑痣、蜘蛛痣、毛细血管扩张等皮肤血管性病变,根据病变的不同选择不同的治疗参数,并对疗效进行分析.结果 本组患者215例获随访1年,长脉宽Nd:YAG激光治疗鲜红斑痣的痊愈率为15.4%,显效率为53.8%;治疗蜘蛛痣的痊愈率为76.8%,显效率为17.9%;治疗毛细血管扩张的痊愈率为18.6%,显效率为60.2%;治疗其他血管性病变的痊愈率为18.2%,显效率为54.5%.12例(5.6%)患者在术后发生了短暂性色素沉着;5例(2.3%)患者在术后发生了轻度瘢痕,无严重并发症发生.结论 长脉宽Nd:YAG 激光是一种治疗皮肤血管性病变安全、有效的方法.     

Q-switched Nd:YAG laser treatment for acquired bilateral nevus of ota-like maculae: a long-term follow-up

BACKGROUND AND OBJECTIVE: Acquired bilateral nevus of Ota-like maculae (ABNLM) is not an uncommon dermal melanosis in Asian people. It is known for its recalcitrance to conventional treatment. We proposed Q-switched Nd:YAG laser for the treatment of this entity. STUDY DESIGN/PATIENTS AND METHODS: Seventy female patients with ABNLM, who were 25-40 years old (mean, 37 years), were included in a prospective clinical study. Q-switched Nd:YAG laser at fluence of 8-10 J/cm(2), spot size 2 or 4 mm, and a repetition rate of 10 Hz was used to treat the lesions. RESULTS: Two patients were lost to follow-up. In the remaining 68 cases, all lesions attained a 100% clearance after two to five treatment sessions (mean, 2.8 sessions). The results had persisted at 3-4 years follow-up (mean, 42 months). Temporary hyperpigmentation was found in 50% of patients; there was no scarring or changing of skin texture. CONCLUSION: Q-switched Nd:YAG laser is a safe and effective noninvasive alternative treatment for ABNLM.     

Q开关Nd：YAG激光治疗色素性皮肤病5000例疗效观察

目的：观察Q开关Nd：YAG激光治疗色素性皮肤病的疗效、影响因素及副反应。方法：使用Q开关Nd：YAG激光治疗色素性皮肤病患者5000例,浅表性色素损害雀斑、咖啡斑和老年斑采用Q532nm波长,太田痣和文身采用Q1064nm波长。结果：本组患者经1～6次治疗,总有效率达96．14％,术后出现暂时性色素沉着269例（5．38％）,无瘢痕发生。结论：Q开关Nd：YAG激光治疗色素性皮肤病疗效较好,安全性高。     

非剥脱性Q开关Nd：YAG 1 064 nm激光对黄褐斑的治疗效果

目的 观察非剥脱性Q开关Nd：YAG 1 064 nm激光对黄褐斑的治疗效果.方法 应用Q开关Nd：YAG 1 064 nm激光对23例黄褐斑患者进行治疗,其光斑直径6 mm,脉宽5～7 ns,频率10 Hz,能量密度1.8～2.0 J/cm2.一般需8～10次治疗,每次治疗间隔1周.结果 23例经8～10次治疗后,黄褐斑明显淡化或消失,局部出现轻度充血,无水泡和结痂形成,基本治愈率达52.17%.5例出现眼睑紫癜,3 d后自行消退,无色素沉着及瘢痕发生.术后随访6个月以上,其中7例（占30.4%）出现复发,继续治疗仍然有效.结论 非剥脱性Q开关Nd：YAG 1 064 nm激光治疗黄褐斑虽有复发,仍不失为一种比较可行的治疗方法 ,有一定效果,操作简单、安全,不影响患者的工作和生活.     

非剥脱性Q开关Nd:YAG 1 064 nm激光对黄褐斑的治疗效果

目的 观察非剥脱性Q开关Nd:YAG 1 064 nm激光对黄褐斑的治疗效果.方法 应用Q开关Nd:YAG 1 064 nm激光对23例黄褐斑患者进行治疗,其光斑直径6 mm,脉宽5～7 ns,频率10 Hz,能量密度1.8～2.0 J/cm2.一般需8～10次治疗,每次治疗间隔1周.结果 23例经8～10次治疗后,黄褐斑明显淡化或消失,局部出现轻度充血,无水泡和结痂形成,基本治愈率达52.17%.5例出现眼睑紫癜,3 d后自行消退,无色素沉着及瘢痕发生.术后随访6个月以上,其中7例(占30.4%)出现复发,继续治疗仍然有效.结论 非剥脱性Q开关Nd:YAG 1 064 nm激光治疗黄褐斑虽有复发,仍不失为一种比较可行的治疗方法 ,有一定效果,操作简单、安全,不影响患者的工作和生活.     

非剥脱性Q开关Nd:YAG 1 064 nm激光对黄褐斑的治疗效果

目的 观察非剥脱性Q开关Nd:YAG 1 064 nm激光对黄褐斑的治疗效果.方法 应用Q开关Nd:YAG 1 064 nm激光对23例黄褐斑患者进行治疗,其光斑直径6 mm,脉宽5～7 ns,频率10 Hz,能量密度1.8～2.0 J/cm2.一般需8～10次治疗,每次治疗间隔1周.结果 23例经8～10次治疗后,黄褐斑明显淡化或消失,局部出现轻度充血,无水泡和结痂形成,基本治愈率达52.17%.5例出现眼睑紫癜,3 d后自行消退,无色素沉着及瘢痕发生.术后随访6个月以上,其中7例(占30.4%)出现复发,继续治疗仍然有效.结论 非剥脱性Q开关Nd:YAG 1 064 nm激光治疗黄褐斑虽有复发,仍不失为一种比较可行的治疗方法 ,有一定效果,操作简单、安全,不影响患者的工作和生活.     

The pulsed dye laser versus the Q-switched Nd:YAG laser in laser-induced shock-wave lithotripsy

To date, there are two fairly well-established alternatives for laser-induced shock-wave lithotripsy in clinical practice. The Q-switched Nd:YAG laser is distinguished by the high-stone selectivity of its coupler systems. The necessity of a coupler system and its fairly small conversion rate of light energy into mechanical energy present serious drawbacks. Furthermore, the minimal outer diameter of the transmission system is 1.8 mm. The pulsed-dye laser can be used with a highly flexible and uncomplicated 200-micron fiber. However, the laser system itself is more complicated than the Q-switched Nd:YAG laser and requires a great deal of maintenance. Biological evaluation of damage caused by direct irradiation shows that both laser systems produce minor damage of different degrees. YAG laser lithotripsy with the optomechanical coupler was assessed in 31 patients with ureteral calculi. The instability and limited effectiveness of the fiber application system necessitated auxiliary lithotripsy methods in 14 cases. Dye-laser lithotripsy is currently being tested in clinical application. Further development, such as systems for blind application or electronic feedback mechanisms to limit adverse tissue effects, have yet to be optimized. Nevertheless, laser-induced shock-wave lithotripsy has the potential to become a standard procedure in the endourologic management of stone disease.     

A study on the clinical characteristics of treating nevus of Ota by Q-switched Nd:YAG laser

The purpose of this study was to retrospectively analyze the clinical characteristics of treating nevus of Ota by Q-switched Nd:YAG laser in Laser Cosmetology Center of Department of Dermatology, the Second Hospital, Xi’an Jiaotong University. The data of 1168 patients of nevus of Ota were analyzed retrospectively, which included the correlation among lesion color, treatment sessions, sex, age, lesion types, and effect. The Q-switched (QS) Nd:YAG laser system had a higher number of treatment sessions which were positively associated with a better response to treatment. Other variables, including gender, age, the categorization of the lesion according to Tanino’s classification, and the color of the lesion, were not associated with the response to treatment. The treatment of nevus of Ota with QS Nd:YAG laser is safe and effective, with rare complications.     

Q-switched double frequency Nd:YAG 532-nm nanosecond laser vs. double frequency Nd:YAG 532-nm picosecond laser for the treatment of solar lentigines in Asians

Solar lentigines are common pigmentary lesions. Q-switched lasers are effective treatment options but postinflammatory hyperpigmentation (PIH) is common in darker skin. The objective of the study is to compare the efficacy and safety in solar lentigines of Asian skin treated by Q-switched potassium titanyl phosphate (KTP) 532-nm nanosecond laser vs. KTP 532-nm picosecond laser for the treatment of solar lentigines in Asians. Thirty patients with at least 2 solar lentigines on the upper extremities were enrolled. A total of 30 paired lentiginous lesions were randomly treated with a single treatment of either Q-switched KTP 532-nm nanosecond laser vs. KTP 532-nm picosecond laser. In terms of efficacy, mean luminance score was evaluated at baseline, at 6th, and 12th week. Degree of pigment clearance was assessed by a blinded physician and the patients. Satisfaction score was rated by patients using visual analogue scale. Adverse events were also recorded. Twenty-eight patients completed the study. Both lasers showed significant improvement in mean luminance score from baseline (p?<?0.05). Likewise, there was no significant difference in pigment clearance between two lasers either assessed by physician or patients. However, patients’ satisfaction score was significantly higher with the picosecond laser (p?=?0.014). Adverse events and pain were not different between groups. Q-switched KTP 532-nm nanosecond laser and KTP 532-nm picosecond laser are safe and effective for treating solar lentigines in Asians. Based on cost-effectiveness, Q-switched KTP 532-nm nanosecond laser remains the main treatment while KTP 532-nm picosecond laser can be considered as a treatment option.